[A comparative study of the antiheparin activity and acute toxicity of stellins].
Identifieur interne : 000741 ( PubMed/Corpus ); précédent : 000740; suivant : 000742[A comparative study of the antiheparin activity and acute toxicity of stellins].
Auteurs : L V Grigorova ; M Ia Rozkin ; V K Rybin ; V S Efimov ; N V MakarovSource :
- Farmakologiia i toksikologiia [ 0014-8318 ]
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Heparin Antagonists, Protamines.
- chemical , toxicity : Heparin Antagonists, Protamines.
- chemical : Fish Proteins.
- drug effects : Blood Coagulation.
- Animals, In Vitro Techniques, Lethal Dose 50, Mice, Rabbits, Time Factors.
Abstract
The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.
PubMed: 2081565
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pubmed:2081565Le document en format XML
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The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2081565</PMID><DateCreated><Year>1991</Year><Month>05</Month><Day>07</Day></DateCreated><DateCompleted><Year>1991</Year><Month>05</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-8318</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>6</Issue><PubDate><MedlineDate>1990 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Farmakologiia i toksikologiia</Title><ISOAbbreviation>Farmakol Toksikol</ISOAbbreviation></Journal><ArticleTitle>[A comparative study of the antiheparin activity and acute toxicity of stellins].</ArticleTitle><Pagination><MedlinePgn>31-3</MedlinePgn></Pagination><Abstract><AbstractText>The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grigorova</LastName><ForeName>L V</ForeName><Initials>LV</Initials></Author><Author ValidYN="Y"><LastName>Rozkin</LastName><ForeName>M Ia</ForeName><Initials>MIa</Initials></Author><Author ValidYN="Y"><LastName>Rybin</LastName><ForeName>V K</ForeName><Initials>VK</Initials></Author><Author ValidYN="Y"><LastName>Efimov</LastName><ForeName>V S</ForeName><Initials>VS</Initials></Author><Author ValidYN="Y"><LastName>Makarov</LastName><ForeName>N V</ForeName><Initials>NV</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Sravnitel'noe issledovanie antigeparinovoĭ aktivnosti i ostroĭ toksichnosti stellinov.</VernacularTitle></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Farmakol Toksikol</MedlineTA><NlmUniqueID>16920420R</NlmUniqueID><ISSNLinking>0014-8318</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029941">Fish Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006494">Heparin Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011479">Protamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>58739-75-6</RegistryNumber><NameOfSubstance UI="C029829">protamine B, Acipenser gueldenstaedtii</NameOfSubstance></Chemical><Chemical><RegistryNumber>59041-50-8</RegistryNumber><NameOfSubstance UI="C025098">Stellin</NameOfSubstance></Chemical><Chemical><RegistryNumber>69680-76-8</RegistryNumber><NameOfSubstance UI="C029828">protamine A, Acipenser stellatus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001777" MajorTopicYN="N">Blood Coagulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029941" MajorTopicYN="Y">Fish Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006494" MajorTopicYN="N">Heparin Antagonists</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007928" MajorTopicYN="N">Lethal Dose 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011479" MajorTopicYN="N">Protamines</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>11</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2081565</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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