Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity.
Identifieur interne : 000733 ( PubMed/Checkpoint ); précédent : 000732; suivant : 000734Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity.
Auteurs : Shannon M. Snyder [États-Unis] ; Josh D. Reber ; Brenner L. Freeman ; Kfir Orgad ; Dennis L. Eggett ; Tory L. ParkerSource :
- Nutrition research (New York, N.Y.) [ 1879-0739 ] ; 2011.
English descriptors
- KwdEn :
- Adolescent, Adult, Antioxidants (metabolism), Antioxidants (pharmacology), Ascorbic Acid (pharmacology), Citrus sinensis (chemistry), Cross-Over Studies, Dietary Sucrose (pharmacology), Female, Flavonoids (pharmacology), Humans, Lipoproteins (metabolism), Male, Oxidation-Reduction, Oxidative Stress (drug effects), Phenols (blood), Plant Extracts (blood), Plant Extracts (pharmacology), Postprandial Period (drug effects), Postprandial Period (physiology), Reactive Oxygen Species (blood), Young Adult.
- MESH :
- chemical , blood : Phenols, Plant Extracts, Reactive Oxygen Species.
- chemical , metabolism : Antioxidants, Lipoproteins.
- chemical , pharmacology : Antioxidants, Ascorbic Acid, Dietary Sucrose, Flavonoids, Plant Extracts.
- chemistry : Citrus sinensis.
- drug effects : Oxidative Stress, Postprandial Period.
- physiology : Postprandial Period.
- Adolescent, Adult, Cross-Over Studies, Female, Humans, Male, Oxidation-Reduction, Young Adult.
Abstract
Fruit and vegetable consumption reduces the risk for cardiovascular disease development. The postprandial state is an important contributor to chronic disease development. Orange flavonoids may reduce postprandial oxidation. It was hypothesized that a mixture of orange flavonoids would reduce postprandial oxidation better than a single orange flavonoid or orange sugar and ascorbic acid, but not as well as orange juice, when consumed with a typical breakfast. A placebo-controlled crossover trial (16 male and female participants, 4 treatments, 4 visits) was carried out. Treatments were placebo (ascorbic acid and sugar equivalent to orange juice); placebo plus hesperidin; placebo plus hesperidin, luteolin, and naringenin (mixture; found to have synergistic antioxidant properties in vitro in previous work); and orange juice (positive control). Serum oxygen radical absorbance capacity (ORAC), total plasma phenolics (TP), and serum lipoprotein oxidation (LO) were measured after a 12-hour baseline fast and at 1, 2, and 3 hours after sample consumption. The placebo plus mixture and orange juice groups were significantly increased in ORAC and LO lag time. Data for TP were inconsistent with ORAC and LO. Contrary to previous studies attributing the protective postprandial effect to fructose and ascorbate in other fruit trials, orange phenolic compounds contribute directly to the postprandial oxidative protection of serum, despite an inconsistent change in serum TP.
DOI: 10.1016/j.nutres.2011.06.006
PubMed: 21840468
Affiliations:
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Reber</name></author><author><name sortKey="Freeman, Brenner L" sort="Freeman, Brenner L" uniqKey="Freeman B" first="Brenner L" last="Freeman">Brenner L. Freeman</name></author><author><name sortKey="Orgad, Kfir" sort="Orgad, Kfir" uniqKey="Orgad K" first="Kfir" last="Orgad">Kfir Orgad</name></author><author><name sortKey="Eggett, Dennis L" sort="Eggett, Dennis L" uniqKey="Eggett D" first="Dennis L" last="Eggett">Dennis L. Eggett</name></author><author><name sortKey="Parker, Tory L" sort="Parker, Tory L" uniqKey="Parker T" first="Tory L" last="Parker">Tory L. Parker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21840468</idno><idno type="pmid">21840468</idno><idno type="doi">10.1016/j.nutres.2011.06.006</idno><idno type="wicri:Area/PubMed/Corpus">000727</idno><idno type="wicri:Area/PubMed/Curation">000727</idno><idno type="wicri:Area/PubMed/Checkpoint">000727</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity.</title><author><name sortKey="Snyder, Shannon M" sort="Snyder, Shannon M" uniqKey="Snyder S" first="Shannon M" last="Snyder">Shannon M. 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Parker</name></author></analytic><series><title level="j">Nutrition research (New York, N.Y.)</title><idno type="eISSN">1879-0739</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antioxidants (metabolism)</term><term>Antioxidants (pharmacology)</term><term>Ascorbic Acid (pharmacology)</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Dietary Sucrose (pharmacology)</term><term>Female</term><term>Flavonoids (pharmacology)</term><term>Humans</term><term>Lipoproteins (metabolism)</term><term>Male</term><term>Oxidation-Reduction</term><term>Oxidative Stress (drug effects)</term><term>Phenols (blood)</term><term>Plant Extracts (blood)</term><term>Plant Extracts (pharmacology)</term><term>Postprandial Period (drug effects)</term><term>Postprandial Period (physiology)</term><term>Reactive Oxygen Species (blood)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Phenols</term><term>Plant Extracts</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Lipoproteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Ascorbic Acid</term><term>Dietary