Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats.
Identifieur interne : 000388 ( PubMed/Corpus ); précédent : 000387; suivant : 000389Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats.
Auteurs : Blanca Escudero-L Pez ; Luca Calani ; María-Soledad Fernández-Pach N ; Angeles Ortega ; Furio Brighenti ; Alan Crozier ; Daniele Del RioSource :
- BioFactors (Oxford, England) [ 1872-8081 ]
English descriptors
- KwdEn :
- Administration, Oral, Animals, Beverages, Citrus sinensis (chemistry), Fermentation, Fruit (chemistry), Gastrointestinal Absorption, Male, Plant Extracts (administration & dosage), Plant Extracts (pharmacokinetics), Polyphenols (administration & dosage), Polyphenols (pharmacokinetics), Rats, Wistar.
- MESH :
- chemical , administration & dosage : Plant Extracts, Polyphenols.
- chemistry : Citrus sinensis, Fruit.
- chemical , pharmacokinetics : Plant Extracts, Polyphenols.
- Administration, Oral, Animals, Beverages, Fermentation, Gastrointestinal Absorption, Male, Rats, Wistar.
Abstract
Two milliliters of a fermented, pasteurized orange juice containing ~1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC-mass spectrometry. The main constituents in the juice were hesperetin and naringenin-O-glycosides, apigenin-6,8-C-diglucoside, and ferulic acid-4'-O-glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin-7-O-glucuronide, naringenin-4'-O-glucuronide, and an isosakuranetin-O-glucuronide, peaking 6 h after intake at concentrations of ~10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid-4'-O-glucuronide and dihydroferulic acid-4'-O-sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid-4'-glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion.
DOI: 10.1002/biof.1152
PubMed: 24255025
Links to Exploration step
pubmed:24255025Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats.</title><author><name sortKey="Escudero L Pez, Blanca" sort="Escudero L Pez, Blanca" uniqKey="Escudero L Pez B" first="Blanca" last="Escudero-L Pez">Blanca Escudero-L Pez</name><affiliation><nlm:affiliation>Department of Molecular Biology and Biochemistry Engineering, Area of Nutrition and Food Sciences, Universidad Pablo de Olavide, Carretera de Utrera Km 1, Sevilla, Spain; Department of Food Science, The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, University of Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Calani, Luca" sort="Calani, Luca" uniqKey="Calani L" first="Luca" last="Calani">Luca Calani</name></author><author><name sortKey="Fernandez Pach N, Maria Soledad" sort="Fernandez Pach N, Maria Soledad" uniqKey="Fernandez Pach N M" first="María-Soledad" last="Fernández-Pach N">María-Soledad Fernández-Pach N</name></author><author><name sortKey="Ortega, Angeles" sort="Ortega, Angeles" uniqKey="Ortega A" first="Angeles" last="Ortega">Angeles Ortega</name></author><author><name sortKey="Brighenti, Furio" sort="Brighenti, Furio" uniqKey="Brighenti F" first="Furio" last="Brighenti">Furio Brighenti</name></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name></author><author><name sortKey="Del Rio, Daniele" sort="Del Rio, Daniele" uniqKey="Del Rio D" first="Daniele" last="Del Rio">Daniele Del Rio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2014 May-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:24255025</idno><idno type="pmid">24255025</idno><idno type="doi">10.1002/biof.1152</idno><idno type="wicri:Area/PubMed/Corpus">000388</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats.</title><author><name sortKey="Escudero L Pez, Blanca" sort="Escudero L Pez, Blanca" uniqKey="Escudero L Pez B" first="Blanca" last="Escudero-L Pez">Blanca Escudero-L Pez</name><affiliation><nlm:affiliation>Department of Molecular Biology and Biochemistry Engineering, Area of Nutrition and Food Sciences, Universidad Pablo de Olavide, Carretera de Utrera Km 1, Sevilla, Spain; Department of Food Science, The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, University of Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Calani, Luca" sort="Calani, Luca" uniqKey="Calani L" first="Luca" last="Calani">Luca Calani</name></author><author><name sortKey="Fernandez Pach N, Maria Soledad" sort="Fernandez Pach N, Maria Soledad" uniqKey="Fernandez Pach N M" first="María-Soledad" last="Fernández-Pach N">María-Soledad Fernández-Pach N</name></author><author><name sortKey="Ortega, Angeles" sort="Ortega, Angeles" uniqKey="Ortega A" first="Angeles" last="Ortega">Angeles Ortega</name></author><author><name sortKey="Brighenti, Furio" sort="Brighenti, Furio" uniqKey="Brighenti F" first="Furio" last="Brighenti">Furio Brighenti</name></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name></author><author><name sortKey="Del Rio, Daniele" sort="Del Rio, Daniele" uniqKey="Del Rio D" first="Daniele" last="Del Rio">Daniele Del Rio</name></author></analytic><series><title level="j">BioFactors (Oxford, England)</title><idno