Quantitative determination of the diagnostic accuracy of the synovitis score and its components
Identifieur interne : 000B07 ( Istex/Corpus ); précédent : 000B06; suivant : 000B08Quantitative determination of the diagnostic accuracy of the synovitis score and its components
Auteurs : Elisabeth Slansky ; Jialiang Li ; Thomas H Upl ; Lars Morawietz ; Veit Krenn ; Frank PesslerSource :
- Histopathology [ 0309-0167 ] ; 2010-09.
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Abstract
Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F
(2010) Histopathology 57, 436–443
Quantitative determination of the diagnostic accuracy of the synovitis score and its components
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DOI: 10.1111/j.1365-2559.2010.03641.x
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ISTEX:553D6B5A3C6FE12706F58F81E88ACF989200BBBELe document en format XML
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Carus’</mods:affiliation></affiliation><affiliation><mods:affiliation>University Children’s Hospital, Technical University of Dresden, Germany</mods:affiliation></affiliation></author><author><name sortKey="Li, Jialiang" sort="Li, Jialiang" uniqKey="Li J" first="Jialiang" last="Li">Jialiang Li</name><affiliation><mods:affiliation>Department of Biostatistics and Applied Probability, National University of Singapore, Singapore</mods:affiliation></affiliation></author><author><name sortKey="H Upl, Thomas" sort="H Upl, Thomas" uniqKey="H Upl T" first="Thomas" last="H Upl">Thomas H Upl</name><affiliation><mods:affiliation>Department of Rheumatology</mods:affiliation></affiliation></author><author><name sortKey="Morawietz, Lars" sort="Morawietz, Lars" uniqKey="Morawietz L" first="Lars" last="Morawietz">Lars Morawietz</name><affiliation><mods:affiliation>Institute for Pathology, Charité Universitätsmedizin, Berlin</mods:affiliation></affiliation></author><author><name sortKey="Krenn, Veit" 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(2010) Histopathology 57, 436–443
Quantitative determination of the diagnostic accuracy of the synovitis score and its components</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elisabeth Slansky</name><affiliations><json:string>Medical Faculty ‘Carl Gustav Carus’</json:string><json:string>University Children’s Hospital, Technical University of Dresden, Germany</json:string></affiliations></json:item><json:item><name>Jialiang Li</name><affiliations><json:string>Department of Biostatistics and Applied Probability, National University of Singapore, Singapore</json:string></affiliations></json:item><json:item><name>Thomas Häupl</name><affiliations><json:string>Department of Rheumatology</json:string></affiliations></json:item><json:item><name>Lars Morawietz</name><affiliations><json:string>Institute for Pathology, Charité Universitätsmedizin, Berlin</json:string></affiliations></json:item><json:item><name>Veit Krenn</name><affiliations><json:string>Centre for Histology, Cytology and Molecular Diagnostics, Trier</json:string></affiliations></json:item><json:item><name>Frank Pessler</name><affiliations><json:string>University Children’s Hospital, Technical University of Dresden, Germany</json:string><json:string>Helmholtz Centre for Infection Research, Braunschweig, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>osteoarthritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>receiver operating characteristic analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rheumatoid arthritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>synovitis</value></json:item></subject><articleId><json:string>HIS3641</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.446</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>188</abstractCharCount><pdfWordCount>4122</pdfWordCount><pdfCharCount>26752</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>27</abstractWordCount></qualityIndicators><title>Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title><refBibs><json:item><author><json:item><name>V Krenn</name></json:item><json:item><name>L Morawietz</name></json:item><json:item><name>GR Burmester</name></json:item></author><host><volume>49</volume><pages><last>364</last><first>358</first></pages><author></author><title>Histopathology</title></host><title>Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title></json:item><json:item><author><json:item><name>V Krenn</name></json:item><json:item><name>L Morawietz</name></json:item><json:item><name>GR Burmester</name></json:item><json:item><name>T Häupl</name></json:item></author><host><volume>64</volume><pages><last>342</last><first>334</first></pages><author></author><title>Z. 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Dai</name></json:item></author><host><volume>15</volume><pages><last>190</last><first>183</first></pages><author></author><title>Biomarkers</title></host><title>Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysis</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>57</volume><publisherId><json:string>HIS</json:string></publisherId><pages><total>8</total><last>443</last><first>436</first></pages><issn><json:string>0309-0167</json:string></issn><issue>3</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2559</json:string></eissn><title>Histopathology</title><doi><json:string>10.1111/(ISSN)1365-2559</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>cell 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xml:lang="en">Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>© 2010 Blackwell Publishing Limited</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title><author xml:id="author-1"><persName><forename type="first">Elisabeth</forename><surname>Slansky</surname></persName><affiliation>Medical Faculty ‘Carl Gustav Carus’</affiliation><affiliation>University Children’s Hospital, Technical University of Dresden, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Jialiang</forename><surname>Li</surname></persName><affiliation>Department of Biostatistics and Applied Probability, National University of Singapore, Singapore</affiliation></author><author xml:id="author-3"><persName><forename type="first">Thomas</forename><surname>Häupl</surname></persName><affiliation>Department