Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework.
Identifieur interne : 000258 ( Main/Exploration ); précédent : 000257; suivant : 000259Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework.
Auteurs : Alex J. Krotulski [États-Unis] ; Amanda L A. Mohr [États-Unis] ; Francis X. Diamond [États-Unis] ; Barry K. Logan [États-Unis]Source :
- Drug testing and analysis [ 1942-7611 ] ; 2020.
Descripteurs français
- KwdFr :
- Cannabinoïdes (métabolisme), Cannabinoïdes (sang), Cannabinoïdes (urine), Chromatographie gazeuse-spectrométrie de masse (méthodes), Détection d'abus de substances (méthodes), Humains (MeSH), Psychoanaleptiques (métabolisme), Psychoanaleptiques (sang), Psychoanaleptiques (urine), Spectroscopie par résonance magnétique (méthodes), Toxicologie médicolégale (MeSH).
- MESH :
- métabolisme : Cannabinoïdes, Psychoanaleptiques.
- méthodes : Chromatographie gazeuse-spectrométrie de masse, Détection d'abus de substances, Spectroscopie par résonance magnétique.
- sang : Cannabinoïdes, Psychoanaleptiques.
- urine : Cannabinoïdes, Psychoanaleptiques.
- Humains, Toxicologie médicolégale.
English descriptors
- KwdEn :
- Cannabinoids (blood), Cannabinoids (metabolism), Cannabinoids (urine), Forensic Toxicology (MeSH), Gas Chromatography-Mass Spectrometry (methods), Humans (MeSH), Illicit Drugs (blood), Illicit Drugs (metabolism), Illicit Drugs (urine), Magnetic Resonance Spectroscopy (methods), Psychotropic Drugs (blood), Psychotropic Drugs (metabolism), Psychotropic Drugs (urine), Substance Abuse Detection (methods).
- MESH :
- chemical , blood : Cannabinoids, Illicit Drugs, Psychotropic Drugs.
- chemical , metabolism : Cannabinoids, Illicit Drugs, Psychotropic Drugs.
- chemical , urine : Cannabinoids, Illicit Drugs, Psychotropic Drugs.
- methods : Gas Chromatography-Mass Spectrometry, Magnetic Resonance Spectroscopy, Substance Abuse Detection.
- Forensic Toxicology, Humans.
Abstract
New psychoactive substances (NPS) continue to emerge around the world. APP-BINACA (or APP-BUTINACA), a novel synthetic cannabinoid, was first reported in Europe in January 2019 and later in the United States in March 2019. APP-BINACA was identified in the United States for the first time in blood sample extracts from forensic casework by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). To date, APP-BINACA has been identified in 11 forensic toxicology cases from five states and in both medicolegal death investigations and drug impaired driving investigations. APP-BINACA was commonly found in combination with 4F-MDMB-BINACA. Subsequent to its discovery in biological samples, APP-BINACA was detected and characterized in seized drug material by gas chromatography mass spectrometry (GC-MS), LC-QTOF-MS, and nuclear magnetic resonance (NMR) spectroscopy. Further analysis of biological specimens resulted in the identification of five metabolites, including 4-HO-APP-BINACA and APP-BINACA 3-phenylpropanoic acid. The frequency of APP-BINACA detection appears to be increasing and this new synthetic cannabinoid has been identified as a possible contributory factor in adverse events, including death. This is the first literature report regarding the characterization of the new synthetic cannabinoid APP-BINACA in humans. Since it is not widely tested for, it is not yet known the extent to which APP-BINACA is contributing to morbidity and mortality, but forensic scientists, public health officials, and others should be aware of its possible presence and impact. Laboratories should incorporate APP-BINACA into testing workflows for detection and confirmation, where possible.
