Neuropeptide regulation of feeding in catfish, Ictalurus punctatus : a role for glucagon-like peptide-1 (GLP-1)?
Identifieur interne : 000E22 ( Istex/Corpus ); précédent : 000E21; suivant : 000E23Neuropeptide regulation of feeding in catfish, Ictalurus punctatus : a role for glucagon-like peptide-1 (GLP-1)?
Auteurs : Jeffrey T. Silverstein ; Vera M. Bondareva ; Jill B. K. Leonard ; Erika M. PlisetskayaSource :
- Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology [ 1096-4959 ] ; 2001.
English descriptors
- KwdEn :
Abstract
Glucagon-like peptide 1 is a compound known to cause reduced food intake in mammals, though its action on feed intake in fish is unknown. The clear differences in the effects of GLP-1 on mammalian and teleostean glucose homeostasis suggest that we cannot assume a similar action of GLP-1 on feeding in mammals and fish. In this study the effects and specificity of centrally administered GLP-1 on feed intake were examined. It was demonstrated that intracerebroventricular (ICV) injection of glucagon-like peptide 1 (GLP-1) in the channel catfish (Ictalurus punctatus) is a potent inhibitor of feed intake with a dose of 0.25 ng g−1 body wt. reducing feed intake by 50%. The weak response to intraperitoneal (i.p.) and intravenous (i.v.) injection treatments with GLP-1 suggests the major effects on feed intake are centrally mediated. GLP-1 action on feed intake was not antagonized by ICV injection of exendin9–39. Immunoneutralization of GLP-1 by ICV injection of antisalmon GLP-1 antisera did not affect feed intake over 48 h, while ICV injection of GLP-1 at a dose of 30 ng g−1 body wt. reduced feed intake for over 20 h. Additionally, there is some evidence that GLP-1 caused gastric evacuation. We conclude that GLP-1 is a potent inhibitor of feeding in fish, but its involvement in feed intake regulation under physiological conditions remains to be clarified.
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DOI: 10.1016/S1096-4959(01)00357-8
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<front><div type="abstract" xml:lang="en">Glucagon-like peptide 1 is a compound known to cause reduced food intake in mammals, though its action on feed intake in fish is unknown. The clear differences in the effects of GLP-1 on mammalian and teleostean glucose homeostasis suggest that we cannot assume a similar action of GLP-1 on feeding in mammals and fish. In this study the effects and specificity of centrally administered GLP-1 on feed intake were examined. It was demonstrated that intracerebroventricular (ICV) injection of glucagon-like peptide 1 (GLP-1) in the channel catfish (Ictalurus punctatus) is a potent inhibitor of feed intake with a dose of 0.25 ng g−1 body wt. reducing feed intake by 50%. The weak response to intraperitoneal (i.p.) and intravenous (i.v.) injection treatments with GLP-1 suggests the major effects on feed intake are centrally mediated. GLP-1 action on feed intake was not antagonized by ICV injection of exendin9–39. Immunoneutralization of GLP-1 by ICV injection of antisalmon GLP-1 antisera did not affect feed intake over 48 h, while ICV injection of GLP-1 at a dose of 30 ng g−1 body wt. reduced feed intake for over 20 h. Additionally, there is some evidence that GLP-1 caused gastric evacuation. We conclude that GLP-1 is a potent inhibitor of feeding in fish, but its involvement in feed intake regulation under physiological conditions remains to be clarified.</div>
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<notesStmt><note type="content">Fig. 1: Dose response in feed intake (% BW) to ICV injected cfGLP-1. Sample size was n=8 for control and n=4 for each dose. Points with different superscripts indicate significant difference at P<0.01. The dose at which intake was 50% of controls is indicated by the arrow.</note>
<note type="content">Fig. 2: (a) Feed intake following i.v. injection of cfGLP-1, 150 ng g−1 BW. The asterisk indicates a significant difference (P<0.04) between cfGLP-1 injected Norris fish compared with their PBS injected counterparts, the difference in USDA-103 fish was not significant (n=8). (b) Intraperitoneal injection of fish from the Norris strain with PBS or 100 ng g−1 BW cfGLP-1 (n=6).</note>