of Rheumatology</affiliation></author><author xml:id="author-4"><persName><forename type="first">Lars</forename><surname>Morawietz</surname></persName><affiliation>Institute for Pathology, Charité Universitätsmedizin, Berlin</affiliation></author><author xml:id="author-5"><persName><forename type="first">Veit</forename><surname>Krenn</surname></persName><affiliation>Centre for Histology, Cytology and Molecular Diagnostics, Trier</affiliation></author><author xml:id="author-6"><persName><forename type="first">Frank</forename><surname>Pessler</surname></persName><affiliation>University Children’s Hospital, Technical University of Dresden, Germany</affiliation><affiliation>Helmholtz Centre for Infection Research, Braunschweig, Germany</affiliation></author></analytic><monogr><title level="j">Histopathology</title><idno type="pISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><idno type="DOI">10.1111/(ISSN)1365-2559</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-09"></date><biblScope unit="volume">57</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="436">436</biblScope><biblScope unit="page" to="443">443</biblScope></imprint></monogr><idno type="istex">553D6B5A3C6FE12706F58F81E88ACF989200BBBE</idno><idno type="DOI">10.1111/j.1365-2559.2010.03641.x</idno><idno type="ArticleID">HIS3641</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F
(2010) Histopathology 57, 436–443
Quantitative determination of the diagnostic accuracy of the synovitis score and its components</p></abstract><abstract><p>Aims: To assess the diagnostic accuracy of a three‐component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power.</p></abstract><abstract><p>Methods and results: The synovitis score was determined in 666 synovial specimens: normal synovium, n = 33; post‐traumatic arthropathy (PtA), n = 29; osteoarthritis (OA), n = 221; psoriatic arthritis (PsA), n = 42; and rheumatoid arthritis (RA), n = 341. The discriminatory abilities of the score and its components were quantified with binary and multicategory receiver operating characteristic (ROC) analysis. The score differentiated all arthropathies accurately from normal tissue (area under the ROC curve, AUC: 0.87–0.98) and RA from OA or PtA (AUC: 0.85 for both), but could not distinguish well within pairs of inflammatory or degenerative arthropathies. AUCs of the intimal hyperplasia and stromal cellularity components correlated with the AUCs of the complete score markedly more strongly (r = 0.94 and 0.91, respectively) than the inflammatory infiltration component (r = 0.60). Multicategory ROC analysis ranked the score several‐fold higher than any of its components, and the components in the order stromal cellularity>intimal hyperplasia>infiltration.</p></abstract><abstract><p>Conclusion: Combining three distinct histological parameters into a three‐component score produces greatly increased overall diagnostic power. The discriminatory ability of the score stems more from measuring proliferative than infiltrative aspects of synovitis.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>osteoarthritis</term></item><item><term>receiver operating characteristic analysis</term></item><item><term>rheumatoid arthritis</term></item><item><term>synovitis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/553D6B5A3C6FE12706F58F81E88ACF989200BBBE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" 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type="unit" value="HIS3641"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 Blackwell Publishing Limited</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.19 mode:FullText" date="2010-09-14"></event><event type="publishedOnlineFinalForm" date="2010-09-14"></event><event type="firstOnline" date="2010-09-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="436">436</numbering><numbering type="pageLast" number="443">443</numbering></numberingGroup><correspondenceTo>F Pessler, University Children’s Hospital, Division of Rheumatology/Immunology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. e‐mail: <email normalForm="frank.pessler@uniklinikum-dresden.de">frank.pessler@uniklinikum‐dresden.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HIS.HIS3641.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Date of submission 27 August 2009 Accepted for publication 19 January 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title><title type="shortAuthors"><i>E Slansky et al.</i></title><title type="short"><i>Diagnostic accuracy of the synovitis score</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Elisabeth</givenNames><familyName>Slansky</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>Jialiang</givenNames><familyName>Li</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4"><personName><givenNames>Thomas</givenNames><familyName>Häupl</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a5"><personName><givenNames>Lars</givenNames><familyName>Morawietz</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a6"><personName><givenNames>Veit</givenNames><familyName>Krenn</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2 #a7"><personName><givenNames>Frank</givenNames><familyName>Pessler</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Medical Faculty ‘Carl Gustav Carus’</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>University Children’s Hospital, Technical University of Dresden, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="SG"><unparsedAffiliation>Department of Biostatistics and Applied Probability, National University of Singapore, Singapore</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Department of Rheumatology</unparsedAffiliation></affiliation><affiliation xml:id="a5"><unparsedAffiliation>Institute for Pathology, Charité Universitätsmedizin, Berlin</unparsedAffiliation></affiliation><affiliation xml:id="a6"><unparsedAffiliation>Centre for Histology, Cytology and Molecular Diagnostics, Trier</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="DE"><unparsedAffiliation>Helmholtz Centre for Infection Research, Braunschweig, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">osteoarthritis</keyword><keyword xml:id="k2">receiver operating characteristic analysis</keyword><keyword xml:id="k3">rheumatoid arthritis</keyword><keyword xml:id="k4">synovitis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F
