Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.
Identifieur interne : 000D04 ( Main/Exploration ); précédent : 000D03; suivant : 000D05Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.
Auteurs : I. Frías [Espagne] ; J M Trujillo ; J. Romero ; J. Hernandez ; J A PérezSource :
- Biochimie [ 0300-9084 ] ; 1995.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : Horseradish peroxidase, Peroxidases.
- enzymologie : Basidiomycota.
- pharmacologie : Alcools benzyliques, Cinnamates, Lignanes.
- Agents colorants, Anthraquinones, Polymères.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Horseradish Peroxidase, Peroxidases.
- chemical , pharmacology : Benzyl Alcohols, Cinnamates, Lignans.
- chemical : Anthraquinones, Coloring Agents, Polymers.
- enzymology : Basidiomycota.
Abstract
The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.
DOI: 10.1016/0300-9084(96)88186-7
PubMed: 8789460
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Romero</name></author><author><name sortKey="Hernandez, J" sort="Hernandez, J" uniqKey="Hernandez J" first="J" last="Hernandez">J. Hernandez</name></author><author><name sortKey="Perez, J A" sort="Perez, J A" uniqKey="Perez J" first="J A" last="Pérez">J A Pérez</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:8789460</idno><idno type="pmid">8789460</idno><idno type="doi">10.1016/0300-9084(96)88186-7</idno><idno type="wicri:Area/Main/Corpus">000D17</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000D17</idno><idno type="wicri:Area/Main/Curation">000D17</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000D17</idno><idno type="wicri:Area/Main/Exploration">000D17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.</title><author><name sortKey="Frias, I" sort="Frias, I" uniqKey="Frias I" first="I" last="Frías">I. Frías</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Bioquímica, Universidad de La Laguna, Tenerife Canary Islands, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Bioquímica, Universidad de La Laguna, Tenerife Canary Islands</wicri:regionArea><wicri:noRegion>Tenerife Canary Islands</wicri:noRegion></affiliation></author><author><name sortKey="Trujillo, J M" sort="Trujillo, J M" uniqKey="Trujillo J" first="J M" last="Trujillo">J M Trujillo</name></author><author><name sortKey="Romero, J" sort="Romero, J" uniqKey="Romero J" first="J" last="Romero">J. Romero</name></author><author><name sortKey="Hernandez, J" sort="Hernandez, J" uniqKey="Hernandez J" first="J" last="Hernandez">J. Hernandez</name></author><author><name sortKey="Perez, J A" sort="Perez, J A" uniqKey="Perez J" first="J A" last="Pérez">J A Pérez</name></author></analytic><series><title level="j">Biochimie</title><idno type="ISSN">0300-9084</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthraquinones (MeSH)</term><term>Basidiomycota (enzymology)</term><term>Benzyl Alcohols (pharmacology)</term><term>Cinnamates (pharmacology)</term><term>Coloring Agents (MeSH)</term><term>Horseradish Peroxidase (antagonists & inhibitors)</term><term>Lignans (pharmacology)</term><term>Peroxidases (antagonists & inhibitors)</term><term>Polymers (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents colorants (MeSH)</term><term>Alcools benzyliques (pharmacologie)</term><term>Anthraquinones (MeSH)</term><term>Basidiomycota (enzymologie)</term><term>Cinnamates (pharmacologie)</term><term>Horseradish peroxidase (antagonistes et inhibiteurs)</term><term>Lignanes (pharmacologie)</term><term>Peroxidases (antagonistes et inhibiteurs)</term><term>Polymères (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Horseradish Peroxidase</term><term>Peroxidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzyl Alcohols</term><term>Cinnamates</term><term>Lignans</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anthraquinones</term><term>Coloring Agents</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Horseradish peroxidase</term><term>Peroxidases</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Basidiomycota</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Basidiomycota</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alcools benzyliques</term><term>Cinnamates</term><term>Lignanes</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Agents colorants</term><term>Anthraquinones</term><term>Polymères</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8789460</PMID><DateCompleted><Year>1996</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0300-9084</ISSN><JournalIssue CitedMedium="Print"><Volume>77</Volume><Issue>9</Issue><PubDate><Year>1995</Year></PubDate></JournalIssue><Title>Biochimie</Title><ISOAbbreviation>Biochimie</ISOAbbreviation></Journal><ArticleTitle>Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.</ArticleTitle><Pagination><MedlinePgn>707-12</MedlinePgn></Pagination><Abstract><AbstractText>The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Frías</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Departamento de Bioquímica, Universidad de La Laguna, Tenerife Canary Islands, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trujillo</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hernandez</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Pérez</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biochimie</MedlineTA><NlmUniqueID>1264604</NlmUniqueID><ISSNLinking>0300-9084</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000880">Anthraquinones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001592">Benzyl Alcohols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002934">Cinnamates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004396">Coloring Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017705">Lignans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011108">Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>68816-54-6</RegistryNumber><NameOfSubstance UI="C017971">poly R-478</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="D006735">Horseradish Peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="D010544">Peroxidases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="C042858">lignin peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>MB4T4A711H</RegistryNumber><NameOfSubstance UI="C042197">veratryl alcohol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000880" MajorTopicYN="N">Anthraquinones</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001487" MajorTopicYN="N">Basidiomycota</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001592" MajorTopicYN="N">Benzyl Alcohols</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002934" MajorTopicYN="N">Cinnamates</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004396" MajorTopicYN="N">Coloring Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006735" MajorTopicYN="N">Horseradish Peroxidase</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017705" MajorTopicYN="N">Lignans</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010544" MajorTopicYN="N">Peroxidases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011108" MajorTopicYN="N">Polymers</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8789460</ArticleId><ArticleId IdType="pii">0300-9084(96)88186-7</ArticleId><ArticleId IdType="doi">10.1016/0300-9084(96)88186-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Hernandez, J" sort="Hernandez, J" uniqKey="Hernandez J" first="J" last="Hernandez">J. Hernandez</name><name sortKey="Perez, J A" sort="Perez, J A" uniqKey="Perez J" first="J A" last="Pérez">J A Pérez</name><name sortKey="Romero, J" sort="Romero, J" uniqKey="Romero J" first="J" last="Romero">J. Romero</name><name sortKey="Trujillo, J M" sort="Trujillo, J M" uniqKey="Trujillo J" first="J M" last="Trujillo">J M Trujillo</name></noCountry><country name="Espagne"><noRegion><name sortKey="Frias, I" sort="Frias, I" uniqKey="Frias I" first="I" last="Frías">I. Frías</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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