CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS
Identifieur interne : 001853 ( Istex/Corpus ); précédent : 001852; suivant : 001854CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS
Auteurs : Ali Reza Waladkhani ; Peter Kunz ; Werner Zimmermann ; Michael Roland ClemensSource :
- Alcohol and Alcoholism [ 0735-0414 ] ; 1997-11.
Abstract
Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with cis-retinoic acid (cRA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, P < 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with cRA. Sex-related differences were observed on total ADH activity after 1 week of treatment with cRA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.
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DOI: 10.1093/oxfordjournals.alcalc.a008324
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title><author><name sortKey="Waladkhani, Ali Reza" sort="Waladkhani, Ali Reza" uniqKey="Waladkhani A" first="Ali Reza" last="Waladkhani">Ali Reza Waladkhani</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kunz, Peter" sort="Kunz, Peter" uniqKey="Kunz P" first="Peter" last="Kunz">Peter Kunz</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zimmermann, Werner" sort="Zimmermann, Werner" uniqKey="Zimmermann W" first="Werner" last="Zimmermann">Werner Zimmermann</name><affiliation><mods:affiliation>Pharmazeutisches Institut der Uiniversität Tübingen 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Clemens, Michael Roland" sort="Clemens, Michael Roland" uniqKey="Clemens M" first="Michael Roland" last="Clemens">Michael Roland Clemens</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C64FCEFA475FA6384BEE1956271879F2AEADC4FB</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1093/oxfordjournals.alcalc.a008324</idno><idno type="url">https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001853</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001853</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title><author><name sortKey="Waladkhani, Ali Reza" sort="Waladkhani, Ali Reza" uniqKey="Waladkhani A" first="Ali Reza" last="Waladkhani">Ali Reza Waladkhani</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kunz, Peter" sort="Kunz, Peter" uniqKey="Kunz P" first="Peter" last="Kunz">Peter Kunz</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zimmermann, Werner" sort="Zimmermann, Werner" uniqKey="Zimmermann W" first="Werner" last="Zimmermann">Werner Zimmermann</name><affiliation><mods:affiliation>Pharmazeutisches Institut der Uiniversität Tübingen 72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Clemens, Michael Roland" sort="Clemens, Michael Roland" uniqKey="Clemens M" first="Michael Roland" last="Clemens">Michael Roland Clemens</name><affiliation><mods:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Alcohol and Alcoholism</title><idno type="ISSN">0735-0414</idno><idno type="eISSN">1464-3502</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1997-11">1997-11</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="739">739</biblScope><biblScope unit="page" to="743">743</biblScope></imprint><idno type="ISSN">0735-0414</idno></series><idno type="istex">C64FCEFA475FA6384BEE1956271879F2AEADC4FB</idno><idno type="DOI">10.1093/oxfordjournals.alcalc.a008324</idno><idno type="ArticleID">32.6.739</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0735-0414</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with cis-retinoic acid (cRA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, P < 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with cRA. Sex-related differences were observed on total ADH activity after 1 week of treatment with cRA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>ALI REZA WALADKHANI</name><affiliations><json:string>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</json:string></affiliations></json:item><json:item><name>PETER KUNZ</name><affiliations><json:string>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</json:string></affiliations></json:item><json:item><name>WERNER ZIMMERMANN</name><affiliations><json:string>Pharmazeutisches Institut der Uiniversität Tübingen 72076 Tübingen, Germany</json:string></affiliations></json:item><json:item><name>MICHAEL ROLAND CLEMENS</name><affiliations><json:string>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</json:string></affiliations></json:item></author><subject><json:item><value>ORIGINAL ARTICLES</value></json:item></subject><articleId><json:string>32.6.739</json:string></articleId><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with cis-retinoic acid (cRA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, P > 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with cRA. Sex-related differences were observed on total ADH activity after 1 week of treatment with cRA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.