Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
Identifieur interne : 002232 ( Main/Corpus ); précédent : 002231; suivant : 002233Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
Auteurs : Yan Zhao ; Guosheng Tang ; Enbo Cai ; Shuangli Liu ; Lianxue Zhang ; Shijie WangSource :
- Natural product research [ 1478-6427 ] ; 2014.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (isolation & purification), Antioxidants (pharmacology), Biphenyl Compounds (pharmacology), Cholesterol, HDL (blood), Cholesterol, LDL (blood), Diet, High-Fat (MeSH), Ethanol (MeSH), Flavonoids (isolation & purification), Flavonoids (pharmacology), Hypolipidemic Agents (isolation & purification), Hypolipidemic Agents (pharmacology), Mice (MeSH), Phenols (isolation & purification), Phenols (pharmacology), Picrates (pharmacology), Populus (chemistry), Triglycerides (blood).
- MESH :
- chemical , blood : Cholesterol, HDL, Cholesterol, LDL, Triglycerides.
- chemical , isolation & purification : Antioxidants, Flavonoids, Hypolipidemic Agents, Phenols.
- chemical , pharmacology : Antioxidants, Biphenyl Compounds, Flavonoids, Hypolipidemic Agents, Phenols, Picrates.
- chemistry : Populus.
- Animals, Diet, High-Fat, Ethanol, Mice.
Abstract
This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.
DOI: 10.1080/14786419.2014.905564
PubMed: 24730759
Links to Exploration step
pubmed:24730759Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.</title><author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name><affiliation><nlm:affiliation>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Guosheng" sort="Tang, Guosheng" uniqKey="Tang G" first="Guosheng" last="Tang">Guosheng Tang</name></author><author><name sortKey="Cai, Enbo" sort="Cai, Enbo" uniqKey="Cai E" first="Enbo" last="Cai">Enbo Cai</name></author><author><name sortKey="Liu, Shuangli" sort="Liu, Shuangli" uniqKey="Liu S" first="Shuangli" last="Liu">Shuangli Liu</name></author><author><name sortKey="Zhang, Lianxue" sort="Zhang, Lianxue" uniqKey="Zhang L" first="Lianxue" last="Zhang">Lianxue Zhang</name></author><author><name sortKey="Wang, Shijie" sort="Wang, Shijie" uniqKey="Wang S" first="Shijie" last="Wang">Shijie Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24730759</idno><idno type="pmid">24730759</idno><idno type="doi">10.1080/14786419.2014.905564</idno><idno type="wicri:Area/Main/Corpus">002232</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.</title><author><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name><affiliation><nlm:affiliation>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Guosheng" sort="Tang, Guosheng" uniqKey="Tang G" first="Guosheng" last="Tang">Guosheng Tang</name></author><author><name sortKey="Cai, Enbo" sort="Cai, Enbo" uniqKey="Cai E" first="Enbo" last="Cai">Enbo Cai</name></author><author><name sortKey="Liu, Shuangli" sort="Liu, Shuangli" uniqKey="Liu S" first="Shuangli" last="Liu">Shuangli Liu</name></author><author><name sortKey="Zhang, Lianxue" sort="Zhang, Lianxue" uniqKey="Zhang L" first="Lianxue" last="Zhang">Lianxue Zhang</name></author><author><name sortKey="Wang, Shijie" sort="Wang, Shijie" uniqKey="Wang S" first="Shijie" last="Wang">Shijie Wang</name></author></analytic><series><title level="j">Natural product research</title><idno type="eISSN">1478-6427</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antioxidants (isolation & purification)</term><term>Antioxidants (pharmacology)</term><term>Biphenyl Compounds (pharmacology)</term><term>Cholesterol, HDL (blood)</term><term>Cholesterol, LDL (blood)</term><term>Diet, High-Fat (MeSH)</term><term>Ethanol (MeSH)</term><term>Flavonoids (isolation & purification)</term><term>Flavonoids (pharmacology)</term><term>Hypolipidemic Agents (isolation & purification)</term><term>Hypolipidemic Agents (pharmacology)</term><term>Mice (MeSH)</term><term>Phenols (isolation & purification)</term><term>Phenols (pharmacology)</term><term>Picrates (pharmacology)</term><term>Populus (chemistry)</term><term>Triglycerides (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antioxidants</term><term>Flavonoids</term><term>Hypolipidemic Agents</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Biphenyl Compounds</term><term>Flavonoids</term><term>Hypolipidemic Agents</term><term>Phenols</term><term>Picrates</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diet, High-Fat</term><term>Ethanol</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24730759</PMID><DateCompleted><Year>2014</Year><Month>12</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1478-6427</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>18</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Natural product research</Title><ISOAbbreviation>Nat Prod Res</ISOAbbreviation></Journal><ArticleTitle>Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.</ArticleTitle><Pagination><MedlinePgn>1467-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14786419.2014.905564</ELocationID><Abstract><AbstractText>This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a College of Chinese Medicinal Materials, Jilin Agriculture University , Changchun , 130118 , Jilin , P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Guosheng</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Enbo</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Shuangli</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lianxue</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Shijie</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Prod Res</MedlineTA><NlmUniqueID>101167924</NlmUniqueID><ISSNLinking>1478-6419</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008076">Cholesterol, HDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000960">Hypolipidemic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010851">Picrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014280">Triglycerides</NameOfSubstance></Chemical><Chemical><RegistryNumber>3K9958V90M</RegistryNumber><NameOfSubstance UI="D000431">Ethanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>DFD3H4VGDH</RegistryNumber><NameOfSubstance UI="C004931">1,1-diphenyl-2-picrylhydrazyl</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008076" MajorTopicYN="N">Cholesterol, HDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008078" MajorTopicYN="N">Cholesterol, LDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000960" MajorTopicYN="N">Hypolipidemic Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010851" MajorTopicYN="N">Picrates</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Flos populi</Keyword><Keyword MajorTopicYN="N">antioxidant</Keyword><Keyword MajorTopicYN="N">flavonoids</Keyword><Keyword MajorTopicYN="N">hypolipidaemic</Keyword><Keyword MajorTopicYN="N">phenols</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24730759</ArticleId><ArticleId IdType="doi">10.1080/14786419.2014.905564</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002232 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002232 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PoplarV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:24730759
|texte= Hypolipidaemic and antioxidant properties of ethanol extract from Flos populi.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:24730759" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |