Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
Identifieur interne : 000A69 ( PubMed/Checkpoint ); précédent : 000A68; suivant : 000A70Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
Auteurs : Francesco Cimino [Italie] ; Mariateresa Cristani ; Antonina Saija ; Franco Paolo Bonina ; Fabio VirgiliSource :
- BioFactors (Oxford, England) [ 0951-6433 ] ; 2007.
English descriptors
- KwdEn :
- Anthocyanins (analysis), Apoptosis (drug effects), Ascorbic Acid (analysis), Blotting, Western, Cell Line, Transformed, Citrus sinensis (chemistry), Coumaric Acids (analysis), Electrophoretic Mobility Shift Assay, Flavanones (analysis), Fruit (chemistry), Humans, Inflammation (prevention & control), Keratinocytes (drug effects), Keratinocytes (radiation effects), Phytotherapy, Plant Extracts (chemistry), Plant Extracts (pharmacology), Ultraviolet Rays (adverse effects).
- MESH :
- chemical , analysis : Anthocyanins, Ascorbic Acid, Coumaric Acids, Flavanones.
- adverse effects : Ultraviolet Rays.
- chemistry : Citrus sinensis, Fruit, Plant Extracts.
- drug effects : Apoptosis, Keratinocytes.
- chemical , pharmacology : Plant Extracts.
- prevention & control : Inflammation.
- radiation effects : Keratinocytes.
- Blotting, Western, Cell Line, Transformed, Electrophoretic Mobility Shift Assay, Humans, Phytotherapy.
Abstract
UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.
PubMed: 18356584
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:18356584Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.</title><author><name sortKey="Cimino, Francesco" sort="Cimino, Francesco" uniqKey="Cimino F" first="Francesco" last="Cimino">Francesco Cimino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Farmaco-Biologico, University of Messina, Messina, Italy. fcimino@pharma.unime.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Farmaco-Biologico, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Cristani, Mariateresa" sort="Cristani, Mariateresa" uniqKey="Cristani M" first="Mariateresa" last="Cristani">Mariateresa Cristani</name></author><author><name sortKey="Saija, Antonina" sort="Saija, Antonina" uniqKey="Saija A" first="Antonina" last="Saija">Antonina Saija</name></author><author><name sortKey="Bonina, Franco Paolo" sort="Bonina, Franco Paolo" uniqKey="Bonina F" first="Franco Paolo" last="Bonina">Franco Paolo Bonina</name></author><author><name sortKey="Virgili, Fabio" sort="Virgili, Fabio" uniqKey="Virgili F" first="Fabio" last="Virgili">Fabio Virgili</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18356584</idno><idno type="pmid">18356584</idno><idno type="wicri:Area/PubMed/Corpus">000B70</idno><idno type="wicri:Area/PubMed/Curation">000B70</idno><idno type="wicri:Area/PubMed/Checkpoint">000B70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.</title><author><name sortKey="Cimino, Francesco" sort="Cimino, Francesco" uniqKey="Cimino F" first="Francesco" last="Cimino">Francesco Cimino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Farmaco-Biologico, University of Messina, Messina, Italy. fcimino@pharma.unime.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Farmaco-Biologico, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Cristani, Mariateresa" sort="Cristani, Mariateresa" uniqKey="Cristani M" first="Mariateresa" last="Cristani">Mariateresa Cristani</name></author><author><name sortKey="Saija, Antonina" sort="Saija, Antonina" uniqKey="Saija A" first="Antonina" last="Saija">Antonina Saija</name></author><author><name sortKey="Bonina, Franco Paolo" sort="Bonina, Franco Paolo" uniqKey="Bonina F" first="Franco Paolo" last="Bonina">Franco Paolo Bonina</name></author><author><name sortKey="Virgili, Fabio" sort="Virgili, Fabio" uniqKey="Virgili F" first="Fabio" last="Virgili">Fabio Virgili</name></author></analytic><series><title level="j">BioFactors (Oxford, England)</title><idno type="ISSN">0951-6433</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthocyanins (analysis)</term><term>Apoptosis (drug effects)</term><term>Ascorbic Acid (analysis)</term><term>Blotting, Western</term><term>Cell Line, Transformed</term><term>Citrus sinensis (chemistry)</term><term>Coumaric Acids (analysis)</term><term>Electrophoretic Mobility Shift Assay</term><term>Flavanones (analysis)</term><term>Fruit (chemistry)</term><term>Humans</term><term>Inflammation (prevention & control)</term><term>Keratinocytes (drug effects)</term><term>Keratinocytes (radiation effects)</term><term>Phytotherapy</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Ultraviolet Rays (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Anthocyanins</term><term>Ascorbic Acid</term><term>Coumaric Acids</term><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Ultraviolet Rays</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Keratinocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Keratinocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blotting, Western</term><term>Cell Line, Transformed</term><term>Electrophoretic Mobility Shift Assay</term><term>Humans</term><term>Phytotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18356584</PMID><DateCreated><Year>2008</Year><Month>3</Month><Day>21</Day></DateCreated><DateCompleted><Year>2008</Year><Month>05</Month><Day>01</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0951-6433</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2007</Year></PubDate></JournalIssue><Title>BioFactors (Oxford, England)</Title><ISOAbbreviation>Biofactors</ISOAbbreviation></Journal><ArticleTitle>Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.</ArticleTitle><Pagination><MedlinePgn>129-38</MedlinePgn></Pagination><Abstract><AbstractText>UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cimino</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Farmaco-Biologico, University of Messina, Messina, Italy. fcimino@pharma.unime.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cristani</LastName><ForeName>Mariateresa</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Saija</LastName><ForeName>Antonina</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bonina</LastName><ForeName>Franco Paolo</ForeName><Initials>FP</Initials></Author><Author ValidYN="Y"><LastName>Virgili</LastName><ForeName>Fabio</ForeName><Initials>F</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biofactors</MedlineTA><NlmUniqueID>8807441</NlmUniqueID><ISSNLinking>0951-6433</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000872">Anthocyanins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003373">Coumaric Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber><NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000872" MajorTopicYN="N">Anthocyanins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002461" MajorTopicYN="N">Cell Line, Transformed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003373" MajorTopicYN="N">Coumaric Acids</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024202" MajorTopicYN="N">Electrophoretic Mobility Shift Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014466" MajorTopicYN="N">Ultraviolet Rays</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>5</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18356584</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Bonina, Franco Paolo" sort="Bonina, Franco Paolo" uniqKey="Bonina F" first="Franco Paolo" last="Bonina">Franco Paolo Bonina</name><name sortKey="Cristani, Mariateresa" sort="Cristani, Mariateresa" uniqKey="Cristani M" first="Mariateresa" last="Cristani">Mariateresa Cristani</name><name sortKey="Saija, Antonina" sort="Saija, Antonina" uniqKey="Saija A" first="Antonina" last="Saija">Antonina Saija</name><name sortKey="Virgili, Fabio" sort="Virgili, Fabio" uniqKey="Virgili F" first="Fabio" last="Virgili">Fabio Virgili</name></noCountry><country name="Italie"><noRegion><name sortKey="Cimino, Francesco" sort="Cimino, Francesco" uniqKey="Cimino F" first="Francesco" last="Cimino">Francesco Cimino</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A69 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000A69 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:18356584
|texte= Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:18356584" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |