A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana.
Identifieur interne : 000064 ( Main/Corpus ); précédent : 000063; suivant : 000065A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana.
Auteurs : Sevasti Maistrou ; Véronique Paris ; Annette B. Jensen ; Jens Rolff ; Nicolai V. Meyling ; Caroline ZanchiSource :
- Developmental and comparative immunology [ 1879-0089 ] ; 2018.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antifungal Agents, Insect Proteins, Peptides.
- drug effects : Beauveria.
- drug therapy : Mycoses.
- immunology : Host-Pathogen Interactions.
- microbiology : Coleoptera, Mycoses, Tenebrio.
- Animals.
Abstract
Antimicrobial peptides have been well studied in the context of bacterial infections. Antifungal peptides have received comparatively less attention. Fungal pathogens of insects and their hosts represent a unique opportunity to study host-pathogen interactions due to the million of years of co-evolution they share. In this study, we investigated role of a constitutively expressed thaumatin-like peptide with antifungal activity expressed by the mealworm beetle Tenebrio molitor, named Tenecin 3, during a natural infection with the entomopathogenic fungus Beauveria bassiana. We monitored the effect of the expression of Tenecin 3 on the survival of infected hosts as well as on the progression of the fungal infection inside the host. Finally, we tested the activity of Tenecin 3 against B. bassiana. These findings could help improving biocontrol strategies and help understanding the evolution of antifungal peptides as a defense mechanism.
DOI: 10.1016/j.dci.2018.04.015
PubMed: 29698631
Links to Exploration step
pubmed:29698631Le document en format XML
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<author><name sortKey="Rolff, Jens" sort="Rolff, Jens" uniqKey="Rolff J" first="Jens" last="Rolff">Jens Rolff</name>
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<author><name sortKey="Zanchi, Caroline" sort="Zanchi, Caroline" uniqKey="Zanchi C" first="Caroline" last="Zanchi">Caroline Zanchi</name>
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<author><name sortKey="Zanchi, Caroline" sort="Zanchi, Caroline" uniqKey="Zanchi C" first="Caroline" last="Zanchi">Caroline Zanchi</name>
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<series><title level="j">Developmental and comparative immunology</title>
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<term>Antifungal Agents (pharmacology)</term>
<term>Beauveria (drug effects)</term>
<term>Coleoptera (microbiology)</term>
<term>Host-Pathogen Interactions (immunology)</term>
<term>Insect Proteins (pharmacology)</term>
<term>Mycoses (drug therapy)</term>
<term>Mycoses (microbiology)</term>
<term>Peptides (pharmacology)</term>
<term>Tenebrio (microbiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term>
<term>Insect Proteins</term>
<term>Peptides</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Beauveria</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Mycoses</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coleoptera</term>
<term>Mycoses</term>
<term>Tenebrio</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
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<front><div type="abstract" xml:lang="en">Antimicrobial peptides have been well studied in the context of bacterial infections. Antifungal peptides have received comparatively less attention. Fungal pathogens of insects and their hosts represent a unique opportunity to study host-pathogen interactions due to the million of years of co-evolution they share. In this study, we investigated role of a constitutively expressed thaumatin-like peptide with antifungal activity expressed by the mealworm beetle Tenebrio molitor, named Tenecin 3, during a natural infection with the entomopathogenic fungus Beauveria bassiana. We monitored the effect of the expression of Tenecin 3 on the survival of infected hosts as well as on the progression of the fungal infection inside the host. Finally, we tested the activity of Tenecin 3 against B. bassiana. These findings could help improving biocontrol strategies and help understanding the evolution of antifungal peptides as a defense mechanism.</div>
</front>
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