Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults
Identifieur interne : 000E80 ( Istex/Corpus ); précédent : 000E79; suivant : 000E81Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults
Auteurs : C. Kirschbaum ; O. T Wolf ; M. May ; W. Wippich ; D. H HellhammerSource :
- Life Sciences [ 0024-3205 ] ; 1996.
Abstract
Two studies investigated the association between cortisol levels and memory performance in healthy adults. In a first study, 13 subjects were exposed to a brief psychosocial laboratory stress (“Trier Social Stress Test”) with a subsequent test of declarative memory performance. Results indicated a significant negative relationship between stress-induced cortisol levels and performance in the memory Task, I.e. subjects with high cortisol response to the stressor showed poorer memory performance. In a second experiment it was investigated if cortisol alone, i.e. independent of psychological stress, would also impair memory function. In this study, 40 healthy subjects received either 10 mg cortisol or placebo orally. One hour later they were tested for procedural and declarative memory and spatial thinking. Subjects who received cortisol showed impaired performance in the declarative memory and spatial thinking tasks but not in the procedural memory task. From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.
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DOI: 10.1016/0024-3205(96)00118-X
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May</name><affiliation><mods:affiliation>Institute for Cognitive Research, University of the Armed Forces, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wippich, W" sort="Wippich, W" uniqKey="Wippich W" first="W" last="Wippich">W. Wippich</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H" last="Hellhammer">D. H Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychology, University of Trier, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FA9A1690CACC489515E201E6ACF5DA3AC3ED0741</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0024-3205(96)00118-X</idno><idno type="url">https://api.istex.fr/document/FA9A1690CACC489515E201E6ACF5DA3AC3ED0741/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults</title><author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C" last="Kirschbaum">C. Kirschbaum</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychology, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T" last="Wolf">O. T Wolf</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="May, M" sort="May, M" uniqKey="May M" first="M" last="May">M. May</name><affiliation><mods:affiliation>Institute for Cognitive Research, University of the Armed Forces, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wippich, W" sort="Wippich, W" uniqKey="Wippich W" first="W" last="Wippich">W. Wippich</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H" last="Hellhammer">D. H Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychology, University of Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">58</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="1475">1475</biblScope><biblScope unit="page" to="1483">1483</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">FA9A1690CACC489515E201E6ACF5DA3AC3ED0741</idno><idno type="DOI">10.1016/0024-3205(96)00118-X</idno><idno type="PII">0024-3205(96)00118-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two studies investigated the association between cortisol levels and memory performance in healthy adults. In a first study, 13 subjects were exposed to a brief psychosocial laboratory stress (“Trier Social Stress Test”) with a subsequent test of declarative memory performance. Results indicated a significant negative relationship between stress-induced cortisol levels and performance in the memory Task, I.e. subjects with high cortisol response to the stressor showed poorer memory performance. In a second experiment it was investigated if cortisol alone, i.e. independent of psychological stress, would also impair memory function. In this study, 40 healthy subjects received either 10 mg cortisol or placebo orally. One hour later they were tested for procedural and declarative memory and spatial thinking. Subjects who received cortisol showed impaired performance in the declarative memory and spatial thinking tasks but not in the procedural memory task. From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C Kirschbaum</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</json:string><json:string>Department of Psychology, University of Trier, Germany</json:string></affiliations></json:item><json:item><name>O.T Wolf</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</json:string></affiliations></json:item><json:item><name>M May</name><affiliations><json:string>Institute for Cognitive Research, University of the Armed Forces, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>W Wippich</name><affiliations><json:string>Department of Psychology, University of Trier, Germany</json:string></affiliations></json:item><json:item><name>D.H Hellhammer</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</json:string><json:string>Department of Psychology, University of Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cortisol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>saliva</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>memory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampus</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Two studies investigated the association between cortisol levels and memory performance in healthy adults. 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From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.</abstract><qualityIndicators><score>5.411</score><pdfVersion>1.2</pdfVersion><pdfPageSize>504 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1096</abstractCharCount><pdfWordCount>3515</pdfWordCount><pdfCharCount>21881</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>158</abstractWordCount></qualityIndicators><title>Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults</title><pii><json:string>0024-3205(96)00118-X</json:string></pii><refBibs><json:item><host><volume>168</volume><pages><last>757</last><first>753</first></pages><author></author><title>J. Nerv. Mental Dis.</title></host></json:item><json:item><host><volume>19</volume><pages><last>188</last><first>177</first></pages><author></author><title>Psychiat. 