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<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">New species of
<italic>Cladosporium</italic>
associated with human and animal infections</title>
<author>
<name sortKey="Sandoval Denis, M" sort="Sandoval Denis, M" uniqKey="Sandoval Denis M" first="M." last="Sandoval-Denis">M. Sandoval-Denis</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gene, J" sort="Gene, J" uniqKey="Gene J" first="J." last="Gené">J. Gené</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sutton, D A" sort="Sutton, D A" uniqKey="Sutton D" first="D. A." last="Sutton">D. A. Sutton</name>
<affiliation>
<nlm:aff id="A2"> Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wiederhold, N P" sort="Wiederhold, N P" uniqKey="Wiederhold N" first="N. P." last="Wiederhold">N. P. Wiederhold</name>
<affiliation>
<nlm:aff id="A2"> Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cano Lira, J F" sort="Cano Lira, J F" uniqKey="Cano Lira J" first="J. F." last="Cano-Lira">J. F. Cano-Lira</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guarro, J" sort="Guarro, J" uniqKey="Guarro J" first="J." last="Guarro">J. Guarro</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">27616793</idno>
<idno type="pmc">4988372</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988372</idno>
<idno type="RBID">PMC:4988372</idno>
<idno type="doi">10.3767/003158516X691951</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">001247</idno>
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<title xml:lang="en" level="a" type="main">New species of
<italic>Cladosporium</italic>
associated with human and animal infections</title>
<author>
<name sortKey="Sandoval Denis, M" sort="Sandoval Denis, M" uniqKey="Sandoval Denis M" first="M." last="Sandoval-Denis">M. Sandoval-Denis</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gene, J" sort="Gene, J" uniqKey="Gene J" first="J." last="Gené">J. Gené</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sutton, D A" sort="Sutton, D A" uniqKey="Sutton D" first="D. A." last="Sutton">D. A. Sutton</name>
<affiliation>
<nlm:aff id="A2"> Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wiederhold, N P" sort="Wiederhold, N P" uniqKey="Wiederhold N" first="N. P." last="Wiederhold">N. P. Wiederhold</name>
<affiliation>
<nlm:aff id="A2"> Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cano Lira, J F" sort="Cano Lira, J F" uniqKey="Cano Lira J" first="J. F." last="Cano-Lira">J. F. Cano-Lira</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Guarro, J" sort="Guarro, J" uniqKey="Guarro J" first="J." last="Guarro">J. Guarro</name>
<affiliation>
<nlm:aff id="A1"> Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Persoonia : Molecular Phylogeny and Evolution of Fungi</title>
<idno type="ISSN">0031-5850</idno>
<idno type="eISSN">1878-9080</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">
<p>
<italic>Cladosporium</italic>
is mainly known as a ubiquitous environmental saprobic fungus or plant endophyte, and to date, just a few species have been documented as etiologic agents in vertebrate hosts, including humans. In the present study, 10 new species of the genus were isolated from human and animal clinical specimens from the USA. They are proposed and characterized on the basis of their morphology and a molecular phylogenetic analysis using DNA sequences from three loci (the ITS region of the rDNA, and partial fragments of the translation elongation factor 1-alpha and actin genes). Six of those species belong to the
<italic>C. cladosporioides</italic>
species complex, i.e.,
<italic>C. alboflavescens</italic>
,
<italic>C. angulosum</italic>
,
<italic>C. anthropophilum</italic>
,
<italic>C. crousii</italic>
,
<italic>C. flavovirens</italic>
and
<italic>C. xantochromaticum</italic>
, three new species belong to the
<italic>C. herbarum</italic>
species complex, i.e.,
<italic>C. floccosum</italic>
,
<italic>C. subcinereum</italic>
and
<italic>C. tuberosum</italic>
; and one to the
<italic>C. sphaerospermum</italic>
species complex, namely,
<italic>C. succulentum</italic>
. Differential morphological features of the new taxa are provided together with molecular barcodes to distinguish them from the currently accepted species of the genus.</p>
</div>
</front>
<back>
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</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Persoonia</journal-id>
<journal-id journal-id-type="iso-abbrev">Persoonia</journal-id>
<journal-id journal-id-type="publisher-id">Persoonia</journal-id>
<journal-title-group>
<journal-title>Persoonia : Molecular Phylogeny and Evolution of Fungi</journal-title>
</journal-title-group>
<issn pub-type="ppub">0031-5850</issn>
<issn pub-type="epub">1878-9080</issn>
<publisher>
<publisher-name>Naturalis Biodiversity Center & Centraallbureau voor Schimmelcultures</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">27616793</article-id>
<article-id pub-id-type="pmc">4988372</article-id>
<article-id pub-id-type="doi">10.3767/003158516X691951</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>New species of
<italic>Cladosporium</italic>
associated with human and animal infections</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Sandoval-Denis</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gené</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="COR1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sutton</surname>
<given-names>D.A.</given-names>
</name>
<xref ref-type="aff" rid="A2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wiederhold</surname>
<given-names>N.P.</given-names>
</name>
<xref ref-type="aff" rid="A2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cano-Lira</surname>
<given-names>J.F.</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guarro</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;</aff>
<aff id="A2">
<label>2</label>
Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas.</aff>
<author-notes>
<corresp id="COR1">corresponding author e-mail:
<email>josepa.gene@urv.cat</email>
.</corresp>
</author-notes>
<pub-date pub-type="epub">
<day>24</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub">
<month>6</month>
<year>2016</year>
</pub-date>
<volume>36</volume>
<fpage>281</fpage>
<lpage>298</lpage>
<history>
<date date-type="received">
<day>22</day>
<month>12</month>
<year>2015</year>
</date>
<date date-type="accepted">
<day>6</day>
<month>4</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>© 2016 Naturalis Biodiversity Center & Centraalbureau voor Schimmelcultures</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode">
<license-p>You are free to share - to copy, distribute and transmit the work, under the following conditions:</license-p>
<license-p>Attribution: You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).</license-p>
<license-p>Non-commercial: You may not use this work for commercial purposes.</license-p>
<license-p>No derivative works: You may not alter, transform, or build upon this work.</license-p>
<license-p>For any reuse or distribution, you must make clear to others the license terms of this work, which can be found at
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode">http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode</ext-link>
. Any of the above conditions can be waived if you get permission from the copyright holder. Nothing in this license impairs or restricts the author’s moral rights.</license-p>
</license>
</permissions>
<abstract abstract-type="executive-summary">
<p>
<italic>Cladosporium</italic>
is mainly known as a ubiquitous environmental saprobic fungus or plant endophyte, and to date, just a few species have been documented as etiologic agents in vertebrate hosts, including humans. In the present study, 10 new species of the genus were isolated from human and animal clinical specimens from the USA. They are proposed and characterized on the basis of their morphology and a molecular phylogenetic analysis using DNA sequences from three loci (the ITS region of the rDNA, and partial fragments of the translation elongation factor 1-alpha and actin genes). Six of those species belong to the
