Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging.
Identifieur interne : 002D62 ( Main/Exploration ); précédent : 002D61; suivant : 002D63Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging.
Auteurs : Stéphanie Dudonné [France] ; Pascal Poupard ; Philippe Coutière ; Marion Woillez ; Tristan Richard ; Jean-Michel Mérillon ; Xavier VitracSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2011.
Descripteurs français
- KwdFr :
- Antioxydants (pharmacologie), Expression des gènes (effets des médicaments et des substances chimiques), Extraits de plantes (pharmacologie), Humains (MeSH), Peau (effets des médicaments et des substances chimiques), Peau (métabolisme), Phénols (pharmacologie), Populus (composition chimique), Transcription génétique (effets des médicaments et des substances chimiques), Vieillissement de la peau (effets des médicaments et des substances chimiques), Vieillissement de la peau (génétique).
- MESH :
- composition chimique : Populus.
- effets des médicaments et des substances chimiques : Expression des gènes, Peau, Transcription génétique, Vieillissement de la peau.
- génétique : Vieillissement de la peau.
- métabolisme : Peau.
- pharmacologie : Antioxydants, Extraits de plantes, Phénols.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antioxidants, Phenols, Plant Extracts.
- chemistry : Populus.
- drug effects : Gene Expression, Skin, Skin Aging, Transcription, Genetic.
- genetics : Skin Aging.
- metabolism : Skin.
- Humans.
Abstract
The Populus species possess great potential for therapeutical applications, especially for their known anti-inflammatory properties. The antioxidant properties of propolis, a hive product collected by honey bees mainly from poplar bud exudates, suggest that poplar buds also possess antioxidant properties. Here is reported the characterization of the antioxidant properties of an aqueous poplar bud (Populus nigra) extract. It presented a high total phenolic content, and moderate antioxidant properties as determined by ORAC assay. The main phenolic compounds identified were phenolic acids and flavonoid aglycons. These phenolic compounds were analyzed by ORAC assay for their individual antioxidant activity, in order to determine the major contributors to the total antioxidant activity of the extract. Thanks to their high antioxidant activity, caffeic and p-coumaric acids were identified as the major antioxidant components. Representing only 3.5% of its dry weight, these compounds represented together about 50% of the total antioxidant activity of the extract. The antioxidant properties of poplar bud extract and the phenolic compounds identified were also analyzed by cellular antioxidant activity assay (CAA), which was weakly correlated with ORAC assay. The transcriptional effect of poplar bud extract on skin aging was evaluated in vitro on a replicative senescence model of normal human dermal fibroblasts, using a customized DNA macroarray specifically designed to investigate skin aging markers. Among the detected genes, poplar bud extract significantly regulated genes involved in antioxidant defenses, inflammatory response and cell renewal. The collective antioxidant properties and transcriptional effect of this extract suggest potential antiaging properties which could be utilized in cosmetic and nutraceutical formulations.
DOI: 10.1021/jf104791t
PubMed: 21425781
Affiliations:
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Coutière</name></author><author><name sortKey="Woillez, Marion" sort="Woillez, Marion" uniqKey="Woillez M" first="Marion" last="Woillez">Marion Woillez</name></author><author><name sortKey="Richard, Tristan" sort="Richard, Tristan" uniqKey="Richard T" first="Tristan" last="Richard">Tristan Richard</name></author><author><name sortKey="Merillon, Jean Michel" sort="Merillon, Jean Michel" uniqKey="Merillon J" first="Jean-Michel" last="Mérillon">Jean-Michel Mérillon</name></author><author><name sortKey="Vitrac, Xavier" sort="Vitrac, Xavier" uniqKey="Vitrac X" first="Xavier" last="Vitrac">Xavier Vitrac</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21425781</idno><idno type="pmid">21425781</idno><idno type="doi">10.1021/jf104791t</idno><idno type="wicri:Area/Main/Corpus">002E78</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002E78</idno><idno 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scheme="MESH" qualifier="genetics" xml:lang="en"><term>Skin Aging</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vieillissement de la peau</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peau</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term><term>Extraits de plantes</term><term>Phénols</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Populus species possess great potential for therapeutical applications, especially for their known anti-inflammatory properties. The antioxidant properties of propolis, a hive product collected by honey bees mainly from poplar bud exudates, suggest that poplar buds also possess antioxidant properties. Here is reported the characterization of the antioxidant properties of an aqueous poplar bud (Populus nigra) extract. It presented a high total phenolic content, and moderate antioxidant properties as determined by ORAC assay. The main phenolic compounds identified were phenolic acids and flavonoid aglycons. These phenolic compounds were analyzed by ORAC assay for their individual