Construction of a variability map for eukaryotic large subunit ribosomal RNA
Identifieur interne : 001707 ( Main/Merge ); précédent : 001706; suivant : 001708Construction of a variability map for eukaryotic large subunit ribosomal RNA
Auteurs : Abdelghani Ben Ali [Allemagne] ; Jan Wuyts [Allemagne] ; Rupert De Wachter [Allemagne] ; Axel Meyer [Allemagne] ; Yves Van De Peer [Allemagne]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 1999-07.
Abstract
In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.
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DOI: 10.1093/nar/27.14.2825
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last="Ali">Abdelghani Ben Ali</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Constance (Allemagne)</settlement></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Wuyts, Jan" sort="Wuyts, Jan" uniqKey="Wuyts J" first="Jan" last="Wuyts">Jan Wuyts</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District 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The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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