<italic>C. cladosporioides</italic>
species complex, i.e.,
<italic>C. alboflavescens</italic>
,
<italic>C. angulosum</italic>
,
<italic>C. anthropophilum</italic>
,
<italic>C. crousii</italic>
,
<italic>C. flavovirens</italic>
and
<italic>C. xantochromaticum</italic>
, three new species belong to the
<italic>C. herbarum</italic>
species complex, i.e.,
<italic>C. floccosum</italic>
,
<italic>C. subcinereum</italic>
and
<italic>C. tuberosum</italic>
; and one to the
<italic>C. sphaerospermum</italic>
species complex, namely,
<italic>C. succulentum</italic>
. Differential morphological features of the new taxa are provided together with molecular barcodes to distinguish them from the currently accepted species of the genus.</p>
</abstract>
<kwd-group>
<kwd>
<italic>Capnodiales</italic>
</kwd>
<kwd>
<italic>Cladosporiaceae</italic>
</kwd>
<kwd>
<italic>Dothideomycetes</italic>
</kwd>
<kwd>phylogeny</kwd>
<kwd>taxonomy</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec id="s1">
<title>INTRODUCTION</title>
<p>The genus
<italic>Cladosporium</italic>
(
<italic>Cladosporiaceae</italic>
,
<italic>Capnodiales</italic>
) is a large genus of the
<italic>Ascomycota</italic>
. It comprises 189 species, mostly saprobes with a worldwide distribution and isolated from a wide range of substrates (
<xref rid="R13" ref-type="bibr">David 1997</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
,
<xref rid="R2" ref-type="bibr">2015</xref>
,
<xref rid="R11" ref-type="bibr">Crous et al. 2014</xref>
). The genus also includes common endophytes, plant pathogens often causing leaf spots or other lesions, as well as hyperparasites of other fungi (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Certain species are relevant as potential biocontrol agents for plant diseases (
<xref rid="R25" ref-type="bibr">Köhl et al. 2015</xref>
) or, in the food industry, as fruit contaminants causing spoilage in low temperature storage or on cereals such as barley, oat, rye and wheat (
<xref rid="R30" ref-type="bibr">Samson et al. 2010</xref>
,
<xref rid="R27" ref-type="bibr">Kulik et al. 2014</xref>
,
<xref rid="R19" ref-type="bibr">Frasz & Miller 2015</xref>
). The role of cladosporia is not well understood in human pathology. Their small conidia are easily dispersed, making them one of the most common air-borne microorganisms (
<xref rid="R13" ref-type="bibr">David 1997</xref>
,
<xref rid="R15" ref-type="bibr">De Hoog et al. 2011</xref>
). They are among the most important allergenic fungi linked to allergic rhinitis and respiratory arrest in asthmatic patients (
<xref rid="R4" ref-type="bibr">Black et al. 2000</xref>
,
<xref rid="R34" ref-type="bibr">Sellart-Altisent et al. 2007</xref>
). Some species are described as a cause of opportunistic phaeohyphomycosis, including subcutaneous and deep infections in humans and animals (
<xref rid="R15" ref-type="bibr">De Hoog et al. 2011</xref>
,
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
), although, their ubiquitous nature suggests that in some reports they may be mere colonizers.</p>
<p>Species identification in
<italic>Cladosporium</italic>
has always relied on the morphology of the conidiogenous apparatus together with data on host ranges (
<xref rid="R9" ref-type="bibr">Crous et al. 2007b</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Traditionally, those dematiaceous fungi showing branched acropetal chains of aseptate to septate conidia were included in
<italic>Cladosporium</italic>
, which has made it a large and complex group of fungi difficult to differentiate (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). However, recent phylogenetic studies have helped to clarify the taxonomy of these fungi and demonstrated that most of the well-known morphologically-defined species comprises several phylogenetically cryptic species practically impossible to identify using morphological criteria alone (
<xref rid="R5" ref-type="bibr">Braun et al. 2003</xref>
,
<xref rid="R6" ref-type="bibr">2008</xref>
;
<xref rid="R9" ref-type="bibr">Crous et al. 2007b</xref>
,
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R32" ref-type="bibr">2009</xref>
,
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
,
<xref rid="R1" ref-type="bibr">2012</xref>
,
<xref rid="R2" ref-type="bibr">2015</xref>
). In its current circumscription, the genus
<italic>Cladosporium</italic>
includes dematiaceous fungi with solitary to fasciculate conidiophores, proliferating mostly sympodially and forming unbranched or branched acropetal conidial chains. However, the most characteristic feature is the presence of a thick refractive to darkened cladosporioid or coronate scar, defined as a raised periclinal rim with a central convex dome (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). The sexual morph (previously assigned to the genus
<italic>Davidiella</italic>
) is characterised by pseudothecial ascomata, 8-spored obovoid to subcylindrical asci, and hyaline, obovoid to ellipsoid ascospores showing irregular luminar inclusions (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
).</p>
<p>In recent years, the survey of unexplored habitats and sources by using molecular techniques has expanded our knowledge of fungal diversity. Similarly, clinical specimens have become an important source of undescribed fungi, including both true pathogens and/or also contaminants/colonizers (
<xref rid="R21" ref-type="bibr">Gilgado et al. 2005</xref>
,
<xref rid="R29" ref-type="bibr">Perdomo et al. 2013</xref>
,
<xref rid="R22" ref-type="bibr">Giraldo et al. 2014</xref>
,
<xref rid="R23" ref-type="bibr">Guinea et al. 2015</xref>
,
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
) that had not been recognizable previously because of their poor morphological differentiation (
<xref rid="R14" ref-type="bibr">De Hoog et al. 2015</xref>
).</p>
<p>In order to assess the real prevalence of
<italic>Cladosporium</italic>
in the clinical setting and the spectrum of species associated with clinical samples, we studied a large set of
<italic>Cladosporium</italic>
isolates from human and animal clinical origin using both molecular characterisation and phenotypic features (
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). Surprisingly, we found that nearly 40 % of the isolates could not be assigned to any known species and probably represented new species for the genus. The objective of the present study is therefore to determine the phylogenetic relationships of those previously unidentified isolates by using the criteria currently accepted in the taxonomy of this genus.</p>
</sec>
<sec sec-type="materials|methods" id="s2">
<title>MATERIALS AND METHODS</title>
<sec id="s2a">
<title>Fungal isolates</title>
<p>A total of 48 isolates from clinical origin and belonging to the genus
<italic>Cladosporium</italic>
were included in this study, 35 of which corresponded to putatively undescribed species (
<xref ref-type="table" rid="T1">Table 1</xref>
). All the isolates were obtained from human and animal clinical specimens from the United States, submitted to the Fungus Testing Laboratory at the University of Texas Health Science Center at San Antonio (UTHSCSA) from different geographic regions of the country for either identification purposes and/or antifungal susceptibility studies.</p>
</sec>
<sec id="s2b">
<title>Phenotypic studies</title>
<p>Macroscopic cultural characteristics of the isolates were recorded after incubation for 14 d at 25 °C, using oatmeal agar (OA) (30 g of filtered oat flakes, 20 g of agar, water 1 L), potato dextrose agar (PDA: Pronadisa, Spain) and synthetic nutrient-poor agar (SNA; KH
<sub>2</sub>
PO
<sub>4</sub>
1 g, KNO
<sub>3</sub>
1 g, MgSO
<sub>4</sub>
× 7H
<sub>2</sub>
O 0.5 g, KCl 0.5 g, glucose 0.2 g, sucrose 0.2 g, agar 14 g, water 1 L) with and without pieces of sterilised paper as carbon source. In descriptions, colour notations of the colonies were from
<xref rid="R26" ref-type="bibr">Kornerup & Wanscher (1978)</xref>
