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Antimicrobial Effect and Mode of Action of Terpeneless Cold Pressed Valencia Orange Essential Oil on Methicillin-Resistant Staphylococcus aureus

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Antimicrobial Effect and Mode of Action of Terpeneless Cold Pressed Valencia Orange Essential Oil on Methicillin-Resistant Staphylococcus aureus

Auteurs : Arunachalam Muthaiyan [États-Unis] ; Elizabeth M. Martin [États-Unis] ; Senthil Natesan [États-Unis] ; Philip G. Crandall [États-Unis] ; Brian J. Wilkinson [États-Unis] ; Steven C. Ricke [États-Unis]

Source :

Journal of Applied Microbiology [ 1364-5072 ] ; 2012.

RBID : PMC:3324624

Abstract

Aims

The objective of this study was to evaluate the antistaphylococcal effect and elucidate the mechanism of action of orange essential oil against antibiotic resistant Staphylococcus aureus strains.

Methods and Results

Inhibitory effect of commercial orange essential oil (EO) against six S. aureus strains was tested by disc diffusion and agar dilution methods. The mechanism of EO action on MRSA was analyzed by transcriptional profiling. Morphological changes of EO treated S. aureus were examined by transmission electron microscopy. Results showed that 0.1% of cold pressed terpeneless Valencia orange oil (CPV) induced the cell wall stress stimulon consistent with inhibition of cell wall synthesis. Transmission electron microscopic observation revealed cell lysis and suggested a cell wall-lysis related mechanism of CPV.

Conclusions

CPV inhibits the growth of S. aureus, causes gene expression changes consistent with inhibition of cell wall synthesis and triggers cell lysis.

Significance and Impact of the Study

Multiple antibiotics resistance is becoming a serious problem in the management of S. aureus infections. In this study the altered expression of cell wall associated genes and subsequent cell lysis in MRSA caused by CPV suggests that it may be a potential antimicrobial agent to control antibiotic resistant S. aureus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324624

DOI: 10.1111/j.1365-2672.2012.05270.x
PubMed: 22372962
PubMed Central: 3324624

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aims</title>
<p id="P1">The objective of this study was to evaluate the antistaphylococcal effect and elucidate the mechanism of action of orange essential oil against antibiotic resistant <italic>Staphylococcus aureus</italic>
 strains.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods and Results</title>
<p id="P2">Inhibitory effect of commercial orange essential oil (EO) against six <italic>S. aureus</italic>
 strains was tested by disc diffusion and agar dilution methods. The mechanism of EO action on MRSA was analyzed by transcriptional profiling. Morphological changes of EO treated <italic>S. aureus</italic>
 were examined by transmission electron microscopy. Results showed that 0.1% of cold pressed terpeneless Valencia orange oil (CPV) induced the cell wall stress stimulon consistent with inhibition of cell wall synthesis. Transmission electron microscopic observation revealed cell lysis and suggested a cell wall-lysis related mechanism of CPV.</p>
</sec>
<sec id="S3"><title>Conclusions</title>
<p id="P3">CPV inhibits the growth of <italic>S. aureus</italic>
, causes gene expression changes consistent with inhibition of cell wall synthesis and triggers cell lysis.</p>
</sec>
<sec id="S4"><title>Significance and Impact of the Study</title>
<p id="P4">Multiple antibiotics resistance is becoming a serious problem in the management of <italic>S. aureus</italic>
 infections. In this study the altered expression of cell wall associated genes and subsequent cell lysis in MRSA caused by CPV suggests that it may be a potential antimicrobial agent to control antibiotic resistant <italic>S. aureus</italic>
.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9706280</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20567</journal-id>
<journal-id journal-id-type="nlm-ta">J Appl Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Appl. Microbiol.</journal-id>
<journal-title-group><journal-title>Journal of Applied Microbiology</journal-title>
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<issn pub-type="ppub">1364-5072</issn>
<issn pub-type="epub">1365-2672</issn>
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<article-id pub-id-type="manuscript">NIHMS359571</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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</article-categories>
<title-group><article-title>Antimicrobial Effect and Mode of Action of Terpeneless Cold Pressed Valencia Orange Essential Oil on Methicillin-Resistant <italic>Staphylococcus aureus</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Muthaiyan</surname>
<given-names>Arunachalam</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Elizabeth M.</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Natesan</surname>
<given-names>Senthil</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crandall</surname>
<given-names>Philip G.</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilkinson</surname>
<given-names>Brian J.</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ricke</surname>
<given-names>Steven C.</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
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</contrib-group>
<aff id="A1"><label>1</label>
Center for Food Safety and Department of Food Science, University of Arkansas Fayetteville, AR 72701</aff>
<aff id="A2"><label>2</label>
Albany College of Pharmacy and Health Sciences-Vermont Campus, Colchester, VT 05446</aff>
<aff id="A3"><label>3</label>
Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790</aff>
<author-notes><corresp id="FN1">Correspondence: Steven C. Ricke, Center for Food Safety-Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA. Tel: 479-575-4678; Fax: 479-575-6936; <email>sricke@uark.edu</email>
. Arunachalam Muthaiyan, Center for Food Safety-Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA. Tel: 479-575-7110; Fax: 479-575-3941; <email>amuthai@gmail.com</email>
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</author-notes>
<pub-date pub-type="nihms-submitted"><day>28</day>
<month>2</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>20</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>112</volume>
<issue>5</issue>
<fpage>1020</fpage>
<lpage>1033</lpage>
<abstract><sec id="S1"><title>Aims</title>
<p id="P1">The objective of this study was to evaluate the antistaphylococcal effect and elucidate the mechanism of action of orange essential oil against antibiotic resistant <italic>Staphylococcus aureus</italic>
 strains.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods and Results</title>
<p id="P2">Inhibitory effect of commercial orange essential oil (EO) against six <italic>S. aureus</italic>
 strains was tested by disc diffusion and agar dilution methods. The mechanism of EO action on MRSA was analyzed by transcriptional profiling. Morphological changes of EO treated <italic>S. aureus</italic>
 were examined by transmission electron microscopy. Results showed that 0.1% of cold pressed terpeneless Valencia orange oil (CPV) induced the cell wall stress stimulon consistent with inhibition of cell wall synthesis. Transmission electron microscopic observation revealed cell lysis and suggested a cell wall-lysis related mechanism of CPV.</p>
</sec>
<sec id="S3"><title>Conclusions</title>
<p id="P3">CPV inhibits the growth of <italic>S. aureus</italic>
, causes gene expression changes consistent with inhibition of cell wall synthesis and triggers cell lysis.</p>
</sec>
<sec id="S4"><title>Significance and Impact of the Study</title>
<p id="P4">Multiple antibiotics resistance is becoming a serious problem in the management of <italic>S. aureus</italic>
 infections. In this study the altered expression of cell wall associated genes and subsequent cell lysis in MRSA caused by CPV suggests that it may be a potential antimicrobial agent to control antibiotic resistant <italic>S. aureus</italic>
.</p>
</sec>
</abstract>
<kwd-group><kwd><italic>Staphylococcus aureus</italic>
</kwd>
<kwd>MRSA</kwd>
<kwd>Natural antimicrobial</kwd>
<kwd>Mechanism of Essential Oil</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R15 AI084006-01 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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Antimicrobial Effect and Mode of Action of Terpeneless Cold Pressed Valencia Orange Essential Oil on Methicillin-Resistant Staphylococcus aureus

Antimicrobial Effect and Mode of Action of Terpeneless Cold Pressed Valencia Orange Essential Oil on Methicillin-Resistant Staphylococcus aureus

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Abstract

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