Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.
Identifieur interne : 000C44 ( Main/Corpus ); précédent : 000C43; suivant : 000C45Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.
Auteurs : Abdelkader Bounaama ; Shabnam Enayat ; Muserref Seyma Ceyhan ; Hichem Moulahoum ; Bahia Djerdjouri ; Sreeparna BanerjeeSource :
- Nutrition and cancer [ 1532-7914 ] ; 2016.
English descriptors
- KwdEn :
- 1,2-Dimethylhydrazine (toxicity), Aberrant Crypt Foci (chemically induced), Aberrant Crypt Foci (drug therapy), Aberrant Crypt Foci (pathology), Animals (MeSH), Anticarcinogenic Agents (chemistry), Anticarcinogenic Agents (pharmacology), Carcinogens (toxicity), Chromatography, High Pressure Liquid (MeSH), Colonic Neoplasms (chemically induced), Colonic Neoplasms (pathology), Colonic Neoplasms (prevention & control), Ethanol (chemistry), HCT116 Cells (drug effects), Humans (MeSH), Inhibitory Concentration 50 (MeSH), Male (MeSH), Mice (MeSH), Oxidative Stress (drug effects), Plant Bark (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Salix (chemistry).
- MESH :
- chemical , chemistry : Anticarcinogenic Agents, Ethanol, Plant Extracts.
- chemical , pharmacology : Anticarcinogenic Agents, Plant Extracts.
- chemical , toxicity : 1,2-Dimethylhydrazine, Carcinogens.
- chemically induced : Aberrant Crypt Foci, Colonic Neoplasms.
- chemistry : Plant Bark, Salix.
- drug effects : HCT116 Cells, Oxidative Stress.
- drug therapy : Aberrant Crypt Foci.
- pathology : Aberrant Crypt Foci, Colonic Neoplasms.
- prevention & control : Colonic Neoplasms.
- Animals, Chromatography, High Pressure Liquid, Humans, Inhibitory Concentration 50, Male, Mice.
Abstract
We have previously shown that ethanolic extract from bark (EEB) of Salix aegyptiaca (Musk Willow) can inhibit proliferation and motility and induce apoptosis in colon cancer cells. Tandem mass spectrometry revealed EEB to be rich in catechin, catechol, and salicin. The present study investigated the chemopreventive effect of HPLC-fingerprinted EEB on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in mice. DMH (20 mg/kg body weight) was weekly injected subcutaneously to mice for the first 2 weeks. EEB (100 and 400 mg/kg body weight) was provided orally from the 7th to 14th week, after which colon tissues were evaluated histologically and biochemically. DMH treatment induced high number of ACF; EEB significantly reduced the number and multiplicity of ACF, along with a restoration in goblet cells and mucin accumulation. EEB supplementation improved the markers of inflammation (myeloperoxidase and neutrophil infiltration) and oxidative stress. More importantly, EEB amplified apoptosis of neoplastic cells in the colon mucosa of DMH-treated mice. It also lowered levels of markers for early transformation events such as EGFR, nuclear β-catenin, and COX-2 in colon cancer cell lines HT-29 and HCT-116. The innocuity of EEB (up to 1600 mg/kg) to mice reinforces its potential as a chemopreventive agent.
DOI: 10.1080/01635581.2016.1152379
PubMed: 27093594
Links to Exploration step
pubmed:27093594Le document en format XML
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uniqKey="Ceyhan M" first="Muserref Seyma" last="Ceyhan">Muserref Seyma Ceyhan</name><affiliation><nlm:affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Moulahoum, Hichem" sort="Moulahoum, Hichem" uniqKey="Moulahoum H" first="Hichem" last="Moulahoum">Hichem Moulahoum</name><affiliation><nlm:affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Djerdjouri, Bahia" sort="Djerdjouri, Bahia" uniqKey="Djerdjouri B" first="Bahia" last="Djerdjouri">Bahia Djerdjouri</name><affiliation><nlm:affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Banerjee, Sreeparna" sort="Banerjee, Sreeparna" uniqKey="Banerjee S" first="Sreeparna" last="Banerjee">Sreeparna Banerjee</name><affiliation><nlm:affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27093594</idno><idno type="pmid">27093594</idno><idno type="doi">10.1080/01635581.2016.1152379</idno><idno type="wicri:Area/Main/Corpus">000C44</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.</title><author><name sortKey="Bounaama, Abdelkader" sort="Bounaama, Abdelkader" uniqKey="Bounaama A" first="Abdelkader" last="Bounaama">Abdelkader Bounaama</name><affiliation><nlm:affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Enayat, Shabnam" sort="Enayat, Shabnam" uniqKey="Enayat S" first="Shabnam" last="Enayat">Shabnam Enayat</name><affiliation><nlm:affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Ceyhan, Muserref Seyma" sort="Ceyhan, Muserref Seyma" uniqKey="Ceyhan M" first="Muserref Seyma" last="Ceyhan">Muserref Seyma Ceyhan</name><affiliation><nlm:affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Moulahoum, Hichem" sort="Moulahoum, Hichem" uniqKey="Moulahoum H" first="Hichem" last="Moulahoum">Hichem Moulahoum</name><affiliation><nlm:affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Djerdjouri, Bahia" sort="Djerdjouri, Bahia" uniqKey="Djerdjouri B" first="Bahia" last="Djerdjouri">Bahia Djerdjouri</name><affiliation><nlm:affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Banerjee, Sreeparna" sort="Banerjee, Sreeparna" uniqKey="Banerjee S" first="Sreeparna" last="Banerjee">Sreeparna Banerjee</name><affiliation><nlm:affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nutrition and cancer</title><idno type="eISSN">1532-7914</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1,2-Dimethylhydrazine (toxicity)</term><term>Aberrant Crypt Foci (chemically induced)</term><term>Aberrant Crypt Foci (drug therapy)</term><term>Aberrant Crypt Foci (pathology)</term><term>Animals (MeSH)</term><term>Anticarcinogenic Agents (chemistry)</term><term>Anticarcinogenic Agents (pharmacology)</term><term>Carcinogens (toxicity)</term><term>Chromatography, High Pressure Liquid (MeSH)</term><term>Colonic Neoplasms (chemically induced)</term><term>Colonic Neoplasms (pathology)</term><term>Colonic Neoplasms (prevention & control)</term><term>Ethanol (chemistry)</term><term>HCT116 Cells (drug effects)</term><term>Humans (MeSH)</term><term>Inhibitory Concentration 50 (MeSH)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Plant Bark (chemistry)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Salix (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Ethanol</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>1,2-Dimethylhydrazine</term><term>Carcinogens</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Aberrant Crypt Foci</term><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plant Bark</term><term>Salix</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HCT116 Cells</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Aberrant Crypt Foci</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aberrant Crypt Foci</term><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromatography, High Pressure Liquid</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Male</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously shown that ethanolic extract from bark (EEB) of Salix aegyptiaca (Musk Willow) can inhibit proliferation and motility and induce apoptosis in colon cancer cells. Tandem mass spectrometry revealed EEB to be rich in catechin, catechol, and salicin. The present study investigated the chemopreventive effect of HPLC-fingerprinted EEB on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in mice. DMH (20 mg/kg body weight) was weekly injected subcutaneously to mice for the first 2 weeks. EEB (100 and 400 mg/kg body weight) was provided orally from the 7th to 14th week, after which colon tissues were evaluated histologically and biochemically. DMH treatment induced high number of ACF; EEB significantly reduced the number and multiplicity of ACF, along with a restoration in goblet cells and mucin accumulation. EEB supplementation improved the markers of inflammation (myeloperoxidase and neutrophil infiltration) and oxidative stress. More importantly, EEB amplified apoptosis of neoplastic cells in the colon mucosa of DMH-treated mice. It also lowered levels of markers for early transformation events such as EGFR, nuclear β-catenin, and COX-2 in colon cancer cell lines HT-29 and HCT-116. The innocuity of EEB (up to 1600 mg/kg) to mice reinforces its potential as a chemopreventive agent.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27093594</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1532-7914</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>3</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Nutrition and cancer</Title><ISOAbbreviation>Nutr Cancer</ISOAbbreviation></Journal><ArticleTitle>Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.</ArticleTitle><Pagination><MedlinePgn>495-506</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/01635581.2016.1152379</ELocationID><Abstract><AbstractText>We have previously shown that ethanolic extract from bark (EEB) of Salix aegyptiaca (Musk Willow) can inhibit proliferation and motility and induce apoptosis in colon cancer cells. Tandem mass spectrometry revealed EEB to be rich in catechin, catechol, and salicin. The present study investigated the chemopreventive effect of HPLC-fingerprinted EEB on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in mice. DMH (20 mg/kg body weight) was weekly injected subcutaneously to mice for the first 2 weeks. EEB (100 and 400 mg/kg body weight) was provided orally from the 7th to 14th week, after which colon tissues were evaluated histologically and biochemically. DMH treatment induced high number of ACF; EEB significantly reduced the number and multiplicity of ACF, along with a restoration in goblet cells and mucin accumulation. EEB supplementation improved the markers of inflammation (myeloperoxidase and neutrophil infiltration) and oxidative stress. More importantly, EEB amplified apoptosis of neoplastic cells in the colon mucosa of DMH-treated mice. It also lowered levels of markers for early transformation events such as EGFR, nuclear β-catenin, and COX-2 in colon cancer cell lines HT-29 and HCT-116. The innocuity of EEB (up to 1600 mg/kg) to mice reinforces its potential as a chemopreventive agent.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bounaama</LastName><ForeName>Abdelkader</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enayat</LastName><ForeName>Shabnam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ceyhan</LastName><ForeName>Muserref Seyma</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moulahoum</LastName><ForeName>Hichem</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djerdjouri</LastName><ForeName>Bahia</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>a Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene , Bab-Ezzouar , Algiers , Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banerjee</LastName><ForeName>Sreeparna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>b Middle East Technical University , Department of Biology , Ankara , Turkey.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nutr Cancer</MedlineTA><NlmUniqueID>7905040</NlmUniqueID><ISSNLinking>0163-5581</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016588">Anticarcinogenic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002273">Carcinogens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>3K9958V90M</RegistryNumber><NameOfSubstance UI="D000431">Ethanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>IX068S9745</RegistryNumber><NameOfSubstance UI="D019813">1,2-Dimethylhydrazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019813" MajorTopicYN="N">1,2-Dimethylhydrazine</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058739" MajorTopicYN="N">Aberrant Crypt Foci</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016588" MajorTopicYN="N">Anticarcinogenic Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002273" MajorTopicYN="N">Carcinogens</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003110" MajorTopicYN="N">Colonic Neoplasms</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045325" MajorTopicYN="N">HCT116 Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024301" MajorTopicYN="N">Plant Bark</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032108" MajorTopicYN="N">Salix</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27093594</ArticleId><ArticleId IdType="doi">10.1080/01635581.2016.1152379</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous 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