. Observations and measurements of the microscopic structures were carried out from colonies on SNA after incubation for 7 d at 25 °C, mounted on Shear’s solution (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R12" ref-type="bibr">Crous et al. 2009</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Photographs were made using a Zeiss Axio Imager M1 light microscope (Zeiss, Oberkochen, Germany) with a mounted DeltaPix Infinity X digital camera using Nomarski differential interference contrast and phase contrast optics. Scanning electron microscope (SEM) micrographs were obtained with a Jeol JSM-6400 apparatus, following the protocols described by
<xref rid="R18" ref-type="bibr">Figueras & Guarro (1988)</xref>
. Cardinal temperatures of growth were determined culturing the isolates on PDA for 14 d at temperatures ranging from 15 °C to 35 °C at intervals of 5 °C.</p>
</sec>
<sec id="s2c">
<title>DNA extraction, PCR amplification and sequencing</title>
<p>Total genomic DNA was extracted, amplified and sequenced in a previous work, using protocols described elsewhere (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
,
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). Briefly, the primer pair ITS5/ITS4 (
<xref rid="R38" ref-type="bibr">White et al. 1990</xref>
) was used to amplify a region spanning the internal transcribed spacers 1 and 2 and the 5.8S gene of the rRNA (ITS), and the primer pairs EF-728F/EF-986R and ACT-512F/ACT-783R (
<xref rid="R7" ref-type="bibr">Carbone & Kohn 1999</xref>
) were used to amplify a partial fragment of the translation elongation factor 1-α gene (
<italic>tef1</italic>
) and the actin gene (
<italic>actA</italic>
), respectively.</p>
<p>Sequences were generated using the same PCR primers at Macrogen Europe (Macrogen Inc. Amsterdam, The Netherlands). Consensus sequences were assembled using SeqMan v. 7.0.0 (DNAStar Lasergene, Madison, WI, USA).</p>
</sec>
<sec id="s2d">
<title>Sequence alignment and phylogenetic analyses</title>
<p>Multiple sequence alignments of each locus were performed with MEGA v. 6.06 (
<xref rid="R36" ref-type="bibr">Tamura et al. 2013</xref>
), using the ClustalW algorithm (
<xref rid="R37" ref-type="bibr">Thompson et al. 1994</xref>
) and refined with MUSCLE (
<xref rid="R17" ref-type="bibr">Edgar 2004</xref>
) or manually if necessary. The alignment included sequences from the clinical isolates complemented with sequences representing all the available ex-types and numerous reference strains of
<italic>Cladosporium</italic>
spp. retrieved from GenBank and mainly published by
<xref rid="R1" ref-type="bibr">Bensch et al. (2012</xref>
,
<xref rid="R2" ref-type="bibr">2015)</xref>
. These latter sequences were selected on the basis of sequence similarity with the putative new taxa as determined by BLAST searches on the NCBI database using ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
loci (
<xref ref-type="table" rid="T1">Table 1</xref>
).</p>
<p>Phylogenetic reconstructions were performed using the maximum-likelihood (ML) and Bayesian Inference (BI) approaches under MEGA v. 6.06 and MrBayes v. 3.2 (
<xref rid="R24" ref-type="bibr">Huelsenbeck & Ronquist 2001</xref>
), respectively. MrModelTest v. 2.3 (
<xref rid="R28" ref-type="bibr">Nylander 2004</xref>
) was used to determine the best nucleotide substitution model for each dataset (SYM+G for ITS and GTR+G+I for
<italic>tef1</italic>
and
<italic>actA</italic>
). Sequence alignments generated in this study were deposited in TreeBASE (
<ext-link ext-link-type="uri" xlink:href="http://treebase.org">http://treebase.org</ext-link>
).</p>
<p>For the ML analyses, support for the internal branches was assessed by a search of 1 000 bootstrapped sets of data. A bootstrap support (bs) of ≥ 70 % was considered significant. For BI analyses, four Markov chains were performed in two simultaneous runs for 10 000 000 generations with a sampling rate of 1 000 generations. Once checked for the convergence of the runs (average standard deviation of split frequencies parameter below 0.01), the 50 % majority-rule consensus tree and posterior probability values (pp) were calculated after discarding 2 500 trees for burn-in. A pp value ≥ 0.95 was considered significant. Phylogenetic concordance of the ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
gene datasets was evaluated with the partition-homogeneity test implemented with PAUP v. 4.0b10 (
<xref rid="R35" ref-type="bibr">Swofford 2003</xref>
) and also by visual comparison of the individual phylogenies in order to assess for any incongruent results between nodes with high statistical support. Taxonomic novelties were deposited in MycoBank (
<xref rid="R10" ref-type="bibr">Crous et al. 2004</xref>
).</p>
</sec>
</sec>
<sec id="s3">
<title>RESULTS</title>
<sec id="s3a">
<title>Phylogeny</title>
<p>The different partitions were congruent as determined by visual comparison of the individual phylogenies (data not shown) and by the partition homogeneity test (p = 0.16). Phylogenies obtained by ML and BI also showed topological congruence. The final combined analysis of the three mentioned loci datasets encompassed 197 sequences representing 101 taxa, including
<italic>Cercospora beticola</italic>
(CBS 116456) as the outgroup, and comprised 1 026 bp (ITS 448 bp,
<italic>tef1</italic>
357 bp and
<italic>actA</italic>
221 bp) from which 546 bp were variable (ITS 108 bp,
<italic>tef1</italic>
291 bp and
<italic>actA</italic>
147 bp) and 399 bp phylogenetically informative (ITS 42 bp,
<italic>tef1</italic>
234 bp and
<italic>actA</italic>
123 bp). Unique site pattern values for the Bayesian analyses were 92, 322 and 167 for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
datasets, respectively (
<xref ref-type="fig" rid="F1">Fig. 1</xref>
). Of the 35 unidentified isolates, 21 clustered into ten groups that received strong statistical support with the exception of two monotypic lineages (CBS 140465 and CBS 140466), which, however, were genetically and morphologically differentiated from their closest phylogenetic relatives. The remaining 14 isolates were identified here as
<italic>C. pseudocladosporioides</italic>
(13 isolates) and
<italic>C. allicinum</italic>
(one isolate). The isolates representing putative new taxa grouped mainly in the
<italic>C. cladosporioides</italic>
species complex in which 16 isolates were distributed in three terminal clades and three monotypic linages. Five isolates belonged to the
<italic>C. herbarum</italic>
species complex, two of them (CBS 140693 and UTHSC DI-13-219) grouped in a terminal clade, located in a basal position to the remaining species of the complex, while three isolates formed monotypic lineages. The
<italic>C. sphaerospermum</italic>
species complex included a single unidentified isolate (CBS 140466) forming a genetically and morphologically distinct lineage. The 10 phylogenetic groups are thus considered new species of
<italic>Cladosporium</italic>
and are described in the taxonomy section below.</p>
</sec>
</sec>
<sec id="s4">
<title>TAXONOMY</title>
<p>
<bold>
<italic>Cladosporium alboflavescens</italic>
</bold>
Sandoval-Denis, Gené & Cano,
<italic>sp. nov.</italic>
— MycoBank MB815332;
<xref ref-type="fig" rid="F2">Fig. 2</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>albus</italic>
‘white’
<italic>flavus</italic>
‘yellow’, referring to the colony colour of the species.</p>
<p>Colonies on OA attaining 20–23 mm diam after 14 d at 25 °C, white to grey-yellow (4A1/C4), flat, velvety, margin regular and with abundant submerged mycelium; reverse olive brown (4D5/F8), without diffusible pigments. On PDA attaining 34–36 mm diam after 14 d at 25 °C, yellow-grey to olive brown (4B2/D4), with prominent light yellow (3A4) exudate, flat or umbonate, folded, margin regular; reverse grey-yellow to olive brown (4B4/F4) to black. On SNA reaching 22–25 mm after 14 d at 25 °C, obverse and reverse olive (3D5/E8), flat, velvety with granular centre, margin undulate and with abundant submerged mycelium.
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 2.5–5 μm wide, subhyaline to pale brown, smooth to slightly roughened, thin-walled hyphae.