</abstract><qualityIndicators><score>7.678</score><pdfVersion>1.2</pdfVersion><pdfPageSize>526 x 704 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>1608</abstractCharCount><pdfWordCount>2678</pdfWordCount><pdfCharCount>16133</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>269</abstractWordCount></qualityIndicators><title>CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title><refBibs><json:item><author><json:item><name>E,M Algar</name></json:item><json:item><name>T,L Seeley</name></json:item><json:item><name>R,S Holmes</name></json:item></author><host><volume>137</volume><pages><last>147</last><first>139</first></pages><author></author><title>European Journal of Biochemistry</title><publicationDate>1983</publicationDate></host><title>Purification and molecular properties of mouse alcohol dehydrogenase isozymes</title><publicationDate>1983</publicationDate></json:item><json:item><author><json:item><name>R,D Batt</name></json:item></author><host><pages><last>8</last><first>3</first></pages><author></author><title>Pharmacokinetics, Medicolegal Aspects, and General Interest, Crow, K. 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Liao</name></json:item><json:item><name>C,M Chen</name></json:item><json:item><name>C,W Wu</name></json:item></author><host><volume>22</volume><pages><last>835</last><first>829</first></pages><author></author><title>Biochemistry International</title><publicationDate>1990</publicationDate></host><title>Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties</title><publicationDate>1990</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>32</volume><publisherId><json:string>alcalc</json:string></publisherId><pages><last>743</last><first>739</first></pages><issn><json:string>0735-0414</json:string></issn><issue>6</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1464-3502</json:string></eissn><title>Alcohol and Alcoholism</title></host><categories><wos><json:string>social science</json:string><json:string>substance abuse</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>public health & health services</json:string><json:string>substance abuse</json:string></scienceMetrix></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1093/oxfordjournals.alcalc.a008324</json:string></doi><id>C64FCEFA475FA6384BEE1956271879F2AEADC4FB</id><score>0.46057338</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>© Medical Council on Alcoholism</p></availability><date>1997</date></publicationStmt><notesStmt><note>*Author to whom correspondence should be addressed</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title><author xml:id="author-1"><persName><forename type="first">ALI REZA</forename><surname>WALADKHANI</surname></persName><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">PETER</forename><surname>KUNZ</surname></persName><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">WERNER</forename><surname>ZIMMERMANN</surname></persName><affiliation>Pharmazeutisches Institut der Uiniversität Tübingen 72076 Tübingen, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">MICHAEL ROLAND</forename><surname>CLEMENS</surname></persName><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation></author></analytic><monogr><title level="j">Alcohol and Alcoholism</title><idno type="pISSN">0735-0414</idno><idno type="eISSN">1464-3502</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1997-11"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="739">739</biblScope><biblScope unit="page" to="743">743</biblScope></imprint></monogr><idno type="istex">C64FCEFA475FA6384BEE1956271879F2AEADC4FB</idno><idno type="DOI">10.1093/oxfordjournals.alcalc.a008324</idno><idno type="ArticleID">32.6.739</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><abstract><p>Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with cis-retinoic acid (cRA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, P < 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with cRA. Sex-related differences were observed on total ADH activity after 1 week of treatment with cRA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>ORIGINAL ARTICLES</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-11">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">alcalc</journal-id><journal-id journal-id-type="publisher-id">alcalc</journal-id><journal-id journal-id-type="pmc">alcalc</journal-id><journal-title>Alcohol and Alcoholism</journal-title><issn pub-type="epub">1464-3502</issn><issn pub-type="ppub">0735-0414</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32.6.739</article-id><article-id pub-id-type="doi">10.1093/oxfordjournals.alcalc.a008324</article-id><article-categories><subj-group><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>WALADKHANI</surname><given-names>ALI REZA</given-names></name><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>KUNZ</surname><given-names>PETER</given-names></name></contrib><contrib contrib-type="author"><name><surname>ZIMMERMANN</surname><given-names>WERNER</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>CLEMENS</surname><given-names>MICHAEL