DOI: 10.1002/dta.2698
PubMed: 31788963
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework.</title>
<author><name sortKey="Krotulski, Alex J" sort="Krotulski, Alex J" uniqKey="Krotulski A" first="Alex J" last="Krotulski">Alex J. Krotulski</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mohr, Amanda L A" sort="Mohr, Amanda L A" uniqKey="Mohr A" first="Amanda L A" last="Mohr">Amanda L A. Mohr</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diamond, Francis X" sort="Diamond, Francis X" uniqKey="Diamond F" first="Francis X" last="Diamond">Francis X. Diamond</name>
<affiliation wicri:level="2"><nlm:affiliation>NMS Labs, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NMS Labs, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>NMS Labs, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NMS Labs, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:31788963</idno>
<idno type="pmid">31788963</idno>
<idno type="doi">10.1002/dta.2698</idno>
<idno type="wicri:Area/Main/Corpus">000330</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000330</idno>
<idno type="wicri:Area/Main/Curation">000330</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000330</idno>
<idno type="wicri:Area/Main/Exploration">000330</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework.</title>
<author><name sortKey="Krotulski, Alex J" sort="Krotulski, Alex J" uniqKey="Krotulski A" first="Alex J" last="Krotulski">Alex J. Krotulski</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mohr, Amanda L A" sort="Mohr, Amanda L A" uniqKey="Mohr A" first="Amanda L A" last="Mohr">Amanda L A. Mohr</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diamond, Francis X" sort="Diamond, Francis X" uniqKey="Diamond F" first="Francis X" last="Diamond">Francis X. Diamond</name>
<affiliation wicri:level="2"><nlm:affiliation>NMS Labs, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NMS Labs, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>NMS Labs, Willow Grove, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NMS Labs, Willow Grove, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Drug testing and analysis</title>
<idno type="eISSN">1942-7611</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cannabinoids (blood)</term>
<term>Cannabinoids (metabolism)</term>
<term>Cannabinoids (urine)</term>
<term>Forensic Toxicology (MeSH)</term>
<term>Gas Chromatography-Mass Spectrometry (methods)</term>
<term>Humans (MeSH)</term>
<term>Illicit Drugs (blood)</term>
<term>Illicit Drugs (metabolism)</term>
<term>Illicit Drugs (urine)</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Psychotropic Drugs (blood)</term>
<term>Psychotropic Drugs (metabolism)</term>
<term>Psychotropic Drugs (urine)</term>
<term>Substance Abuse Detection (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cannabinoïdes (métabolisme)</term>
<term>Cannabinoïdes (sang)</term>
<term>Cannabinoïdes (urine)</term>
<term>Chromatographie gazeuse-spectrométrie de masse (méthodes)</term>
<term>Détection d'abus de substances (méthodes)</term>
<term>Humains (MeSH)</term>
<term>Psychoanaleptiques (métabolisme)</term>
<term>Psychoanaleptiques (sang)</term>
<term>Psychoanaleptiques (urine)</term>
<term>Spectroscopie par résonance magnétique (méthodes)</term>
<term>Toxicologie médicolégale (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cannabinoids</term>
<term>Illicit Drugs</term>
<term>Psychotropic Drugs</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cannabinoids</term>
<term>Illicit Drugs</term>
<term>Psychotropic Drugs</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Cannabinoids</term>
<term>Illicit Drugs</term>
<term>Psychotropic Drugs</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gas Chromatography-Mass Spectrometry</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Substance Abuse Detection</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cannabinoïdes</term>
<term>Psychoanaleptiques</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Chromatographie gazeuse-spectrométrie de masse</term>
<term>Détection d'abus de substances</term>
<term>Spectroscopie par résonance magnétique</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cannabinoïdes</term>
<term>Psychoanaleptiques</term>
</keywords>
<keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Cannabinoïdes</term>
