Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis
Identifieur interne : 000905 ( Istex/Corpus ); précédent : 000904; suivant : 000906Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis
Auteurs : V. Krenn ; L. Morawietz ; G-R Burmester ; R W Kinne ; U. Mueller-Ladner ; B. Muller ; T. HauplSource :
- Histopathology [ 0309-0167 ] ; 2006-10.
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Abstract
Aims : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.
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DOI: 10.1111/j.1365-2559.2006.02508.x
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Morawietz</name><affiliation><mods:affiliation>Institute for Pathology, Trier,Institute for Pathology</mods:affiliation></affiliation></author><author><name sortKey="Burmester, G" sort="Burmester, G" uniqKey="Burmester G" first="G-R" last="Burmester">G-R Burmester</name><affiliation><mods:affiliation>Department for Rheumatology, Charité University Hospital, Berlin</mods:affiliation></affiliation></author><author><name sortKey="Kinne, R W" sort="Kinne, R W" uniqKey="Kinne R" first="R W" last="Kinne">R W Kinne</name><affiliation><mods:affiliation>Experimental Rheumatology, University Jena, Jena</mods:affiliation></affiliation></author><author><name sortKey="Mueller Adner, U" sort="Mueller Adner, U" uniqKey="Mueller Adner U" first="U" last="Mueller-Ladner">U. Mueller-Ladner</name><affiliation><mods:affiliation>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</mods:affiliation></affiliation></author><author><name sortKey="Muller, B" sort="Muller, B" uniqKey="Muller B" first="B" last="Muller">B. Muller</name><affiliation><mods:affiliation>Institute for Immunology, University Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Haupl, T" sort="Haupl, T" uniqKey="Haupl T" first="T" last="Haupl">T. Haupl</name><affiliation><mods:affiliation>Department for Rheumatology, Charité University Hospital, Berlin</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7AC73E820C450440C2F592A7700B7AD9F5ABD123</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1111/j.1365-2559.2006.02508.x</idno><idno type="url">https://api.istex.fr/document/7AC73E820C450440C2F592A7700B7AD9F5ABD123/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000905</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000905</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation><mods:affiliation>Institute for Pathology, Trier,Institute for Pathology</mods:affiliation></affiliation></author><author><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name><affiliation><mods:affiliation>Institute for Pathology, Trier,Institute for Pathology</mods:affiliation></affiliation></author><author><name sortKey="Burmester, G" sort="Burmester, G" uniqKey="Burmester G" first="G-R" last="Burmester">G-R Burmester</name><affiliation><mods:affiliation>Department for Rheumatology, Charité University Hospital, Berlin</mods:affiliation></affiliation></author><author><name sortKey="Kinne, R W" sort="Kinne, R W" uniqKey="Kinne R" first="R W" last="Kinne">R W Kinne</name><affiliation><mods:affiliation>Experimental Rheumatology, University Jena, Jena</mods:affiliation></affiliation></author><author><name sortKey="Mueller Adner, U" sort="Mueller Adner, U" uniqKey="Mueller Adner U" first="U" last="Mueller-Ladner">U. Mueller-Ladner</name><affiliation><mods:affiliation>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</mods:affiliation></affiliation></author><author><name sortKey="Muller, B" sort="Muller, B" uniqKey="Muller B" first="B" last="Muller">B. Muller</name><affiliation><mods:affiliation>Institute for Immunology, University Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Haupl, T" sort="Haupl, T" uniqKey="Haupl T" first="T" last="Haupl">T. Haupl</name><affiliation><mods:affiliation>Department for Rheumatology, Charité University Hospital, Berlin</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Histopathology</title><idno type="ISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="358">358</biblScope><biblScope unit="page" to="364">364</biblScope></imprint><idno type="ISSN">0309-0167</idno></series><idno type="istex">7AC73E820C450440C2F592A7700B7AD9F5ABD123</idno><idno type="DOI">10.1111/j.1365-2559.2006.02508.x</idno><idno type="ArticleID">HIS2508</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0309-0167</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>grading</term><term>histopathology</term><term>osteoarthritis</term><term>rheumatoid arthritis</term><term>synovitis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aims : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>V Krenn</name><affiliations><json:string>Institute for Pathology, Trier,Institute for Pathology</json:string></affiliations></json:item><json:item><name>L Morawietz</name><affiliations><json:string>Institute for