Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload
Identifieur interne : 000E81 ( Istex/Corpus ); précédent : 000E80; suivant : 000E82Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload
Auteurs : Peter Schulz ; Clemens Kirschbaum ; Jens Prü Ner ; Dirk HellhammerSource :
- Stress Medicine [ 0748-8386 ] ; 1998-04.
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Abstract
The present study investigated the association between chronic stress and cortisol changes during the first hour after awakening in the morning. According to results of a pilot study, it was hypothesized that chronically stressed subjects would show a more enhanced and prolonged increase of cortisol level after awakening compared to non‐stressed subjects. In 100 subjects, chronic stress was assessed twice with a 1‐week interval between measures and cortisol was repeatedly measured during the first hour of awakening on 3 consecutive days. Results showed that chronically stressed subjects had a significantly larger increase in cortisol (+15.5 nmol/l) compared to unstressed subjects (+9.1 nmol/l). Further analysis indicated a significant sex difference with larger increases in chronically stressed women (+16.5 nmol/l) compared to stressed men (+11.8 nmol/l). From these data we conclude that a repeated measurement of free cortisol in response to awakening should be considered a possible biological correlate of chronic stress. Possible causes, consequences and clinical relevance of this hypercortisolism in chronically stressed subjects are briefly discussed. © 1998 John Wiley & Sons, Ltd.
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DOI: 10.1002/(SICI)1099-1700(199804)14:2<91::AID-SMI765>3.0.CO;2-S
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<front><div type="abstract" xml:lang="en">The present study investigated the association between chronic stress and cortisol changes during the first hour after awakening in the morning. According to results of a pilot study, it was hypothesized that chronically stressed subjects would show a more enhanced and prolonged increase of cortisol level after awakening compared to non‐stressed subjects. In 100 subjects, chronic stress was assessed twice with a 1‐week interval between measures and cortisol was repeatedly measured during the first hour of awakening on 3 consecutive days. Results showed that chronically stressed subjects had a significantly larger increase in cortisol (+15.5 nmol/l) compared to unstressed subjects (+9.1 nmol/l). Further analysis indicated a significant sex difference with larger increases in chronically stressed women (+16.5 nmol/l) compared to stressed men (+11.8 nmol/l). From these data we conclude that a repeated measurement of free cortisol in response to awakening should be considered a possible biological correlate of chronic stress. Possible causes, consequences and clinical relevance of this hypercortisolism in chronically stressed subjects are briefly discussed. © 1998 John Wiley & Sons, Ltd.</div>
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