(2010) <i>Histopathology</i> <b>57</b>, 436–443
<b>Quantitative determination of the diagnostic accuracy of the synovitis score and its components</b></p><p><b>Aims: </b> To assess the diagnostic accuracy of a three‐component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power.</p><p><b>Methods and results: </b> The synovitis score was determined in 666 synovial specimens: normal synovium, <i>n</i> = 33; post‐traumatic arthropathy (PtA), <i>n</i> = 29; osteoarthritis (OA), <i>n</i> = 221; psoriatic arthritis (PsA), <i>n</i> = 42; and rheumatoid arthritis (RA), <i>n</i> = 341. The discriminatory abilities of the score and its components were quantified with binary and multicategory receiver operating characteristic (ROC) analysis. The score differentiated all arthropathies accurately from normal tissue (area under the ROC curve, AUC: 0.87–0.98) and RA from OA or PtA (AUC: 0.85 for both), but could not distinguish well within pairs of inflammatory or degenerative arthropathies. AUCs of the intimal hyperplasia and stromal cellularity components correlated with the AUCs of the complete score markedly more strongly (<i>r</i> = 0.94 and 0.91, respectively) than the inflammatory infiltration component (<i>r</i> = 0.60). Multicategory ROC analysis ranked the score several‐fold higher than any of its components, and the components in the order stromal cellularity>intimal hyperplasia>infiltration.</p><p><b>Conclusion: </b> Combining three distinct histological parameters into a three‐component score produces greatly increased overall diagnostic power. The discriminatory ability of the score stems more from measuring proliferative than infiltrative aspects of synovitis.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Diagnostic accuracy of the synovitis score</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Quantitative determination of the diagnostic accuracy of the synovitis score and its components</title></titleInfo><name type="personal"><namePart type="given">Elisabeth</namePart><namePart type="family">Slansky</namePart><affiliation>Medical Faculty ‘Carl Gustav Carus’</affiliation><affiliation>University Children’s Hospital, Technical University of Dresden, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jialiang</namePart><namePart type="family">Li</namePart><affiliation>Department of Biostatistics and Applied Probability, National University of Singapore, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Häupl</namePart><affiliation>Department of Rheumatology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Morawietz</namePart><affiliation>Institute for Pathology, Charité Universitätsmedizin, Berlin</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Veit</namePart><namePart type="family">Krenn</namePart><affiliation>Centre for Histology, Cytology and Molecular Diagnostics, Trier</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Pessler</namePart><affiliation>University Children’s Hospital, Technical University of Dresden, Germany</affiliation><affiliation>Helmholtz Centre for Infection Research, Braunschweig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-09</dateIssued><edition>Date of submission 27 August 2009 Accepted for publication 19 January 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent></physicalDescription><abstract>Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F
(2010) Histopathology 57, 436–443
Quantitative determination of the diagnostic accuracy of the synovitis score and its components</abstract><abstract>Aims: To assess the diagnostic accuracy of a three‐component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power.</abstract><abstract>Methods and results: The synovitis score was determined in 666 synovial specimens: normal synovium, n = 33; post‐traumatic arthropathy (PtA), n = 29; osteoarthritis (OA), n = 221; psoriatic arthritis (PsA), n = 42; and rheumatoid arthritis (RA), n = 341. The discriminatory abilities of the score and its components were quantified with binary and multicategory receiver operating characteristic (ROC) analysis. The score differentiated all arthropathies accurately from normal tissue (area under the ROC curve, AUC: 0.87–0.98) and RA from OA or PtA (AUC: 0.85 for both), but could not distinguish well within pairs of inflammatory or degenerative arthropathies. AUCs of the intimal hyperplasia and stromal cellularity components correlated with the AUCs of the complete score markedly more strongly (r = 0.94 and 0.91, respectively) than the inflammatory infiltration component (r = 0.60). Multicategory ROC analysis ranked the score several‐fold higher than any of its components, and the components in the order stromal cellularity>intimal hyperplasia>infiltration.</abstract><abstract>Conclusion: Combining three distinct histological parameters into a three‐component score produces greatly increased overall diagnostic power. The discriminatory ability of the score stems more from measuring proliferative than infiltrative aspects of synovitis.</abstract><subject lang="en"><genre>keywords</genre><topic>osteoarthritis</topic><topic>receiver operating characteristic analysis</topic><topic>rheumatoid arthritis</topic><topic>synovitis</topic></subject><relatedItem type="host"><titleInfo><title>Histopathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0309-0167</identifier><identifier type="eISSN">1365-2559</identifier><identifier type="DOI">10.1111/(ISSN)1365-2559</identifier><identifier type="PublisherID">HIS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>436</start><end>443</end><total>8</total></extent></part></relatedItem><identifier type="istex">553D6B5A3C6FE12706F58F81E88ACF989200BBBE</identifier><identifier type="DOI">10.1111/j.1365-2559.2010.03641.x</identifier><identifier type="ArticleID">HIS3641</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 Blackwell Publishing Limited</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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