Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions
Identifieur interne : 001639 ( Istex/Curation ); précédent : 001638; suivant : 001640Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions
Auteurs : Laura Domínguez [Espagne] ; Ruth Morona [Espagne] ; Agustín González [Espagne] ; Nerea Moreno [Espagne]Source :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2013-03-01.
English descriptors
- KwdEn :
Abstract
The patterns of expression of a set of conserved developmental regulatory transcription factors and neuronal markers were analyzed in the alar hypothalamus of Xenopus laevis throughout development. Combined immunohistochemical and in situ hybridization techniques were used for the identification of subdivisions and their boundaries. The alar hypothalamus was located rostral to the diencephalon in the secondary prosencephalon and represents the rostral continuation of the alar territories of the diencephalon and brainstem, according to the prosomeric model. It is composed of the supraoptoparaventricular (dorsal) and the suprachiasmatic (ventral) regions, and limits dorsally with the preoptic region, caudally with the prethalamic eminence and the prethalamus, and ventrally with the basal hypothalamus. The supraoptoparaventricular area is defined by the orthopedia (Otp) expression and is subdivided into rostral and caudal portions, on the basis of the Nkx2.2 expression only in the rostral portion. This region is the source of many neuroendocrine cells, primarily located in the rostral subdivision. The suprachiasmatic region is characterized by Dll4/Isl1 expression, and was also subdivided into rostral and caudal portions, based on the expression of Nkx2.1/Nkx2.2 and Lhx1/7 exclusively in the rostral portion. Both alar regions are mainly connected with subpallial areas strongly implicated in the limbic system and show robust intrahypothalamic connections. Caudally, both regions project to brainstem centers and spinal cord. All these data support that in terms of topology, molecular specification, and connectivity the subdivisions of the anuran alar hypothalamus possess many features shared with their counterparts in amniotes, likely controlling similar reflexes, responses, and behaviors. J. Comp. Neurol. 521:725–759, 2013. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/cne.23222
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001641
Links to Exploration step
ISTEX:D5DCEAEE30AEF21C6D34CA15A4F5BE8752843901Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions</title>
<author><name sortKey="Dominguez, Laura" sort="Dominguez, Laura" uniqKey="Dominguez L" first="Laura" last="Domínguez">Laura Domínguez</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morona, Ruth" sort="Morona, Ruth" uniqKey="Morona R" first="Ruth" last="Morona">Ruth Morona</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Agustin" sort="Gonzalez, Agustin" uniqKey="Gonzalez A" first="Agustín" last="González">Agustín González</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moreno, Nerea" sort="Moreno, Nerea" uniqKey="Moreno N" first="Nerea" last="Moreno">Nerea Moreno</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Dept. of Cell Biology, Faculty of Biology, University Complutense of Madrid, 28040 Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Dept. of Cell Biology, Faculty of Biology, University Complutense of Madrid, 28040 Madrid</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D5DCEAEE30AEF21C6D34CA15A4F5BE8752843901</idno>
<date when="2013" year="2013">2013</date>
<idno type="doi">10.1002/cne.23222</idno>
<idno type="url">https://api.istex.fr/document/D5DCEAEE30AEF21C6D34CA15A4F5BE8752843901/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001641</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001641</idno>
<idno type="wicri:Area/Istex/Curation">001639</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions</title>
<author><name sortKey="Dominguez, Laura" sort="Dominguez, Laura" uniqKey="Dominguez L" first="Laura" last="Domínguez">Laura Domínguez</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morona, Ruth" sort="Morona, Ruth" uniqKey="Morona R" first="Ruth" last="Morona">Ruth Morona</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Agustin" sort="Gonzalez, Agustin" uniqKey="Gonzalez A" first="Agustín" last="González">Agustín González</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moreno, Nerea" sort="Moreno, Nerea" uniqKey="Moreno N" first="Nerea" last="Moreno">Nerea Moreno</name>
<affiliation wicri:level="1"><mods:affiliation>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Faculty of Biology, Department of Cell Biology, University Complutense of Madrid, Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Dept. of Cell Biology, Faculty of Biology, University Complutense of Madrid, 28040 Madrid, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Dept. of Cell Biology, Faculty of Biology, University Complutense of Madrid, 28040 Madrid</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Comparative Neurology</title>
<title level="j" type="abbrev">J. Comp. Neurol.</title>
<idno type="ISSN">0021-9967</idno>
<idno type="eISSN">1096-9861</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2013-03-01">2013-03-01</date>
<biblScope unit="volume">521</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="725">725</biblScope>
<biblScope unit="page" to="759">759</biblScope>
</imprint>
<idno type="ISSN">0021-9967</idno>
</series>
<idno type="istex">D5DCEAEE30AEF21C6D34CA15A4F5BE8752843901</idno>
<idno type="DOI">10.1002/cne.23222</idno>
<idno type="ArticleID">CNE23222</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0021-9967</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amphibians</term>
<term>evolution</term>
<term>forebrain patterning</term>
<term>homology</term>
<term>preoptic area</term>
<term>suprachiasmatic nucleus</term>
<term>supraoptoparaventricular region</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The patterns of expression of a set of conserved developmental regulatory transcription factors and neuronal markers were analyzed in the alar hypothalamus of Xenopus laevis throughout development. Combined immunohistochemical and in situ hybridization techniques were used for the identification of subdivisions and their boundaries. The alar hypothalamus was located rostral to the diencephalon in the secondary prosencephalon and represents the rostral continuation of the alar territories of the diencephalon and brainstem, according to the prosomeric model. It is composed of the supraoptoparaventricular (dorsal) and the suprachiasmatic (ventral) regions, and limits dorsally with the preoptic region, caudally with the prethalamic eminence and the prethalamus, and ventrally with the basal hypothalamus. The supraoptoparaventricular area is defined by the orthopedia (Otp) expression and is subdivided into rostral and caudal portions, on the basis of the Nkx2.2 expression only in the rostral portion. This region is the source of many neuroendocrine cells, primarily located in the rostral subdivision. The suprachiasmatic region is characterized by Dll4/Isl1 expression, and was also subdivided into rostral and caudal portions, based on the expression of Nkx2.1/Nkx2.2 and Lhx1/7 exclusively in the rostral portion. Both alar regions are mainly connected with subpallial areas strongly implicated in the limbic system and show robust intrahypothalamic connections. Caudally, both regions project to brainstem centers and spinal cord. All these data support that in terms of topology, molecular specification, and connectivity the subdivisions of the anuran alar hypothalamus possess many features shared with their counterparts in amniotes, likely controlling similar reflexes, responses, and behaviors. J. Comp. Neurol. 521:725–759, 2013. © 2012 Wiley Periodicals, Inc.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001639 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001639 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Eau |area= EsturgeonV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:D5DCEAEE30AEF21C6D34CA15A4F5BE8752843901 |texte= Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions }}
![]() | This area was generated with Dilib version V0.6.27. | ![]() |