ROLAND</given-names></name></contrib><aff><institution>Krankenanstalt Mutterhaus der Borromäerinnen</institution> <addr-line>Feldstraße 16, 54219 Trier, Germany</addr-line></aff><aff id="au1"><sup>1</sup><institution>Pharmazeutisches Institut der Uiniversität Tübingen</institution> <addr-line>72076 Tübingen, Germany</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><sup>*</sup>Author to whom correspondence should be addressed</corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>1997</year></pub-date><volume>32</volume><issue>6</issue><fpage>739</fpage><lpage>743</lpage><history><date date-type="received"><day>06</day><month>5</month><year>1997</year></date><date date-type="rev-recd"><day>27</day><month>6</month><year>1997</year></date><date date-type="accepted"><day>04</day><month>7</month><year>1997</year></date></history><copyright-statement>© Medical Council on Alcoholism</copyright-statement><copyright-year>1997</copyright-year><abstract><p>Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with <italic>cis</italic>-retinoic acid (<italic>c</italic>RA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, <italic>P</italic> < 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with <italic>c</italic>RA. Sex-related differences were observed on total ADH activity after 1 week of treatment with <italic>c</italic>RA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>CHANGES IN HUMAN SERUM ALCOHOL DEHYDROGENASE ACTIVITY DURING RETINOIC ACID TREATMENT OF CANCER PATIENTS</title></titleInfo><name type="personal"><namePart type="given">ALI REZA</namePart><namePart type="family">WALADKHANI</namePart><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PETER</namePart><namePart type="family">KUNZ</namePart><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WERNER</namePart><namePart type="family">ZIMMERMANN</namePart><affiliation>Pharmazeutisches Institut der Uiniversität Tübingen 72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MICHAEL ROLAND</namePart><namePart type="family">CLEMENS</namePart><affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Feldstraße 16, 54219 Trier, Germany, 72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>ORIGINAL ARTICLES</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1997-11</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Retinoids can inhibit cell growth and induce cell differentiation in experimental tumour models. Human alcohol dehydrogenase (ADH) exists as a group of enzymes that can be placed into five classes based upon structural and functional distinctions. Human class I ADH catalyses the oxidation of a wide variety of alcohols including ethanol and retinol, whereas human class II ADH does not catalyse the oxidation of retinol. Using specific fluorescent substrates, class I and class II ADH activity in human sera was determined. No significant changes in class I or II activity were observed after 4 weeks of treatment with cis-retinoic acid (cRA). While total ADH activity was increased from 84 ± 78 mU/I to 206 ± 70 mU/I (mean ± SD, P < 0.02) after 1 week of treatment, there were no further significant changes after 4 weeks of treatment with cRA. Sex-related differences were observed on total ADH activity after 1 week of treatment with cRA. Although total ADH activity of patients with cancer of the cervix increased significantly after 1 week of treatment, there were no significant changes in total activity in head and neck cancer patients. This sex-related difference might be dependent on the stage of the menstrual cycle. The elimination of ethanol in women can be either faster or slower than in men depending on the stage of menstrual cycle. This study therefore suggests that the main ADH activity observed in serum belongs to class II, and not to class I ADH. The data from this study also suggest that retinoic acid has a positive feedback effect on total ADH activity after 1 week of treatment.</abstract><note type="author-notes">*Author to whom correspondence should be addressed</note><relatedItem type="host"><titleInfo><title>Alcohol and Alcoholism</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0735-0414</identifier><identifier type="eISSN">1464-3502</identifier><identifier type="PublisherID">alcalc</identifier><identifier type="PublisherID-hwp">alcalc</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>739</start><end>743</end></extent></part></relatedItem><identifier type="istex">C64FCEFA475FA6384BEE1956271879F2AEADC4FB</identifier><identifier type="DOI">10.1093/oxfordjournals.alcalc.a008324</identifier><identifier type="ArticleID">32.6.739</identifier><accessCondition type="use and reproduction" contentType="copyright">© Medical Council on Alcoholism</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/C64FCEFA475FA6384BEE1956271879F2AEADC4FB/annexes/pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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