Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.
Identifieur interne : 000D17 ( Main/Curation ); précédent : 000D16; suivant : 000D18Lignan models as inhibitors of Phanerochaete chrysosporium lignin peroxidase.
Auteurs : I. Frías [Espagne] ; J M Trujillo ; J. Romero ; J. Hernandez ; J A PérezSource :
- Biochimie [ 0300-9084 ] ; 1995.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : Horseradish peroxidase, Peroxidases.
- enzymologie : Basidiomycota.
- pharmacologie : Alcools benzyliques, Cinnamates, Lignanes.
- Agents colorants, Anthraquinones, Polymères.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Horseradish Peroxidase, Peroxidases.
- chemical , pharmacology : Benzyl Alcohols, Cinnamates, Lignans.
- chemical : Anthraquinones, Coloring Agents, Polymers.
- enzymology : Basidiomycota.
Abstract
The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.
DOI: 10.1016/0300-9084(96)88186-7
PubMed: 8789460
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pubmed:8789460Le document en format XML
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<author><name sortKey="Frias, I" sort="Frias, I" uniqKey="Frias I" first="I" last="Frías">I. Frías</name>
<affiliation wicri:level="1"><nlm:affiliation>Departamento de Bioquímica, Universidad de La Laguna, Tenerife Canary Islands, Spain.</nlm:affiliation>
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<wicri:regionArea>Departamento de Bioquímica, Universidad de La Laguna, Tenerife Canary Islands</wicri:regionArea>
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<author><name sortKey="Trujillo, J M" sort="Trujillo, J M" uniqKey="Trujillo J" first="J M" last="Trujillo">J M Trujillo</name>
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<author><name sortKey="Romero, J" sort="Romero, J" uniqKey="Romero J" first="J" last="Romero">J. Romero</name>
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<author><name sortKey="Hernandez, J" sort="Hernandez, J" uniqKey="Hernandez J" first="J" last="Hernandez">J. Hernandez</name>
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<author><name sortKey="Perez, J A" sort="Perez, J A" uniqKey="Perez J" first="J A" last="Pérez">J A Pérez</name>
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<author><name sortKey="Romero, J" sort="Romero, J" uniqKey="Romero J" first="J" last="Romero">J. Romero</name>
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<series><title level="j">Biochimie</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthraquinones (MeSH)</term>
<term>Basidiomycota (enzymology)</term>
<term>Benzyl Alcohols (pharmacology)</term>
<term>Cinnamates (pharmacology)</term>
<term>Coloring Agents (MeSH)</term>
<term>Horseradish Peroxidase (antagonists & inhibitors)</term>
<term>Lignans (pharmacology)</term>
<term>Peroxidases (antagonists & inhibitors)</term>
<term>Polymers (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agents colorants (MeSH)</term>
<term>Alcools benzyliques (pharmacologie)</term>
<term>Anthraquinones (MeSH)</term>
<term>Basidiomycota (enzymologie)</term>
<term>Cinnamates (pharmacologie)</term>
<term>Horseradish peroxidase (antagonistes et inhibiteurs)</term>
<term>Lignanes (pharmacologie)</term>
<term>Peroxidases (antagonistes et inhibiteurs)</term>
<term>Polymères (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Horseradish Peroxidase</term>
<term>Peroxidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzyl Alcohols</term>
<term>Cinnamates</term>
<term>Lignans</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anthraquinones</term>
<term>Coloring Agents</term>
<term>Polymers</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Horseradish peroxidase</term>
<term>Peroxidases</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Basidiomycota</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Basidiomycota</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alcools benzyliques</term>
<term>Cinnamates</term>
<term>Lignanes</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Agents colorants</term>
<term>Anthraquinones</term>
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<front><div type="abstract" xml:lang="en">The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.</div>
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<Abstract><AbstractText>The lignan 8,8'-bis-(methylenedioxy)cinnamic acid (BMDCA) is a powerful competitive inhibitor (K1 = 2.0 microM) of the lignin peroxidase (LiP) from Phanerochaete chrysosporium and of the extracellular peroxidase of Phlebia radiata (I0.5 = 10 microM). BMDCA derivatives with the same double bond system also inhibited these enzymes to some extent. If the double bonds were hydrogenated, the inhibitory effect was lost. HRP-VIII and HRP-XI were slightly inhibited by BMDCA (I0.5 > 50 microM) and two plant peroxidases described as efficient lignan synthesizers were unaffected. Liquid cultures of P chrysosporium did not discolour the dve Poly R478 when 250 microM of BMDCA was present.</AbstractText>
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