Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection
Identifieur interne : 001B32 ( Istex/Corpus ); précédent : 001B31; suivant : 001B33Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection
Auteurs : G. Harms ; P. Binz ; H. Feldmeier ; K. Zwingenberger ; D. Schleehauf ; W. Dewes ; I. Kress-Hermesdorf ; C. Klindworth ; U. BienzleSource :
- Clinical Infectious Diseases [ 1058-4838 ] ; 1993-10.
Abstract
The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to T. spiralis after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.
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DOI: 10.1093/clinids/17.4.637
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Feldmeier</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zwingenberger, K" sort="Zwingenberger, K" uniqKey="Zwingenberger K" first="K." last="Zwingenberger">K. Zwingenberger</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schleehauf, D" sort="Schleehauf, D" uniqKey="Schleehauf D" first="D." last="Schleehauf">D. Schleehauf</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dewes, W" sort="Dewes, W" uniqKey="Dewes W" first="W." last="Dewes">W. Dewes</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kress Hermesdorf, I" sort="Kress Hermesdorf, I" uniqKey="Kress Hermesdorf I" first="I." last="Kress-Hermesdorf">I. Kress-Hermesdorf</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klindworth, C" sort="Klindworth, C" uniqKey="Klindworth C" first="C." last="Klindworth">C. Klindworth</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bienzle, U" sort="Bienzle, U" uniqKey="Bienzle U" first="U." last="Bienzle">U. 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Harms</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Binz, P" sort="Binz, P" uniqKey="Binz P" first="P." last="Binz">P. Binz</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Feldmeier, H" sort="Feldmeier, H" uniqKey="Feldmeier H" first="H." last="Feldmeier">H. Feldmeier</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zwingenberger, K" sort="Zwingenberger, K" uniqKey="Zwingenberger K" first="K." last="Zwingenberger">K. Zwingenberger</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schleehauf, D" sort="Schleehauf, D" uniqKey="Schleehauf D" first="D." last="Schleehauf">D. Schleehauf</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dewes, W" sort="Dewes, W" uniqKey="Dewes W" first="W." last="Dewes">W. Dewes</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kress Hermesdorf, I" sort="Kress Hermesdorf, I" uniqKey="Kress Hermesdorf I" first="I." last="Kress-Hermesdorf">I. Kress-Hermesdorf</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klindworth, C" sort="Klindworth, C" uniqKey="Klindworth C" first="C." last="Klindworth">C. Klindworth</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bienzle, U" sort="Bienzle, U" uniqKey="Bienzle U" first="U." last="Bienzle">U. Bienzle</name><affiliation><mods:affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1993-10">1993-10</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="637">637</biblScope><biblScope unit="page" to="643">643</biblScope></imprint><idno type="ISSN">1058-4838</idno></series><idno type="istex">CE18B3468CFD2EC9B97B9C4AA842553419C67BEB</idno><idno type="DOI">10.1093/clinids/17.4.637</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to T. spiralis after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>G. Harms</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>P. Binz</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>H. Feldmeier</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>K. Zwingenberger</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>D. Schleehauf</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>W. Dewes</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>I. Kress-Hermesdorf</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>C. Klindworth</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>U. Bienzle</name><affiliations><json:string>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</json:string></affiliations></json:item></author><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to T. spiralis after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.</abstract><qualityIndicators><score>8.562</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595.28 x 782.36 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1388</abstractCharCount><pdfWordCount>4210</pdfWordCount><pdfCharCount>26166</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>196</abstractWordCount></qualityIndicators><title>Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</title><refBibs><json:item><author><json:item><name>T Ancelle</name></json:item><json:item><name>J Dupouy-Camet</name></json:item><json:item><name>M-E 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Lennette</name></json:item><json:item><name>Ja Levy</name></json:item></author><host><volume>338</volume><pages><last>12</last><first>707</first></pages><author></author><title>Lancet</title><publicationDate>1991</publicationDate></host><title>Chronic fatigue syndrome: clinical condition associated with immune activation</title><publicationDate>1991</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>17</volume><publisherId><json:string>cid</json:string></publisherId><pages><last>643</last><first>637</first></pages><issn><json:string>1058-4838</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1537-6591</json:string></eissn><title>Clinical Infectious Diseases</title></host><categories><wos><json:string>science</json:string><json:string>microbiology</json:string><json:string>infectious diseases</json:string><json:string>immunology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>microbiology</json:string></scienceMetrix></categories><publicationDate>1993</publicationDate><copyrightDate>1993</copyrightDate><doi><json:string>10.1093/clinids/17.4.637</json:string></doi><id>CE18B3468CFD2EC9B97B9C4AA842553419C67BEB</id><score>0.71671534</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><p>© 1993 by The University of Chicago</p></availability><date>1993</date></publicationStmt><notesStmt><note>Reprints or correspondence: Dr. Gundel Harms, Landesinstitut fur Tropenmedizin, Engeldamm 62, 10179 Berlin, Germany.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</title><author xml:id="author-1" corresp="yes"><persName><forename type="first">G.</forename><surname>Harms</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">P.</forename><surname>Binz</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">H.</forename><surname>Feldmeier</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">K.</forename><surname>Zwingenberger</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">D.</forename><surname>Schleehauf</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">W.