Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat
Identifieur interne : 000F56 ( Main/Merge ); précédent : 000F55; suivant : 000F57Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat
Auteurs : N. Mirabella [Italie] ; C. Squillacioti [Italie] ; A. Genovese [Italie] ; I. Paone [Italie] ; G. Paino [Italie]Source :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
Introduction: Neurotrophic factors constitute a group of growth factor families, which have important effects on survival and differentiation of neuronal cells. The neurotrophin family is composed of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin (NT)3 and NT 4/5. Neurotrophins act by means of high (TrkA, TrkB and TrkC) and low (p75) affinity receptors on numerous neuronal populations of central and peripheral nervous system. The family of glial derived neurotrophic factor (GDNF) includes, besides the GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). They bind to a common receptor Ret, but the binding specificity is due to a group of proteins (GFRα 1–4). These factors show a trophic effect on dorsal ganglia, motor neurons and autonomic nervous system. The aim of the present study is to evaluate the expression of NGF, BDNF and GDNF in the vas deferens and accessory genital glands of normal and castrated rats.
Url:
DOI: 10.1111/j.1439-0264.2005.00669_76.x
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