EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS
Identifieur interne : 001A56 ( Istex/Corpus ); précédent : 001A55; suivant : 001A57EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS
Auteurs : Ali Reza Waladkhani ; Michael R. Clemens ; J. Christian Bode ; Christiane BodeSource :
- Alcohol and Alcoholism [ 0735-0414 ] ; 1996-09.
Abstract
The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of Δ6-and Δ5-desaturases.
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DOI: 10.1093/oxfordjournals.alcalc.a008180
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Clemens</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bode, J Christian" sort="Bode, J Christian" uniqKey="Bode J" first="J. Christian" last="Bode">J. Christian Bode</name><affiliation><mods:affiliation>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin Abteilung I 70376 Stuttgart, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bode, Christiane" sort="Bode, Christiane" uniqKey="Bode C" first="Christiane" last="Bode">Christiane Bode</name><affiliation><mods:affiliation>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie 70593 Stuttgart, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:36150FAB8339AC3CD137982D68B8ABBD84A982C4</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1093/oxfordjournals.alcalc.a008180</idno><idno type="url">https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A56</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</title><author><name sortKey="Waladkhani, Ali Reza" sort="Waladkhani, Ali Reza" uniqKey="Waladkhani A" first="Ali Reza" last="Waladkhani">Ali Reza Waladkhani</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</mods:affiliation></affiliation></author><author><name sortKey="Clemens, Michael R" sort="Clemens, Michael R" uniqKey="Clemens M" first="Michael R." last="Clemens">Michael R. Clemens</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bode, J Christian" sort="Bode, J Christian" uniqKey="Bode J" first="J. Christian" last="Bode">J. Christian Bode</name><affiliation><mods:affiliation>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin Abteilung I 70376 Stuttgart, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bode, Christiane" sort="Bode, Christiane" uniqKey="Bode C" first="Christiane" last="Bode">Christiane Bode</name><affiliation><mods:affiliation>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie 70593 Stuttgart, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Alcohol and Alcoholism</title><idno type="ISSN">0735-0414</idno><idno type="eISSN">1464-3502</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1996-09">1996-09</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="469">469</biblScope></imprint><idno type="ISSN">0735-0414</idno></series><idno type="istex">36150FAB8339AC3CD137982D68B8ABBD84A982C4</idno><idno type="DOI">10.1093/oxfordjournals.alcalc.a008180</idno><idno type="ArticleID">31.5.463</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0735-0414</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of Δ6-and Δ5-desaturases.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>ALI REZA WALADKHANI</name><affiliations><json:string>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</json:string></affiliations></json:item><json:item><name>MICHAEL R. CLEMENS</name><affiliations><json:string>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</json:string></affiliations></json:item><json:item><name>J. CHRISTIAN BODE</name><affiliations><json:string>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin Abteilung I 70376 Stuttgart, Germany</json:string></affiliations></json:item><json:item><name>CHRISTIANE BODE</name><affiliations><json:string>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie 70593 Stuttgart, Germany</json:string></affiliations></json:item></author><subject><json:item><value>Articles</value></json:item></subject><articleId><json:string>31.5.463</json:string></articleId><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. 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sciences</json:string><json:string>public health & health services</json:string><json:string>substance abuse</json:string></scienceMetrix></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1093/oxfordjournals.alcalc.a008180</json:string></doi><id>36150FAB8339AC3CD137982D68B8ABBD84A982C4</id><score>0.40527767</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>© 1996 Medical Council on Alcoholism</p></availability><date>1996</date></publicationStmt><notesStmt><note>*Author to whom correspondence should be addressed</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</title><author xml:id="author-1"><persName><forename type="first">ALI REZA</forename><surname>WALADKHANI</surname></persName><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">MICHAEL R.