Determination of gamma-aminobutyric acid in food matrices by isotope dilution hydrophilic interaction chromatography coupled to mass spectrometry.
Identifieur interne : 000935 ( PubMed/Curation ); précédent : 000934; suivant : 000936Determination of gamma-aminobutyric acid in food matrices by isotope dilution hydrophilic interaction chromatography coupled to mass spectrometry.
Auteurs : Raniero Zazzeroni [Royaume-Uni] ; Andrew Homan ; Emma ThainSource :
- Journal of chromatographic science [ 0021-9665 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : gamma-Aminobutyric Acid.
- analysis : Beverages.
- chemistry : Citrus sinensis, Malus, Solanum tuberosum, Soybeans.
- methods : Chromatography, Liquid, Food Analysis, Spectrometry, Mass, Electrospray Ionization.
- Diet, Humans.
Abstract
The estimation of the dietary intake of gamma-aminobutyric acid (GABA) is dependent upon the knowledge of its concentration values in food matrices. To this end, an isotope dilution liquid chromatography-mass spectrometry method has been developed employing the hydrophilic interaction chromatography technique for analyte separation. This approach enabled accurate quantification of GABA in apple, potato, soybeans, and orange juice without the need of a pre- or post-column derivatization reaction. A selective and precise analytical measurement has been obtained with a triple quadrupole mass spectrometer operating in multiple reaction monitoring using the method of standard additions and GABA-d(6) as an internal standard. The concentrations of GABA found in the matrices tested are 7 microg/g of apple, 342 microg/g of potatoes, 211 microg/g of soybeans, and 344 microg/mL of orange juice.
PubMed: 19772728
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To this end, an isotope dilution liquid chromatography-mass spectrometry method has been developed employing the hydrophilic interaction chromatography technique for analyte separation. This approach enabled accurate quantification of GABA in apple, potato, soybeans, and orange juice without the need of a pre- or post-column derivatization reaction. A selective and precise analytical measurement has been obtained with a triple quadrupole mass spectrometer operating in multiple reaction monitoring using the method of standard additions and GABA-d(6) as an internal standard. The concentrations of GABA found in the matrices tested are 7 microg/g of apple, 342 microg/g of potatoes, 211 microg/g of soybeans, and 344 microg/mL of orange juice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19772728</PMID><DateCreated><Year>2009</Year><Month>9</Month><Day>23</Day></DateCreated><DateCompleted><Year>2009</Year><Month>10</Month><Day>23</Day></DateCompleted><DateRevised><Year>2009</Year><Month>9</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0021-9665</ISSN><JournalIssue CitedMedium="Print"><Volume>47</Volume><Issue>7</Issue><PubDate><Year>2009</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of chromatographic science</Title><ISOAbbreviation>J Chromatogr Sci</ISOAbbreviation></Journal><ArticleTitle>Determination of gamma-aminobutyric acid in food matrices by isotope dilution hydrophilic interaction chromatography coupled to mass spectrometry.</ArticleTitle><Pagination><MedlinePgn>564-8</MedlinePgn></Pagination><Abstract><AbstractText>The estimation of the dietary intake of gamma-aminobutyric acid (GABA) is dependent upon the knowledge of its concentration values in food matrices. To this end, an isotope dilution liquid chromatography-mass spectrometry method has been developed employing the hydrophilic interaction chromatography technique for analyte separation. This approach enabled accurate quantification of GABA in apple, potato, soybeans, and orange juice without the need of a pre- or post-column derivatization reaction. A selective and precise analytical measurement has been obtained with a triple quadrupole mass spectrometer operating in multiple reaction monitoring using the method of standard additions and GABA-d(6) as an internal standard. 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