<italic>Conidiophores</italic>
erect, straight, cylindrical, non-nodulose, septate, simple or branched, up to 130 μm long, 2.5–4 μm wide, pale brown, smooth or sparingly verrucose with darkened and refractive scars.
<italic>Conidiogenous cells</italic>
terminal or intercalary, cylindrical, geniculate, 7–36 × 2–4 μm, with up to five apical loci of 1.5–2 μm diam, thickened and refractive.
<italic>Ramoconidia</italic>
aseptate, subcylindrical to cylindrical, 11–36 × 2–3 μm, pale brown, smooth-walled.
<italic>Conidia</italic>
forming branched chains with up to three conidia in the terminal unbranched part, pale brown, sparingly verrucose, with protuberant, somewhat darkened and refractive conidial hila; small terminal conidia aseptate, oval, 5–6.5 × 2–3.5 μm (av. (± SD) 5.9 (± 0.4) × 2.8 (± 0.4)); intercalary conidia aseptate, ellipsoidal to almost cylindrical with attenuated ends, 7–13 × 2.5–3 μm (av. (± SD) 10.6 (± 2.5) × 2.6 (± 0.2)); secondary ramoconidia 0–1-septate, ellipsoidal, 8.5–18 × 2–3 μm (av. (± SD) 14.3 (± 3.3) × 2.6 (± 0.5)).</p>
<p>Cardinal temperature for growth — Optimum 20–25 °C, maximum 30 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined.</italic>
USA, California, from animal bronchoalveolar lavage fluid, Mar. 2009,
<italic>D.A. Sutton</italic>
(holotype CBS H-22379, culture ex-type CBS 140690 = UTHSC DI-13-225 = FMR 13338).</p>
<p>Notes —
<italic>Cladosporium alboflavescens</italic>
is morphologically similar to
<italic>C. pini-ponderosae</italic>
and
<italic>C. verrucocladosporioides</italic>
(
<xref rid="R32" ref-type="bibr">Schubert et al. 2009</xref>
,
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
). However, the new species differs mainly by its pale coloured vegetative structures, and its yellow to pale olive colonies on OA and PDA vs olivaceous grey in the two latter species. The phylogenetically closely related species
<italic>C. iranicum</italic>
(
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
) also shows similar micro-morphological characteristics to
<italic>C. alboflavescens</italic>
, but it differs in forming longer conidial chains with up to 10 conidia in the terminal unbranched part and often showing subrostrate intercalary conidia, while conidial chains of the novel species are much shorter and intercalary conidia ellipsoidal to cylindrical being also genetically well differentiated (99.8 %, 87.9 % and 90.1 % sequence similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively).</p>
<p>
<bold>
<italic>Cladosporium angulosum</italic>
</bold>
Sandoval-Denis, Deanna A. Sutton & Guarro,
<italic>sp. nov.</italic>
— MycoBank MB815333;
<xref ref-type="fig" rid="F3">Fig. 3</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>angulosus</italic>
‘full of corners’, referring to the shape of the conidiophore.</p>
<p>Colonies on OA reaching 52–55 mm after 14 d at 25 °C, olive brown (4E3/F8), flat, velvety to granular, with regular margin; reverse olive brown (4E3/F8) to black. On PDA attaining 50–56 mm diam after 14 d at 25 °C, olive brown (4F4/F8), with a raised or umbonate centre and radially folded towards the periphery, velvety to dusty or granular, with regular margin; reverse dark green (30F8) to black. On SNA reaching 37–40 mm after 14 d at 25 °C, olive brown (4D4/F6), flat, velvety, with lobulated margin; reverse olive brown (4D4/F6) to black.
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 1.5–3 μm wide, pale olivaceous brown, with smooth and thin-walled hyphae.
<italic>Conidiophores</italic>
erect, cylindrical, non-nodulose, septate, septa darkened, branched, frequently branching near the base in a 90° angle, up to 150 μm long, 3–4 μm wide, pale brown, smooth and thin-walled.
<italic>Conidiogenous cells</italic>
terminal or intercalary, cylindrical, 8–46 × 2–3.5 μm, bearing up to four conidiogenous loci of 1–1.5 μm diam, darkened and refringent.
<italic>Ramoconidia</italic>
aseptate, subcylindrical, straight, 24.5–46 × 2–3.5 μm, pale brown, finely roughened, with scars protuberant, thickened and darkened.
<italic>Conidia</italic>
forming long branched chains with up to 14 conidia in the terminal unbranched part, pale olivaceous brown, smooth and thin-walled, with protuberant conidial hila, not darkened; small terminal conidia aseptate, obovate to nearly cylindrical, 3.5–4.5 × 2–2.5 μm (av. (± SD) 4.1 (± 0.3) × 2.3 (± 0.3)); intercalary conidia aseptate, ellipsoidal, 4–6 × 2–3 μm (av. (± SD) 5.3 (± 0.6) × 2.4 (± 0.4)); secondary ramoconidia 0–1-septate, usually constricted at septum, subcylindrical, 8–17 × 2.5–3 μm (av. (± SD) 12.2 (± 2.6) × 2.8 (± 0.3)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 35 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Texas, from human bronchoalveolar lavage fluid, Sept. 2008,
<italic>D.A. Sutton</italic>
(holotype CBS H-22380, culture ex-type CBS 140692 = UTHSC DI-13-235 = FMR 13348).</p>
<p>Notes — The clade representative of
<italic>C. angulosum</italic>
includes several strains previously identified as
<italic>C. perangustum</italic>
, a species accepted with a considerable morphological and genetic diversity by
<xref rid="R3" ref-type="bibr">Bensch et al. (2010</xref>
,
<xref rid="R1" ref-type="bibr">2012</xref>
,
<xref rid="R2" ref-type="bibr">2015)</xref>
. However, it shows a sufficient genetic distance (ITS, 100 %;
<italic>tef1</italic>
, 77 %;
<italic>actA</italic>
, 85.4 % similarity) with respect to the ex-type strain of
<italic>C. perangustum</italic>
to be considered a distinct species. Morphologically,
<italic>C. angulosum</italic>
can be mainly differentiated from
<italic>C. perangustum</italic>
by its conidiophores, which are usually branched forming a 90° angle, while those of the latter are only occasionally branched. In addition, the new species produces smaller secondary ramoconidia and intercalary conidia (up to 17 μm and 6 μm long, respectively, vs 6–30(–34) μm and 4–16(–19) μm long, respectively, in
<italic>C. perangustum</italic>
) (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Another closely related species is
<italic>C. xantochromaticum</italic>
, but it is genetically well differentiated from
<italic>C. angulosum</italic>
(99.1 %, 81.1 % and 90.8 % similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively), and morphologically it has longer conidiogenous cells (up to 32 μm long vs 27 μm long in
<italic>C. angulosum</italic>
), smaller ramoconidia (up to 39 μm long vs 46 μm long in
<italic>C. angulosum</italic>
) and does not grow at 35 °C.</p>
<p>
<bold>
<italic>Cladosporium</italic>
</bold>
<bold>
<italic>anthropophilum</italic>
</bold>
Sandoval-Denis, Gené & Wiederhold,
<italic>sp. nov.</italic>
— MycoBank MB815334,
<xref ref-type="fig" rid="F4">Fig. 4</xref>
</p>
<p>
<italic>Etymology</italic>
. From the Greek
<italic>ánthrōpos</italic>
(áνθρωποζ) ‘human’ and
<italic>philos</italic>
(φíλοζ) ‘fondness’, referring to the source of the ex-type, human clinical samples.</p>
<p>Colonies on OA attaining 27–32 mm diam after 14 d at 25 °C, olive to olive brown (3F2/4F8), flat, dusty or granular, aerial mycelium scarce, with fimbriate margin; reverse olive brown (4F8) to black, without diffusible pigment. On PDA attaining 17–39 mm diam after 14 d at 25 °C, grey-green to deep green (28D7/D8), flat or folded, velvety to dusty or granular, aerial mycelium scarce, sometimes showing cottony to floccose white to grey cushions, with a regular margin; reverse dark green (28F8) to black. On SNA reaching 23–26 mm after 14 d at 25 °C, olive to olive brown (3F2/4F8), flat, dusty to cottony, aerial mycelium abundant, often with irregular to arachnoid margins; reverse olive to olive brown (3F2/4F8).
