Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat
Identifieur interne : 000E81 ( Istex/Corpus ); précédent : 000E80; suivant : 000E82Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat
Auteurs : N. Mirabella ; C. Squillacioti ; A. Genovese ; I. Paone ; G. PainoSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
Introduction: Neurotrophic factors constitute a group of growth factor families, which have important effects on survival and differentiation of neuronal cells. The neurotrophin family is composed of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin (NT)3 and NT 4/5. Neurotrophins act by means of high (TrkA, TrkB and TrkC) and low (p75) affinity receptors on numerous neuronal populations of central and peripheral nervous system. The family of glial derived neurotrophic factor (GDNF) includes, besides the GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). They bind to a common receptor Ret, but the binding specificity is due to a group of proteins (GFRα 1–4). These factors show a trophic effect on dorsal ganglia, motor neurons and autonomic nervous system. The aim of the present study is to evaluate the expression of NGF, BDNF and GDNF in the vas deferens and accessory genital glands of normal and castrated rats.
Url:
DOI: 10.1111/j.1439-0264.2005.00669_76.x
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Rat</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><availability><p>WILEY</p></availability><date>2005</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat</title><author xml:id="author-1"><persName><forename type="first">N.</forename><surname>Mirabella</surname></persName><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation></author><author xml:id="author-2"><persName><forename type="first">C.</forename><surname>Squillacioti</surname></persName><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation></author><author xml:id="author-3"><persName><forename type="first">A.</forename><surname>Genovese</surname></persName><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation></author><author xml:id="author-4"><persName><forename type="first">I.</forename><surname>Paone</surname></persName><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation></author><author xml:id="author-5"><persName><forename 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The neurotrophin family is composed of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin (NT)3 and NT 4/5. Neurotrophins act by means of high (TrkA, TrkB and TrkC) and low (p75) affinity receptors on numerous neuronal populations of central and peripheral nervous system. The family of glial derived neurotrophic factor (GDNF) includes, besides the GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). They bind to a common receptor Ret, but the binding specificity is due to a group of proteins (GFRα 1–4). These factors show a trophic effect on dorsal ganglia, motor neurons and autonomic nervous system. The aim of the present study is to evaluate the expression of NGF, BDNF and GDNF in the vas deferens and accessory genital glands of normal and castrated rats.</p><p><b>Methods: </b> Immunohistochemistry, enzyme linked immunoassay (ELISA), reverse transcriptase (RT)‐polymerase chain reaction (PCR).</p><p><b>Results and Discussion: </b> Immunoreactivity to NGF, BDNF and GDNF was observed in all the investigated tracts. Generally, this immunoreactivity seemed to increase in castrated rats. ELISA and RT‐PCR were performed to evaluate the levels of BDNF protein and its mRNA. In the normals, the greatest concentration of BDNF was observed in the vesicular gland, the lowest in the prostate. In the castrated, the BDNF concentration significantly decreased in the vas deferens. Conversely, it increased in the vesicular gland and in the ventral and dorsal prostate. BDNF transcripts were detected in both normal and castrated rats. These results suggest that neurotrophic factors are produced by the vas deferens and accessory genital glands and, in normal conditions, they are downregulated by androgens.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of Castration on the Expression of Neurotrophic Factors in the Vas Deferens and Accessory Genital Glands of the Rat</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Mirabella</namePart><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Squillacioti</namePart><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Genovese</namePart><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Paone</namePart><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Paino</namePart><affiliation>Department of structures, functions and biological technologies, Faculty of Veterinary Medicine, University of Naples Federico II, 80137, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Verlag GmbH</publisher><place><placeTerm type="text">Berlin, Germany</placeTerm></place><dateIssued encoding="w3cdtf">2005-12</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Introduction: Neurotrophic factors constitute a group of growth factor families, which have important effects on survival and differentiation of neuronal cells. The neurotrophin family is composed of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin (NT)3 and NT 4/5. Neurotrophins act by means of high (TrkA, TrkB and TrkC) and low (p75) affinity receptors on numerous neuronal populations of central and peripheral nervous system. The family of glial derived neurotrophic factor (GDNF) includes, besides the GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). They bind to a common receptor Ret, but the binding specificity is due to a group of proteins (GFRα 1–4). These factors show a trophic effect on dorsal ganglia, motor neurons and autonomic nervous system. The aim of the present study is to evaluate the expression of NGF, BDNF and GDNF in the vas deferens and accessory genital glands of normal and castrated rats.</abstract><abstract>Methods: Immunohistochemistry, enzyme linked immunoassay (ELISA), reverse transcriptase (RT)‐polymerase chain reaction (PCR).</abstract><abstract>Results and Discussion: Immunoreactivity to NGF, BDNF and GDNF was observed in all the investigated tracts. Generally, this immunoreactivity seemed to increase in castrated rats. ELISA and RT‐PCR were performed to evaluate the levels of BDNF protein and its mRNA. In the normals, the greatest concentration of BDNF was observed in the vesicular gland, the lowest in the prostate. In the castrated, the BDNF concentration significantly decreased in the vas deferens. Conversely, it increased in the vesicular gland and in the ventral and dorsal prostate. BDNF transcripts were detected in both normal and castrated rats. These results suggest that neurotrophic factors are produced by the vas deferens and accessory genital glands and, in normal conditions, they are downregulated by androgens.</abstract><relatedItem type="host"><titleInfo><title>Anatomia, Histologia, Embryologia</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0340-2096</identifier><identifier type="eISSN">1439-0264</identifier><identifier type="DOI">10.1111/(ISSN)1439-0264</identifier><identifier type="PublisherID">AHE</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>33</start><end>34</end></extent></part></relatedItem><identifier type="istex">6D17412AFE3C4FFDCE22D8724CBC2E290E42026B</identifier><identifier type="DOI">10.1111/j.1439-0264.2005.00669_76.x</identifier><identifier type="ArticleID">AHE669_76_76</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Verlag GmbH</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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