</forename><surname>Dewes</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">I.</forename><surname>Kress-Hermesdorf</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-8"><persName><forename type="first">C.</forename><surname>Klindworth</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author><author xml:id="author-9"><persName><forename type="first">U.</forename><surname>Bienzle</surname></persName><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation></author></analytic><monogr><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="pISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1993-10"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="637">637</biblScope><biblScope unit="page" to="643">643</biblScope></imprint></monogr><idno type="istex">CE18B3468CFD2EC9B97B9C4AA842553419C67BEB</idno><idno type="DOI">10.1093/clinids/17.4.637</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1993</date></creation><abstract><p>The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to T. spiralis after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.</p></abstract></profileDesc><revisionDesc><change when="1993-10">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title>Clinical Infectious Diseases</journal-title><abbrev-journal-title>Clinical Infectious Diseases</abbrev-journal-title><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>The University of Chicago Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/clinids/17.4.637</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Infectious Disease Articles</subject></subj-group></article-categories><title-group><article-title>Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Harms</surname><given-names>G.</given-names></name><xref rid="cor1" ref-type="corresp"></xref></contrib><contrib contrib-type="author"><name><surname>Binz</surname><given-names>P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Feldmeier</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zwingenberger</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schleehauf</surname><given-names>D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dewes</surname><given-names>W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kress-Hermesdorf</surname><given-names>I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Klindworth</surname><given-names>C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bienzle</surname><given-names>U.</given-names></name></contrib><aff>From the <institution>Institute of Tropical Medicine</institution>, <addr-line>Berlin</addr-line>; the <institution>Clinic for Neurology and Psychiatry</institution>, <addr-line>Trier</addr-line>; and the <institution>Section of MR-Tomography, University of the Saarland</institution>, <addr-line>Homburg/Saar</addr-line>, <country>Germany</country></aff></contrib-group><author-notes><corresp id="cor1">Reprints or correspondence: Dr. Gundel Harms, Landesinstitut fur Tropenmedizin, Engeldamm 62, 10179 Berlin, Germany.</corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>1993</year></pub-date><volume>17</volume><issue>4</issue><fpage>637</fpage><lpage>643</lpage><history><date date-type="received"><day>4</day><month>12</month><year>1992</year></date><date date-type="rev-recd"><day>23</day><month>3</month><year>1993</year></date></history><copyright-statement>© 1993 by The University of Chicago</copyright-statement><copyright-year>1993</copyright-year><abstract><p>The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with <italic>Trichinella spiralis</italic>, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to <italic>T. spiralis</italic> after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">G.</namePart><namePart type="family">Harms</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Binz</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Feldmeier</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Zwingenberger</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Schleehauf</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Dewes</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Kress-Hermesdorf</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Klindworth</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Bienzle</namePart><affiliation>Institute of Tropical Medicine, Berlin, Trier, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">1993-10</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we conducted a prospective controlled study of the patients involved. At the termination of this investigation, we undertook clinical, biochemical, serological, immunologic, neuroradiological, radiological, and psychological studies of 128 originally infected persons and 16 controls. The categories of symptoms most often documented in persons who had been infected were muscular (90%), ocular (59%), neurological (52%), and psychological (52%). Impaired muscle strength (56%), conjunctivitis (55%), and impaired coordination (32%) were the clinical manifestations most frequently encountered. Thirty-eight percent of the 128 originally infected patients still had IgG antibodies to T. spiralis after 10 years. Magnetic resonance imaging of the brain revealed no abnormalities. No calcifications of residual larvae were detected by mammography or muscle biopsy. The level of performance in psychometric tests was lower in the originally infected population than in the general population. Although patients who had had trichinosis differed significantly from controls in terms of a variety of parameters even after 10 years, we found insufficient evidence on which to conclude that chronic trichinosis exists as a distinct entity.</abstract><note type="author-notes">Reprints or correspondence: Dr. Gundel Harms, Landesinstitut fur Tropenmedizin, Engeldamm 62, 10179 Berlin, Germany.</note><relatedItem type="host"><titleInfo><title>Clinical Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Clinical Infectious Diseases</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1058-4838</identifier><identifier type="eISSN">1537-6591</identifier><identifier type="PublisherID">cid</identifier><identifier type="PublisherID-hwp">cid</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>637</start><end>643</end></extent></part></relatedItem><identifier type="istex">CE18B3468CFD2EC9B97B9C4AA842553419C67BEB</identifier><identifier type="DOI">10.1093/clinids/17.4.637</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1993 by The University of Chicago</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/covers/tiff</uri></json:item></covers><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CE18B3468CFD2EC9B97B9C4AA842553419C67BEB/annexes/pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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