Functional and evolutionary genomic inferences in Populus through genome and population sequencing of American and European aspen.
Identifieur interne : 000B97 ( Main/Corpus ); précédent : 000B96; suivant : 000B98Functional and evolutionary genomic inferences in Populus through genome and population sequencing of American and European aspen.
Auteurs : Yao-Cheng Lin ; Jing Wang ; Nicolas Delhomme ; Bastian Schiffthaler ; Görel Sundström ; Andrea Zuccolo ; Björn Nystedt ; Torgeir R. Hvidsten ; Amanda De La Torre ; Rosa M. Cossu ; Marc P. Hoeppner ; Henrik Lantz ; Douglas G. Scofield ; Neda Zamani ; Anna Johansson ; Chanaka Mannapperuma ; Kathryn M. Robinson ; Niklas M Hler ; Ilia J. Leitch ; Jaume Pellicer ; Eung-Jun Park ; Marc Van Montagu ; Yves Van De Peer ; Manfred Grabherr ; Stefan Jansson ; P R K. Ingvarsson ; Nathaniel R. StreetSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2018.
English descriptors
- KwdEn :
- Biological Evolution (MeSH), DNA, Plant (genetics), Evolution, Molecular (MeSH), Genetic Variation (MeSH), Genetics, Population (methods), Genome, Plant (MeSH), Genomics (MeSH), Linkage Disequilibrium (genetics), Phylogeny (MeSH), Populus (genetics), Selection, Genetic (genetics), Sequence Analysis, DNA (methods), Trees (genetics).
- MESH :
- chemical , genetics : DNA, Plant.
- genetics : Linkage Disequilibrium, Populus, Selection, Genetic, Trees.
- methods : Genetics, Population, Sequence Analysis, DNA.
- Biological Evolution, Evolution, Molecular, Genetic Variation, Genome, Plant, Genomics, Phylogeny.
Abstract
The Populus genus is one of the major plant model systems, but genomic resources have thus far primarily been available for poplar species, and primarily Populus trichocarpa (Torr. & Gray), which was the first tree with a whole-genome assembly. To further advance evolutionary and functional genomic analyses in Populus, we produced genome assemblies and population genetics resources of two aspen species, Populus tremula L. and Populus tremuloides Michx. The two aspen species have distributions spanning the Northern Hemisphere, where they are keystone species supporting a wide variety of dependent communities and produce a diverse array of secondary metabolites. Our analyses show that the two aspens share a similar genome structure and a highly conserved gene content with P. trichocarpa but display substantially higher levels of heterozygosity. Based on population resequencing data, we observed widespread positive and negative selection acting on both coding and noncoding regions. Furthermore, patterns of genetic diversity and molecular evolution in aspen are influenced by a number of features, such as expression level, coexpression network connectivity, and regulatory variation. To maximize the community utility of these resources, we have integrated all presented data within the PopGenIE web resource (PopGenIE.org).
