Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study.
Identifieur interne : 000934 ( PubMed/Curation ); précédent : 000933; suivant : 000935Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study.
Auteurs : Julius Oben [Cameroun] ; Ebangha Enonchong ; Shil Kothari ; Walter Chambliss ; Robert Garrison ; Deanne DolnickSource :
- Nutrition journal [ 1475-2891 ] ; 2009.
English descriptors
- KwdEn :
- Adult, C-Reactive Protein (metabolism), Citrus (chemistry), Dietary Supplements, Double-Blind Method, Female, Humans, Joints (drug effects), Male, Middle Aged, Osteoarthritis (drug therapy), Overweight (drug therapy), Phellodendron (chemistry), Pilot Projects, Plant Extracts (administration & dosage), Plant Extracts (therapeutic use).
- MESH :
- chemical , administration & dosage : Plant Extracts.
- chemical , metabolism : C-Reactive Protein.
- chemistry : Citrus, Phellodendron.
- drug effects : Joints.
- drug therapy : Osteoarthritis, Overweight.
- chemical , therapeutic use : Plant Extracts.
- Adult, Dietary Supplements, Double-Blind Method, Female, Humans, Male, Middle Aged, Pilot Projects.
Abstract
The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on joint health in overweight and normal weight adults diagnosed with osteoarthritis.
DOI: 10.1186/1475-2891-8-38
PubMed: 19682376
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Kothari</name></author><author><name sortKey="Chambliss, Walter" sort="Chambliss, Walter" uniqKey="Chambliss W" first="Walter" last="Chambliss">Walter Chambliss</name></author><author><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name></author><author><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19682376</idno><idno type="pmid">19682376</idno><idno type="doi">10.1186/1475-2891-8-38</idno><idno type="wicri:Area/PubMed/Corpus">000934</idno><idno type="wicri:Area/PubMed/Curation">000934</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study.</title><author><name sortKey="Oben, Julius" sort="Oben, Julius" uniqKey="Oben J" first="Julius" last="Oben">Julius Oben</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</nlm:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I</wicri:regionArea></affiliation></author><author><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name></author><author><name sortKey="Kothari, Shil" sort="Kothari, Shil" uniqKey="Kothari S" first="Shil" last="Kothari">Shil Kothari</name></author><author><name sortKey="Chambliss, Walter" sort="Chambliss, Walter" uniqKey="Chambliss W" first="Walter" last="Chambliss">Walter Chambliss</name></author><author><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name></author><author><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name></author></analytic><series><title level="j">Nutrition journal</title><idno type="eISSN">1475-2891</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>C-Reactive Protein (metabolism)</term><term>Citrus (chemistry)</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Joints (drug effects)</term><term>Male</term><term>Middle Aged</term><term>Osteoarthritis (drug therapy)</term><term>Overweight (drug therapy)</term><term>Phellodendron (chemistry)</term><term>Pilot Projects</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Phellodendron</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Joints</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Osteoarthritis</term><term>Overweight</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on joint health in overweight and normal weight adults diagnosed with osteoarthritis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19682376</PMID><DateCreated><Year>2009</Year><Month>9</Month><Day>9</Day></DateCreated><DateCompleted><Year>2009</Year><Month>12</Month><Day>04</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>7</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1475-2891</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><PubDate><Year>2009</Year><Month>Aug</Month><Day>14</Day></PubDate></JournalIssue><Title>Nutrition journal</Title><ISOAbbreviation>Nutr J</ISOAbbreviation></Journal><ArticleTitle>Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study.</ArticleTitle><Pagination><MedlinePgn>38</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1475-2891-8-38</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on joint health in overweight and normal weight adults diagnosed with osteoarthritis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An 8-week placebo-controlled, randomized, double-blind study was conducted with four groups comparing the effects of NP 06-1 to placebo on overweight and normal weight subjects diagnosed with primary osteoarthritis of the knee. NP 06-1 (a combination of two botanical extracts; Phellodendron amurense bark and Citrus sinensis peel) or matching placebo were given in a dose of two capsules (370 mg each) twice daily. The outcome measures were the Lequesne Algofunctional Index (LAI) for joint pain and movement as well as biomarkers of inflammation (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty (80) subjects were enrolled and 45 subjects completed the study. No serious adverse events were reported. The mean total LAI scores at baseline for the four groups ranged from 11.4 to 12.4 (SD 1.2 to 2.4). Treatment for 8 weeks resulted in a statistical improvement in the LAI score in the overweight treatment group compared to placebo (6.3 +/- 2.3 vs 11.8 +/- 1.5; p < 0.0001). At 8 weeks, a similar result was observed in the normal weight groups (7.7 +/- 1.4 vs 9.9 +/- 0.9; p < 0.0001). There was a reduction in CRP levels with treatment in the overweight treatment group at 8 weeks (-0.62 +/- 0.2; 49%) compared to baseline (p < 0.001) and to placebo (p < 0.001). For the normal weight participants, there were significant reductions in CRP compared to baseline, but not to the matched placebo group. Both overweight and normal weight treatment groups lost a significant amount of weight compared to their placebo groups. The overweight treatment group lost an average of 5% body weight after 8 weeks. There was no significant change in ESR in any of the groups.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this pilot study, NP 06-1 had beneficial effects on symptoms of osteoarthritis of the knee as measured using LAI scores and had anti-inflammatory effects as measured using CRP. Administration of NP 06-1 was also associated with weight loss, which may have been a contributing factor to the other benefits.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oben</LastName><ForeName>Julius</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enonchong</LastName><ForeName>Ebangha</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kothari</LastName><ForeName>Shil</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Chambliss</LastName><ForeName>Walter</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Garrison</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dolnick</LastName><ForeName>Deanne</ForeName><Initials>D</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D017426">Clinical Trial, Phase I</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>Aug</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nutr J</MedlineTA><NlmUniqueID>101152213</NlmUniqueID><ISSNLinking>1475-2891</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C545281">NP 06-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Immunopharmacol Immunotoxicol. 1999 Nov;21(4):771-86</RefSource><PMID Version="1">10584211</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocr Rev. 2008 Dec;29(7):777-822</RefSource><PMID Version="1">18971485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Life Sci. 2003 Aug 1;73(11):1401-12</RefSource><PMID Version="1">12850501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Lett. 2004 Jan 20;203(2):127-37</RefSource><PMID Version="1">14732220</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lipids. 2004 Feb;39(2):143-51</RefSource><PMID Version="1">15134141</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Agric Food Chem. 2004 May 19;52(10):2879-86</RefSource><PMID 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MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007596" MajorTopicYN="N">Joints</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010003" MajorTopicYN="N">Osteoarthritis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050177" MajorTopicYN="N">Overweight</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032102" MajorTopicYN="N">Phellodendron</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" 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