Pathology, Trier,Institute for Pathology</json:string></affiliations></json:item><json:item><name>G‐R Burmester</name><affiliations><json:string>Department for Rheumatology, Charité University Hospital, Berlin</json:string></affiliations></json:item><json:item><name>R W Kinne</name><affiliations><json:string>Experimental Rheumatology, University Jena, Jena</json:string></affiliations></json:item><json:item><name>U Mueller‐Ladner</name><affiliations><json:string>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</json:string></affiliations></json:item><json:item><name>B Muller</name><affiliations><json:string>Institute for Immunology, University Rostock, Rostock, Germany</json:string></affiliations></json:item><json:item><name>T Haupl</name><affiliations><json:string>Department for Rheumatology, Charité University Hospital, Berlin</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>grading</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>histopathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteoarthritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rheumatoid arthritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>synovitis</value></json:item></subject><articleId><json:string>HIS2508</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>3.641</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>174</abstractCharCount><pdfWordCount>3365</pdfWordCount><pdfCharCount>22081</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>23</abstractWordCount></qualityIndicators><title>Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title><refBibs><json:item><host><author></author><title>Fassbender HG. 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medicine</json:string><json:string>pathology</json:string></scienceMetrix></categories><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1111/j.1365-2559.2006.02508.x</json:string></doi><id>7AC73E820C450440C2F592A7700B7AD9F5ABD123</id><score>0.35124362</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/7AC73E820C450440C2F592A7700B7AD9F5ABD123/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/7AC73E820C450440C2F592A7700B7AD9F5ABD123/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/7AC73E820C450440C2F592A7700B7AD9F5ABD123/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2006</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title><author xml:id="author-1"><persName><forename type="first">V</forename><surname>Krenn</surname></persName><affiliation>Institute for Pathology, Trier,Institute for Pathology</affiliation></author><author xml:id="author-2"><persName><forename type="first">L</forename><surname>Morawietz</surname></persName><affiliation>Institute for Pathology, Trier,Institute for Pathology</affiliation></author><author xml:id="author-3"><persName><forename type="first">G‐R</forename><surname>Burmester</surname></persName><affiliation>Department for Rheumatology, Charité University Hospital, Berlin</affiliation></author><author xml:id="author-4"><persName><forename type="first">R W</forename><surname>Kinne</surname></persName><affiliation>Experimental Rheumatology, University Jena, Jena</affiliation></author><author xml:id="author-5"><persName><forename type="first">U</forename><surname>Mueller‐Ladner</surname></persName><affiliation>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</affiliation></author><author xml:id="author-6"><persName><forename type="first">B</forename><surname>Muller</surname></persName><affiliation>Institute for Immunology, University Rostock, Rostock, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">T</forename><surname>Haupl</surname></persName><affiliation>Department for Rheumatology, Charité University Hospital, Berlin</affiliation></author></analytic><monogr><title level="j">Histopathology</title><idno type="pISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><idno type="DOI">10.1111/(ISSN)1365-2559</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-10"></date><biblScope unit="volume">49</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="358">358</biblScope><biblScope unit="page" to="364">364</biblScope></imprint></monogr><idno type="istex">7AC73E820C450440C2F592A7700B7AD9F5ABD123</idno><idno type="DOI">10.1111/j.1365-2559.2006.02508.x</idno><idno type="ArticleID">HIS2508</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Aims : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.