<note type="content">Fig. 3: (a) Feed consumption following ICV injection of PBS (control), cfGLP-1 (0.3 ng g−1 BW), the putative GLP-1 receptor antagonist exendin9–39 (12.5 ng g−1 BW), and cfGLP-1+exendin9–39 (same doses as above). All treatments (n=14) were administered in 2 μl volume. Feed consumption was normalized to controls. Bars with different superscripts are significantly different (P<0.005). (b) Time course of feed consumption (normalized to control initial intake value) after ICV injection of hGLP-1 (30 ng g−1 BW), PBS and undiluted antisera against salmon GLP-1 (GLPab). All injections were in 2 μl volume. At times 1 and 3 h: n=4, and at 8, 20 and 48 h: n=8. Bars with different superscripts within a time point are significantly different (P<0.05).</note>
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<ce:footnote id="FN1"><ce:label>1</ce:label>
<ce:note-para>Current address: Biology Department, Northern Michigan University, Marquette, MI 49855, USA.</ce:note-para>
</ce:footnote>
</ce:author-group>
<ce:date-received day="10" month="10" year="2000"></ce:date-received>
<ce:date-revised day="5" month="1" year="2001"></ce:date-revised>
<ce:date-accepted day="15" month="1" year="2001"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Glucagon-like peptide 1 is a compound known to cause reduced food intake in mammals, though its action on feed intake in fish is unknown. The clear differences in the effects of GLP-1 on mammalian and teleostean glucose homeostasis suggest that we cannot assume a similar action of GLP-1 on feeding in mammals and fish. In this study the effects and specificity of centrally administered GLP-1 on feed intake were examined. It was demonstrated that intracerebroventricular (ICV) injection of glucagon-like peptide 1 (GLP-1) in the channel catfish (<ce:italic>Ictalurus punctatus</ce:italic>
) is a potent inhibitor of feed intake with a dose of 0.25 ng g<ce:sup>−1</ce:sup>
body wt. reducing feed intake by 50%. The weak response to intraperitoneal (i.p.) and intravenous (i.v.) injection treatments with GLP-1 suggests the major effects on feed intake are centrally mediated. GLP-1 action on feed intake was not antagonized by ICV injection of exendin<ce:inf>9–39</ce:inf>
. Immunoneutralization of GLP-1 by ICV injection of antisalmon GLP-1 antisera did not affect feed intake over 48 h, while ICV injection of GLP-1 at a dose of 30 ng g<ce:sup>−1</ce:sup>
body wt. reduced feed intake for over 20 h. Additionally, there is some evidence that GLP-1 caused gastric evacuation. We conclude that GLP-1 is a potent inhibitor of feeding in fish, but its involvement in feed intake regulation under physiological conditions remains to be clarified.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>Feeding</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Feed intake regulation</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Glucagon-like peptide-1</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Intracerebroventricular injection</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Exendin<ce:inf>9–39</ce:inf>
</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Immunoneutralization</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Catfish</ce:text>
</ce:keyword>
<ce:keyword><ce:text><ce:italic>Ictalurus punctatus</ce:italic>
</ce:text>
</ce:keyword>
</ce:keywords>
</head>
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<mods version="3.6"><titleInfo lang="en"><title>Neuropeptide regulation of feeding in catfish, Ictalurus punctatus : a role for glucagon-like peptide-1 (GLP-1)?</title>
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<titleInfo type="alternative" lang="en" contentType="CDATA"><title>Neuropeptide regulation of feeding in catfish,</title>
</titleInfo>
<name type="personal"><namePart type="given">Jeffrey T.</namePart>
<namePart type="family">Silverstein</namePart>
<affiliation>E-mail: jsilvers@ars.usda.gov</affiliation>
<affiliation>USDA, ARS, Catfish Genetics Research Unit, Thad Cochran National Warmwater Aquaculture Center, Stoneville, MS, 38776, USA</affiliation>
<description>Corresponding author. Tel.: +1-662-686-3591; fax: +1-662-686-3567</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Vera M.</namePart>
<namePart type="family">Bondareva</namePart>
<affiliation>Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jill B.K.</namePart>
<namePart type="family">Leonard</namePart>
<affiliation>USDA, ARS, Catfish Genetics Research Unit, Thad Cochran National Warmwater Aquaculture Center, Stoneville, MS, 38776, USA</affiliation>
<description>Current address: Biology Department, Northern Michigan University, Marquette, MI 49855, USA.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Erika M.</namePart>