<term>Psychoanaleptiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Forensic Toxicology</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Toxicologie médicolégale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">New psychoactive substances (NPS) continue to emerge around the world. APP-BINACA (or APP-BUTINACA), a novel synthetic cannabinoid, was first reported in Europe in January 2019 and later in the United States in March 2019. APP-BINACA was identified in the United States for the first time in blood sample extracts from forensic casework by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). To date, APP-BINACA has been identified in 11 forensic toxicology cases from five states and in both medicolegal death investigations and drug impaired driving investigations. APP-BINACA was commonly found in combination with 4F-MDMB-BINACA. Subsequent to its discovery in biological samples, APP-BINACA was detected and characterized in seized drug material by gas chromatography mass spectrometry (GC-MS), LC-QTOF-MS, and nuclear magnetic resonance (NMR) spectroscopy. Further analysis of biological specimens resulted in the identification of five metabolites, including 4-HO-APP-BINACA and APP-BINACA 3-phenylpropanoic acid. The frequency of APP-BINACA detection appears to be increasing and this new synthetic cannabinoid has been identified as a possible contributory factor in adverse events, including death. This is the first literature report regarding the characterization of the new synthetic cannabinoid APP-BINACA in humans. Since it is not widely tested for, it is not yet known the extent to which APP-BINACA is contributing to morbidity and mortality, but forensic scientists, public health officials, and others should be aware of its possible presence and impact. Laboratories should incorporate APP-BINACA into testing workflows for detection and confirmation, where possible.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31788963</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1942-7611</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Drug testing and analysis</Title>
<ISOAbbreviation>Drug Test Anal</ISOAbbreviation>
</Journal>
<ArticleTitle>Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework.</ArticleTitle>
<Pagination><MedlinePgn>136-144</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/dta.2698</ELocationID>
<Abstract><AbstractText>New psychoactive substances (NPS) continue to emerge around the world. APP-BINACA (or APP-BUTINACA), a novel synthetic cannabinoid, was first reported in Europe in January 2019 and later in the United States in March 2019. APP-BINACA was identified in the United States for the first time in blood sample extracts from forensic casework by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). To date, APP-BINACA has been identified in 11 forensic toxicology cases from five states and in both medicolegal death investigations and drug impaired driving investigations. APP-BINACA was commonly found in combination with 4F-MDMB-BINACA. Subsequent to its discovery in biological samples, APP-BINACA was detected and characterized in seized drug material by gas chromatography mass spectrometry (GC-MS), LC-QTOF-MS, and nuclear magnetic resonance (NMR) spectroscopy. Further analysis of biological specimens resulted in the identification of five metabolites, including 4-HO-APP-BINACA and APP-BINACA 3-phenylpropanoic acid. The frequency of APP-BINACA detection appears to be increasing and this new synthetic cannabinoid has been identified as a possible contributory factor in adverse events, including death. This is the first literature report regarding the characterization of the new synthetic cannabinoid APP-BINACA in humans. Since it is not widely tested for, it is not yet known the extent to which APP-BINACA is contributing to morbidity and mortality, but forensic scientists, public health officials, and others should be aware of its possible presence and impact. Laboratories should incorporate APP-BINACA into testing workflows for detection and confirmation, where possible.</AbstractText>
<CopyrightInformation>© 2019 John Wiley & Sons, Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krotulski</LastName>
<ForeName>Alex J</ForeName>
<Initials>AJ</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-1775-1882</Identifier>
<AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mohr</LastName>
<ForeName>Amanda L A</ForeName>
<Initials>ALA</Initials>
<AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Diamond</LastName>
