Extraction process optimization of polyphenols from Indian Citrus sinensis - as novel antiglycative agents in the management of diabetes mellitus.
Identifieur interne : 000386 ( PubMed/Corpus ); précédent : 000385; suivant : 000387Extraction process optimization of polyphenols from Indian Citrus sinensis - as novel antiglycative agents in the management of diabetes mellitus.
Auteurs : Asaithambi Shakthi Deve ; Thiyagarajan Sathish Kumar ; Kuppamuthu Kumaresan ; Vinohar Stephen RaphealSource :
- Journal of diabetes and metabolic disorders ; 2014.
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose level. It has become an epidemic disease in the 21st century where, India leads the world with largest number of diabetic subjects. Non-enzymatic glycosylation (glycation) is severe form of diabetes, occurs between reducing sugar and proteins which results in the formation of advanced glycation end products (AGEs) that leads to the other complicated secondary disorders. In this context, Mangifera indica (Mango), Syzygium cumini (Jambul), Vitis vinifera (Grapes), Citrus sinensis (Orange), Artocarpus heterophyllus (Jackfruit), Manilkara zapota (Sapodilla) seeds were evaluated for their antiglyation activity. Attempts were made to isolate the polyphenols in the seeds that have recorded the maximum activity.
DOI: 10.1186/2251-6581-13-11
PubMed: 24397983
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Extraction process optimization of polyphenols from Indian Citrus sinensis - as novel antiglycative agents in the management of diabetes mellitus.</title><author><name sortKey="Shakthi Deve, Asaithambi" sort="Shakthi Deve, Asaithambi" uniqKey="Shakthi Deve A" first="Asaithambi" last="Shakthi Deve">Asaithambi Shakthi Deve</name></author><author><name sortKey="Sathish Kumar, Thiyagarajan" sort="Sathish Kumar, Thiyagarajan" uniqKey="Sathish Kumar T" first="Thiyagarajan" last="Sathish Kumar">Thiyagarajan Sathish Kumar</name><affiliation><nlm:affiliation>Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641 049, Tamil Nadu, India. sathishkumart29@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kumaresan, Kuppamuthu" sort="Kumaresan, Kuppamuthu" uniqKey="Kumaresan K" first="Kuppamuthu" last="Kumaresan">Kuppamuthu Kumaresan</name></author><author><name sortKey="Rapheal, Vinohar Stephen" sort="Rapheal, Vinohar Stephen" uniqKey="Rapheal V" first="Vinohar Stephen" last="Rapheal">Vinohar Stephen Rapheal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24397983</idno><idno type="pmid">24397983</idno><idno type="doi">10.1186/2251-6581-13-11</idno><idno type="wicri:Area/PubMed/Corpus">000386</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Extraction process optimization of polyphenols from Indian Citrus sinensis - as novel antiglycative agents in the management of diabetes mellitus.</title><author><name sortKey="Shakthi Deve, Asaithambi" sort="Shakthi Deve, Asaithambi" uniqKey="Shakthi Deve A" first="Asaithambi" last="Shakthi Deve">Asaithambi Shakthi Deve</name></author><author><name sortKey="Sathish Kumar, Thiyagarajan" sort="Sathish Kumar, Thiyagarajan" uniqKey="Sathish Kumar T" first="Thiyagarajan" last="Sathish Kumar">Thiyagarajan Sathish Kumar</name><affiliation><nlm:affiliation>Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641 049, Tamil Nadu, India. sathishkumart29@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kumaresan, Kuppamuthu" sort="Kumaresan, Kuppamuthu" uniqKey="Kumaresan K" first="Kuppamuthu" last="Kumaresan">Kuppamuthu Kumaresan</name></author><author><name sortKey="Rapheal, Vinohar Stephen" sort="Rapheal, Vinohar Stephen" uniqKey="Rapheal V" first="Vinohar Stephen" last="Rapheal">Vinohar Stephen Rapheal</name></author></analytic><series><title level="j">Journal of diabetes and metabolic disorders</title><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose level. It has become an epidemic disease in the 21st century where, India leads the world with largest number of diabetic subjects. Non-enzymatic glycosylation (glycation) is severe form of diabetes, occurs between reducing sugar and proteins which results in the formation of advanced glycation end products (AGEs) that leads to the other complicated secondary disorders. In this context, Mangifera indica (Mango), Syzygium cumini (Jambul), Vitis vinifera (Grapes), Citrus sinensis (Orange), Artocarpus heterophyllus (Jackfruit), Manilkara zapota (Sapodilla) seeds were evaluated for their antiglyation activity. Attempts were made to isolate the polyphenols in the seeds that have recorded the maximum activity.