Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model.
Identifieur interne : 001E88 ( Main/Merge ); précédent : 001E87; suivant : 001E89Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model.
Auteurs : N E Buroker [États-Unis] ; J R Brown ; T A Gilbert ; P J O'Hara ; A T Beckenbach ; W K Thomas ; M J SmithSource :
- Genetics [ 0016-6731 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Mitochondrial.
- chemical , metabolism : DNA, Mitochondrial.
- genetics : Fishes.
- Animals, Base Sequence, DNA Replication, Models, Genetic, Molecular Sequence Data, Nucleic Acid Conformation, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid.
Abstract
Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.
PubMed: 1968410
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pubmed:1968410Le document en format XML
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The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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