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In a first study, 13 subjects were exposed to a brief psychosocial laboratory stress (“Trier Social Stress Test”) with a subsequent test of declarative memory performance. Results indicated a significant negative relationship between stress-induced cortisol levels and performance in the memory Task, I.e. subjects with high cortisol response to the stressor showed poorer memory performance. In a second experiment it was investigated if cortisol alone, i.e. independent of psychological stress, would also impair memory function. In this study, 40 healthy subjects received either 10 mg cortisol or placebo orally. One hour later they were tested for procedural and declarative memory and spatial thinking. Subjects who received cortisol showed impaired performance in the declarative memory and spatial thinking tasks but not in the procedural memory task. From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>cortisol</term></item><item><term>saliva</term></item><item><term>memory</term></item><item><term>hippocampus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/FA9A1690CACC489515E201E6ACF5DA3AC3ED0741/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LFS</jid><aid>9600118X</aid><ce:pii>0024-3205(96)00118-X</ce:pii><ce:doi>10.1016/0024-3205(96)00118-X</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:title>Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults</ce:title><ce:author-group><ce:author><ce:given-name>C</ce:given-name><ce:surname>Kirschbaum</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>O.T</ce:given-name><ce:surname>Wolf</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M</ce:given-name><ce:surname>May</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>W</ce:given-name><ce:surname>Wippich</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.H</ce:given-name><ce:surname>Hellhammer</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Psychology, University of Trier, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Institute for Cognitive Research, University of the Armed Forces, Hamburg, Germany</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="26" month="2" year="1996"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Two studies investigated the association between cortisol levels and memory performance in healthy adults. In a first study, 13 subjects were exposed to a brief psychosocial laboratory stress (“Trier Social Stress Test”) with a subsequent test of declarative memory performance. Results indicated a significant negative relationship between stress-induced cortisol levels and performance in the memory Task, I.e. subjects with high cortisol response to the stressor showed poorer memory performance. In a second experiment it was investigated if cortisol alone, i.e. independent of psychological stress, would also impair memory function. In this study, 40 healthy subjects received either 10 mg cortisol or placebo orally. One hour later they were tested for procedural and declarative memory and spatial thinking. Subjects who received cortisol showed impaired performance in the declarative memory and spatial thinking tasks but not in the procedural memory task. From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>cortisol</ce:text></ce:keyword><ce:keyword><ce:text>saliva</ce:text></ce:keyword><ce:keyword><ce:text>memory</ce:text></ce:keyword><ce:keyword><ce:text>hippocampus</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Kirschbaum</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</affiliation><affiliation>Department of Psychology, University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.T</namePart><namePart type="family">Wolf</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">May</namePart><affiliation>Institute for Cognitive Research, University of the Armed Forces, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Wippich</namePart><affiliation>Department of Psychology, University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.H</namePart><namePart type="family">Hellhammer</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany</affiliation><affiliation>Department of Psychology, University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Two studies investigated the association between cortisol levels and memory performance in healthy adults. In a first study, 13 subjects were exposed to a brief psychosocial laboratory stress (“Trier Social Stress Test”) with a subsequent test of declarative memory performance. Results indicated a significant negative relationship between stress-induced cortisol levels and performance in the memory Task, I.e. subjects with high cortisol response to the stressor showed poorer memory performance. In a second experiment it was investigated if cortisol alone, i.e. independent of psychological stress, would also impair memory function. In this study, 40 healthy subjects received either 10 mg cortisol or placebo orally. One hour later they were tested for procedural and declarative memory and spatial thinking. Subjects who received cortisol showed impaired performance in the declarative memory and spatial thinking tasks but not in the procedural memory task. From these results we conclude that in healthy adults elevated free cortisol levels are associated with impaired memory function.</abstract><subject><genre>Keywords</genre><topic>cortisol</topic><topic>saliva</topic><topic>memory</topic><topic>hippocampus</topic></subject><relatedItem type="host"><titleInfo><title>Life Sciences</title></titleInfo><titleInfo type="abbreviated"><title>LFS</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19960322</dateIssued></originInfo><identifier type="ISSN">0024-3205</identifier><identifier type="PII">S0024-3205(00)X0015-X</identifier><part><date>19960322</date><detail type="volume"><number>58</number><caption>vol.</caption></detail><detail type="issue"><number>17</number><caption>no.</caption></detail><extent unit="issue pages"><start>PL287</start><end>PL294</end></extent><extent unit="issue pages"><start>1387</start><end>1483</end></extent><extent unit="pages"><start>1475</start><end>1483</end></extent></part></relatedItem><identifier type="istex">FA9A1690CACC489515E201E6ACF5DA3AC3ED0741</identifier><identifier type="DOI">10.1016/0024-3205(96)00118-X</identifier><identifier type="PII">0024-3205(96)00118-X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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