Tumour necrosis factor alpha inhibitor treatment for sarcoidosis refractory to conventional treatments: a report of five patients.
Identifieur interne : 001D39 ( Main/Exploration ); précédent : 001D38; suivant : 001D40Tumour necrosis factor alpha inhibitor treatment for sarcoidosis refractory to conventional treatments: a report of five patients.
Auteurs : C. Pritchard [États-Unis] ; K. NadarajahSource :
- Annals of the rheumatic diseases [ 0003-4967 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Anticorps monoclonaux (usage thérapeutique), Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs), Femelle (MeSH), Humains (MeSH), Infliximab (MeSH), Maladie chronique (MeSH), Mâle (MeSH), Résultat thérapeutique (MeSH), Sarcoïdose (traitement médicamenteux), Sujet âgé (MeSH).
- MESH :
- antagonistes et inhibiteurs : Facteur de nécrose tumorale alpha.
- traitement médicamenteux : Sarcoïdose.
- usage thérapeutique : Anticorps monoclonaux.
- Adulte, Femelle, Humains, Infliximab, Maladie chronique, Mâle, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Antibodies, Monoclonal.
- drug therapy : Sarcoidosis.
- Adult, Aged, Chronic Disease, Female, Humans, Infliximab, Male, Treatment Outcome.
Abstract
OBJECTIVE
To study the effectiveness of tumour necrosis factor alpha (TNFalpha) inhibitor treatment for sarcoidosis refractory to conventional treatments.
METHODS
Five patients (two men, three women) were treated with infliximab. All patients received a loading dose of 3 mg/kg at 0, 2, and 6 weeks and then maintenance infusions every 4-8 weeks. Patients had their dose increased or the dosing interval reduced when the disease relapsed. These patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. All patients had a negative tuberculin skin test.
RESULTS
Sarcoidosis in all patients improved significantly without any serious adverse reactions.
CONCLUSION
This study suggests that TNFalpha is effective in patients for whom conventional treatment fails.
DOI: 10.1136/ard.2002.004226
PubMed: 14962969
PubMed Central: PMC1754920
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Pritchard, C" sort="Pritchard, C" uniqKey="Pritchard C" first="C" last="Pritchard">C. Pritchard</name>
<affiliation wicri:level="2"><nlm:affiliation>Rheumatology Specialty Center, 2400 Maryland Road, Suite 40, Willow Grove, PA 19090, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rheumatology Specialty Center, 2400 Maryland Road, Suite 40, Willow Grove, PA 19090</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Nadarajah, K" sort="Nadarajah, K" uniqKey="Nadarajah K" first="K" last="Nadarajah">K. Nadarajah</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Chronic Disease (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infliximab (MeSH)</term>
<term>Male (MeSH)</term>
<term>Sarcoidosis (drug therapy)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infliximab (MeSH)</term>
<term>Maladie chronique (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sarcoïdose (traitement médicamenteux)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Sarcoidosis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sarcoïdose</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Chronic Disease</term>
<term>Female</term>
<term>Humans</term>
<term>Infliximab</term>
<term>Male</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infliximab</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To study the effectiveness of tumour necrosis factor alpha (TNFalpha) inhibitor treatment for sarcoidosis refractory to conventional treatments.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Five patients (two men, three women) were treated with infliximab. All patients received a loading dose of 3 mg/kg at 0, 2, and 6 weeks and then maintenance infusions every 4-8 weeks. Patients had their dose increased or the dosing interval reduced when the disease relapsed. These patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. All patients had a negative tuberculin skin test.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Sarcoidosis in all patients improved significantly without any serious adverse reactions.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>This study suggests that TNFalpha is effective in patients for whom conventional treatment fails.</p>
</div>
</front>
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<Title>Annals of the rheumatic diseases</Title>
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<AbstractText Label="METHODS" NlmCategory="METHODS">Five patients (two men, three women) were treated with infliximab. All patients received a loading dose of 3 mg/kg at 0, 2, and 6 weeks and then maintenance infusions every 4-8 weeks. Patients had their dose increased or the dosing interval reduced when the disease relapsed. These patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. All patients had a negative tuberculin skin test.</AbstractText>
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