</forename><surname>CLEMENS</surname></persName><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">J. CHRISTIAN</forename><surname>BODE</surname></persName><affiliation>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin Abteilung I 70376 Stuttgart, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">CHRISTIANE</forename><surname>BODE</surname></persName><affiliation>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie 70593 Stuttgart, Germany</affiliation></author></analytic><monogr><title level="j">Alcohol and Alcoholism</title><idno type="pISSN">0735-0414</idno><idno type="eISSN">1464-3502</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1996-09"></date><biblScope unit="volume">31</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="469">469</biblScope></imprint></monogr><idno type="istex">36150FAB8339AC3CD137982D68B8ABBD84A982C4</idno><idno type="DOI">10.1093/oxfordjournals.alcalc.a008180</idno><idno type="ArticleID">31.5.463</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><abstract><p>The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of Δ6-and Δ5-desaturases.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-09">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">alcalc</journal-id><journal-id journal-id-type="publisher-id">alcalc</journal-id><journal-id journal-id-type="pmc">alcalc</journal-id><journal-title>Alcohol and Alcoholism</journal-title><issn pub-type="epub">1464-3502</issn><issn pub-type="ppub">0735-0414</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31.5.463</article-id><article-id pub-id-type="doi">10.1093/oxfordjournals.alcalc.a008180</article-id><article-categories><subj-group><subject>Articles</subject></subj-group></article-categories><title-group><article-title>EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>WALADKHANI</surname><given-names>ALI REZA</given-names></name></contrib><contrib contrib-type="author"><name><surname>CLEMENS</surname><given-names>MICHAEL R.</given-names></name><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>BODE</surname><given-names>J. CHRISTIAN</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>BODE</surname><given-names>CHRISTIANE</given-names></name><xref ref-type="aff" rid="au2"><sup>2</sup></xref></contrib><aff><institution>Krankenanstalt Mutterhaus der Borromäerinnen</institution> <addr-line>54219 Trier, Germany</addr-line></aff><aff id="au1"><sup>1</sup><institution>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin</institution> <addr-line>Abteilung I 70376 Stuttgart, Germany</addr-line></aff><aff id="au2"><sup>2</sup><institution>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie</institution> <addr-line>70593 Stuttgart, Germany</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><sup>*</sup>Author to whom correspondence should be addressed</corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>1996</year></pub-date><volume>31</volume><issue>5</issue><fpage>463</fpage><lpage>469</lpage><history><date date-type="received"><day>25</day><month>9</month><year>1995</year></date><date date-type="rev-recd"><day>13</day><month>6</month><year>1996</year></date><date date-type="accepted"><day>13</day><month>6</month><year>1996</year></date></history><copyright-statement>© 1996 Medical Council on Alcoholism</copyright-statement><copyright-year>1996</copyright-year><abstract><p>The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of Δ6-and Δ5-desaturases.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>EFFECT OF METHIONINE ON THE FATTY ACID COMPOSITION OF CELLULAR MEMBRANES IN RATS WITH CHRONIC ETHANOL CONSUMPTION AND JEJUNOILEAL BYPASS</title></titleInfo><name type="personal"><namePart type="given">ALI REZA</namePart><namePart type="family">WALADKHANI</namePart><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MICHAEL R.</namePart><namePart type="family">CLEMENS</namePart><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, 54219 Trier, Germany, Abteilung I 70376 Stuttgart, Germany, 70593 Stuttgart, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. CHRISTIAN</namePart><namePart type="family">BODE</namePart><affiliation>Robert-Bosch-Krankenhaus Stuttgart, Zentnim für Innere Mcdizin Abteilung I 70376 Stuttgart, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CHRISTIANE</namePart><namePart type="family">BODE</namePart><affiliation>Universität Hohenheim Institut für Biologische Chemie und Ernährungswissenschaften, Abteilung Ernährungsphysiologie 70593 Stuttgart, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Articles</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1996-09</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32 and 160 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of Δ6-and Δ5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid, and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of Δ6-and Δ5-desaturases.</abstract><note type="author-notes">*Author to whom correspondence should be addressed</note><relatedItem type="host"><titleInfo><title>Alcohol and Alcoholism</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0735-0414</identifier><identifier type="eISSN">1464-3502</identifier><identifier type="PublisherID">alcalc</identifier><identifier type="PublisherID-hwp">alcalc</identifier><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>463</start><end>469</end></extent></part></relatedItem><identifier type="istex">36150FAB8339AC3CD137982D68B8ABBD84A982C4</identifier><identifier type="DOI">10.1093/oxfordjournals.alcalc.a008180</identifier><identifier type="ArticleID">31.5.463</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1996 Medical Council on Alcoholism</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/36150FAB8339AC3CD137982D68B8ABBD84A982C4/annexes/pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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