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24397983</PMID><DateCreated><Year>2014</Year><Month>2</Month><Day>20</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>20</Day></DateCompleted><DateRevised><Year>2014</Year><Month>3</Month><Day>6</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Jan</Month><Day>07</Day></PubDate></JournalIssue><Title>Journal of diabetes and metabolic disorders</Title><ISOAbbreviation>J Diabetes Metab Disord</ISOAbbreviation></Journal><ArticleTitle>Extraction process optimization of polyphenols from Indian Citrus sinensis - as novel antiglycative agents in the management of diabetes mellitus.</ArticleTitle><Pagination><MedlinePgn>11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/2251-6581-13-11</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose level. It has become an epidemic disease in the 21st century where, India leads the world with largest number of diabetic subjects. Non-enzymatic glycosylation (glycation) is severe form of diabetes, occurs between reducing sugar and proteins which results in the formation of advanced glycation end products (AGEs) that leads to the other complicated secondary disorders. In this context, Mangifera indica (Mango), Syzygium cumini (Jambul), Vitis vinifera (Grapes), Citrus sinensis (Orange), Artocarpus heterophyllus (Jackfruit), Manilkara zapota (Sapodilla) seeds were evaluated for their antiglyation activity. Attempts were made to isolate the polyphenols in the seeds that have recorded the maximum activity.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Different extraction methods (shake flask, centrifugation and pressurized hot water) using various extractants (organic solvents, hot water and pressurized hot water) were adopted to investigate the in vitro antiglycation activity. Central composite (CCD) design based Response Surface Methodology (RSM) was espoused to optimize the extraction process of polyphenols from the fruit seeds that have recorded poor antiglycation activity. The PTLC analysis was performed to isolate the polyphenols (Flavonoids and phenolic acids) and LC-PDA-MS analysis was done for structure prediction.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Pressurized hot water extraction of Artocarpus heterophyllus (87.52%) and Citrus sinensis seeds (74.79%) was found to possess high and low antiglycation activity, respectively. The RSM mediated optimization process adopted for the Citrus sinensis seeds have revealed that 1:15 solvent ratio (hexane to heptane), 6 minutes and 1:20 solid to liquid ratio as the optimal conditions for the extraction of polyphenols with a maximum antiglycation activity (89.79%). The LC-PDA-MS analysis of preparative thin layer chromatography (PTLC) eluates of Artocarpus heterophyllus seed has showed the presence of compounds like quercetin (301.2), 4-hydroxy phenyl acetic acid (149.0), rhamnosyl-di-hexosyl quercetin sulphate (857.6), quercetin-3-O-xyloside (428.2), rutin (613.4), diosmetin (298.1) and luteolin (283.0).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The Artocarpus heterophyllus was observed to possess a significant antiglycation activity and the activity of Citrus sinensis was improved after the optimization process, which proved that both the seeds may be used as a traditional medicine in the management of chronic diabetes mellitus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shakthi Deve</LastName><ForeName>Asaithambi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Sathish Kumar</LastName><ForeName>Thiyagarajan</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641 049, Tamil Nadu, India. sathishkumart29@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumaresan</LastName><ForeName>Kuppamuthu</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Rapheal</LastName><ForeName>Vinohar Stephen</ForeName><Initials>VS</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>Jan</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Diabetes Metab Disord</MedlineTA><NlmUniqueID>101590741</NlmUniqueID><ISSNLinking>2251-6581</ISSNLinking></MedlineJournalInfo><OtherID Source="NLM">PMC3929254</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>6</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>9</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24397983</ArticleId><ArticleId IdType="pii">2251-6581-13-11</ArticleId><ArticleId IdType="doi">10.1186/2251-6581-13-11</ArticleId><ArticleId IdType="pmc">PMC3929254</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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