Surface markers of fish T-cells
Identifieur interne : 000D37 ( Istex/Checkpoint ); précédent : 000D36; suivant : 000D38Surface markers of fish T-cells
Auteurs : Sylvie Partula [Suède]Source :
- Fish and Shellfish Immunology [ 1050-4648 ] ; 1999.
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Abstract
Two immunological reactions against foreign antigens can be distinguished: (1) the humoral immune response, involving the production of immunoglobulins by plasma cells; (2) the cell-mediated immune responses, mediated by thymus-derived cells. All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.
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DOI: 10.1006/fsim.1998.0190
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All jawed vertebrates show these two immunological pathways. In lower vertebrates, the existence of cell-mediated immunity has been shown by transplantation experiments resulting in allograft rejection. The basic phenomena observed are similar to those in mammals. Lymphocyte heterogeneity, particularly the participation of T-like lymphocytes in fish immunity, is now well established. T-like cells were defined as sIg−cells which proliferate in the presence of specific mitogens for mammalian T lymphocytes (Con A and PHA). The mixed leucocyte reaction (MLR) has been demonstrated in all vertebrates, from shark to mammals. The in vitro anti-hapten antibody response to a T-dependent antigen requires the participation of sIg+and sIg−cells and monocytes. In addition, fish sIg−lymphocytes specifically proliferate in the presence of processed and presented antigen, reminiscent of the mammalian classical T-cell/B-cell/APC collaboration. Hitherto, only a few attempts to generate antibodies, reacting exlusively with fish T-cell markers, have been successful. The use of molecular tehniques such as PCR and library screening has allowed the identification of cDNA clones encoding TCR-α and -β chains in several fish species. TCRδ-like chains not yet detected in teleosts have been isolated in shark, suggesting that TCRγδ-like receptors should exist in all gnathostomes. Whereas the teleost TCRβ locus shows a translocon organisation comparable to that of its mammalian counterpart, elasmobranch TCRβ genes are arranged in multiple clusters. As in mammals, the TCR repertoire in fish species appears to be considerable.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>East Middle Sweden</li><li>Svealand</li></region><settlement><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Partula, Sylvie" sort="Partula, Sylvie" uniqKey="Partula S" first="Sylvie" last="Partula">Sylvie Partula</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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