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 2–3 μm wide, subhyaline to pale green, smooth and thick-walled, anastomosing hyphae.
<italic>Conidiophores</italic>
erect, cylindrical, non-nodulose, geniculate, septate, usually branched, up to 550 μm long, 2–5 μm wide, pale green-brown, slightly roughened to verruculose toward the base, with a thickened and refractive wall.
<italic>Conidiogenous cells</italic>
terminal and intercalary, cylindrical or subcylindrical, 15–54 × 3–5 μm, often with a swollen apex, bearing 3–8(–10), protuberant, subdenticulate, 1–2.5 μm diam, thickened and somewhat darkened conidiogenous loci.
<italic>Ramoconidia</italic>
aseptate, cylindrical, 20–42 × 2–5 μm, pale green, smooth, with conidial scars protuberant, thickened and darkened.
<italic>Conidia</italic>
forming short branched chains with up to four conidia in the terminal unbranched part of the chain, aseptate, smooth or finely roughened, reticulate under SEM; small terminal conidia oval to ellipsoidal, 3.5–9 × 2–3 μm (av. (± SD) 5.6 (± 1.2) × 2.5 (± 0.4)), subhyaline; intercalary conidia limoniform to ellipsoidal, 4.5–11 × 2–3 μm (av. (± SD) 6.9 (± 1.8) × 2.7 (± 0.3)), light green-brown; secondary ramoconidia 0–1-septate, ellipsoidal to subcylindrical, usually attenuated at the centre, 7–28 × 2–5 μm (av. (± SD) 13.7 (± 4.8) × 3.4 (± 0.6)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 35 °C, minimum 5 °C.</p>
<p>
<italic>Specimens examined</italic>
. USA, Minnesota, from human bronchoalveolar lavage fluid, Sept. 2012,
<italic>D.A. Sutton</italic>
(holotype CBS H-22381, culture ex-type CBS 140685 = UTHSC DI-13-269 = FMR 13382); from human bronchoalveolar lavage fluid, Sept. 2012,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-168 = FMR 13293; California, from a hand, Oct. 2010,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-179 = FMR 13304; Florida, from human bronchoalveolar lavage fluid, Jan. 2007,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-271 = FMR 13384; from human bronchoalveolar lavage fluid, Mar. 2007,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-246 = FMR 13359; from an animal abscess, Jan. 2012,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-178 = FMR 13303; Massachusetts, from human bronchoalveolar lavage fluid, Mar. 2012,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-169 = FMR 13294; Texas, from human cerebrospinal fluid, Mar. 2009,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-207 = FMR 13320; from human bronchoalveolar lavage fluid, Jan. 2009,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-226 = FMR 13339; from human foot skin, May 2008,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-228 = FMR 13341; from human pleural fluid, Apr. 2008,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-244 = FMR 13357.</p>
<p>Notes —
<italic>Cladosporium anthropophilum</italic>
is probably a common saprobic fungus, as determined by the number of isolates evaluated, and can also represent a clinically relevant fungus, being the second most prevalent species identified in a set of clinical isolates from the USA after
<italic>C. halotolerans</italic>
(
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). The new taxon is morphologically similar to
<italic>C. cladosporioides</italic>
and
<italic>C. pseudocladosporioides</italic>
, but phylogenetically distant. Although the three species are difficult to separate morphologically,
<italic>C. anthropophilum</italic>
mainly differs by its longer (up to 550 μm) conidiophores and oval to ellipsoidal terminal conidia (3.5–9 μm long) showing a fine reticulation under SEM. The conidiophores of
<italic>C. cladosporioides</italic>
and
<italic>C. pseudocladosporioides</italic>
are 10–250 μm and 15–155 μm long, respectively, and their terminal conidia are subglobose to limoniform ((3–)4–8(–11) μm long) and with a irregularly reticulate or striped wall in the former, and obovoid to ellipsoidal (3–5.5 μm long) and smooth-walled or almost so in the latter species (
<xref rid="R16" ref-type="bibr">De Vries 1952</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
).
<italic>Cladosporium anthropophilum</italic>
also resembles
<italic>C. tenuissimum</italic>
, a species previously described as human opportunistic pathogen (
<xref rid="R15" ref-type="bibr">De Hoog et al. 2011</xref>
). However both are genetically well differentiated (99.3 %, 87.7 % and 89.9 % similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively) and, morphologically,
<italic>C. anthropophilum</italic>
shows longer terminal conidia (3.5–9 μm long (av. (± SD) 5.6 (± 1.2)) vs (2–)2.5–5(–6) μm long (av. (± SD) 3.7 ± 1.0)) in
<italic>C. tenuissimum</italic>
) and shorter intercalary conidia (4.5–11 μm long (av. (± SD) 6.9 (± 1.8)) vs 4–12(–17) μm long (av. (± SD) 8.1 (± 2.7)) in
<italic>C. tenuissimum</italic>
) (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
).</p>
<p>
<bold>
<italic>Cladosporium crousii</italic>
</bold>
Sandoval-Denis, Cano & Guarro,
<italic>sp. nov.</italic>
— MycoBank MB815341;
<xref ref-type="fig" rid="F5">Fig. 5</xref>
</p>
<p>
<italic>Etymology.</italic>
In honour of Pedro W. Crous for his extensive work on
<italic>Cladosporium</italic>
.</p>
<p>Colonies on OA attaining 47–50 mm diam after 14 d at 25 °C, olive to dark green (3F8/30F8), flat, velvety to granular, aerial mycelium scarce, margin fimbriate and with abundant submerged mycelia; reverse olive to dark green (3F8/30F8) to black, without diffusible pigment. On PDA attaining 73–77 mm diam after 14 d at 25 °C, olive brown (4E3/E6), radially folded, velvety or granular with floccose centre and regular margin; reverse at first dark brown (7F8) turning black. On SNA reaching 39–41 mm after 14 d at 25 °C, olive brown (4D5/F8), flat, velvety with floccose centre, margin fimbriate and with abundant submerged mycelium; reverse black
<italic>. Mycelium</italic>
superficial and immersed, composed of septate, branched, 2.5–3.5 μm wide, subhyaline hyphae, with slightly roughened walls.
<italic>Conidiophores</italic>
erect, cylindrical, septate, usually unbranched or sparingly branched, up to 230 μm long, 2–3.5 μm wide, pale green-brown, smooth-walled.
<italic>Conidiogenous cells</italic>
terminal and intercalary, cylindrical, sometimes geniculate toward the apex, 11–23 × 2.5–4 μm, bearing 1–4 conidiogenous loci of 1.5–2 μm diam, protuberant, black and refringent.
<italic>Ramoconidia</italic>
0–1-septate, subcylindrical to cylindrical, 19–39 × 2–3 μm, pale brown, smooth.