DOI: 10.1073/pnas.1801437115
PubMed: 30373829
PubMed Central: PMC6243237
Links to Exploration step
pubmed:30373829Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional and evolutionary genomic inferences in <i>Populus</i> through genome and population sequencing of American and European aspen.</title><author><name sortKey="Lin, Yao Cheng" sort="Lin, Yao Cheng" uniqKey="Lin Y" first="Yao-Cheng" last="Lin">Yao-Cheng Lin</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biotechnology Center in Southern Taiwan, Academia Sinica, Tainan 74145, Taiwan.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Agricultural Biotechnology Research Center, Academia Sinica, Tainan 74145, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, 5003 Ås, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Delhomme, Nicolas" sort="Delhomme, Nicolas" uniqKey="Delhomme N" first="Nicolas" last="Delhomme">Nicolas Delhomme</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Schiffthaler, Bastian" sort="Schiffthaler, Bastian" uniqKey="Schiffthaler B" first="Bastian" last="Schiffthaler">Bastian Schiffthaler</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Sundstrom, Gorel" sort="Sundstrom, Gorel" uniqKey="Sundstrom G" first="Görel" last="Sundström">Görel Sundström</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zuccolo, Andrea" sort="Zuccolo, Andrea" uniqKey="Zuccolo A" first="Andrea" last="Zuccolo">Andrea Zuccolo</name><affiliation><nlm:affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nystedt, Bjorn" sort="Nystedt, Bjorn" uniqKey="Nystedt B" first="Björn" last="Nystedt">Björn Nystedt</name><affiliation><nlm:affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hvidsten, Torgeir R" sort="Hvidsten, Torgeir R" uniqKey="Hvidsten T" first="Torgeir R" last="Hvidsten">Torgeir R. Hvidsten</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="De La Torre, Amanda" sort="De La Torre, Amanda" uniqKey="De La Torre A" first="Amanda" last="De La Torre">Amanda De La Torre</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>School of Forestry, Northern Arizona University, Flagstaff, AZ 86011.</nlm:affiliation></affiliation></author><author><name sortKey="Cossu, Rosa M" sort="Cossu, Rosa M" uniqKey="Cossu R" first="Rosa M" last="Cossu">Rosa M. Cossu</name><affiliation><nlm:affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Hoeppner, Marc P" sort="Hoeppner, Marc P" uniqKey="Hoeppner M" first="Marc P" last="Hoeppner">Marc P. Hoeppner</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lantz, Henrik" sort="Lantz, Henrik" uniqKey="Lantz H" first="Henrik" last="Lantz">Henrik Lantz</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Bioinformatics Infrastructure Sweden, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Scofield, Douglas G" sort="Scofield, Douglas G" uniqKey="Scofield D" first="Douglas G" last="Scofield">Douglas G. Scofield</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Ecology and Genetics: Evolutionary Biology, Uppsala University, 751 05 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Uppsala Multidisciplinary Center for Advanced Computational Science, Uppsala University, 751 05 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zamani, Neda" sort="Zamani, Neda" uniqKey="Zamani N" first="Neda" last="Zamani">Neda Zamani</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, Anna" sort="Johansson, Anna" uniqKey="Johansson A" first="Anna" last="Johansson">Anna Johansson</name><affiliation><nlm:affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mannapperuma, Chanaka" sort="Mannapperuma, Chanaka" uniqKey="Mannapperuma C" first="Chanaka" last="Mannapperuma">Chanaka Mannapperuma</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Kathryn M" sort="Robinson, Kathryn M" uniqKey="Robinson K" first="Kathryn M" last="Robinson">Kathryn M. Robinson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="M Hler, Niklas" sort="M Hler, Niklas" uniqKey="M Hler N" first="Niklas" last="M Hler">Niklas M Hler</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leitch, Ilia J" sort="Leitch, Ilia J" uniqKey="Leitch I" first="Ilia J" last="Leitch">Ilia J. Leitch</name><affiliation><nlm:affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pellicer, Jaume" sort="Pellicer, Jaume" uniqKey="Pellicer J" first="Jaume" last="Pellicer">Jaume Pellicer</name><affiliation><nlm:affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Eung Jun" sort="Park, Eung Jun" uniqKey="Park E" first="Eung-Jun" last="Park">Eung-Jun Park</name><affiliation><nlm:affiliation>Forest Biotechnology Division, National Institute of Forest Science, Suwon 16631, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Van Montagu, Marc" sort="Van Montagu, Marc" uniqKey="Van Montagu M" first="Marc" last="Van Montagu">Marc Van Montagu</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Peer, Yves" sort="Van De Peer, Yves" uniqKey="Van De Peer Y" first="Yves" last="Van De Peer">Yves Van De Peer</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0001, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Grabherr, Manfred" sort="Grabherr, Manfred" uniqKey="Grabherr M" first="Manfred" last="Grabherr">Manfred Grabherr</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jansson, Stefan" sort="Jansson, Stefan" uniqKey="Jansson S" first="Stefan" last="Jansson">Stefan