Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.
Identifieur interne : 000373 ( PubMed/Corpus ); précédent : 000372; suivant : 000374Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.
Auteurs : Olivier Perche ; Juliette Vergnaud-Gauduchon ; Christine Morand ; Claude Dubray ; Andrzej Mazur ; Marie-Paule VassonSource :
- Clinical nutrition (Edinburgh, Scotland) [ 1532-1983 ] ; 2014.
English descriptors
- KwdEn :
- Antioxidants, B-Lymphocytes (drug effects), B-Lymphocytes (metabolism), Beverages, Citrus sinensis (chemistry), Cross-Over Studies, Healthy Volunteers, Hesperidin (pharmacology), Humans, Immunomodulation, Interleukin-2 (secretion), Interleukin-4 (secretion), Killer Cells, Natural (immunology), Male, Middle Aged, Monocytes (drug effects), Monocytes (metabolism), Neutrophils (drug effects), Neutrophils (metabolism), Polyphenols (pharmacology), Reactive Oxygen Species, T-Lymphocytes (drug effects), T-Lymphocytes (metabolism).
- MESH :
- chemical , pharmacology : Hesperidin, Polyphenols.
- chemical , secretion : Interleukin-2, Interleukin-4.
- chemical : Antioxidants, Reactive Oxygen Species.
- chemistry : Citrus sinensis.
- drug effects : B-Lymphocytes, Monocytes, Neutrophils, T-Lymphocytes.
- immunology : Killer Cells, Natural.
- metabolism : B-Lymphocytes, Monocytes, Neutrophils, T-Lymphocytes.
- Beverages, Cross-Over Studies, Healthy Volunteers, Humans, Immunomodulation, Male, Middle Aged.
Abstract
Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Reactive Oxygen Species (ROS) burst by polymorphonuclear neutrophil cells (PMN).
DOI: 10.1016/j.clnu.2013.03.012
PubMed: 23602614
Links to Exploration step
pubmed:23602614Le document en format XML
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Electronic address: m-paule.vasson@udamail.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23602614</idno><idno type="pmid">23602614</idno><idno type="doi">10.1016/j.clnu.2013.03.012</idno><idno type="wicri:Area/PubMed/Corpus">000373</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.</title><author><name sortKey="Perche, Olivier" sort="Perche, Olivier" uniqKey="Perche O" first="Olivier" last="Perche">Olivier Perche</name><affiliation><nlm:affiliation>Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, CLARA, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vergnaud Gauduchon, Juliette" sort="Vergnaud Gauduchon, Juliette" uniqKey="Vergnaud Gauduchon J" first="Juliette" last="Vergnaud-Gauduchon">Juliette Vergnaud-Gauduchon</name><affiliation><nlm:affiliation>Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, CLARA, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation><nlm:affiliation>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name><affiliation><nlm:affiliation>CHU Clermont-Ferrand, Centre de Pharmacologie Clinique, Inserm, CIC 501, Univ Clermont 1, Faculté de Médecine, F-63001 Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><affiliation><nlm:affiliation>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vasson, Marie Paule" sort="Vasson, Marie Paule" uniqKey="Vasson M" first="Marie-Paule" last="Vasson">Marie-Paule Vasson</name><affiliation><nlm:affiliation>Centre anticancéreux Jean-Perrin, CHU, Unité de Nutrition, CLARA, F-63000 Clermont-Ferrand, France. Electronic address: m-paule.vasson@udamail.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical nutrition (Edinburgh, Scotland)</title><idno type="eISSN">1532-1983</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants</term><term>B-Lymphocytes (drug effects)</term><term>B-Lymphocytes (metabolism)</term><term>Beverages</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Healthy Volunteers</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Immunomodulation</term><term>Interleukin-2 (secretion)</term><term>Interleukin-4 (secretion)</term><term>Killer Cells, Natural (immunology)</term><term>Male</term><term>Middle Aged</term><term>Monocytes (drug effects)</term><term>Monocytes (metabolism)</term><term>Neutrophils (drug effects)</term><term>Neutrophils (metabolism)</term><term>Polyphenols (pharmacology)</term><term>Reactive Oxygen Species</term><term>T-Lymphocytes (drug effects)</term><term>T-Lymphocytes (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hesperidin</term><term>Polyphenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Interleukin-2</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antioxidants</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>B-Lymphocytes</term><term>Monocytes</term><term>Neutrophils</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term><term>Monocytes</term><term>Neutrophils</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Beverages</term><term>Cross-Over Studies</term><term>Healthy Volunteers</term><term>Humans</term><term>Immunomodulation</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Reactive Oxygen Species (ROS) burst by polymorphonuclear neutrophil cells (PMN).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23602614</PMID><DateCreated><Year>2014</Year><Month>1</Month><Day>21</Day></DateCreated><DateCompleted><Year>2014</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2014</Year><Month>1</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-1983</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Clinical nutrition (Edinburgh, Scotland)</Title><ISOAbbreviation>Clin Nutr</ISOAbbreviation></Journal><ArticleTitle>Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.</ArticleTitle><Pagination><MedlinePgn>130-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clnu.2013.03.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0261-5614(13)00090-3</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Reactive Oxygen Species (ROS) burst by polymorphonuclear neutrophil cells (PMN).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The protocol design was divided into three 4-week treatment periods separated by 3-week wash-out intervals, for total study duration of 18 weeks. During treatment periods, volunteers (n = 24) consumed daily 500 mL of orange juice, or an isocaloric control beverage with hesperidin (292 mg in a capsule), or of the same control beverage with a placebo.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Whatever the intake was, no variations were recorded on leukocyte subset distributions (PMN, B and T lymphocytes, NK cells and monocytes), ROS production by stimulated PMNs, lytic activity of NK cells or cytokine production capacity of leukocytes in well-nourished healthy volunteers.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We show that consumption within the usual daily intake range of orange juice and its major polyphenol hesperidin do not induce immunomodulation of cell immune function in healthy well-nourished humans.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perche</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, CLARA, BP 10448, F-63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vergnaud-Gauduchon</LastName><ForeName>Juliette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clermont Université, Université d'Auvergne, UMR 1019, Unité de Nutrition Humaine, CRNH-Auvergne, CLARA, BP 10448, F-63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morand</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubray</LastName><ForeName>Claude</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CHU Clermont-Ferrand, Centre de Pharmacologie Clinique, Inserm, CIC 501, Univ Clermont 1, Faculté de Médecine, F-63001 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazur</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vasson</LastName><ForeName>Marie-Paule</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Centre anticancéreux Jean-Perrin, CHU, Unité de Nutrition, CLARA, F-63000 Clermont-Ferrand, France. Electronic address: m-paule.vasson@udamail.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>Mar</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Nutr</MedlineTA><NlmUniqueID>8309603</NlmUniqueID><ISSNLinking>0261-5614</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007376">Interleukin-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064368" MajorTopicYN="N">Healthy Volunteers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056747" MajorTopicYN="Y">Immunomodulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007376" MajorTopicYN="N">Interleukin-2</DescriptorName><QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015847" MajorTopicYN="N">Interleukin-4</DescriptorName><QualifierName 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