Construction of a variability map for eukaryotic large subunit ribosomal RNA
Identifieur interne : 000927 ( Istex/Corpus ); précédent : 000926; suivant : 000928Construction of a variability map for eukaryotic large subunit ribosomal RNA
Auteurs : Abdelghani Ben Ali ; Jan Wuyts ; Rupert De Wachter ; Axel Meyer ; Yves Van De PeerSource :
- Nucleic Acids Research [ 0305-1048 ] ; 1999-07.
Abstract
In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.
Url:
DOI: 10.1093/nar/27.14.2825
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Tel: +49 7531 88 2763; Fax: +49 7531 88 3018; Email: <email>yves.vandepeer@uni-konstanz.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>07</month><year>1999</year></pub-date><volume>27</volume><issue>14</issue><fpage>2825</fpage><lpage>2831</lpage><history><date date-type="received"><day>14</day><month>5</month><year>1999</year></date><date date-type="accepted"><day>27</day><month>5</month><year>1999</year></date></history><copyright-statement>© 1999 Oxford University Press</copyright-statement><copyright-year>1999</copyright-year><abstract><p>In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Construction of a variability map for eukaryotic large subunit ribosomal RNA</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Construction of a variability map for eukaryotic large subunit ribosomal RNA</title></titleInfo><name type="personal"><namePart type="given">Abdelghani Ben</namePart><namePart type="family">Ali</namePart><affiliation>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Wuyts</namePart><affiliation>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rupert</namePart><namePart type="family">De Wachter</namePart><affiliation>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Axel</namePart><namePart type="family">Meyer</namePart><affiliation>Department of Biology, University of Konstanz, D-78457 Konstanz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Yves</namePart><namePart type="family">Van de Peer</namePart><affiliation>Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium, D-78457 Konstanz, Germany</affiliation><affiliation>E-mail: yves.vandepeer@uni-konstanz.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1999-07</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. 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