Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii).
Identifieur interne : 001147 ( Main/Exploration ); précédent : 001146; suivant : 001148Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii).
Auteurs : Xiaolin Hou [République populaire de Chine] ; Jianzhong Shen ; Suxia Zhang ; Haiyang Jiang ; Joel R. CoatsSource :
- Journal of agricultural and food chemistry [ 0021-8561 ] ; 2003.
English descriptors
- KwdEn :
- Animals, Anti-Infective Agents (administration & dosage), Anti-Infective Agents (analysis), Anti-Infective Agents (pharmacokinetics), Chromatography, High Pressure Liquid, Female, Fishes (metabolism), Kinetics, Male, Muscle, Skeletal (chemistry), Muscle, Skeletal (metabolism), Sulfamethazine (administration & dosage), Sulfamethazine (analysis), Sulfamethazine (pharmacokinetics), Water (analysis).
- MESH :
- chemical , administration & dosage : Anti-Infective Agents, Sulfamethazine.
- chemical , analysis : Anti-Infective Agents, Sulfamethazine, Water.
- chemical , pharmacokinetics : Anti-Infective Agents, Sulfamethazine.
- chemistry : Muscle, Skeletal.
- metabolism : Fishes, Muscle, Skeletal.
- Animals, Chromatography, High Pressure Liquid, Female, Kinetics, Male.
Abstract
A steady-state bioconcentration and elimination of sulfamethazine (SM(2)) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM(2), respectively. SM(2) and its main metabolite, N(4)-acetyl-SM(2), were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after approximately 3 days. The bioconcentration factor in muscle (BCF(m)) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t(1/2)) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM(2) will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF(m) was relatively higher under the low-concentration exposure.
DOI: 10.1021/jf030492+
PubMed: 14664536
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000572
- to stream PubMed, to step Curation: 000572
- to stream PubMed, to step Checkpoint: 000572
- to stream Ncbi, to step Merge: 000108
- to stream Ncbi, to step Curation: 000108
- to stream Ncbi, to step Checkpoint: 000108
- to stream Main, to step Merge: 001201
- to stream Main, to step Curation: 001147
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii).</title>
<author><name sortKey="Hou, Xiaolin" sort="Hou, Xiaolin" uniqKey="Hou X" first="Xiaolin" last="Hou">Xiaolin Hou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shen, Jianzhong" sort="Shen, Jianzhong" uniqKey="Shen J" first="Jianzhong" last="Shen">Jianzhong Shen</name>
</author>
<author><name sortKey="Zhang, Suxia" sort="Zhang, Suxia" uniqKey="Zhang S" first="Suxia" last="Zhang">Suxia Zhang</name>
</author>
<author><name sortKey="Jiang, Haiyang" sort="Jiang, Haiyang" uniqKey="Jiang H" first="Haiyang" last="Jiang">Haiyang Jiang</name>
</author>
<author><name sortKey="Coats, Joel R" sort="Coats, Joel R" uniqKey="Coats J" first="Joel R" last="Coats">Joel R. Coats</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:14664536</idno>
<idno type="pmid">14664536</idno>
<idno type="doi">10.1021/jf030492+</idno>
<idno type="wicri:Area/PubMed/Corpus">000572</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000572</idno>
<idno type="wicri:Area/PubMed/Curation">000572</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000572</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000572</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000572</idno>
<idno type="wicri:Area/Ncbi/Merge">000108</idno>
<idno type="wicri:Area/Ncbi/Curation">000108</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000108</idno>
<idno type="wicri:doubleKey">0021-8561:2003:Hou X:bioconcentration:and:elimination</idno>
<idno type="wicri:Area/Main/Merge">001201</idno>
<idno type="wicri:Area/Main/Curation">001147</idno>
<idno type="wicri:Area/Main/Exploration">001147</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii).</title>
<author><name sortKey="Hou, Xiaolin" sort="Hou, Xiaolin" uniqKey="Hou X" first="Xiaolin" last="Hou">Xiaolin Hou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University, Beijing 100094</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shen, Jianzhong" sort="Shen, Jianzhong" uniqKey="Shen J" first="Jianzhong" last="Shen">Jianzhong Shen</name>
</author>
<author><name sortKey="Zhang, Suxia" sort="Zhang, Suxia" uniqKey="Zhang S" first="Suxia" last="Zhang">Suxia Zhang</name>
</author>
<author><name sortKey="Jiang, Haiyang" sort="Jiang, Haiyang" uniqKey="Jiang H" first="Haiyang" last="Jiang">Haiyang Jiang</name>
</author>
<author><name sortKey="Coats, Joel R" sort="Coats, Joel R" uniqKey="Coats J" first="Joel R" last="Coats">Joel R. Coats</name>
</author>
</analytic>
<series><title level="j">Journal of agricultural and food chemistry</title>
<idno type="ISSN">0021-8561</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Anti-Infective Agents (administration & dosage)</term>
<term>Anti-Infective Agents (analysis)</term>
<term>Anti-Infective Agents (pharmacokinetics)</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Female</term>
<term>Fishes (metabolism)</term>
<term>Kinetics</term>
<term>Male</term>
<term>Muscle, Skeletal (chemistry)</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Sulfamethazine (administration & dosage)</term>
<term>Sulfamethazine (analysis)</term>
<term>Sulfamethazine (pharmacokinetics)</term>
<term>Water (analysis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Sulfamethazine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Sulfamethazine</term>
<term>Water</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Sulfamethazine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fishes</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Female</term>
<term>Kinetics</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A steady-state bioconcentration and elimination of sulfamethazine (SM(2)) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM(2), respectively. SM(2) and its main metabolite, N(4)-acetyl-SM(2), were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after approximately 3 days. The bioconcentration factor in muscle (BCF(m)) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t(1/2)) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM(2) will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF(m) was relatively higher under the low-concentration exposure.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Coats, Joel R" sort="Coats, Joel R" uniqKey="Coats J" first="Joel R" last="Coats">Joel R. Coats</name>
<name sortKey="Jiang, Haiyang" sort="Jiang, Haiyang" uniqKey="Jiang H" first="Haiyang" last="Jiang">Haiyang Jiang</name>
<name sortKey="Shen, Jianzhong" sort="Shen, Jianzhong" uniqKey="Shen J" first="Jianzhong" last="Shen">Jianzhong Shen</name>
<name sortKey="Zhang, Suxia" sort="Zhang, Suxia" uniqKey="Zhang S" first="Suxia" last="Zhang">Suxia Zhang</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Hou, Xiaolin" sort="Hou, Xiaolin" uniqKey="Hou X" first="Xiaolin" last="Hou">Xiaolin Hou</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001147 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001147 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Eau |area= EsturgeonV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:14664536 |texte= Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii). }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:14664536" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a EsturgeonV1
![]() | This area was generated with Dilib version V0.6.27. | ![]() |