[A comparative study of the antiheparin activity and acute toxicity of stellins].
Identifieur interne : 000842 ( PubMed/Checkpoint ); précédent : 000841; suivant : 000843[A comparative study of the antiheparin activity and acute toxicity of stellins].
Auteurs : L V Grigorova ; M Ia Rozkin ; V K Rybin ; V S Efimov ; N V MakarovSource :
- Farmakologiia i toksikologiia [ 0014-8318 ]
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Heparin Antagonists, Protamines.
- chemical , toxicity : Heparin Antagonists, Protamines.
- chemical : Fish Proteins.
- drug effects : Blood Coagulation.
- Animals, In Vitro Techniques, Lethal Dose 50, Mice, Rabbits, Time Factors.
Abstract
The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.
PubMed: 2081565
Affiliations:
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pubmed:2081565Le document en format XML
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<author><name sortKey="Grigorova, L V" sort="Grigorova, L V" uniqKey="Grigorova L" first="L V" last="Grigorova">L V Grigorova</name>
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<author><name sortKey="Rozkin, M Ia" sort="Rozkin, M Ia" uniqKey="Rozkin M" first="M Ia" last="Rozkin">M Ia Rozkin</name>
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<author><name sortKey="Rybin, V K" sort="Rybin, V K" uniqKey="Rybin V" first="V K" last="Rybin">V K Rybin</name>
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<author><name sortKey="Efimov, V S" sort="Efimov, V S" uniqKey="Efimov V" first="V S" last="Efimov">V S Efimov</name>
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<author><name sortKey="Makarov, N V" sort="Makarov, N V" uniqKey="Makarov N" first="N V" last="Makarov">N V Makarov</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[A comparative study of the antiheparin activity and acute toxicity of stellins].</title>
<author><name sortKey="Grigorova, L V" sort="Grigorova, L V" uniqKey="Grigorova L" first="L V" last="Grigorova">L V Grigorova</name>
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<author><name sortKey="Rozkin, M Ia" sort="Rozkin, M Ia" uniqKey="Rozkin M" first="M Ia" last="Rozkin">M Ia Rozkin</name>
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<series><title level="j">Farmakologiia i toksikologiia</title>
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<term>Blood Coagulation (drug effects)</term>
<term>Fish Proteins</term>
<term>Heparin Antagonists (pharmacology)</term>
<term>Heparin Antagonists (toxicity)</term>
<term>In Vitro Techniques</term>
<term>Lethal Dose 50</term>
<term>Mice</term>
<term>Protamines (pharmacology)</term>
<term>Protamines (toxicity)</term>
<term>Rabbits</term>
<term>Time Factors</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Heparin Antagonists</term>
<term>Protamines</term>
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<term>Protamines</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>In Vitro Techniques</term>
<term>Lethal Dose 50</term>
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<term>Rabbits</term>
<term>Time Factors</term>
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<front><div type="abstract" xml:lang="en">The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.</div>
</front>
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<DateCreated><Year>1991</Year>
<Month>05</Month>
<Day>07</Day>
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<DateCompleted><Year>1991</Year>
<Month>05</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>11</Month>
<Day>20</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-8318</ISSN>
<JournalIssue CitedMedium="Print"><Volume>53</Volume>
<Issue>6</Issue>
<PubDate><MedlineDate>1990 Nov-Dec</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Farmakologiia i toksikologiia</Title>
<ISOAbbreviation>Farmakol Toksikol</ISOAbbreviation>
</Journal>
<ArticleTitle>[A comparative study of the antiheparin activity and acute toxicity of stellins].</ArticleTitle>
<Pagination><MedlinePgn>31-3</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grigorova</LastName>
<ForeName>L V</ForeName>
<Initials>LV</Initials>
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<Author ValidYN="Y"><LastName>Rozkin</LastName>
<ForeName>M Ia</ForeName>
<Initials>MIa</Initials>
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<Author ValidYN="Y"><LastName>Rybin</LastName>
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<Author ValidYN="Y"><LastName>Efimov</LastName>
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<Author ValidYN="Y"><LastName>Makarov</LastName>
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<VernacularTitle>Sravnitel'noe issledovanie antigeparinovoĭ aktivnosti i ostroĭ toksichnosti stellinov.</VernacularTitle>
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<MedlineJournalInfo><Country>Russia (Federation)</Country>
<MedlineTA>Farmakol Toksikol</MedlineTA>
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<Chemical><RegistryNumber>58739-75-6</RegistryNumber>
<NameOfSubstance UI="C029829">protamine B, Acipenser gueldenstaedtii</NameOfSubstance>
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<Chemical><RegistryNumber>59041-50-8</RegistryNumber>
<NameOfSubstance UI="C025098">Stellin</NameOfSubstance>
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<Chemical><RegistryNumber>69680-76-8</RegistryNumber>
<NameOfSubstance UI="C029828">protamine A, Acipenser stellatus</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D006494" MajorTopicYN="N">Heparin Antagonists</DescriptorName>
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<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
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<MeshHeading><DescriptorName UI="D011479" MajorTopicYN="N">Protamines</DescriptorName>
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<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
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<MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName>
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<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
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<name sortKey="Grigorova, L V" sort="Grigorova, L V" uniqKey="Grigorova L" first="L V" last="Grigorova">L V Grigorova</name>
<name sortKey="Makarov, N V" sort="Makarov, N V" uniqKey="Makarov N" first="N V" last="Makarov">N V Makarov</name>
<name sortKey="Rozkin, M Ia" sort="Rozkin, M Ia" uniqKey="Rozkin M" first="M Ia" last="Rozkin">M Ia Rozkin</name>
<name sortKey="Rybin, V K" sort="Rybin, V K" uniqKey="Rybin V" first="V K" last="Rybin">V K Rybin</name>
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