PhytophthoraV1, Main, Corpus, bibRecord, 000F84

Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.

Identifieur interne : 000F84 ( Main/Corpus ); précédent : 000F83; suivant : 000F85

Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.

Auteurs : Tingli Liu ; Tianqiao Song ; Xiong Zhang ; Hongbo Yuan ; Liming Su ; Wanlin Li ; Jing Xu ; Shiheng Liu ; Linlin Chen ; Tianzi Chen ; Meixiang Zhang ; Lichuan Gu ; Baolong Zhang ; Daolong Dou

Source :

Nature communications [ 2041-1723 ] ; 2014.

RBID : pubmed:25156390

English descriptors

KwdEn :
- Catalytic Domain (MeSH), Fungal Proteins (metabolism), Gossypium (microbiology), Gossypium (physiology), Host-Pathogen Interactions (MeSH), Hydrolases (genetics), Hydrolases (metabolism), Organisms, Genetically Modified (MeSH), Phytophthora (genetics), Phytophthora (metabolism), Phytophthora (pathogenicity), Plant Diseases (microbiology), Protein Transport (MeSH), Salicylates (metabolism), Verticillium (genetics), Verticillium (metabolism), Verticillium (pathogenicity), Virulence Factors (genetics), Virulence Factors (metabolism).
MESH :
- chemical , genetics : Hydrolases, Virulence Factors.
- chemical , metabolism : Fungal Proteins, Hydrolases, Salicylates, Virulence Factors.
- genetics : Phytophthora, Verticillium.
- metabolism : Phytophthora, Verticillium.
- microbiology : Gossypium, Plant Diseases.
- pathogenicity : Phytophthora, Verticillium.
- physiology : Gossypium.
- Catalytic Domain, Host-Pathogen Interactions, Organisms, Genetically Modified, Protein Transport.

Abstract

Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host-pathogen interactions.

