Gastroenteropancreatic hormones (insulin, glucagon, somatostatin, and multiple forms of PYY) from the pallid sturgeon, Scaphirhynchus albus (Acipenseriformes).
Identifieur interne : 001591 ( Main/Merge ); précédent : 001590; suivant : 001592Gastroenteropancreatic hormones (insulin, glucagon, somatostatin, and multiple forms of PYY) from the pallid sturgeon, Scaphirhynchus albus (Acipenseriformes).
Auteurs : J B Kim [États-Unis] ; V. Gadsb Ll ; J. Whittaker ; B A Barton ; J M ConlonSource :
- General and comparative endocrinology [ 0016-6480 ] ; 2000.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Binding, Competitive, Chromatography, Gel, Chromatography, High Pressure Liquid, Digestive System (chemistry), Dipeptides (chemistry), Dipeptides (isolation & purification), Dipeptides (metabolism), Fishes, Glucagon (chemistry), Glucagon (isolation & purification), Glucagon (metabolism), Humans, Insulin (chemistry), Insulin (isolation & purification), Insulin (metabolism), Molecular Sequence Data, Pancreas (chemistry), Receptor, Insulin (metabolism), Sequence Homology, Somatostatin (chemistry), Somatostatin (isolation & purification), Somatostatin (metabolism).
- MESH :
- chemical , chemistry : Dipeptides, Glucagon, Insulin, Somatostatin.
- chemistry : Digestive System, Pancreas.
- chemical , isolation & purification : Dipeptides, Glucagon, Insulin, Somatostatin.
- chemical , metabolism : Dipeptides, Glucagon, Insulin, Receptor, Insulin, Somatostatin.
- Amino Acid Sequence, Animals, Binding, Competitive, Chromatography, Gel, Chromatography, High Pressure Liquid, Fishes, Humans, Molecular Sequence Data, Sequence Homology.
Abstract
Insulin, glucagon, somatostatin-14, and three structurally related molecular forms of peptide tyrosine-tyrosine (PYY) were isolated from an extract of the combined pancreas and gastrointestinal tract of the pallid sturgeon, Scaphirhynchus albus. Pallid sturgeon insulin was identical to insulin from the Russian sturgeon, Acipenser guldenstaedti, and to insulin-2 from the paddlefish, Polyodon spathula, and was approximately twofold less potent than human insulin in inhibiting the binding of [3-[(125)I] iodotyrosine-A14] human insulin to the soluble human insulin receptor. The sturgeon glucagon (HSQGMFTNDY(10)-SKYLEEKLAQ(20) EFVEWLKNGK(30)S), like the two paddlefish glucagons, contains 31 rather than 29 amino acid residues, indicative of an anomalous pathway of posttranslational processing of proglucagon. Pallid sturgeon somatostatin, identical to human somatostatin-14, was also isolated in a second molecular form containing an oxidized tryptophan residue, but [Pro(2)]somatostatin-14, previously isolated from the pituitary of A. guldenstaedti, was not identified. Sturgeon PYY (FPPKPEHPGD(10)DAPAEDVAKY(20)YTALRHYINL(30) ITRQRY.HN(2)) was also isolated in variant forms containing the substitutions (Phe(1) --> Ala) and (Ala(18) --> Val), indicative of at least two gene duplications occurring within the Acipenseriformes lineage. The amino acid sequences of the pallidsturgeon PYY peptides are appreciably different from the proposed "ancestral" PYY sequence that has otherwise been very strongly conserved among the actinopterygian and elasmobranch fish.