</p></abstract><abstract><p>Methods and results : Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and each feature was graded separately. The sum provided the synovitis score, which was interpreted as follows: 0–1, no synovitis; 2–4, low‐grade synovitis; 5–9, high‐grade synovitis. Five hundred and fifty‐nine synovectomy specimens were graded by two independent observers. Clinical diagnoses were osteoarthrosis (n = 212), post‐traumatic arthritis (n = 21), rheumatoid arthritis (n = 246), psoriatic arthritis (n = 22), reactive arthritis (n = 9), as well as controls (n = 49) from autopsies of patients without joint damage. Median synovitis scores when correlated with clinical diagnoses were: controls 1.0, osteoarthritis 2.0, post‐traumatic arthritis 2.0, psoriatic arthritis 3.5, reactive arthritis 5.0 and rheumatoid arthritis 5.0. The scores differed significantly between most disease groups, especially between degenerative and rheumatic diseases. A high‐grade synovitis was strongly associated with rheumatic joint diseases (P < 0.001, sensitivity 61.7%, specificity 96.1%). The correlation between the two observers was high (r = 0.941).</p></abstract><abstract><p>Conclusion : The proposed synovitis score is based on well‐defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non‐rheumatic joint diseases.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>grading</term></item><item><term>histopathology</term></item><item><term>osteoarthritis</term></item><item><term>rheumatoid arthritis</term></item><item><term>synovitis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/7AC73E820C450440C2F592A7700B7AD9F5ABD123/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2559</doi><issn type="print">0309-0167</issn><issn type="electronic">1365-2559</issn><idGroup><id type="product" value="HIS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="HISTOPATHOLOGY">Histopathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="10004"><doi origin="wiley">10.1111/his.2006.49.issue-4</doi><numberingGroup><numbering type="journalVolume" number="49">49</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2006-10">October 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1365-2559.2006.02508.x</doi><idGroup><id type="unit" value="HIS2508"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original articles</title></titleGroup><eventGroup><event type="firstOnline" date="2006-08-10"></event><event type="publishedOnlineFinalForm" date="2006-09-15"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-29"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="358">358</numbering><numbering type="pageLast" number="364">364</numbering></numberingGroup><correspondenceTo>Prof. Dr med. Veit Krenn, Institute for Pathology, Moltkestrasse 32, D‐54292 Trier, Germany.
e‐mail: <email normalForm="krenn@patho-trier.de">krenn@patho‐trier.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HIS.HIS2508.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Date of submission 7 October 2005 Accepted for publication 22 January 2006</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="27"></count><count type="wordTotal" number="2866"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title><title type="shortAuthors"><i>V Krenn et al.</i></title><title type="short"><i>Grading of chronic synovitis</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>V</givenNames><familyName>Krenn</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>L</givenNames><familyName>Morawietz</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>G‐R</givenNames><familyName>Burmester</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>R W</givenNames><familyName>Kinne</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>U</givenNames><familyName>Mueller‐Ladner</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a5"><personName><givenNames>B</givenNames><familyName>Muller</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>T</givenNames><familyName>Haupl</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Institute for Pathology, Trier,Institute for Pathology</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department for Rheumatology, Charité University Hospital, Berlin</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Experimental Rheumatology, University Jena, Jena</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="DE"><unparsedAffiliation>Institute for Immunology, University Rostock, Rostock, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">grading</keyword><keyword xml:id="k2">histopathology</keyword><keyword xml:id="k3">osteoarthritis</keyword><keyword xml:id="k4">rheumatoid arthritis</keyword><keyword xml:id="k5">synovitis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Krenn V, Morawietz L, Burmester G-R, Kinne R W, Mueller-Ladner U, Muller B & Haupl T
(2006) Histopathology49, 358–364
