Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.
Identifieur interne : 000336 ( Main/Corpus ); précédent : 000335; suivant : 000337Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.
Auteurs : Christina Oberhuber ; Sean M. Bulley ; Barbara K. Ballmer-Weber ; Merima Bublin ; Sonja Gaier ; Asa Marknell Dewitt ; Peter Briza ; Gerlinde Hofstetter ; Jonas Lidholm ; Stefan Vieths ; Karin Hoffmann-SommergruberSource :
- Molecular nutrition & food research [ 1613-4133 ] ; 2008.
English descriptors
- KwdEn :
- Actinidia (immunology), Adult (MeSH), Allergens (chemistry), Allergens (isolation & purification), Amino Acid Sequence (MeSH), Antigens, Plant (MeSH), Cloning, Molecular (MeSH), Cross Reactions (MeSH), Enzyme-Linked Immunosorbent Assay (MeSH), Food Hypersensitivity (etiology), Humans (MeSH), Immunoblotting (MeSH), Immunoglobulin E (blood), Middle Aged (MeSH), Molecular Sequence Data (MeSH), Plant Proteins (chemistry), Plant Proteins (isolation & purification), Polymerase Chain Reaction (MeSH), Recombinant Proteins (isolation & purification), Rhinitis, Allergic, Seasonal (etiology).
- MESH :
- chemical , blood : Immunoglobulin E.
- chemical , chemistry : Allergens, Plant Proteins.
- etiology : Food Hypersensitivity, Rhinitis, Allergic, Seasonal.
- immunology : Actinidia.
- chemical , isolation & purification : Allergens, Plant Proteins, Recombinant Proteins.
- Adult, Amino Acid Sequence, Antigens, Plant, Cloning, Molecular, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Humans, Immunoblotting, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction.
Abstract
Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.
DOI: 10.1002/mnfr.200800146
PubMed: 18925615
Links to Exploration step
pubmed:18925615Le document en format XML
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Ballmer-Weber</name></author><author><name sortKey="Bublin, Merima" sort="Bublin, Merima" uniqKey="Bublin M" first="Merima" last="Bublin">Merima Bublin</name></author><author><name sortKey="Gaier, Sonja" sort="Gaier, Sonja" uniqKey="Gaier S" first="Sonja" last="Gaier">Sonja Gaier</name></author><author><name sortKey="Dewitt, Asa Marknell" sort="Dewitt, Asa Marknell" uniqKey="Dewitt A" first="Asa Marknell" last="Dewitt">Asa Marknell Dewitt</name></author><author><name sortKey="Briza, Peter" sort="Briza, Peter" uniqKey="Briza P" first="Peter" last="Briza">Peter Briza</name></author><author><name sortKey="Hofstetter, Gerlinde" sort="Hofstetter, Gerlinde" uniqKey="Hofstetter G" first="Gerlinde" last="Hofstetter">Gerlinde Hofstetter</name></author><author><name sortKey="Lidholm, Jonas" sort="Lidholm, Jonas" uniqKey="Lidholm J" first="Jonas" last="Lidholm">Jonas Lidholm</name></author><author><name sortKey="Vieths, Stefan" sort="Vieths, Stefan" uniqKey="Vieths S" first="Stefan" last="Vieths">Stefan Vieths</name></author><author><name sortKey="Hoffmann Sommergruber, Karin" sort="Hoffmann Sommergruber, Karin" uniqKey="Hoffmann Sommergruber K" first="Karin" last="Hoffmann-Sommergruber">Karin Hoffmann-Sommergruber</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18925615</idno><idno type="pmid">18925615</idno><idno type="doi">10.1002/mnfr.200800146</idno><idno type="wicri:Area/Main/Corpus">000336</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.</title><author><name sortKey="Oberhuber, Christina" sort="Oberhuber, Christina" uniqKey="Oberhuber C" first="Christina" last="Oberhuber">Christina Oberhuber</name><affiliation><nlm:affiliation>Biomay AG, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bulley, Sean M" sort="Bulley, Sean M" uniqKey="Bulley S" first="Sean M" last="Bulley">Sean M. Bulley</name></author><author><name sortKey="Ballmer Weber, Barbara K" sort="Ballmer Weber, Barbara K" uniqKey="Ballmer Weber B" first="Barbara K" last="Ballmer-Weber">Barbara K. Ballmer-Weber</name></author><author><name sortKey="Bublin, Merima" sort="Bublin, Merima" uniqKey="Bublin M" first="Merima" last="Bublin">Merima Bublin</name></author><author><name sortKey="Gaier, Sonja" sort="Gaier, Sonja" uniqKey="Gaier S" first="Sonja" last="Gaier">Sonja Gaier</name></author><author><name sortKey="Dewitt, Asa Marknell" sort="Dewitt, Asa Marknell" uniqKey="Dewitt A" first="Asa Marknell" last="Dewitt">Asa Marknell Dewitt</name></author><author><name sortKey="Briza, Peter" sort="Briza, Peter" uniqKey="Briza P" first="Peter" last="Briza">Peter Briza</name></author><author><name sortKey="Hofstetter, Gerlinde" sort="Hofstetter, Gerlinde" uniqKey="Hofstetter G" first="Gerlinde" last="Hofstetter">Gerlinde Hofstetter</name></author><author><name sortKey="Lidholm, Jonas" sort="Lidholm, Jonas" uniqKey="Lidholm J" first="Jonas" last="Lidholm">Jonas Lidholm</name></author><author><name sortKey="Vieths, Stefan" sort="Vieths, Stefan" uniqKey="Vieths S" first="Stefan" last="Vieths">Stefan Vieths</name></author><author><name sortKey="Hoffmann