<ForeName>Francis X</ForeName>
<Initials>FX</Initials>
<AffiliationInfo><Affiliation>NMS Labs, Willow Grove, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Logan</LastName>
<ForeName>Barry K</ForeName>
<Initials>BK</Initials>
<AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, Willow Grove, PA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>NMS Labs, Willow Grove, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Acronym>CC</Acronym>
<Agency>CDC HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>2017-R2-CX-0021</GrantID>
<Agency>National Institute of Justice</Agency>
<Country></Country>
</Grant>
<Grant><Acronym>CC</Acronym>
<Agency>CDC HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>12</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Drug Test Anal</MedlineTA>
<NlmUniqueID>101483449</NlmUniqueID>
<ISSNLinking>1942-7603</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002186">Cannabinoids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013287">Illicit Drugs</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011619">Psychotropic Drugs</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D002186" MajorTopicYN="N">Cannabinoids</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053593" MajorTopicYN="N">Forensic Toxicology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013287" MajorTopicYN="N">Illicit Drugs</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011619" MajorTopicYN="N">Psychotropic Drugs</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015813" MajorTopicYN="N">Substance Abuse Detection</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Forensic Chemistry</Keyword>
<Keyword MajorTopicYN="N">Forensic Toxicology</Keyword>
<Keyword MajorTopicYN="N">Mass Spectrometry</Keyword>
<Keyword MajorTopicYN="N">Metabolism</Keyword>
<Keyword MajorTopicYN="N">Synthetic Cannabinoid</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>07</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>09</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>09</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>12</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>12</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31788963</ArticleId>
<ArticleId IdType="doi">10.1002/dta.2698</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCES</Title>
<Reference><Citation>Presley BC, Jansen-Varnum SA, Logan BK. Analysis of synthetic cannabinoids in botanical material: a review of analytical methods and findings. Forensic Sci Rev. 2013;25(1):27-46.</Citation>
</Reference>
<Reference><Citation>Abbate V, Schwenk M, Presley BC, Uchiyama N. The ongoing challenge of novel psychoactive drugs of abuse. Part I. synthetic cannabinoids (IUPAC technical report). Pure Appl Chem. 2018;90(8):1255-1282. https://doi.org/10.1515/pac-2017-0605</Citation>
</Reference>
<Reference><Citation>Bretteville-Jensen AL, Tuv SS, Bilgre OR, Fjeld B, Bachs L. Synthetic cannabinoids and cathinones: prevalence and markets. Forensic Sci Rev. 2013;25(1/2):7-26.</Citation>
</Reference>
<Reference><Citation>Ammann J, McLaren JM, Gerostamoulos D, Beyer J. Detection and quantification of new designer drugs in human blood: part 1 - synthetic cannabinoids. J Anal Toxicol. 2012;36(6):372-380. https://doi.org/10.1093/jat/bks048</Citation>
</Reference>
<Reference><Citation>van Amsterdam J, Brunt T, van den Brink W. The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects. J Psychopharmacol (Oxford). 2015;29(3):254-263. https://doi.org/10.1177/0269881114565142</Citation>
</Reference>
<Reference><Citation>Logan BK, Mohr ALA, Friscia M, et al. Reports of adverse events associated with use of novel psychoactive substances, 2013-2016: a review. J Anal Tox. 2017;41(7):573-610.</Citation>
</Reference>
<Reference><Citation>European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019; 2019. http://www.emcdda.europa.eu/system/files/publications/11364/20191724_TDAT19001ENN_PDF.pdf</Citation>
</Reference>
<Reference><Citation>U.S. Department of Justice Drug Enforcement Administration. National Forensic Laboratory Information System (NFLIS-DRUG) 2018 Midyear Report; 2018:28. https://www.nflis.deadiversion.usdoj.gov/DesktopModules/ReportDownloads/Reports/NFLISDrug2018MY.pdf</Citation>
</Reference>
<Reference><Citation>NPS Discovery. The Center for Forensic Science Research & Education. https://www.npsdiscovery.org/. Published 2019.</Citation>