antioxidant activity, in order to determine the major contributors to the total antioxidant activity of the extract. Thanks to their high antioxidant activity, caffeic and p-coumaric acids were identified as the major antioxidant components. Representing only 3.5% of its dry weight, these compounds represented together about 50% of the total antioxidant activity of the extract. The antioxidant properties of poplar bud extract and the phenolic compounds identified were also analyzed by cellular antioxidant activity assay (CAA), which was weakly correlated with ORAC assay. The transcriptional effect of poplar bud extract on skin aging was evaluated in vitro on a replicative senescence model of normal human dermal fibroblasts, using a customized DNA macroarray specifically designed to investigate skin aging markers. Among the detected genes, poplar bud extract significantly regulated genes involved in antioxidant defenses, inflammatory response and cell renewal. The collective antioxidant properties and transcriptional effect of this extract suggest potential antiaging properties which could be utilized in cosmetic and nutraceutical formulations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21425781</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2011</Year><Month>05</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>9</Issue><PubDate><Year>2011</Year><Month>May</Month><Day>11</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J Agric Food Chem</ISOAbbreviation></Journal><ArticleTitle>Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging.</ArticleTitle><Pagination><MedlinePgn>4527-36</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jf104791t</ELocationID><Abstract><AbstractText>The Populus species possess great potential for therapeutical applications, especially for their known anti-inflammatory properties. The antioxidant properties of propolis, a hive product collected by honey bees mainly from poplar bud exudates, suggest that poplar buds also possess antioxidant properties. Here is reported the characterization of the antioxidant properties of an aqueous poplar bud (Populus nigra) extract. It presented a high total phenolic content, and moderate antioxidant properties as determined by ORAC assay. The main phenolic compounds identified were phenolic acids and flavonoid aglycons. These phenolic compounds were analyzed by ORAC assay for their individual antioxidant activity, in order to determine the major contributors to the total antioxidant activity of the extract. Thanks to their high antioxidant activity, caffeic and p-coumaric acids were identified as the major antioxidant components. Representing only 3.5% of its dry weight, these compounds represented together about 50% of the total antioxidant activity of the extract. The antioxidant properties of poplar bud extract and the phenolic compounds identified were also analyzed by cellular antioxidant activity assay (CAA), which was weakly correlated with ORAC assay. The transcriptional effect of poplar bud extract on skin aging was evaluated in vitro on a replicative senescence model of normal human dermal fibroblasts, using a customized DNA macroarray specifically designed to investigate skin aging markers. Among the detected genes, poplar bud extract significantly regulated genes involved in antioxidant defenses, inflammatory response and cell renewal. The collective antioxidant properties and transcriptional effect of this extract suggest potential antiaging properties which could be utilized in cosmetic and nutraceutical formulations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dudonné</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biolandes Route de Bélis, Le Sen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poupard</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Coutière</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Woillez</LastName><ForeName>Marion</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Tristan</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Mérillon</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials></Author><Author 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PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21425781</ArticleId><ArticleId IdType="doi">10.1021/jf104791t</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Coutiere, Philippe" sort="Coutiere, Philippe" uniqKey="Coutiere P" first="Philippe" last="Coutière">Philippe Coutière</name><name sortKey="Merillon, Jean Michel" sort="Merillon, Jean Michel" uniqKey="Merillon J" first="Jean-Michel" last="Mérillon">Jean-Michel Mérillon</name><name sortKey="Poupard, Pascal" sort="Poupard, Pascal" uniqKey="Poupard P" first="Pascal" last="Poupard">Pascal Poupard</name><name sortKey="Richard, Tristan" sort="Richard, Tristan" uniqKey="Richard T" first="Tristan" last="Richard">Tristan Richard</name><name sortKey="Vitrac, Xavier" sort="Vitrac, Xavier" uniqKey="Vitrac X" first="Xavier" last="Vitrac">Xavier Vitrac</name><name sortKey="Woillez, Marion" sort="Woillez, Marion" uniqKey="Woillez M" first="Marion" last="Woillez">Marion Woillez</name></noCountry><country name="France"><noRegion><name sortKey="Dudonne, Stephanie" sort="Dudonne, Stephanie" uniqKey="Dudonne S" first="Stéphanie" last="Dudonné">Stéphanie Dudonné</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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