The mechanism of cartilage subdivision in the reorganization of the zebrafish pectoral fin endoskeleton
Identifieur interne : 000192 ( Istex/Checkpoint ); précédent : 000191; suivant : 000193The mechanism of cartilage subdivision in the reorganization of the zebrafish pectoral fin endoskeleton
Auteurs : Jasper Dewit [Belgique] ; P. Eckhard Witten [Belgique, Norvège] ; Ann Huysseune [Belgique]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2011-12-15.
Abstract
A cartilaginous pectoral fin endoskeleton in zebrafish (Danio rerio) develops early, after which the cartilage of the larval fin endoskeleton undergoes a complete transformation into the adult morphology. This transformation includes multiple subdivisions of a single cartilaginous disk. The type of cartilage subdivision is unique to teleost fish. In this study, we present the timing and the developmental features of these subdivisions and we discuss variation in this process, caused by differences in growth rate. We establish that the cartilage subdivisions are developmentally linked to the formation of lepidotrichia in the fin fold. At the cellular level, we show that neither apoptosis nor resorption by chondroclasts and/or macrophages contributes to the cartilage subdivision. Ultrastructural observations show dedifferentiation of chondrocytes in subdivision zones. Different from forelimb development in other vertebrates, dedifferentiation is an important mechanism in the development of the adult pectoral fin skeleton. We here provide further support for the idea that the phenotype of skeletal tissues is not terminal and that plasticity of differentiated connective tissues can play an important role in various developmental and homeostatic processes. J. Exp. Zool. (Mol. Dev. Evol.) 316:584–597, 2011. © 2011 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jez.b.21433
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Zool.</title><idno type="ISSN">1552-5007</idno><idno type="eISSN">1552-5015</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12-15">2011-12-15</date><biblScope unit="volume">316B</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="584">584</biblScope><biblScope unit="page" to="597">597</biblScope></imprint><idno type="ISSN">1552-5007</idno></series><idno type="istex">0A657ACAD3FB12DF713F0158C1AE7EF5D46B5DB0</idno><idno type="DOI">10.1002/jez.b.21433</idno><idno type="ArticleID">JEZ21433</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-5007</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A cartilaginous pectoral fin endoskeleton in zebrafish (Danio rerio) develops early, after which the cartilage of the larval fin endoskeleton undergoes a complete transformation into the adult morphology. This transformation includes multiple subdivisions of a single cartilaginous disk. The type of cartilage subdivision is unique to teleost fish. In this study, we present the timing and the developmental features of these subdivisions and we discuss variation in this process, caused by differences in growth rate. We establish that the cartilage subdivisions are developmentally linked to the formation of lepidotrichia in the fin fold. At the cellular level, we show that neither apoptosis nor resorption by chondroclasts and/or macrophages contributes to the cartilage subdivision. Ultrastructural observations show dedifferentiation of chondrocytes in subdivision zones. Different from forelimb development in other vertebrates, dedifferentiation is an important mechanism in the development of the adult pectoral fin skeleton. We here provide further support for the idea that the phenotype of skeletal tissues is not terminal and that plasticity of differentiated connective tissues can play an important role in various developmental and homeostatic processes. J. Exp. Zool. (Mol. Dev. 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Eckhard Witten</name></country><country name="Norvège"><noRegion><name sortKey="Witten, P Eckhard" sort="Witten, P Eckhard" uniqKey="Witten P" first="P. Eckhard" last="Witten">P. Eckhard Witten</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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