Sommergruber, Karin" sort="Hoffmann Sommergruber, Karin" uniqKey="Hoffmann Sommergruber K" first="Karin" last="Hoffmann-Sommergruber">Karin Hoffmann-Sommergruber</name></author></analytic><series><title level="j">Molecular nutrition & food research</title><idno type="eISSN">1613-4133</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinidia (immunology)</term><term>Adult (MeSH)</term><term>Allergens (chemistry)</term><term>Allergens (isolation & purification)</term><term>Amino Acid Sequence (MeSH)</term><term>Antigens, Plant (MeSH)</term><term>Cloning, Molecular (MeSH)</term><term>Cross Reactions (MeSH)</term><term>Enzyme-Linked Immunosorbent Assay (MeSH)</term><term>Food Hypersensitivity (etiology)</term><term>Humans (MeSH)</term><term>Immunoblotting (MeSH)</term><term>Immunoglobulin E (blood)</term><term>Middle Aged (MeSH)</term><term>Molecular Sequence Data (MeSH)</term><term>Plant Proteins (chemistry)</term><term>Plant Proteins (isolation & purification)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Recombinant Proteins (isolation & purification)</term><term>Rhinitis, Allergic, Seasonal (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Allergens</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Food Hypersensitivity</term><term>Rhinitis, Allergic, Seasonal</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Actinidia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Allergens</term><term>Plant Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Antigens, Plant</term><term>Cloning, Molecular</term><term>Cross Reactions</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunoblotting</term><term>Middle Aged</term><term>Molecular Sequence Data</term><term>Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18925615</PMID><DateCompleted><Year>2009</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2011</Year><Month>06</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1613-4133</ISSN><JournalIssue CitedMedium="Internet"><Volume>52 Suppl 2</Volume><PubDate><Year>2008</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Molecular nutrition & food research</Title><ISOAbbreviation>Mol Nutr Food Res</ISOAbbreviation></Journal><ArticleTitle>Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.</ArticleTitle><Pagination><MedlinePgn>S230-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mnfr.200800146</ELocationID><Abstract><AbstractText>Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oberhuber</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Biomay AG, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bulley</LastName><ForeName>Sean M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Ballmer-Weber</LastName><ForeName>Barbara K</ForeName><Initials>BK</Initials></Author><Author ValidYN="Y"><LastName>Bublin</LastName><ForeName>Merima</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gaier</LastName><ForeName>Sonja</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>DeWitt</LastName><ForeName>Asa Marknell</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Briza</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Hofstetter</LastName><ForeName>Gerlinde</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Lidholm</LastName><ForeName>Jonas</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Vieths</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hoffmann-Sommergruber</LastName><ForeName>Karin</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Mol Nutr Food Res</MedlineTA><NlmUniqueID>101231818</NlmUniqueID><ISSNLinking>1613-4125</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000485">Allergens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052179">Antigens, Plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>126161-14-6</RegistryNumber><NameOfSubstance UI="C061312">Bet v 1 allergen, Betula</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D029042" MajorTopicYN="N">Actinidia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000485" MajorTopicYN="N">Allergens</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052179" MajorTopicYN="N">Antigens, Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005512" MajorTopicYN="N">Food Hypersensitivity</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015151" MajorTopicYN="N">Immunoblotting</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007073" MajorTopicYN="N">Immunoglobulin E</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006255" MajorTopicYN="N">Rhinitis, Allergic, Seasonal</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>10</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>2</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>10</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18925615</ArticleId><ArticleId IdType="doi">10.1002/mnfr.200800146</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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