Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.
Identifieur interne : 001921 ( Main/Exploration ); précédent : 001920; suivant : 001922Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.
Auteurs : Xiang Li [États-Unis] ; Zhi Liu ; Xin-Feng Zhang ; Li-Juan Wang ; Yi-Nan Zheng ; Chang-Chun Yuan ; Guang-Zhi SunSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2008.
Descripteurs français
- KwdFr :
- Cyclooxygenase 1 (effets des médicaments et des substances chimiques), Cyclooxygenase 2 (effets des médicaments et des substances chimiques), Extraits de plantes (composition chimique), Feuilles de plante (composition chimique), Flavonoïdes (composition chimique), Flavonoïdes (isolement et purification), Flavonoïdes (pharmacologie), Hétérosides (composition chimique), Hétérosides (isolement et purification), Hétérosides (pharmacologie), Inhibiteurs des cyclooxygénases (composition chimique), Inhibiteurs des cyclooxygénases (isolement et purification), Inhibiteurs des cyclooxygénases (pharmacologie), Phénols (composition chimique), Phénols (isolement et purification), Phénols (pharmacologie), Salix (composition chimique), Structure moléculaire (MeSH).
- MESH :
- composition chimique : Extraits de plantes, Feuilles de plante, Flavonoïdes, Hétérosides, Inhibiteurs des cyclooxygénases, Phénols, Salix.
- effets des médicaments et des substances chimiques : Cyclooxygenase 1, Cyclooxygenase 2.
- isolement et purification : Flavonoïdes, Hétérosides, Inhibiteurs des cyclooxygénases, Phénols.
- pharmacologie : Flavonoïdes, Hétérosides, Inhibiteurs des cyclooxygénases, Phénols.
- Structure moléculaire.
English descriptors
- KwdEn :
- Cyclooxygenase 1 (drug effects), Cyclooxygenase 2 (drug effects), Cyclooxygenase Inhibitors (chemistry), Cyclooxygenase Inhibitors (isolation & purification), Cyclooxygenase Inhibitors (pharmacology), Flavonoids (chemistry), Flavonoids (isolation & purification), Flavonoids (pharmacology), Glycosides (chemistry), Glycosides (isolation & purification), Glycosides (pharmacology), Molecular Structure (MeSH), Phenols (chemistry), Phenols (isolation & purification), Phenols (pharmacology), Plant Extracts (chemistry), Plant Leaves (chemistry), Salix (chemistry).
- MESH :
- chemical , chemistry : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols, Plant Extracts.
- chemical , drug effects : Cyclooxygenase 1, Cyclooxygenase 2.
- chemical , isolation & purification : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols.
- chemical , pharmacology : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols.
- chemistry : Plant Leaves, Salix.
- Molecular Structure.
Abstract
A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
DOI: 10.3390/molecules13081530
PubMed: 18794770
PubMed Central: PMC6245188
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<front><div type="abstract" xml:lang="en">A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.</div>
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<Abstract><AbstractText>A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.</AbstractText>
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<name sortKey="Wang, Li Juan" sort="Wang, Li Juan" uniqKey="Wang L" first="Li-Juan" last="Wang">Li-Juan Wang</name>
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