DOI: 10.1006/gcen.2000.7571
PubMed: 11121300
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pubmed:11121300Le document en format XML
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Whittaker</name></author><author><name sortKey="Barton, B A" sort="Barton, B A" uniqKey="Barton B" first="B A" last="Barton">B A Barton</name></author><author><name sortKey="Conlon, J M" sort="Conlon, J M" uniqKey="Conlon J" first="J M" last="Conlon">J M Conlon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11121300</idno><idno type="pmid">11121300</idno><idno type="doi">10.1006/gcen.2000.7571</idno><idno type="wicri:Area/PubMed/Corpus">000636</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000636</idno><idno type="wicri:Area/PubMed/Curation">000636</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000636</idno><idno type="wicri:Area/PubMed/Checkpoint">000636</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000636</idno><idno type="wicri:Area/Ncbi/Merge">000029</idno><idno type="wicri:Area/Ncbi/Curation">000029</idno><idno type="wicri:Area/Ncbi/Checkpoint">000029</idno><idno type="wicri:doubleKey">0016-6480:2000:Kim J:gastroenteropancreatic:hormones:insulin</idno><idno type="wicri:Area/Main/Merge">001591</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gastroenteropancreatic hormones (insulin, glucagon, somatostatin, and multiple forms of PYY) from the pallid sturgeon, Scaphirhynchus albus (Acipenseriformes).</title><author><name sortKey="Kim, J B" sort="Kim, J B" uniqKey="Kim J" first="J B" last="Kim">J B Kim</name><affiliation wicri:level="1"><nlm:affiliation>Regulatory Peptide Center, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regulatory Peptide Center, Creighton University School of Medicine, Omaha, Nebraska 68178</wicri:regionArea><wicri:noRegion>Nebraska 68178</wicri:noRegion></affiliation></author><author><name sortKey="Gadsb Ll, V" sort="Gadsb Ll, V" uniqKey="Gadsb Ll V" first="V" last="Gadsb Ll">V. Gadsb Ll</name></author><author><name sortKey="Whittaker, J" sort="Whittaker, J" uniqKey="Whittaker J" first="J" last="Whittaker">J. Whittaker</name></author><author><name sortKey="Barton, B A" sort="Barton, B A" uniqKey="Barton B" first="B A" last="Barton">B A Barton</name></author><author><name sortKey="Conlon, J M" sort="Conlon, J M" uniqKey="Conlon J" first="J M" last="Conlon">J M Conlon</name></author></analytic><series><title level="j">General and comparative endocrinology</title><idno type="ISSN">0016-6480</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding, Competitive</term><term>Chromatography, Gel</term><term>Chromatography, High Pressure Liquid</term><term>Digestive System (chemistry)</term><term>Dipeptides (chemistry)</term><term>Dipeptides (isolation & purification)</term><term>Dipeptides (metabolism)</term><term>Fishes</term><term>Glucagon (chemistry)</term><term>Glucagon (isolation & purification)</term><term>Glucagon (metabolism)</term><term>Humans</term><term>Insulin (chemistry)</term><term>Insulin (isolation & purification)</term><term>Insulin (metabolism)</term><term>Molecular Sequence Data</term><term>Pancreas (chemistry)</term><term>Receptor, Insulin (metabolism)</term><term>Sequence Homology</term><term>Somatostatin (chemistry)</term><term>Somatostatin (isolation & purification)</term><term>Somatostatin (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dipeptides</term><term>Glucagon</term><term>Insulin</term><term>Somatostatin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Digestive System</term><term>Pancreas</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Dipeptides</term><term>Glucagon</term><term>Insulin</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptides</term><term>Glucagon</term><term>Insulin</term><term>Receptor, Insulin</term><term>Somatostatin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding, Competitive</term><term>Chromatography, Gel</term><term>Chromatography, High Pressure Liquid</term><term>Fishes</term><term>Humans</term><term>Molecular Sequence Data</term><term>Sequence Homology</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin, glucagon, somatostatin-14, and three structurally related molecular forms of peptide tyrosine-tyrosine (PYY) were isolated from an extract of the combined pancreas and gastrointestinal tract of the pallid sturgeon, Scaphirhynchus albus. Pallid sturgeon insulin was identical to insulin from the Russian sturgeon, Acipenser guldenstaedti, and to insulin-2 from the paddlefish, Polyodon spathula, and was approximately twofold less potent than human insulin in inhibiting the binding of [3-[(125)I] iodotyrosine-A14] human insulin to the soluble human insulin receptor. The sturgeon glucagon (HSQGMFTNDY(10)-SKYLEEKLAQ(20) EFVEWLKNGK(30)S), like the two paddlefish glucagons, contains 31 rather than 29 amino acid residues, indicative of an anomalous pathway of posttranslational processing of proglucagon. Pallid sturgeon somatostatin, identical to human somatostatin-14, was also isolated in a second molecular form containing an oxidized tryptophan residue, but [Pro(2)]somatostatin-14, previously isolated from the pituitary of A. guldenstaedti, was not identified. Sturgeon PYY (FPPKPEHPGD(10)DAPAEDVAKY(20)YTALRHYINL(30) ITRQRY.HN(2)) was also isolated in variant forms containing the substitutions (Phe(1) --> Ala) and (Ala(18) --> Val), indicative of at least two gene duplications occurring within the Acipenseriformes lineage. The amino acid sequences of the pallidsturgeon PYY peptides are appreciably different from the proposed "ancestral" PYY sequence that has otherwise been very strongly conserved among the actinopterygian and elasmobranch fish.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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