Sucrose</term><term>Flavonoids</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term><term>Postprandial Period</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postprandial Period</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cross-Over Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Oxidation-Reduction</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fruit and vegetable consumption reduces the risk for cardiovascular disease development. The postprandial state is an important contributor to chronic disease development. Orange flavonoids may reduce postprandial oxidation. It was hypothesized that a mixture of orange flavonoids would reduce postprandial oxidation better than a single orange flavonoid or orange sugar and ascorbic acid, but not as well as orange juice, when consumed with a typical breakfast. A placebo-controlled crossover trial (16 male and female participants, 4 treatments, 4 visits) was carried out. Treatments were placebo (ascorbic acid and sugar equivalent to orange juice); placebo plus hesperidin; placebo plus hesperidin, luteolin, and naringenin (mixture; found to have synergistic antioxidant properties in vitro in previous work); and orange juice (positive control). Serum oxygen radical absorbance capacity (ORAC), total plasma phenolics (TP), and serum lipoprotein oxidation (LO) were measured after a 12-hour baseline fast and at 1, 2, and 3 hours after sample consumption. The placebo plus mixture and orange juice groups were significantly increased in ORAC and LO lag time. Data for TP were inconsistent with ORAC and LO. Contrary to previous studies attributing the protective postprandial effect to fructose and ascorbate in other fruit trials, orange phenolic compounds contribute directly to the postprandial oxidative protection of serum, despite an inconsistent change in serum TP.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21840468</PMID><DateCreated><Year>2011</Year><Month>8</Month><Day>15</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1879-0739</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Nutrition research (New York, N.Y.)</Title><ISOAbbreviation>Nutr Res</ISOAbbreviation></Journal><ArticleTitle>Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity.</ArticleTitle><Pagination><MedlinePgn>519-26</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nutres.2011.06.006</ELocationID><Abstract><AbstractText>Fruit and vegetable consumption reduces the risk for cardiovascular disease development. The postprandial state is an important contributor to chronic disease development. Orange flavonoids may reduce postprandial oxidation. It was hypothesized that a mixture of orange flavonoids would reduce postprandial oxidation better than a single orange flavonoid or orange sugar and ascorbic acid, but not as well as orange juice, when consumed with a typical breakfast. A placebo-controlled crossover trial (16 male and female participants, 4 treatments, 4 visits) was carried out. Treatments were placebo (ascorbic acid and sugar equivalent to orange juice); placebo plus hesperidin; placebo plus hesperidin, luteolin, and naringenin (mixture; found to have synergistic antioxidant properties in vitro in previous work); and orange juice (positive control). Serum oxygen radical absorbance capacity (ORAC), total plasma phenolics (TP), and serum lipoprotein oxidation (LO) were measured after a 12-hour baseline fast and at 1, 2, and 3 hours after sample consumption. The placebo plus mixture and orange juice groups were significantly increased in ORAC and LO lag time. Data for TP were inconsistent with ORAC and LO. Contrary to previous studies attributing the protective postprandial effect to fructose and ascorbate in other fruit trials, orange phenolic compounds contribute directly to the postprandial oxidative protection of serum, despite an inconsistent change in serum TP.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Inc. 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UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber><NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic 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PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21840468</ArticleId><ArticleId IdType="pii">S0271-5317(11)00129-1</ArticleId><ArticleId IdType="doi">10.1016/j.nutres.2011.06.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Eggett, Dennis L" sort="Eggett, Dennis L" uniqKey="Eggett D" first="Dennis L" last="Eggett">Dennis L. Eggett</name><name sortKey="Freeman, Brenner L" sort="Freeman, Brenner L" uniqKey="Freeman B" first="Brenner L" last="Freeman">Brenner L. Freeman</name><name sortKey="Orgad, Kfir" sort="Orgad, Kfir" uniqKey="Orgad K" first="Kfir" last="Orgad">Kfir Orgad</name><name sortKey="Parker, Tory L" sort="Parker, Tory L" uniqKey="Parker T" first="Tory L" last="Parker">Tory L. Parker</name><name sortKey="Reber, Josh D" sort="Reber, Josh D" uniqKey="Reber J" first="Josh D" last="Reber">Josh D. Reber</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Snyder, Shannon M" sort="Snyder, Shannon M" uniqKey="Snyder S" first="Shannon M" last="Snyder">Shannon M. Snyder</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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