Synovitis score: discrimination between chronic low-grade and high-grade synovitis --><p><b>Aims</b> : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.</p><p><b>Methods and results</b> : Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and each feature was graded separately. The sum provided the synovitis score, which was interpreted as follows: 0–1, no synovitis; 2–4, low‐grade synovitis; 5–9, high‐grade synovitis. Five hundred and fifty‐nine synovectomy specimens were graded by two independent observers. Clinical diagnoses were osteoarthrosis (<i>n</i> = 212), post‐traumatic arthritis (<i>n</i> = 21), rheumatoid arthritis (<i>n</i> = 246), psoriatic arthritis (<i>n</i> = 22), reactive arthritis (<i>n</i> = 9), as well as controls (<i>n</i> = 49) from autopsies of patients without joint damage. Median synovitis scores when correlated with clinical diagnoses were: controls 1.0, osteoarthritis 2.0, post‐traumatic arthritis 2.0, psoriatic arthritis 3.5, reactive arthritis 5.0 and rheumatoid arthritis 5.0. The scores differed significantly between most disease groups, especially between degenerative and rheumatic diseases. A high‐grade synovitis was strongly associated with rheumatic joint diseases (<i>P <</i> 0.001, sensitivity 61.7%, specificity 96.1%). The correlation between the two observers was high (<i>r =</i> 0.941).</p><p><b>Conclusion</b> : The proposed synovitis score is based on well‐defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non‐rheumatic joint diseases.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>V.K. and L.M. contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Grading of chronic synovitis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Krenn</namePart><affiliation>Institute for Pathology, Trier,Institute for Pathology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Morawietz</namePart><affiliation>Institute for Pathology, Trier,Institute for Pathology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G‐R</namePart><namePart type="family">Burmester</namePart><affiliation>Department for Rheumatology, Charité University Hospital, Berlin</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R W</namePart><namePart type="family">Kinne</namePart><affiliation>Experimental Rheumatology, University Jena, Jena</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Mueller‐Ladner</namePart><affiliation>Hospital for Internal Medicine III, Justus‐Liebig‐University, Giessen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Muller</namePart><affiliation>Institute for Immunology, University Rostock, Rostock, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Haupl</namePart><affiliation>Department for Rheumatology, Charité University Hospital, Berlin</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-10</dateIssued><edition>Date of submission 7 October 2005 Accepted for publication 22 January 2006</edition><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">27</extent><extent unit="words">2866</extent></physicalDescription><abstract>Aims : To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non‐rheumatic joint diseases.</abstract><abstract>Methods and results : Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and each feature was graded separately. The sum provided the synovitis score, which was interpreted as follows: 0–1, no synovitis; 2–4, low‐grade synovitis; 5–9, high‐grade synovitis. Five hundred and fifty‐nine synovectomy specimens were graded by two independent observers. Clinical diagnoses were osteoarthrosis (n = 212), post‐traumatic arthritis (n = 21), rheumatoid arthritis (n = 246), psoriatic arthritis (n = 22), reactive arthritis (n = 9), as well as controls (n = 49) from autopsies of patients without joint damage. Median synovitis scores when correlated with clinical diagnoses were: controls 1.0, osteoarthritis 2.0, post‐traumatic arthritis 2.0, psoriatic arthritis 3.5, reactive arthritis 5.0 and rheumatoid arthritis 5.0. The scores differed significantly between most disease groups, especially between degenerative and rheumatic diseases. A high‐grade synovitis was strongly associated with rheumatic joint diseases (P < 0.001, sensitivity 61.7%, specificity 96.1%). The correlation between the two observers was high (r = 0.941).</abstract><abstract>Conclusion : The proposed synovitis score is based on well‐defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non‐rheumatic joint diseases.</abstract><subject lang="en"><genre>keywords</genre><topic>grading</topic><topic>histopathology</topic><topic>osteoarthritis</topic><topic>rheumatoid arthritis</topic><topic>synovitis</topic></subject><relatedItem type="host"><titleInfo><title>Histopathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0309-0167</identifier><identifier type="eISSN">1365-2559</identifier><identifier type="DOI">10.1111/(ISSN)1365-2559</identifier><identifier type="PublisherID">HIS</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>358</start><end>364</end><total>7</total></extent></part></relatedItem><identifier type="istex">7AC73E820C450440C2F592A7700B7AD9F5ABD123</identifier><identifier type="DOI">10.1111/j.1365-2559.2006.02508.x</identifier><identifier type="ArticleID">HIS2508</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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