<namePart type="family">Plisetskaya</namePart>
<affiliation>University of Washington, School of Fisheries, Seattle, WA 98195 USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<abstract lang="en">Glucagon-like peptide 1 is a compound known to cause reduced food intake in mammals, though its action on feed intake in fish is unknown. The clear differences in the effects of GLP-1 on mammalian and teleostean glucose homeostasis suggest that we cannot assume a similar action of GLP-1 on feeding in mammals and fish. In this study the effects and specificity of centrally administered GLP-1 on feed intake were examined. It was demonstrated that intracerebroventricular (ICV) injection of glucagon-like peptide 1 (GLP-1) in the channel catfish (Ictalurus punctatus) is a potent inhibitor of feed intake with a dose of 0.25 ng g−1 body wt. reducing feed intake by 50%. The weak response to intraperitoneal (i.p.) and intravenous (i.v.) injection treatments with GLP-1 suggests the major effects on feed intake are centrally mediated. GLP-1 action on feed intake was not antagonized by ICV injection of exendin9–39. Immunoneutralization of GLP-1 by ICV injection of antisalmon GLP-1 antisera did not affect feed intake over 48 h, while ICV injection of GLP-1 at a dose of 30 ng g−1 body wt. reduced feed intake for over 20 h. Additionally, there is some evidence that GLP-1 caused gastric evacuation. We conclude that GLP-1 is a potent inhibitor of feeding in fish, but its involvement in feed intake regulation under physiological conditions remains to be clarified.</abstract>
<note type="content">Fig. 1: Dose response in feed intake (% BW) to ICV injected cfGLP-1. Sample size was n=8 for control and n=4 for each dose. Points with different superscripts indicate significant difference at P<0.01. The dose at which intake was 50% of controls is indicated by the arrow.</note>
<note type="content">Fig. 2: (a) Feed intake following i.v. injection of cfGLP-1, 150 ng g−1 BW. The asterisk indicates a significant difference (P<0.04) between cfGLP-1 injected Norris fish compared with their PBS injected counterparts, the difference in USDA-103 fish was not significant (n=8). (b) Intraperitoneal injection of fish from the Norris strain with PBS or 100 ng g−1 BW cfGLP-1 (n=6).</note>
<note type="content">Fig. 3: (a) Feed consumption following ICV injection of PBS (control), cfGLP-1 (0.3 ng g−1 BW), the putative GLP-1 receptor antagonist exendin9–39 (12.5 ng g−1 BW), and cfGLP-1+exendin9–39 (same doses as above). All treatments (n=14) were administered in 2 μl volume. Feed consumption was normalized to controls. Bars with different superscripts are significantly different (P<0.005). (b) Time course of feed consumption (normalized to control initial intake value) after ICV injection of hGLP-1 (30 ng g−1 BW), PBS and undiluted antisera against salmon GLP-1 (GLPab). All injections were in 2 μl volume. At times 1 and 3 h: n=4, and at 8, 20 and 48 h: n=8. Bars with different superscripts within a time point are significantly different (P<0.05).</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Feeding</topic>
<topic>Feed intake regulation</topic>
<topic>Glucagon-like peptide-1</topic>
<topic>Intracerebroventricular injection</topic>
<topic>Exendin9–39</topic>
<topic>Immunoneutralization</topic>
<topic>Catfish</topic>
<topic>Ictalurus punctatus</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>CBB</title>
</titleInfo>
<genre type="journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">200106</dateIssued>
</originInfo>
<identifier type="ISSN">1096-4959</identifier>
<identifier type="PII">S1096-4959(00)X0006-1</identifier>
<part><date>200106</date>
<detail type="issue"><title>4TH International Symposium on Fish Endocrinology</title>
</detail>
<detail type="volume"><number>129</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>2–3</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>205</start>
<end>702</end>
</extent>
<extent unit="pages"><start>623</start>
<end>631</end>
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<identifier type="istex">55329048E08E1F6C15C86FA78D0F4652CEDF10FD</identifier>
<identifier type="DOI">10.1016/S1096-4959(01)00357-8</identifier>
<identifier type="PII">S1096-4959(01)00357-8</identifier>
<accessCondition type="use and reproduction" contentType="copyright">©2001 Elsevier Science Inc.</accessCondition>
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