Jansson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingvarsson, P R K" sort="Ingvarsson, P R K" uniqKey="Ingvarsson P" first="P R K" last="Ingvarsson">P R K. Ingvarsson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Plant Biology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Street, Nathaniel R" sort="Street, Nathaniel R" uniqKey="Street N" first="Nathaniel R" last="Street">Nathaniel R. Street</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30373829</idno><idno type="pmid">30373829</idno><idno type="doi">10.1073/pnas.1801437115</idno><idno type="pmc">PMC6243237</idno><idno type="wicri:Area/Main/Corpus">000B97</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Functional and evolutionary genomic inferences in <i>Populus</i> through genome and population sequencing of American and European aspen.</title><author><name sortKey="Lin, Yao Cheng" sort="Lin, Yao Cheng" uniqKey="Lin Y" first="Yao-Cheng" last="Lin">Yao-Cheng Lin</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biotechnology Center in Southern Taiwan, Academia Sinica, Tainan 74145, Taiwan.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Agricultural Biotechnology Research Center, Academia Sinica, Tainan 74145, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, 5003 Ås, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Delhomme, Nicolas" sort="Delhomme, Nicolas" uniqKey="Delhomme N" first="Nicolas" last="Delhomme">Nicolas Delhomme</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Schiffthaler, Bastian" sort="Schiffthaler, Bastian" uniqKey="Schiffthaler B" first="Bastian" last="Schiffthaler">Bastian Schiffthaler</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Sundstrom, Gorel" sort="Sundstrom, Gorel" uniqKey="Sundstrom G" first="Görel" last="Sundström">Görel Sundström</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zuccolo, Andrea" sort="Zuccolo, Andrea" uniqKey="Zuccolo A" first="Andrea" last="Zuccolo">Andrea Zuccolo</name><affiliation><nlm:affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nystedt, Bjorn" sort="Nystedt, Bjorn" uniqKey="Nystedt B" first="Björn" last="Nystedt">Björn Nystedt</name><affiliation><nlm:affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hvidsten, Torgeir R" sort="Hvidsten, Torgeir R" uniqKey="Hvidsten T" first="Torgeir R" last="Hvidsten">Torgeir R. Hvidsten</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="De La Torre, Amanda" sort="De La Torre, Amanda" uniqKey="De La Torre A" first="Amanda" last="De La Torre">Amanda De La Torre</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>School of Forestry, Northern Arizona University, Flagstaff, AZ 86011.</nlm:affiliation></affiliation></author><author><name sortKey="Cossu, Rosa M" sort="Cossu, Rosa M" uniqKey="Cossu R" first="Rosa M" last="Cossu">Rosa M. Cossu</name><affiliation><nlm:affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Hoeppner, Marc P" sort="Hoeppner, Marc P" uniqKey="Hoeppner M" first="Marc P" last="Hoeppner">Marc P. Hoeppner</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lantz, Henrik" sort="Lantz, Henrik" uniqKey="Lantz H" first="Henrik" last="Lantz">Henrik Lantz</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Bioinformatics Infrastructure Sweden, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Scofield, Douglas G" sort="Scofield, Douglas G" uniqKey="Scofield D" first="Douglas G" last="Scofield">Douglas G. Scofield</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Ecology and Genetics: Evolutionary Biology, Uppsala University, 751 05 Uppsala, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Uppsala Multidisciplinary Center for Advanced Computational Science, Uppsala University, 751 05 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zamani, Neda" sort="Zamani, Neda" uniqKey="Zamani N" first="Neda" last="Zamani">Neda Zamani</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, Anna" sort="Johansson, Anna" uniqKey="Johansson A" first="Anna" last="Johansson">Anna Johansson</name><affiliation><nlm:affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mannapperuma, Chanaka" sort="Mannapperuma, Chanaka" uniqKey="Mannapperuma C" first="Chanaka" last="Mannapperuma">Chanaka Mannapperuma</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Kathryn M" sort="Robinson, Kathryn M" uniqKey="Robinson K" first="Kathryn M" last="Robinson">Kathryn M. Robinson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="M Hler, Niklas" sort="M Hler, Niklas" uniqKey="M Hler N" first="Niklas" last="M Hler">Niklas M Hler</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leitch, Ilia J" sort="Leitch, Ilia J" uniqKey="Leitch I" first="Ilia J" last="Leitch">Ilia J. Leitch</name><affiliation><nlm:affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pellicer, Jaume" sort="Pellicer, Jaume" uniqKey="Pellicer J" first="Jaume" last="Pellicer">Jaume Pellicer</name><affiliation><nlm:affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Eung Jun" sort="Park, Eung Jun" uniqKey="Park E" first="Eung-Jun" last="Park">Eung-Jun Park</name><affiliation><nlm:affiliation>Forest Biotechnology Division, National Institute of Forest Science, Suwon 16631, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Van Montagu, Marc" sort="Van Montagu, Marc" uniqKey="Van Montagu M" first="Marc" last="Van