DOI: 10.1038/ncomms5686
PubMed: 25156390
PubMed Central: PMC4348438

Links to Exploration step

pubmed:25156390

Le document en format XML

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<author><name sortKey="Liu, Tingli" sort="Liu, Tingli" uniqKey="Liu T" first="Tingli" last="Liu">Tingli Liu</name>
<affiliation><nlm:affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2] Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China [3].</nlm:affiliation>
</affiliation>
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<author><name sortKey="Song, Tianqiao" sort="Song, Tianqiao" uniqKey="Song T" first="Tianqiao" last="Song">Tianqiao Song</name>
<affiliation><nlm:affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2].</nlm:affiliation>
</affiliation>
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<author><name sortKey="Zhang, Xiong" sort="Zhang, Xiong" uniqKey="Zhang X" first="Xiong" last="Zhang">Xiong Zhang</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yuan, Hongbo" sort="Yuan, Hongbo" uniqKey="Yuan H" first="Hongbo" last="Yuan">Hongbo Yuan</name>
<affiliation><nlm:affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Su, Liming" sort="Su, Liming" uniqKey="Su L" first="Liming" last="Su">Liming Su</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
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<author><name sortKey="Li, Wanlin" sort="Li, Wanlin" uniqKey="Li W" first="Wanlin" last="Li">Wanlin Li</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
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<author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Liu, Shiheng" sort="Liu, Shiheng" uniqKey="Liu S" first="Shiheng" last="Liu">Shiheng Liu</name>
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<author><name sortKey="Chen, Linlin" sort="Chen, Linlin" uniqKey="Chen L" first="Linlin" last="Chen">Linlin Chen</name>
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<author><name sortKey="Chen, Tianzi" sort="Chen, Tianzi" uniqKey="Chen T" first="Tianzi" last="Chen">Tianzi Chen</name>
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<author><name sortKey="Zhang, Meixiang" sort="Zhang, Meixiang" uniqKey="Zhang M" first="Meixiang" last="Zhang">Meixiang Zhang</name>
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<author><name sortKey="Gu, Lichuan" sort="Gu, Lichuan" uniqKey="Gu L" first="Lichuan" last="Gu">Lichuan Gu</name>
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<author><name sortKey="Zhang, Baolong" sort="Zhang, Baolong" uniqKey="Zhang B" first="Baolong" last="Zhang">Baolong Zhang</name>
<affiliation><nlm:affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</nlm:affiliation>
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<author><name sortKey="Dou, Daolong" sort="Dou, Daolong" uniqKey="Dou D" first="Daolong" last="Dou">Daolong Dou</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.</title>
<author><name sortKey="Liu, Tingli" sort="Liu, Tingli" uniqKey="Liu T" first="Tingli" last="Liu">Tingli Liu</name>
<affiliation><nlm:affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2] Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China [3].</nlm:affiliation>
</affiliation>
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<author><name sortKey="Song, Tianqiao" sort="Song, Tianqiao" uniqKey="Song T" first="Tianqiao" last="Song">Tianqiao Song</name>
<affiliation><nlm:affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2].</nlm:affiliation>
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<author><name sortKey="Zhang, Xiong" sort="Zhang, Xiong" uniqKey="Zhang X" first="Xiong" last="Zhang">Xiong Zhang</name>
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</affiliation>
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<author><name sortKey="Yuan, Hongbo" sort="Yuan, Hongbo" uniqKey="Yuan H" first="Hongbo" last="Yuan">Hongbo Yuan</name>
<affiliation><nlm:affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Su, Liming" sort="Su, Liming" uniqKey="Su L" first="Liming" last="Su">Liming Su</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Wanlin" sort="Li, Wanlin" uniqKey="Li W" first="Wanlin" last="Li">Wanlin Li</name>
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</affiliation>
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<author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Shiheng" sort="Liu, Shiheng" uniqKey="Liu S" first="Shiheng" last="Liu">Shiheng Liu</name>
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<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Tianzi" sort="Chen, Tianzi" uniqKey="Chen T" first="Tianzi" last="Chen">Tianzi Chen</name>
<affiliation><nlm:affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Zhang, Meixiang" sort="Zhang, Meixiang" uniqKey="Zhang M" first="Meixiang" last="Zhang">Meixiang Zhang</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gu, Lichuan" sort="Gu, Lichuan" uniqKey="Gu L" first="Lichuan" last="Gu">Lichuan Gu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Baolong" sort="Zhang, Baolong" uniqKey="Zhang B" first="Baolong" last="Zhang">Baolong Zhang</name>
<affiliation><nlm:affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dou, Daolong" sort="Dou, Daolong" uniqKey="Dou D" first="Daolong" last="Dou">Daolong Dou</name>
<affiliation><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</nlm:affiliation>
</affiliation>
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<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Fungal Proteins (metabolism)</term>
<term>Gossypium (microbiology)</term>
<term>Gossypium (physiology)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Hydrolases (genetics)</term>
<term>Hydrolases (metabolism)</term>
<term>Organisms, Genetically Modified (MeSH)</term>
<term>Phytophthora (genetics)</term>
<term>Phytophthora (metabolism)</term>
<term>Phytophthora (pathogenicity)</term>
<term>Plant Diseases (microbiology)</term>
<term>Protein Transport (MeSH)</term>
<term>Salicylates (metabolism)</term>
<term>Verticillium (genetics)</term>
<term>Verticillium (metabolism)</term>
<term>Verticillium (pathogenicity)</term>
<term>Virulence Factors (genetics)</term>
<term>Virulence Factors (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hydrolases</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term>
<term>Hydrolases</term>
<term>Salicylates</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phytophthora</term>
<term>Verticillium</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phytophthora</term>
<term>Verticillium</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Gossypium</term>
<term>Plant Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora</term>
<term>Verticillium</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gossypium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Catalytic Domain</term>
<term>Host-Pathogen Interactions</term>
<term>Organisms, Genetically Modified</term>
<term>Protein Transport</term>
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<front><div type="abstract" xml:lang="en">Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host-pathogen interactions. </div>
</front>
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<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
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<Month>Aug</Month>
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<Title>Nature communications</Title>
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<ArticleTitle>Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.</ArticleTitle>
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<Abstract><AbstractText>Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host-pathogen interactions. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Tingli</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2] Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China [3].</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Tianqiao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>1] Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China [2].</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiong</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Yuan</LastName>
<ForeName>Hongbo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</Affiliation>
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<ForeName>Liming</ForeName>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wanlin</ForeName>
<Initials>W</Initials>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Shiheng</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Linlin</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Tianzi</ForeName>
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<AffiliationInfo><Affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Meixiang</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gu</LastName>
<ForeName>Lichuan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Baolong</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dou</LastName>
<ForeName>Daolong</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, 1 Weigang Road, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
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<Month>08</Month>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003368" MajorTopicYN="N">Gossypium</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName>
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<MeshHeading><DescriptorName UI="D012459" MajorTopicYN="N">Salicylates</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020172" MajorTopicYN="N">Verticillium</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
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Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.

Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.

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