Surface markers of fish T-cells
Identifieur interne : 001495 ( Istex/Corpus ); précédent : 001494; suivant : 001496Surface markers of fish T-cells
Auteurs : Sylvie PartulaSource :
- Fish and Shellfish Immunology [ 1050-4648 ] ; 1999.
English descriptors
- KwdEn :
Abstract
Two immunological reactions against foreign antigens can be distinguished: (1) the humoral immune response, involving the production of immunoglobulins by plasma cells; (2) the cell-mediated immune responses, mediated by thymus-derived cells. All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.
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DOI: 10.1006/fsim.1998.0190
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All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. 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All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. 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E-mail:sylvie.partula@gmx.de</note><affiliation>*Present address: Institute for Immunology, Johannes Gutenberg University, Mainz, Obere Zahlbacher Str. 67, 55101 Mainz, Germany. E-mail:sylvie.partula@gmx.de</affiliation><affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23, Uppsala, Sweden</affiliation></author></analytic><monogr><title level="j">Fish and Shellfish Immunology</title><title level="j" type="abbrev">YFSIM</title><idno type="pISSN">1050-4648</idno><idno type="PII">S1050-4648(00)X0023-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">9</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="257">257</biblScope></imprint></monogr><idno type="istex">22CB23E51A6E63947BB09795FE6BC6E819FCBDA1</idno><idno type="DOI">10.1006/fsim.1998.0190</idno><idno type="PII">S1050-4648(98)90190-5</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Two immunological reactions against foreign antigens can be distinguished: (1) the humoral immune response, involving the production of immunoglobulins by plasma cells; (2) the cell-mediated immune responses, mediated by thymus-derived cells. All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>T-cell receptor</term></item><item><term>diversity</term></item><item><term>genes</term></item><item><term>fish</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/22CB23E51A6E63947BB09795FE6BC6E819FCBDA1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YFSIM</jid><aid>90190</aid><ce:pii>S1050-4648(98)90190-5</ce:pii><ce:doi>10.1006/fsim.1998.0190</ce:doi><ce:copyright type="full-transfer" year="1999">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Surface markers of fish T-cells</ce:title><ce:author-group><ce:author><ce:given-name>Sylvie</ce:given-name><ce:surname>Partula</ce:surname><ce:cross-ref refid="FN1"><ce:sup>f1</ce:sup><ce:footnote id="FN1"><ce:label>f1</ce:label><ce:note-para>*Present address: Institute for Immunology, Johannes Gutenberg University, Mainz, Obere Zahlbacher Str. 67, 55101 Mainz, Germany. E-mail:sylvie.partula@gmx.de</ce:note-para></ce:footnote></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23, Uppsala, Sweden</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="17" month="8" year="1998"></ce:date-received><ce:date-accepted day="7" month="9" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Two immunological reactions against foreign antigens can be distinguished: (1) the humoral immune response, involving the production of immunoglobulins by plasma cells; (2) the cell-mediated immune responses, mediated by thymus-derived cells. All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg<ce:sup>−</ce:sup>cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The <ce:italic>in vitro</ce:italic> anti-hapten antibody response to a T-dependent antigen requires the participation of sIg<ce:sup>+</ce:sup>and sIg<ce:sup>−</ce:sup>cells and monocytes. In addition, fish sIg<ce:sup>−</ce:sup>lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>T-cell receptor</ce:text></ce:keyword><ce:keyword><ce:text>diversity</ce:text></ce:keyword><ce:keyword><ce:text>genes</ce:text></ce:keyword><ce:keyword><ce:text>fish</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Surface markers of fish T-cells</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Surface markers of fish T-cells</title></titleInfo><name type="personal"><namePart type="given">Sylvie</namePart><namePart type="family">Partula</namePart><affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S-751 23, Uppsala, Sweden</affiliation><description>*Present address: Institute for Immunology, Johannes Gutenberg University, Mainz, Obere Zahlbacher Str. 67, 55101 Mainz, Germany. E-mail:sylvie.partula@gmx.de</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Two immunological reactions against foreign antigens can be distinguished: (1) the humoral immune response, involving the production of immunoglobulins by plasma cells; (2) the cell-mediated immune responses, mediated by thymus-derived cells. All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.</abstract><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>T-cell receptor</topic><topic>diversity</topic><topic>genes</topic><topic>fish</topic></subject><relatedItem type="host"><titleInfo><title>Fish and Shellfish Immunology</title></titleInfo><titleInfo type="abbreviated"><title>YFSIM</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199905</dateIssued></originInfo><identifier type="ISSN">1050-4648</identifier><identifier type="PII">S1050-4648(00)X0023-X</identifier><part><date>199905</date><detail type="volume"><number>9</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>239</start><end>365</end></extent><extent unit="pages"><start>241</start><end>257</end></extent></part></relatedItem><identifier type="istex">22CB23E51A6E63947BB09795FE6BC6E819FCBDA1</identifier><identifier type="DOI">10.1006/fsim.1998.0190</identifier><identifier type="PII">S1050-4648(98)90190-5</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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