Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
Identifieur interne : 002184 ( Main/Exploration ); précédent : 002183; suivant : 002185Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
Auteurs : Yan Zhao [République populaire de Chine] ; Guosheng Tang ; Enbo Cai ; Shuangli Liu ; Lianxue Zhang ; Shijie WangSource :
- Natural product research [ 1478-6427 ] ; 2014.
Descripteurs français
- KwdFr :
- Alimentation riche en graisse (MeSH), Animaux (MeSH), Antioxydants (isolement et purification), Antioxydants (pharmacologie), Cholestérol HDL (sang), Cholestérol LDL (sang), Dérivés du biphényle (pharmacologie), Flavonoïdes (isolement et purification), Flavonoïdes (pharmacologie), Hypolipémiants (isolement et purification), Hypolipémiants (pharmacologie), Phénols (isolement et purification), Phénols (pharmacologie), Picrates (pharmacologie), Populus (composition chimique), Souris (MeSH), Triglycéride (sang), Éthanol (MeSH).
- MESH :
- composition chimique : Populus.
- isolement et purification : Antioxydants, Flavonoïdes, Hypolipémiants, Phénols.
- pharmacologie : Antioxydants, Dérivés du biphényle, Flavonoïdes, Hypolipémiants, Phénols, Picrates.
- sang : Cholestérol HDL, Cholestérol LDL, Triglycéride.
- Alimentation riche en graisse, Animaux, Souris, Éthanol.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (isolation & purification), Antioxidants (pharmacology), Biphenyl Compounds (pharmacology), Cholesterol, HDL (blood), Cholesterol, LDL (blood), Diet, High-Fat (MeSH), Ethanol (MeSH), Flavonoids (isolation & purification), Flavonoids (pharmacology), Hypolipidemic Agents (isolation & purification), Hypolipidemic Agents (pharmacology), Mice (MeSH), Phenols (isolation & purification), Phenols (pharmacology), Picrates (pharmacology), Populus (chemistry), Triglycerides (blood).
- MESH :
- chemical , blood : Cholesterol, HDL, Cholesterol, LDL, Triglycerides.
- chemical , isolation & purification : Antioxidants, Flavonoids, Hypolipidemic Agents, Phenols.
- chemical , pharmacology : Antioxidants, Biphenyl Compounds, Flavonoids, Hypolipidemic Agents, Phenols, Picrates.
- chemistry : Populus.
- Animals, Diet, High-Fat, Ethanol, Mice.
Abstract
This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.
DOI: 10.1080/14786419.2014.905564
PubMed: 24730759
Affiliations:
Links toward previous steps (curation, corpus...)
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin </wicri:regionArea><wicri:noRegion>Jilin </wicri:noRegion></affiliation></author><author><name sortKey="Tang, Guosheng" sort="Tang, Guosheng" uniqKey="Tang G" first="Guosheng" last="Tang">Guosheng Tang</name></author><author><name sortKey="Cai, Enbo" sort="Cai, Enbo" uniqKey="Cai E" first="Enbo" last="Cai">Enbo Cai</name></author><author><name sortKey="Liu, Shuangli" sort="Liu, Shuangli" uniqKey="Liu S" first="Shuangli" last="Liu">Shuangli Liu</name></author><author><name sortKey="Zhang, Lianxue" sort="Zhang, Lianxue" uniqKey="Zhang L" first="Lianxue" last="Zhang">Lianxue Zhang</name></author><author><name sortKey="Wang, Shijie" sort="Wang, Shijie" uniqKey="Wang S" first="Shijie" last="Wang">Shijie Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24730759</idno><idno type="pmid">24730759</idno><idno type="doi">10.1080/14786419.2014.905564</idno><idno type="wicri:Area/Main/Corpus">002232</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002232</idno><idno type="wicri:Area/Main/Curation">002232</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002232</idno><idno type="wicri:Area/Main/Exploration">002232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.</title><author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name><affiliation wicri:level="1"><nlm:affiliation>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin </wicri:regionArea><wicri:noRegion>Jilin </wicri:noRegion></affiliation></author><author><name sortKey="Tang, Guosheng" sort="Tang, Guosheng" uniqKey="Tang G" first="Guosheng" last="Tang">Guosheng Tang</name></author><author><name sortKey="Cai, Enbo" sort="Cai, Enbo" uniqKey="Cai E" first="Enbo" last="Cai">Enbo Cai</name></author><author><name sortKey="Liu, Shuangli" sort="Liu, Shuangli" uniqKey="Liu S" first="Shuangli" last="Liu">Shuangli Liu</name></author><author><name sortKey="Zhang, Lianxue" sort="Zhang, Lianxue" uniqKey="Zhang L" first="Lianxue" last="Zhang">Lianxue Zhang</name></author><author><name sortKey="Wang, Shijie" sort="Wang, Shijie" uniqKey="Wang S" first="Shijie" last="Wang">Shijie Wang</name></author></analytic><series><title level="j">Natural product research</title><idno type="eISSN">1478-6427</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antioxidants (isolation & purification)</term><term>Antioxidants (pharmacology)</term><term>Biphenyl Compounds (pharmacology)</term><term>Cholesterol, HDL (blood)</term><term>Cholesterol, LDL (blood)</term><term>Diet, High-Fat (MeSH)</term><term>Ethanol (MeSH)</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Hypolipidemic Agents (isolation & purification)</term><term>Hypolipidemic Agents (pharmacology)</term><term>Mice (MeSH)</term><term>Phenols (isolation & purification)</term><term>Phenols (pharmacology)</term><term>Picrates (pharmacology)</term><term>Populus (chemistry)</term><term>Triglycerides (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alimentation riche en graisse (MeSH)</term><term>Animaux (MeSH)</term><term>Antioxydants (isolement et purification)</term><term>Antioxydants (pharmacologie)</term><term>Cholestérol HDL (sang)</term><term>Cholestérol LDL (sang)</term><term>Dérivés du biphényle (pharmacologie)</term><term>Flavonoïdes (isolement et purification)</term><term>Flavonoïdes (pharmacologie)</term><term>Hypolipémiants (isolement et purification)</term><term>Hypolipémiants (pharmacologie)</term><term>Phénols (isolement et purification)</term><term>Phénols (pharmacologie)</term><term>Picrates (pharmacologie)</term><term>Populus (composition chimique)</term><term>Souris (MeSH)</term><term>Triglycéride (sang)</term><term>Éthanol (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antioxidants</term><term>Flavonoids</term><term>Hypolipidemic Agents</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Biphenyl Compounds</term><term>Flavonoids</term><term>Hypolipidemic Agents</term><term>Phenols</term><term>Picrates</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antioxydants</term><term>Flavonoïdes</term><term>Hypolipémiants</term><term>Phénols</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term><term>Dérivés du biphényle</term><term>Flavonoïdes</term><term>Hypolipémiants</term><term>Phénols</term><term>Picrates</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cholestérol HDL</term><term>Cholestérol LDL</term><term>Triglycéride</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diet, High-Fat</term><term>Ethanol</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alimentation riche en graisse</term><term>Animaux</term><term>Souris</term><term>Éthanol</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24730759</PMID><DateCompleted><Year>2014</Year><Month>12</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1478-6427</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>18</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Natural product research</Title><ISOAbbreviation>Nat Prod Res</ISOAbbreviation></Journal><ArticleTitle>Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.</ArticleTitle><Pagination><MedlinePgn>1467-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14786419.2014.905564</ELocationID><Abstract><AbstractText>This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Guosheng</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Enbo</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Shuangli</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lianxue</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Shijie</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Prod Res</MedlineTA><NlmUniqueID>101167924</NlmUniqueID><ISSNLinking>1478-6419</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008076">Cholesterol, HDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000960">Hypolipidemic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008076" MajorTopicYN="N">Cholesterol, HDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008078" MajorTopicYN="N">Cholesterol, LDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000960" MajorTopicYN="N">Hypolipidemic Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010851" MajorTopicYN="N">Picrates</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Flos populi</Keyword><Keyword MajorTopicYN="N">antioxidant</Keyword><Keyword MajorTopicYN="N">flavonoids</Keyword><Keyword MajorTopicYN="N">hypolipidaemic</Keyword><Keyword MajorTopicYN="N">phenols</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24730759</ArticleId><ArticleId IdType="doi">10.1080/14786419.2014.905564</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Cai, Enbo" sort="Cai, Enbo" uniqKey="Cai E" first="Enbo" last="Cai">Enbo Cai</name><name sortKey="Liu, Shuangli" sort="Liu, Shuangli" uniqKey="Liu S" first="Shuangli" last="Liu">Shuangli Liu</name><name sortKey="Tang, Guosheng" sort="Tang, Guosheng" uniqKey="Tang G" first="Guosheng" last="Tang">Guosheng Tang</name><name sortKey="Wang, Shijie" sort="Wang, Shijie" uniqKey="Wang S" first="Shijie" last="Wang">Shijie Wang</name><name sortKey="Zhang, Lianxue" sort="Zhang, Lianxue" uniqKey="Zhang L" first="Lianxue" last="Zhang">Lianxue Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document 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