Conformation of sturgeon pituitary somatotropin.
Identifieur interne : 001E77 ( Main/Exploration ); précédent : 001E76; suivant : 001E78Conformation of sturgeon pituitary somatotropin.
Auteurs : T A Bewley ; H. PapkoffSource :
- International journal of peptide and protein research [ 0367-8377 ] ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Peptide Fragments.
- chemical : Growth Hormone, Thermolysin, Trypsin.
- Animals, Fishes, Protein Conformation, Spectrophotometry, Ultraviolet.
Abstract
Pituitary somatotropin (growth hormone) from the sturgeon (Acipenser gulden-stadti) has been studied by zero-order and second-order absorption spectroscopy, as well as by circular dichroism. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 15,000 +/- 110 M-1 cm-1 at 278.5 nm. Comparison of the conformations of sturgeon somatotropin and somatotropins isolated from several mammalian species, including bovine and human, indicates a close relationship between these molecules. Such similarities may be related to the relatively high biopotency of this fish hormone in mammalian assay systems.
PubMed: 3610472
Affiliations:
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Le document en format XML
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<series><title level="j">International journal of peptide and protein research</title>
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<term>Protein Conformation</term>
<term>Spectrophotometry, Ultraviolet</term>
<term>Thermolysin</term>
<term>Trypsin</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Peptide Fragments</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Growth Hormone</term>
<term>Thermolysin</term>
<term>Trypsin</term>
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<front><div type="abstract" xml:lang="en">Pituitary somatotropin (growth hormone) from the sturgeon (Acipenser gulden-stadti) has been studied by zero-order and second-order absorption spectroscopy, as well as by circular dichroism. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 15,000 +/- 110 M-1 cm-1 at 278.5 nm. Comparison of the conformations of sturgeon somatotropin and somatotropins isolated from several mammalian species, including bovine and human, indicates a close relationship between these molecules. Such similarities may be related to the relatively high biopotency of this fish hormone in mammalian assay systems.</div>
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