type="eISSN">1872-8081</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Beverages</term><term>Citrus sinensis (chemistry)</term><term>Fermentation</term><term>Fruit (chemistry)</term><term>Gastrointestinal Absorption</term><term>Male</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (pharmacokinetics)</term><term>Polyphenols (administration & dosage)</term><term>Polyphenols (pharmacokinetics)</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Plant Extracts</term><term>Polyphenols</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Plant Extracts</term><term>Polyphenols</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Beverages</term><term>Fermentation</term><term>Gastrointestinal Absorption</term><term>Male</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two milliliters of a fermented, pasteurized orange juice containing ~1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC-mass spectrometry. The main constituents in the juice were hesperetin and naringenin-O-glycosides, apigenin-6,8-C-diglucoside, and ferulic acid-4'-O-glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin-7-O-glucuronide, naringenin-4'-O-glucuronide, and an isosakuranetin-O-glucuronide, peaking 6 h after intake at concentrations of ~10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid-4'-O-glucuronide and dihydroferulic acid-4'-O-sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid-4'-glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24255025</PMID><DateCreated><Year>2014</Year><Month>6</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>29</Day></DateCompleted><DateRevised><Year>2014</Year><Month>6</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-8081</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>3</Issue><PubDate><MedlineDate>2014 May-Jun</MedlineDate></PubDate></JournalIssue><Title>BioFactors (Oxford, England)</Title><ISOAbbreviation>Biofactors</ISOAbbreviation></Journal><ArticleTitle>Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats.</ArticleTitle><Pagination><MedlinePgn>327-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/biof.1152</ELocationID><Abstract><AbstractText>Two milliliters of a fermented, pasteurized orange juice containing ~1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC-mass spectrometry. The main constituents in the juice were hesperetin and naringenin-O-glycosides, apigenin-6,8-C-diglucoside, and ferulic acid-4'-O-glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin-7-O-glucuronide, naringenin-4'-O-glucuronide, and an isosakuranetin-O-glucuronide, peaking 6 h after intake at concentrations of ~10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid-4'-O-glucuronide and dihydroferulic acid-4'-O-sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid-4'-glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion.</AbstractText><CopyrightInformation>© 2013 International Union of Biochemistry and Molecular Biology, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Escudero-López</LastName><ForeName>Blanca</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology and Biochemistry Engineering, Area of Nutrition and Food Sciences, Universidad Pablo de Olavide, Carretera de Utrera Km 1, Sevilla, Spain; Department of Food Science, The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, University of Parma, Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calani</LastName><ForeName>Luca</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Fernández-Pachón</LastName><ForeName>María-Soledad</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Ortega</LastName><ForeName>Angeles</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Brighenti</LastName><ForeName>Furio</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Crozier</LastName><ForeName>Alan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Del Rio</LastName><ForeName>Daniele</ForeName><Initials>D</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>Nov</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biofactors</MedlineTA><NlmUniqueID>8807441</NlmUniqueID><ISSNLinking>0951-6433</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059808">Polyphenols</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005285" MajorTopicYN="N">Fermentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065569" MajorTopicYN="Y">Gastrointestinal Absorption</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059808" MajorTopicYN="N">Polyphenols</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bioavailability</Keyword><Keyword MajorTopicYN="N">colon microbiota</Keyword><Keyword MajorTopicYN="N">flavanones</Keyword><Keyword MajorTopicYN="N">hydroxycinnamates</Keyword><Keyword MajorTopicYN="N">orange juice</Keyword><Keyword MajorTopicYN="N">rats</Keyword><Keyword MajorTopicYN="N">urinary excretion</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>9</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate 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