<italic>Conidia</italic>
forming long branched chains with up to seven conidia in the terminal unbranched part of the chain, subhyaline, smooth, with protuberant, thickened and darkened conidial hila; small terminal conidia aseptate, ellipsoidal to subcylindrical, with a central constriction, 7–9 × 2–2.5 μm (av. (± SD) 7.8 (± 0.7) × 2.2 (± 0.2)); intercalary conidia aseptate, ellipsoidal to cylindrical, slightly curved, aseptate, 9–10 × 2–3 μm (av. (± SD) 9.5 (± 0.5) × 2.3 (± 0.4)); secondary ramoconidia 0–1-septate, cylindrical, 9.5–24 × 2.5–3.5 μm (av. (± SD) 15.7 (± 4.4) × 2.8 (± 0.3)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 30 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, South Carolina, from human bronchoalveolar lavage fluid, May 2008,
<italic>D.A. Sutton</italic>
(holotype CBS H-22385, culture ex-type CBS 140686 = UTSHC DI-13-247 = FMR 13360).</p>
<p>Notes —
<italic>Cladosporium crousii</italic>
is closely related to
<italic>C. gamsianum</italic>
, but morphologically they are clearly differentiated. The first species is characterised by longer (up to 230 μm long) and pale coloured conidiophores with unthickened walls, and longer ellipsoidal terminal conidia (7–9 μm long). In contrast,
<italic>C. gamsianum</italic>
exhibits dark brown and thick-walled conidiophores of 10–146 μm long, and obovoid terminal conidia of 3–6 μm long (
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
).</p>
<p>
<bold>
<italic>Cladosporium flavovirens</italic>
</bold>
Sandoval-Denis, Gené & Guarro,
<italic>sp. nov.</italic>
— MycoBank MB814508;
<xref ref-type="fig" rid="F6">Fig. 6</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>flavus</italic>
‘yellow’ and
<italic>virens</italic>
‘green’, referring to the colony colour on OA.</p>
<p>Colonies on OA attaining 53–55 mm diam after 14 d at 25 °C, olive yellow to olive (2D8/3F8) with olive grey to olive (2F2/E2) patches, flat, velvety to floccose, margin fimbriate and with abundant submerged mycelium; reverse olive yellow to olive (2D8/3F8) to black, without diffusible pigment. On PDA attaining 63–65 mm diam after 14 d at 25 °C, obverse and reverse green-grey to dark green (30F2/F8), flat or umbonate and radially folded, velvety, with regular margin. On SNA reaching from 30–32 mm after 14 d at 25 °C, olive to olive brown (2E8/3E8), flat, velvety to granular, margin slightly irregular and with abundant submerged mycelium; reverse olive yellow (2D8) to black.
<italic>Mycelium</italic>
superficial and immersed composed of septate, branched, 2–3 μm wide, subhyaline to pale green-brown, rough- and thick-walled hyphae, with abundant anastomoses.
<italic>Conidiophores</italic>
erect, cylindrical, sometimes geniculate, non-nodulose, septate, simple or branched, up to 170 μm long, 4–5 μm wide, medium green-brown, slightly roughened to verruculose, with thick and refractive walls.
<italic>Conidiogenous cells</italic>
terminal or intercalary, subcylindrical or cylindrical, 15–54 × 3–5 μm, bearing up to four conidiogenous loci of 1–2 μm diam, darkened and refringent.
<italic>Ramoconidia</italic>
0–1-septate, subcylindrical to cylindrical, often geniculate, 27–75 × 3–4 μm, smooth or finely verruculose.
<italic>Conidia</italic>
forming branched chains with up to five conidia in the terminal unbranched part, pale green-brown, smooth- and thick-walled, with protuberant and darkened conidial hila; small terminal conidia aseptate, obovoidal to short ellipsoidal, 5–7 × 2.5–3 μm (av. (± SD) 5.9 (± 0.6) × 2.9 (± 0.2)); intercalary conidia aseptate, ellipsoidal, 7–10 × 3–3.5 μm (av. (± SD) 8.3 (± 0.9) × 3.2 (± 0.2)); secondary ramoconidia 0–2-septate, ellipsoidal to cylindrical, 9–30 × 3.5–4 μm (av. (± SD) 16.2 (± 6.7) × 3.8 (± 0.3)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 35 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Florida, from human toenail, Nov. 2006,
<italic>D.A. Sutton</italic>
(holotype CBS H-22326, culture ex-type CBS 140462 = UTHSC DI-13-273 = FMR 13386).</p>
<p>Notes —
<italic>Cladosporium flavovirens</italic>
is morphologically and phylogenetically related to
<italic>C. flabelliforme</italic>
. However, the new species is genetically well differentiated (99.8 %, 80.9 % and 81.8 % sequence similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively) and produces somewhat longer secondary ramoconidia (up to 30 μm) which are often septate, in contrast to the aseptate secondary ramoconidia of
<italic>C. flabelliforme</italic>
which are up to 27 μm long (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
).</p>
<p>
<bold>
<italic>Cladosporium floccosum</italic>
</bold>
Sandoval-Denis, Cano & Guarro,
<italic>sp. nov.</italic>
— MycoBank MB814509;
<xref ref-type="fig" rid="F7">Fig. 7</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>floccosus</italic>
‘spotted with small tufts’, referring to the macroscopic characteristics of the colony.</p>
<p>Colonies on OA reaching 24–27 mm after 14 d at 25 °C, grey-beige to olive brown (4C1/F4), slightly umbonate and radially folded, velvety to dusty with regular margins; reverse olive brown (4D4/F4), without diffusible pigments. On PDA attaining 47–50 mm diam after 14 d at 25 °C, grey-green to dark green (30E5/F7), flat to umbonate and slightly folded, velvety with white cottony centre and regular margin; reverse olive brown (4D8/E8) with black patches. On SNA reaching 15–20 mm after 14 d at 25 °C, olive brown (4D2/F4), flat, velvety to floccose with abundant grey aerial mycelium, margin lobate and fimbriate with abundant submerged mycelium; reverse olive brown to dull green (4E4/30E4).
<italic>Mycelium</italic>
superficial and immersed composed of septate, branched, 1.5–4.5 μm wide, subhyaline to pale brown, verruculose and thin-walled hyphae.
<italic>Conidiophores</italic>
erect, flexuous, subcylindrical, distinctly geniculate, septate, mostly unbranched, up to 100 μm long, 4–5 μm wide, pale to medium olivaceous brown, smooth to slightly roughened, with thickened, darkened and refractive walls.
<italic>Conidiogenous cells</italic>
terminal, cylindrical, nodulose, 16–24 × 3–5 μm, smooth and thick-walled, bearing up to three conspicuous, refractive, slightly darkened conidiogenous loci of 1.5–2.5 μm diam.
<italic>Ramoconidia</italic>
not observed.
