Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.
Identifieur interne : 001873 ( Main/Corpus ); précédent : 001872; suivant : 001874Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.
Auteurs : Xiang Li ; Zhi Liu ; Xin-Feng Zhang ; Li-Juan Wang ; Yi-Nan Zheng ; Chang-Chun Yuan ; Guang-Zhi SunSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2008.
English descriptors
- KwdEn :
- Cyclooxygenase 1 (drug effects), Cyclooxygenase 2 (drug effects), Cyclooxygenase Inhibitors (chemistry), Cyclooxygenase Inhibitors (isolation & purification), Cyclooxygenase Inhibitors (pharmacology), Flavonoids (chemistry), Flavonoids (isolation & purification), Flavonoids (pharmacology), Glycosides (chemistry), Glycosides (isolation & purification), Glycosides (pharmacology), Molecular Structure (MeSH), Phenols (chemistry), Phenols (isolation & purification), Phenols (pharmacology), Plant Extracts (chemistry), Plant Leaves (chemistry), Salix (chemistry).
- MESH :
- chemical , chemistry : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols, Plant Extracts.
- chemical , drug effects : Cyclooxygenase 1, Cyclooxygenase 2.
- chemical , isolation & purification : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols.
- chemical , pharmacology : Cyclooxygenase Inhibitors, Flavonoids, Glycosides, Phenols.
- chemistry : Plant Leaves, Salix.
- Molecular Structure.
Abstract
A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
DOI: 10.3390/molecules13081530
PubMed: 18794770
PubMed Central: PMC6245188
Links to Exploration step
pubmed:18794770Le document en format XML
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China. lixiang@bjmu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zhi" sort="Liu, Zhi" uniqKey="Liu Z" first="Zhi" last="Liu">Zhi Liu</name></author><author><name sortKey="Zhang, Xin Feng" sort="Zhang, Xin Feng" uniqKey="Zhang X" first="Xin-Feng" last="Zhang">Xin-Feng Zhang</name></author><author><name sortKey="Wang, Li Juan" sort="Wang, Li Juan" uniqKey="Wang L" first="Li-Juan" last="Wang">Li-Juan Wang</name></author><author><name sortKey="Zheng, Yi Nan" sort="Zheng, Yi Nan" uniqKey="Zheng Y" first="Yi-Nan" last="Zheng">Yi-Nan Zheng</name></author><author><name sortKey="Yuan, Chang Chun" sort="Yuan, Chang Chun" uniqKey="Yuan C" first="Chang-Chun" last="Yuan">Chang-Chun Yuan</name></author><author><name sortKey="Sun, Guang Zhi" sort="Sun, Guang Zhi" uniqKey="Sun G" first="Guang-Zhi" last="Sun">Guang-Zhi Sun</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18794770</idno><idno type="pmid">18794770</idno><idno type="pmc">PMC6245188</idno><idno type="doi">10.3390/molecules13081530</idno><idno type="wicri:Area/Main/Corpus">001873</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001873</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.</title><author><name sortKey="Li, Xiang" sort="Li, Xiang" uniqKey="Li X" first="Xiang" last="Li">Xiang Li</name><affiliation><nlm:affiliation>College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, P.R. China. lixiang@bjmu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zhi" sort="Liu, Zhi" uniqKey="Liu Z" first="Zhi" last="Liu">Zhi Liu</name></author><author><name sortKey="Zhang, Xin Feng" sort="Zhang, Xin Feng" uniqKey="Zhang X" first="Xin-Feng" last="Zhang">Xin-Feng Zhang</name></author><author><name sortKey="Wang, Li Juan" sort="Wang, Li Juan" uniqKey="Wang L" first="Li-Juan" last="Wang">Li-Juan Wang</name></author><author><name sortKey="Zheng, Yi Nan" sort="Zheng, Yi Nan" uniqKey="Zheng Y" first="Yi-Nan" last="Zheng">Yi-Nan Zheng</name></author><author><name sortKey="Yuan, Chang Chun" sort="Yuan, Chang Chun" uniqKey="Yuan C" first="Chang-Chun" last="Yuan">Chang-Chun Yuan</name></author><author><name sortKey="Sun, Guang Zhi" sort="Sun, Guang Zhi" uniqKey="Sun G" first="Guang-Zhi" last="Sun">Guang-Zhi Sun</name></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cyclooxygenase 1 (drug effects)</term><term>Cyclooxygenase 2 (drug effects)</term><term>Cyclooxygenase Inhibitors (chemistry)</term><term>Cyclooxygenase Inhibitors (isolation & purification)</term><term>Cyclooxygenase Inhibitors (pharmacology)</term><term>Flavonoids (chemistry)</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Glycosides (chemistry)</term><term>Glycosides (isolation & purification)</term><term>Glycosides (pharmacology)</term><term>Molecular Structure (MeSH)</term><term>Phenols (chemistry)</term><term>Phenols (isolation & purification)</term><term>Phenols (pharmacology)</term><term>Plant Extracts (chemistry)</term><term>Plant Leaves (chemistry)</term><term>Salix (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cyclooxygenase Inhibitors</term><term>Flavonoids</term><term>Glycosides</term><term>Phenols</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Cyclooxygenase 1</term><term>Cyclooxygenase 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Cyclooxygenase Inhibitors</term><term>Flavonoids</term><term>Glycosides</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclooxygenase Inhibitors</term><term>Flavonoids</term><term>Glycosides</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plant Leaves</term><term>Salix</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Molecular Structure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18794770</PMID><DateCompleted><Year>2008</Year><Month>12</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>08</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>8</Issue><PubDate><Year>2008</Year><Month>Aug</Month><Day>03</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.</ArticleTitle><Pagination><MedlinePgn>1530-7</MedlinePgn></Pagination><Abstract><AbstractText>A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, P.R. 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