Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus.
Identifieur interne : 000007 ( Ncbi/Checkpoint ); précédent : 000006; suivant : 000008Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus.
Auteurs : J. Alrubaian [États-Unis] ; P. Danielson ; M. Fitzpatrick ; C. Schreck ; R M DoresSource :
- Peptides [ 0196-9781 ] ; 1999.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Complementary (genetics), Fishes (genetics), Gene Duplication, Molecular Sequence Data, Open Reading Frames, Pituitary Gland (chemistry), Point Mutation, Pro-Opiomelanocortin (genetics), Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid.
- MESH :
- chemical , genetics : DNA, Complementary, Pro-Opiomelanocortin.
- chemistry : Pituitary Gland.
- genetics : Fishes.
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Gene Duplication, Molecular Sequence Data, Open Reading Frames, Point Mutation, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid.
Abstract
A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeon POMC B). In both sturgeon POMC cDNAs the open reading frame is 795 nucleotides in length. However, the two sturgeon POMC cDNAs differ at 26 amino acid positions in the opening frame. In addition, the 2 forms of POMC differ at 45 nucleotide positions within the open reading frame. The number and types of point mutations are compared in the 2 sturgeons POMC cDNAs, and the origin of the two POMC genes is discussed.
PubMed: 10458511
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus.</title><author><name sortKey="Alrubaian, J" sort="Alrubaian, J" uniqKey="Alrubaian J" first="J" last="Alrubaian">J. Alrubaian</name><affiliation wicri:level="1"><nlm:affiliation>University of Denver, Department of Biological Sciences, Colorado 80208, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Denver, Department of Biological Sciences, Colorado 80208</wicri:regionArea><wicri:noRegion>Colorado 80208</wicri:noRegion></affiliation></author><author><name sortKey="Danielson, P" sort="Danielson, P" uniqKey="Danielson P" first="P" last="Danielson">P. Danielson</name></author><author><name sortKey="Fitzpatrick, M" sort="Fitzpatrick, M" uniqKey="Fitzpatrick M" first="M" last="Fitzpatrick">M. Fitzpatrick</name></author><author><name sortKey="Schreck, C" sort="Schreck, C" uniqKey="Schreck C" first="C" last="Schreck">C. Schreck</name></author><author><name sortKey="Dores, R M" sort="Dores, R M" uniqKey="Dores R" first="R M" last="Dores">R M Dores</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10458511</idno><idno type="pmid">10458511</idno><idno type="wicri:Area/PubMed/Corpus">000662</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000662</idno><idno type="wicri:Area/PubMed/Curation">000662</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000662</idno><idno type="wicri:Area/PubMed/Checkpoint">000662</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000662</idno><idno type="wicri:Area/Ncbi/Merge">000007</idno><idno type="wicri:Area/Ncbi/Curation">000007</idno><idno type="wicri:Area/Ncbi/Checkpoint">000007</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus.</title><author><name sortKey="Alrubaian, J" sort="Alrubaian, J" uniqKey="Alrubaian J" first="J" last="Alrubaian">J. Alrubaian</name><affiliation wicri:level="1"><nlm:affiliation>University of Denver, Department of Biological Sciences, Colorado 80208, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Denver, Department of Biological Sciences, Colorado 80208</wicri:regionArea><wicri:noRegion>Colorado 80208</wicri:noRegion></affiliation></author><author><name sortKey="Danielson, P" sort="Danielson, P" uniqKey="Danielson P" first="P" last="Danielson">P. Danielson</name></author><author><name sortKey="Fitzpatrick, M" sort="Fitzpatrick, M" uniqKey="Fitzpatrick M" first="M" last="Fitzpatrick">M. Fitzpatrick</name></author><author><name sortKey="Schreck, C" sort="Schreck, C" uniqKey="Schreck C" first="C" last="Schreck">C. Schreck</name></author><author><name sortKey="Dores, R M" sort="Dores, R M" uniqKey="Dores R" first="R M" last="Dores">R M Dores</name></author></analytic><series><title level="j">Peptides</title><idno type="ISSN">0196-9781</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cloning, Molecular</term><term>DNA, Complementary (genetics)</term><term>Fishes (genetics)</term><term>Gene Duplication</term><term>Molecular Sequence Data</term><term>Open Reading Frames</term><term>Pituitary Gland (chemistry)</term><term>Point Mutation</term><term>Pro-Opiomelanocortin (genetics)</term><term>Sequence Analysis, DNA</term><term>Sequence Homology, Amino Acid</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Complementary</term><term>Pro-Opiomelanocortin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Pituitary Gland</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fishes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cloning, Molecular</term><term>Gene Duplication</term><term>Molecular Sequence Data</term><term>Open Reading Frames</term><term>Point Mutation</term><term>Sequence Analysis, DNA</term><term>Sequence Homology, Amino Acid</term><term>Sequence Homology, Nucleic Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeon POMC B). In both sturgeon POMC cDNAs the open reading frame is 795 nucleotides in length. However, the two sturgeon POMC cDNAs differ at 26 amino acid positions in the opening frame. In addition, the 2 forms of POMC differ at 45 nucleotide positions within the open reading frame. The number and types of point mutations are compared in the 2 sturgeons POMC cDNAs, and the origin of the two POMC genes is discussed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Danielson, P" sort="Danielson, P" uniqKey="Danielson P" first="P" last="Danielson">P. Danielson</name><name sortKey="Dores, R M" sort="Dores, R M" uniqKey="Dores R" first="R M" last="Dores">R M Dores</name><name sortKey="Fitzpatrick, M" sort="Fitzpatrick, M" uniqKey="Fitzpatrick M" first="M" last="Fitzpatrick">M. Fitzpatrick</name><name sortKey="Schreck, C" sort="Schreck, C" uniqKey="Schreck C" first="C" last="Schreck">C. Schreck</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Alrubaian, J" sort="Alrubaian, J" uniqKey="Alrubaian J" first="J" last="Alrubaian">J. Alrubaian</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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