<italic>Conidia</italic>
forming unbranched chains with up to three conidia, pale brown, echinulate, with protuberant and darkened conidial hila; small terminal conidia 0–1-septate, sometimes slightly constricted at septa, obovoidal to ovoidal, 8–12.5 × 6–8.5 μm (av. (± SD) 10.7 (± 1.8) × 6.8 (± 0.9)); intercalary conidia 0–1-septate, ellipsoidal, 12–15 × 6–8.5 μm (av. (± SD) 13.7 (± 1.0) × 7.5 (± 0.8)); secondary ramoconidia not observed.</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 30 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Minnesota, from human ethmoid sinus, Sept. 2010,
<italic>D.A. Sutton</italic>
(holotype CBS H-22327, culture ex-type CBS 140463 = UTHSC DI-13-212 = FMR 13325).</p>
<p>Notes —
<italic>Cladosporium floccosum</italic>
is morphologically similar to
<italic>C. sinuosum</italic>
, which is also its closest phylogenetic relative; both species have distinctly geniculate conidiophores and do not form ramoconidia. However,
<italic>C. floccosum</italic>
has considerably smaller (up to 100 μm long) and rarely branched conidiophores and slightly shorter terminal conidia (up to 12.5 μm long) respect to those of
<italic>C. sinuosum</italic>
, which has conidiophores up to 380 μm long and terminal conidia up to 15 μm long (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R2" ref-type="bibr">Bensch et al. 2015</xref>
).</p>
<p>
<bold>
<italic>Cladosporium subcinereum</italic>
</bold>
Sandoval-Denis, Deanna A. Sutton & Gené,
<italic>sp. nov.</italic>
— MycoBank MB814511;
<xref ref-type="fig" rid="F8">Fig. 8</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>subcinereus</italic>
‘somewhat grey’, referring to the colony colour.</p>
<p>Colonies on OA reaching 29–32 mm after 14 d at 25 °C, yellow-grey to olive grey (3B2/E2), flat, velvety to cottony, with regular margin, abundant crystalline exudates occasionally present; reverse yellow-grey to olive grey (3B2/E2) to black. On PDA attaining 34–37 mm diam after 14 d at 25 °C, yellow-grey to olive (3B2/F8), flat to radially folded, velvety to floccose, with regular margin; reverse dark green (30F8) to black. On SNA reaching 14–16 mm after 14 d at 25 °C, obverse and reverse white to olive (3A1/E3), flat, velvety to cottony, with regular margin.
<italic>Mycelium</italic>
superficial and immersed, composed of branched, septate, 2–5 μm wide, subhyaline hyphae with smooth or minutely verruculose and unthickened walls.
<italic>Conidiophores</italic>
erect, flexuous, geniculate and nodulose, septate, simple or branched, up to 140 μm long, 4–6 μm wide, pale to medium-brown, smooth to verruculose and thick-walled.
<italic>Conidiogenous cells</italic>
terminal, subcylindrical, nodulose, geniculate, 16–38 × 4–6 μm, thick-walled, bearing up to three conidiogenous loci of 2–3 μm diam, protuberant, darkened and refractive.
<italic>Ramoconidia</italic>
rarely formed, 0–2 septate, cylindrical, nodulose, 19–59 × 3–6 μm, pale brown, finely roughened.
<italic>Conidia</italic>
in branched chains, with up to three conidia in the terminal unbranched part, pale brown, echinulate, muricate to pustulate under SEM and thick-walled, with protuberant and not darkened conidial hila; small terminal conidia 0–1-septate, globose to subglobose, 5–7 × 4.5–6.5 μm (av. (± SD) 5.6 (± 0.7) × 5.3 (± 0.6)); intercalary conidia 0–1-septate, subglobose, obovoidal to ellipsoidal, 6–10 × 5–6.5 μm (av. (± SD) 8.9 (± 1.4) × 5.9 (± 0.6)); secondary ramoconidia 0–2-septate, sometimes constricted at septum, ellipsoidal to subcylindrical, often inflated at the apex, 8–27 × 4–7 μm (av. (± SD) 16.3 (± 5.6) × 5.0 (± 0.8)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 30 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Montana, from human sputum, Sept. 2007,
<italic>D.A. Sutton</italic>
(holotype CBS H-22329, culture ex-type CBS 140465 = UTHSC DI-13-257 = FMR 13370).</p>
<p>Notes — This species is phylogenetically related to
<italic>C. angustiherbarum</italic>
and
<italic>C. variabile</italic>
. However,
<italic>C. angustiherbarum</italic>
produces shorter and narrower conidiophores (up to 60 μm long and 4 μm wide) and does not form ramoconidia, while
<italic>C. variabile</italic>
produces multiseptate ramoconidia and long chains of broadly ellipsoidal conidia with a fine granulate ornamentation under SEM (
<xref rid="R16" ref-type="bibr">De Vries 1952</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). In
<italic>C. subcinereum</italic>
the ramoconidia are rarely formed and when present they are 0–2-septate, and its conidia are subglobose, obovoidal to ellipsoidal, exhibiting a much prominent muricate to pustulate ornamentation under SEM.
<italic>Cladosporium herbaroides</italic>
and
<italic>C. herbarum</italic>
are also morphologically similar to
<italic>C. subcinereum</italic>
, but they can be mainly differentiated by having larger/longer conidia (3–33 × (2–)3–6(–7) μm and 10–26(–35) × 2–3.5 μm respect to the two types of conidia described in
<italic>C. herbaroides</italic>
, and 4–10 × 3–5(–6) μm in
<italic>C. herbarum</italic>
) (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
).</p>
<p>
<bold>
<italic>Cladosporium succulentum</italic>
</bold>
Sandoval-Denis, Deanna A. Sutton & Cano,
<italic>sp. nov.</italic>
— MycoBank MB814512;
<xref ref-type="fig" rid="F9">Fig. 9</xref>
</p>
<p>
<italic>Etymology</italic>
. From Latin
<italic>succo</italic>
‘juice’ and
<italic>ulentum</italic>
‘full of’, referring to the abundant production of exudates on PDA.</p>
<p>Colonies on OA reaching 23–25 mm after 14 d at 25 °C, dark green (30F3/F8), flat, granular to floccose, with fimbriate margin; reverse olive to dark green (3F8/30F4) turning black. On PDA attaining 28–35 mm diam after 14 d at 25 °C, olive brown (4F4/F8), flat, velvety to granular, with regular margin, producing abundant dark green exudates after 20–25 d; reverse black-blue (20F8) to black. On SNA reaching 27–32 mm after 14 d at 25 °C, obverse and reverse olive to olive brown (3E8/4E8), flat, downy to granular, with regular margin.
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 1.5–3.5 μm wide, subhyaline, smooth- and thin-walled hyphae.
<italic>Conidiophores</italic>
erect, straight or flexuous, septate, highly branched, up to 190 μm long, 2.5–4 μm wide, subhyaline, pale green-brown, smooth to finely roughened and thin-walled.
<italic>Conidiogenous cells</italic>
terminal and intercalary, cylindrical, 13–30 × 2–4 μm, thin-walled, bearing 2–6 conidiogenous loci of 1–2.5 μm diam, darkened and refractive.
<italic>Ramoconidia</italic>
0–1-septate, cylindrical to subcylindrical, flexuous, 20–36 × 2–4 μm, pale green-brown, smooth to finely roughened.