</Reference>
<Reference><Citation>EMCDDA home page|www.emcdda.europa.eu. http://www.emcdda.europa.eu/</Citation>
</Reference>
<Reference><Citation>National Forensic Laboratory Information System (NFLIS). https://www.deadiversion.usdoj.gov/nflis/</Citation>
</Reference>
<Reference><Citation>Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). http://swgdrug.org/</Citation>
</Reference>
<Reference><Citation>Buchler I, Hayes M, Hegde S, et al. Indazole Derivatives. WO 2009/106982 Al. World Intellectual Property Organization. 3 September 2009.</Citation>
</Reference>
<Reference><Citation>Antonides LH, Cannaert A, Norman C, et al. Enantiospecific synthesis, chiral separation, and biological activity of four indazole-3-carboxamide-type synthetic cannabinoid receptor agonists and their detection in seized drug samples. Front Chem. 2019;7. https://doi.org/10.3389/fchem.2019.00321</Citation>
</Reference>
<Reference><Citation>Krotulski AJ, Mohr A, Logan BK. App-BINACA; 2019:1-7. https://www.npsdiscovery.org/wp-content/uploads/2019/05/APP-BINACA_030619_CFSRE_Report.pdf</Citation>
</Reference>
<Reference><Citation>Krotulski AJ, Mohr ALA, Kacinko SL, et al. 4F-MDMB-BINACA: a new synthetic cannabinoid widely implicated in forensic casework. J Forensic Sci. 2019;1-11. https://doi.org/10.1111/1556-4029.14101</Citation>
</Reference>
<Reference><Citation>Tynon M, Homan J, Kacinko S, Ervin A, McMullin M, Logan BK. Rapid and sensitive screening and confirmation of thirty-four aminocarbonyl/carboxamide (NACA) and arylindole synthetic cannabinoid drugs in human whole blood. Drug Test Anal. 2017;9(6):924-934. https://doi.org/10.1002/dta.2096</Citation>
</Reference>
<Reference><Citation>Fabregat-Safont D, Mardal M, Noble C, et al. Comprehensive investigation on synthetic cannabinoids: metabolic behaviour and potency testing, using 5F-APP-PICA and AMB-FUBINACA as model compounds. Drug Test Anal. 2019;11(9):1358-1368. https://doi.org/10.1002/dta.2659</Citation>
</Reference>
<Reference><Citation>Cooman T. In vitro metabolism of the synthetic cannabinoids PX-1, PX-2, PX-3 and a comparison of their clearance rates in human liver microsomes. West Virginia University. Graduate Theses, Dissertations, and Problem Reports. 2019:45.</Citation>
</Reference>
<Reference><Citation>Yeter O, Ozturk YE. Metabolic profiling of synthetic cannabinoid 5F-ADB by human liver microsome incubations and urine samples using high-resolution mass spectrometry. Drug Test Anal. 2019;11(6):847-858. https://doi.org/10.1002/dta.2566</Citation>
</Reference>
<Reference><Citation>Mogler L, Franz F, Rentsch D, et al. Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in ‘legal high' products and human urine samples. Drug Test Anal. 2018;10(1):196-205. https://doi.org/10.1002/dta.2201</Citation>
</Reference>
<Reference><Citation>Krotulski AJ, Mohr A, Logan BK. Trend Report: Q4 2018 - Synthetic Cannabinoids in the United States (Detailed); 2018:1-7. https://www.npsdiscovery.org/wp-content/uploads/2019/05/Synthetic-Cannabinoid-Trend-Report_Detailed_2018-Q4.pdf</Citation>
</Reference>
<Reference><Citation>Krotulski AJ, Mohr A, Logan BK. Trend Report: Q1 2019 - Synthetic Cannabinoids in the United States (Detailed); 2019:1-7. https://www.npsdiscovery.org/wp-content/uploads/2019/05/Synthetic-Cannabinoid-Trend-Report_Detailed_2019-Q1.pdf</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Krotulski, Alex J" sort="Krotulski, Alex J" uniqKey="Krotulski A" first="Alex J" last="Krotulski">Alex J. Krotulski</name>
</region>
<name sortKey="Diamond, Francis X" sort="Diamond, Francis X" uniqKey="Diamond F" first="Francis X" last="Diamond">Francis X. Diamond</name>
<name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name>
<name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name>
<name sortKey="Mohr, Amanda L A" sort="Mohr, Amanda L A" uniqKey="Mohr A" first="Amanda L A" last="Mohr">Amanda L A. Mohr</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/WillowV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000258 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000258 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Bois |area= WillowV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:31788963 |texte= Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31788963" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a WillowV1
This area was generated with Dilib version V0.6.37. |