Montagu">Marc Van Montagu</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Peer, Yves" sort="Van De Peer, Yves" uniqKey="Van De Peer Y" first="Yves" last="Van De Peer">Yves Van De Peer</name><affiliation><nlm:affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0001, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Grabherr, Manfred" sort="Grabherr, Manfred" uniqKey="Grabherr M" first="Manfred" last="Grabherr">Manfred Grabherr</name><affiliation><nlm:affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jansson, Stefan" sort="Jansson, Stefan" uniqKey="Jansson S" first="Stefan" last="Jansson">Stefan Jansson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingvarsson, P R K" sort="Ingvarsson, P R K" uniqKey="Ingvarsson P" first="P R K" last="Ingvarsson">P R K. Ingvarsson</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Plant Biology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Street, Nathaniel R" sort="Street, Nathaniel R" uniqKey="Street N" first="Nathaniel R" last="Street">Nathaniel R. Street</name><affiliation><nlm:affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Evolution (MeSH)</term><term>DNA, Plant (genetics)</term><term>Evolution, Molecular (MeSH)</term><term>Genetic Variation (MeSH)</term><term>Genetics, Population (methods)</term><term>Genome, Plant (MeSH)</term><term>Genomics (MeSH)</term><term>Linkage Disequilibrium (genetics)</term><term>Phylogeny (MeSH)</term><term>Populus (genetics)</term><term>Selection, Genetic (genetics)</term><term>Sequence Analysis, DNA (methods)</term><term>Trees (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Plant</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Linkage Disequilibrium</term><term>Populus</term><term>Selection, Genetic</term><term>Trees</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetics, Population</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biological Evolution</term><term>Evolution, Molecular</term><term>Genetic Variation</term><term>Genome, Plant</term><term>Genomics</term><term>Phylogeny</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The <i>Populus</i> genus is one of the major plant model systems, but genomic resources have thus far primarily been available for poplar species, and primarily <i>Populus trichocarpa</i> (Torr. & Gray), which was the first tree with a whole-genome assembly. To further advance evolutionary and functional genomic analyses in <i>Populus</i>, we produced genome assemblies and population genetics resources of two aspen species, <i>Populus tremula</i> L. and <i>Populus tremuloides</i> Michx. The two aspen species have distributions spanning the Northern Hemisphere, where they are keystone species supporting a wide variety of dependent communities and produce a diverse array of secondary metabolites. Our analyses show that the two aspens share a similar genome structure and a highly conserved gene content with <i>P. trichocarpa</i> but display substantially higher levels of heterozygosity. Based on population resequencing data, we observed widespread positive and negative selection acting on both coding and noncoding regions. Furthermore, patterns of genetic diversity and molecular evolution in aspen are influenced by a number of features, such as expression level, coexpression network connectivity, and regulatory variation. To maximize the community utility of these resources, we have integrated all presented data within the PopGenIE web resource (PopGenIE.org).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30373829</PMID><DateCompleted><Year>2019</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>115</Volume><Issue>46</Issue><PubDate><Year>2018</Year><Month>11</Month><Day>13</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Functional and evolutionary genomic inferences in <i>Populus</i> through genome and population sequencing of American and European aspen.</ArticleTitle><Pagination><MedlinePgn>E10970-E10978</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1801437115</ELocationID><Abstract><AbstractText>The <i>Populus</i> genus is one of the major plant model systems, but genomic resources have thus far primarily been available for poplar species, and primarily <i>Populus trichocarpa</i> (Torr. & Gray), which was the first tree with a whole-genome assembly. To further advance evolutionary and functional genomic analyses in <i>Populus</i>, we produced genome assemblies and population genetics resources of two aspen species, <i>Populus tremula</i> L. and <i>Populus tremuloides</i> Michx. The two aspen species have distributions spanning the Northern Hemisphere, where they are keystone species supporting a wide variety of dependent communities and produce a diverse array of secondary metabolites. Our analyses show that the two aspens share a similar genome structure and a highly conserved gene content with <i>P. trichocarpa</i> but display substantially higher levels of heterozygosity. Based on population resequencing data, we observed widespread positive and negative selection acting on both coding and noncoding regions. Furthermore, patterns of genetic diversity and molecular evolution in aspen are influenced by a number of features, such as expression level, coexpression network connectivity, and regulatory variation. To maximize the community utility of these resources, we have integrated all presented data within the PopGenIE web resource (PopGenIE.org).</AbstractText><CopyrightInformation>Copyright © 2018 the Author(s). Published by PNAS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yao-Cheng</ForeName><Initials>YC</Initials><AffiliationInfo><Affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biotechnology Center in Southern Taiwan, Academia Sinica, Tainan 74145, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Agricultural Biotechnology Research Center, Academia Sinica, Tainan 74145, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, 5003 Ås, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delhomme</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schiffthaler</LastName><ForeName>Bastian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sundström</LastName><ForeName>Görel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuccolo</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-7574-0714</Identifier><AffiliationInfo><Affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nystedt</LastName><ForeName>Björn</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hvidsten</LastName><ForeName>Torgeir R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de la Torre</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Forestry, Northern Arizona University, Flagstaff, AZ 86011.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cossu</LastName><ForeName>Rosa M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Institute of Life Sciences, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoeppner</LastName><ForeName>Marc P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lantz</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Bioinformatics Infrastructure Sweden, Uppsala University, 751 23 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scofield</LastName><ForeName>Douglas G</ForeName><Initials>DG</Initials><Identifier Source="ORCID">0000-0001-5235-6461</Identifier><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ecology and Genetics: Evolutionary Biology, Uppsala University, 751 05 Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Uppsala Multidisciplinary Center for Advanced Computational Science, Uppsala University, 751 05 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zamani</LastName><ForeName>Neda</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 901 83 Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mannapperuma</LastName><ForeName>Chanaka</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Kathryn M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mähler</LastName><ForeName>Niklas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leitch</LastName><ForeName>Ilia J</ForeName><Initials>IJ</Initials><Identifier Source="ORCID">0000-0002-3837-8186</Identifier><AffiliationInfo><Affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pellicer</LastName><ForeName>Jaume</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Character Evolution Team, Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Eung-Jun</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Division, National Institute of Forest Science, Suwon 16631, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Montagu</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van de Peer</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>VIB-UGent Center for Plant Systems Biology and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0001, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grabherr</LastName><ForeName>Manfred</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jansson</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-7906-6891</Identifier><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingvarsson</LastName><ForeName>Pär K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Ecology and Environmental Science, Umeå University 901 87, Umeå, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Biology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Street</LastName><ForeName>Nathaniel R</ForeName><Initials>NR</Initials><AffiliationInfo><Affiliation>Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, 901 87 Umeå, Sweden; marc.vanmontagu@vib-ugent.be nathaniel.street@umu.se.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018744">DNA, Plant</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="N">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018744" MajorTopicYN="N">DNA, Plant</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005828" MajorTopicYN="N">Genetics, Population</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018745" MajorTopicYN="N">Genome, Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023281" MajorTopicYN="N">Genomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012641" MajorTopicYN="N">Selection, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014197" MajorTopicYN="N">Trees</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Populus</Keyword><Keyword MajorTopicYN="Y">coexpression</Keyword><Keyword MajorTopicYN="Y">genome assembly</Keyword><Keyword MajorTopicYN="Y">natural selection</Keyword><Keyword MajorTopicYN="Y">population genetics</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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