Fish Synucleins: An Update
Identifieur interne : 000004 ( Pmc/Curation ); précédent : 000003; suivant : 000005Fish Synucleins: An Update
Auteurs : Mattia Toni ; Carla CioniSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
Abstract
Synucleins (syns) are a family of proteins involved in several human neurodegenerative diseases and tumors. Since the first syn discovery in the brain of the electric ray
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DOI: 10.3390/md13116665
PubMed: 26528989
PubMed Central: 4663547
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fish Synucleins: An Update</title><author><name sortKey="Toni, Mattia" sort="Toni, Mattia" uniqKey="Toni M" first="Mattia" last="Toni">Mattia Toni</name></author><author><name sortKey="Cioni, Carla" sort="Cioni, Carla" uniqKey="Cioni C" first="Carla" last="Cioni">Carla Cioni</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26528989</idno><idno type="pmc">4663547</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663547</idno><idno type="RBID">PMC:4663547</idno><idno type="doi">10.3390/md13116665</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000004</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000004</idno><idno type="wicri:Area/Pmc/Curation">000004</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000004</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fish Synucleins: An Update</title><author><name sortKey="Toni, Mattia" sort="Toni, Mattia" uniqKey="Toni M" first="Mattia" last="Toni">Mattia Toni</name></author><author><name sortKey="Cioni, Carla" sort="Cioni, Carla" uniqKey="Cioni C" first="Carla" last="Cioni">Carla Cioni</name></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Synucleins (syns) are a family of proteins involved in several human neurodegenerative diseases and tumors. Since the first syn discovery in the brain of the electric ray <italic>Torpedo californica</italic>, members of the same family have been identified in all vertebrates and comparative studies have indicated that syn proteins are evolutionary conserved. No counterparts of syns were found in invertebrates suggesting that they are vertebrate-specific proteins. Molecular studies showed that the number of syn members varies among vertebrates. Three genes encode for α-, β- and γ-syn in mammals and birds. However, a variable number of syn genes and encoded proteins is expressed or predicted in fish depending on the species. Among biologically verified sequences, four syn genes were identified in fugu, encoding for α, β and two γ (γ1 and γ2) isoforms, whereas only three genes are expressed in zebrafish, which lacks α-syn gene. The list of “non verified” sequences is much longer and is often found in sequence databases. In this review we provide an overview of published papers and known syn sequences in agnathans and fish that are likely to impact future studies in this field. Indeed, fish models may play a key role in elucidating some of the molecular mechanisms involved in physiological and pathological functions of syn proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carlson, S S" uniqKey="Carlson S">S.S. Carlson</name></author><author><name sortKey="Kelly, R B" uniqKey="Kelly R">R.B. Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maroteaux, L" uniqKey="Maroteaux L">L. Maroteaux</name></author><author><name sortKey="Campanelli, J T" uniqKey="Campanelli J">J.T. Campanelli</name></author><author><name sortKey="Scheller, R H" uniqKey="Scheller R">R.H. Scheller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ueda, K" uniqKey="Ueda K">K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id><journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id><journal-id journal-id-type="publisher-id">marinedrugs</journal-id><journal-title-group><journal-title>Marine Drugs</journal-title></journal-title-group><issn pub-type="epub">1660-3397</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26528989</article-id><article-id pub-id-type="pmc">4663547</article-id><article-id pub-id-type="doi">10.3390/md13116665</article-id><article-id pub-id-type="publisher-id">marinedrugs-13-06665</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Fish Synucleins: An Update</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Toni</surname><given-names>Mattia</given-names></name><xref rid="c1-marinedrugs-13-06665" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Cioni</surname><given-names>Carla</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Perry</surname><given-names>George</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-marinedrugs-13-06665">Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, Via Alfonso Borelli 50, Rome 00161, Italy; E-Mail:<email>carla.cioni@uniroma1.it</email></aff><author-notes><corresp id="c1-marinedrugs-13-06665"><label>*</label>Author to whom correspondence should be addressed; E-Mail: <email>mattia.toni@uniroma1.it</email>; Tel.: +390649918005; Fax: +3906499157516.</corresp></author-notes><pub-date pub-type="epub"><day>30</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>11</month><year>2015</year></pub-date><volume>13</volume><issue>11</issue><fpage>6665</fpage><lpage>6686</lpage><history><date date-type="received"><day>10</day><month>8</month><year>2015</year></date><date date-type="accepted"><day>13</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2015</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Synucleins (syns) are a family of proteins involved in several human neurodegenerative diseases and tumors. Since the first syn discovery in the brain of the electric ray <italic>Torpedo californica</italic>, members of the same family have been identified in all vertebrates and comparative studies have indicated that syn proteins are evolutionary conserved. No counterparts of syns were found in invertebrates suggesting that they are vertebrate-specific proteins. Molecular studies showed that the number of syn members varies among vertebrates. Three genes encode for α-, β- and γ-syn in mammals and birds. However, a variable number of syn genes and encoded proteins is expressed or predicted in fish depending on the species. Among biologically verified sequences, four syn genes were identified in fugu, encoding for α, β and two γ (γ1 and γ2) isoforms, whereas only three genes are expressed in zebrafish, which lacks α-syn gene. The list of “non verified” sequences is much longer and is often found in sequence databases. In this review we provide an overview of published papers and known syn sequences in agnathans and fish that are likely to impact future studies in this field. Indeed, fish models may play a key role in elucidating some of the molecular mechanisms involved in physiological and pathological functions of syn proteins.</p></abstract><kwd-group><kwd>synuclein</kwd><kwd>fish</kwd><kwd>brain</kwd><kwd>zebrafish</kwd><kwd>carp</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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