In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.
Identifieur interne : 000502 ( Main/Corpus ); précédent : 000501; suivant : 000503In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.
Auteurs : Huilin Ni ; Ishfaq Muhammad ; Jichang Li ; Biying Wang ; Zunlai ShengSource :
- Pakistan journal of pharmaceutical sciences [ 1011-601X ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (isolation & purification), Antioxidants (pharmacology), Catalase (metabolism), Chromatography, High Pressure Liquid (MeSH), Female (MeSH), Flavonoids (isolation & purification), Flowers (chemistry), Glutathione Peroxidase (metabolism), Liver (chemistry), Male (MeSH), Malondialdehyde (analysis), Malondialdehyde (blood), Medicine, Chinese Traditional (MeSH), Mice (MeSH), Mice, Inbred BALB C (MeSH), Plant Extracts (pharmacology), Populus (chemistry), Superoxide Dismutase (metabolism).
- MESH :
- chemical , analysis : Malondialdehyde.
- chemical , blood : Malondialdehyde.
- chemical , isolation & purification : Antioxidants, Flavonoids.
- chemical , metabolism : Catalase, Glutathione Peroxidase, Superoxide Dismutase.
- chemical , pharmacology : Antioxidants, Plant Extracts.
- chemistry : Flowers, Liver, Populus.
- Animals, Chromatography, High Pressure Liquid, Female, Male, Medicine, Chinese Traditional, Mice, Mice, Inbred BALB C.
Abstract
Flos populi is a well-known traditional Chinese medicine, obtained from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench. In this study, we aimed to evaluate the antioxidant activities of Flos populi extract by various in-vitro and in-vivo methods. In-vitro results showed that Flos populi extract had strong antioxidant potential in terms of Superoxide radical and ABTS radical scavenging capacity, nitrogen dioxide radical inhibition and the ability to inhibit lipid peroxidation. Mice were given with Flos populi extract via gavage for 1 month to scrutinize the in-vivo antioxidant effects of Flos populi. The results revealed that Flos populi extract had markedly enhanced the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT), while decreased the level of malondialdehvde (MDA) in serums and livers of mice compared to CCl4 treated group. Additionally, the flavonoids content were determined by the colorimetric method was 553.23 ± 23.45mg/g. The extract was further examined by HPLC and showed the presence of flavonoids-including quercetin (16.26±0.58mg/g), luteolin (9.97±1.07mg/g), apigenin (8.57±0.46mg/g), pinocembrin (119.71±1.05mg/g) and chrysin (16.12±0.53mg/g). The study revealed that Flos populi extract had antioxidant activity and could be utilized as a potential natural antioxidant.
PubMed: 31969285
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.</title><author><name sortKey="Ni, Huilin" sort="Ni, Huilin" uniqKey="Ni H" first="Huilin" last="Ni">Huilin Ni</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Muhammad, Ishfaq" sort="Muhammad, Ishfaq" uniqKey="Muhammad I" first="Ishfaq" last="Muhammad">Ishfaq Muhammad</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jichang" sort="Li, Jichang" uniqKey="Li J" first="Jichang" last="Li">Jichang Li</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Biying" sort="Wang, Biying" uniqKey="Wang B" first="Biying" last="Wang">Biying Wang</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Sheng, Zunlai" sort="Sheng, Zunlai" uniqKey="Sheng Z" first="Zunlai" last="Sheng">Zunlai Sheng</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China/Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, PR China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31969285</idno><idno type="pmid">31969285</idno><idno type="wicri:Area/Main/Corpus">000502</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000502</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.</title><author><name sortKey="Ni, Huilin" sort="Ni, Huilin" uniqKey="Ni H" first="Huilin" last="Ni">Huilin Ni</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Muhammad, Ishfaq" sort="Muhammad, Ishfaq" uniqKey="Muhammad I" first="Ishfaq" last="Muhammad">Ishfaq Muhammad</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jichang" sort="Li, Jichang" uniqKey="Li J" first="Jichang" last="Li">Jichang Li</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Biying" sort="Wang, Biying" uniqKey="Wang B" first="Biying" last="Wang">Biying Wang</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Sheng, Zunlai" sort="Sheng, Zunlai" uniqKey="Sheng Z" first="Zunlai" last="Sheng">Zunlai Sheng</name><affiliation><nlm:affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China/Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, PR China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pakistan journal of pharmaceutical sciences</title><idno type="ISSN">1011-601X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antioxidants (isolation & purification)</term><term>Antioxidants (pharmacology)</term><term>Catalase (metabolism)</term><term>Chromatography, High Pressure Liquid (MeSH)</term><term>Female (MeSH)</term><term>Flavonoids (isolation & purification)</term><term>Flowers (chemistry)</term><term>Glutathione Peroxidase (metabolism)</term><term>Liver (chemistry)</term><term>Male (MeSH)</term><term>Malondialdehyde (analysis)</term><term>Malondialdehyde (blood)</term><term>Medicine, Chinese Traditional (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Inbred BALB C (MeSH)</term><term>Plant Extracts (pharmacology)</term><term>Populus (chemistry)</term><term>Superoxide Dismutase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Malondialdehyde</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Malondialdehyde</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antioxidants</term><term>Flavonoids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catalase</term><term>Glutathione Peroxidase</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Flowers</term><term>Liver</term><term>Populus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromatography, High Pressure Liquid</term><term>Female</term><term>Male</term><term>Medicine, Chinese Traditional</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Flos populi is a well-known traditional Chinese medicine, obtained from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench. In this study, we aimed to evaluate the antioxidant activities of Flos populi extract by various in-vitro and in-vivo methods. In-vitro results showed that Flos populi extract had strong antioxidant potential in terms of Superoxide radical and ABTS radical scavenging capacity, nitrogen dioxide radical inhibition and the ability to inhibit lipid peroxidation. Mice were given with Flos populi extract via gavage for 1 month to scrutinize the in-vivo antioxidant effects of Flos populi. The results revealed that Flos populi extract had markedly enhanced the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT), while decreased the level of malondialdehvde (MDA) in serums and livers of mice compared to CCl<sub>4</sub> treated group. Additionally, the flavonoids content were determined by the colorimetric method was 553.23 ± 23.45mg/g. The extract was further examined by HPLC and showed the presence of flavonoids-including quercetin (16.26±0.58mg/g), luteolin (9.97±1.07mg/g), apigenin (8.57±0.46mg/g), pinocembrin (119.71±1.05mg/g) and chrysin (16.12±0.53mg/g). The study revealed that Flos populi extract had antioxidant activity and could be utilized as a potential natural antioxidant.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31969285</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1011-601X</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Pakistan journal of pharmaceutical sciences</Title><ISOAbbreviation>Pak J Pharm Sci</ISOAbbreviation></Journal><ArticleTitle>In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.</ArticleTitle><Pagination><MedlinePgn>2553-2560</MedlinePgn></Pagination><Abstract><AbstractText>Flos populi is a well-known traditional Chinese medicine, obtained from the male inflorescence of Populus tomentosa Carr. or Populus canadensis Moench. In this study, we aimed to evaluate the antioxidant activities of Flos populi extract by various in-vitro and in-vivo methods. In-vitro results showed that Flos populi extract had strong antioxidant potential in terms of Superoxide radical and ABTS radical scavenging capacity, nitrogen dioxide radical inhibition and the ability to inhibit lipid peroxidation. Mice were given with Flos populi extract via gavage for 1 month to scrutinize the in-vivo antioxidant effects of Flos populi. The results revealed that Flos populi extract had markedly enhanced the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT), while decreased the level of malondialdehvde (MDA) in serums and livers of mice compared to CCl<sub>4</sub> treated group. Additionally, the flavonoids content were determined by the colorimetric method was 553.23 ± 23.45mg/g. The extract was further examined by HPLC and showed the presence of flavonoids-including quercetin (16.26±0.58mg/g), luteolin (9.97±1.07mg/g), apigenin (8.57±0.46mg/g), pinocembrin (119.71±1.05mg/g) and chrysin (16.12±0.53mg/g). The study revealed that Flos populi extract had antioxidant activity and could be utilized as a potential natural antioxidant.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ni</LastName><ForeName>Huilin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muhammad</LastName><ForeName>Ishfaq</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jichang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Biying</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheng</LastName><ForeName>Zunlai</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China/Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, PR China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Pakistan</Country><MedlineTA>Pak J Pharm Sci</MedlineTA><NlmUniqueID>9426356</NlmUniqueID><ISSNLinking>1011-601X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>4Y8F71G49Q</RegistryNumber><NameOfSubstance UI="D008315">Malondialdehyde</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.6</RegistryNumber><NameOfSubstance UI="D002374">Catalase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber><NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008315" MajorTopicYN="N">Malondialdehyde</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008516" MajorTopicYN="N">Medicine, Chinese Traditional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" 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