<italic>Conidia</italic>
in branched chains, with up to six conidia in the terminal unbranched part, aseptate, pale green-brown, smooth- and thin-walled, with protuberant and darkened conidial hila; small terminal conidia oval to short clavate, 3–4 × 2–3 μm (av. (± SD) 3.6 (± 0.4) × 2.2 (± 0.4)), aseptate, with conspicuous and darkened conidial scars; intercalary conidia ovoid to limoniform, 4–6 × 2–3 μm (av. (± SD) 5.1 (± 0.6) × 2.3 (± 0.4)), with protuberant and not darkened conidial scars; secondary ramoconidia ellipsoidal to subcylindrical, 5–10 × 2–4.5 μm (av. (± SD) 8.2 (± 1.5) × 2.5 (± 0.4)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 35 °C, minimum 15 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Florida, from a dolphin bronchus, July 2007,
<italic>D.A. Sutton</italic>
(holotype CBS H-22330, culture ex-type CBS 140466 = UTHSC DI-13-262 = FMR 13375).</p>
<p>Notes —
<italic>Cladosporium succulentum</italic>
is morphologically similar but genetically distant to
<italic>C. halotolerans</italic>
(98.4 %, 66.5 % and 79.8 % sequence similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively) and
<italic>C. sphaerospermum</italic>
(97.5 %, 72.7 % and 83.8 % sequence similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively). The latter two species can be differentiated from
<italic>C. succulentum</italic>
by having a maximum growth temperature at 30 °C (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
) (35 °C in
<italic>C. succulentum</italic>
), and in the length and number of septa of their ramoconidia. In
<italic>C. halotolerans</italic>
and
<italic>C. sphaerospermum</italic>
these are 15–37 μm and (11.5–)20.5–40(–48) μm long, respectively, and they have up to five septa (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
), while in
<italic>C. succulentum</italic>
the ramoconidia are 20–36 μm long with 0–1 septa. The phylogenetically closest species to C
<italic>. succulentum</italic>
are
<italic>C. fusiforme</italic>
and
<italic>C. velox</italic>
(sequence similarities less than 99.8 %, 80.7 % and 86.6 % for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively), but the new species can be differentiated by the abundant production of ramoconidia and by its oval to short clavate terminal conidia. Ramoconidia in
<italic>C. fusiforme</italic>
and
<italic>C. velox</italic>
are rarely formed and their terminal conidia are obovoid to fusiform in the first species and globose to ovoid in the latter one (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
).</p>
<p>
<bold>
<italic>Cladosporium tuberosum</italic>
</bold>
Sandoval-Denis, Cano & Wiederhold,
<italic>sp. nov.</italic>
— MycoBank MB815339;
<xref ref-type="fig" rid="F10">Fig. 10</xref>
</p>
<p>
<italic>Etymology.</italic>
From Latin
<italic>tūberōsus</italic>
‘lumpy’ (full of protuberances), because of the nodulose shape of its conidiophores.</p>
<p>Colonies on OA reaching 23–26 mm after 14 d at 25 °C, olive brown (4D5/F7), flat, velvety to floccose, margin regular and with abundant submerged mycelium; reverse olive brown (4D5/F7) to black. On PDA attaining 44–50 mm diam after 14 d at 25 °C, dull green to dark green (30E4/F7), flat and radially folded, velvety to dusty, margin regular and white; reverse olive brown (4E8) to black. On SNA reaching 13–20 mm after 14 d at 25 °C, olive brown (4E4/F4), flat, velvety with cottony patches, margin irregular and with abundant submerged mycelium; reverse olive brown (4E4/F4) to black.
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 3–4.5 μm wide, subhyaline, smooth and thin-walled hyphae.
<italic>Conidiophores</italic>
erect, flexuous, cylindrical-oblong, nodulose, or bent once or several times being geniculate, laterally swollen, septate, unbranched or rarely laterally branched, up to 390 μm long, 5–6 μm wide, pale brown to olivaceous brown, smooth- and thick-walled.
<italic>Conidiogenous cells</italic>
terminal or intercalary, cylindrical or subnodulose, 15–38 × 4–5.5 μm, proliferating sympodially, forming lateral shoulders, bearing 1–2 conidiogenous loci at each shoulder, loci protuberant, 2–2.5 μm diam, darkened and refringent.
<italic>Ramoconidia</italic>
not observed.
<italic>Conidia</italic>
in branched chains, with up to three conidia in the terminal part, 0–1-septate, green-brown to yellow-brown, verrucose to echinulate and thick-walled with protuberant and darkened conidial hila; small terminal conidia oval, obovate or short ellipsoidal, 8–14 × 7–9 μm (av. (± SD) 13.1 (± 0.7) × 8.0 (± 0.8)); intercalary conidia ellipsoidal to limoniform, 11–16 × 7–10 μm (av. (± SD) 13.9 (± 1.7) × 8.5 (± 0.9)); secondary ramoconidia ellipsoidal to subcylindrical, 14–18 × 6–10 μm (av. (± SD) 16.1 (± 1.2) × 7.1 (± 1.3)).</p>
<p>Cardinal temperature for growth — Optimum 25 °C, maximum 30 °C, minimum 5 °C.</p>
<p>
<italic>Specimens examined</italic>
. USA, Florida, from human nasal biopsy, Dec. 2009,
<italic>D.A. Sutton</italic>
(holotype CBS H-22387, culture ex-type CBS 140693 = UTHSC DI-13-217 = FMR 13330); Washington, from human foot, Oct. 2009,
<italic>D.A. Sutton</italic>
, UTHSC DI-13-219 = FMR 13332.</p>
<p>Notes — This species is represented by two isolates of human clinical origin which cluster in a lineage clearly differentiated and together with
<italic>C. basiinflatum</italic>
group in a position basal to the remaining species of the
<italic>C. herbarum</italic>
complex (
<xref ref-type="fig" rid="F1">Fig. 1</xref>
). Despite this basal position, it shows the typical morphological features of the species of the complex.
<italic>Cladosporium tuberosum</italic>
morphologically resembles
<italic>C. sinuosum</italic>
in the production of short conidial chains and the absence of ramoconidia (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
). However, in
<italic>C. tuberosum</italic>
the conidiophores are not as geniculate as in
<italic>C. sinuosum</italic>
and the conidia are always grouped forming short chains, while the conidia in
<italic>C. sinuosum</italic>
are often solitary although short chains can be also present (
<xref rid="R2" ref-type="bibr">Bensch et al. 2015</xref>
). In addition,
<italic>C. tuberosum</italic>
exhibits a faster growth rate on PDA, forming colonies almost black at the obverse rather than the olivaceous grey to pale olivaceous grey colonies of
<italic>C. sinuosum</italic>
(
<xref rid="R2" ref-type="bibr">Bensch et al. 2015</xref>
).</p>
<p>
<bold>
<italic>Cladosporium</italic>
</bold>
<bold>
<italic>xantochromaticum</italic>
</bold>
Sandoval-Denis, Gené & Cano,
<italic>sp. nov.</italic>
— MycoBank MB815340;
<xref ref-type="fig" rid="F11">Fig. 11</xref>
</p>
<p>
<italic>Etymology</italic>
. From Greek
<italic>xanthós</italic>
(ξανθóζ) ‘yellow’ and
<italic>khrôma</italic>
(χρῶμα) ‘colour’, referring to the production of a yellow diffusible pigment on PDA.</p>
<p>Colonies on OA reaching 40–50 mm after 14 d at 25 °C, obverse and reverse olive brown to grey-green (4F8/30E7), flat, granular, radiate, margin regular and with abundant submerged mycelium; diffusible pigment absent. On PDA attaining 60–67 mm diam after 14 d at 25 °C, olive brown (4E8/F8), flat or folded at centre, dusty or granular, velvety toward the periphery, margin regular, white to yellow, and with abundant submerged mycelium; reverse black, with a light yellow to grey-yellow (2A5/B5) diffusible pigment. On SNA reaching 35–37 mm after 14 d at 25 °C, olive brown (4E5/E8), flat, velvety to granular, radiate, margin regular and with abundant submerged mycelium; reverse olive brown (4E5/E8) to black, without diffusible pigment.
<italic>Mycelium</italic>
superficial and immersed, composed of septate, branched, 1.5–3 μm wide, pale brown, smooth and thin-walled hyphae.
<italic>Conidiophores</italic>
erect, flexuous, cylindrical, non-nodulose, septate, simple or branched typically immediately before a septum, up to 210 μm long, 2–4 μm wide, pale brown, smooth and thin-walled.
<italic>Conidiogenous cells</italic>
terminal, cylindrical, sometimes geniculate, 12–32 × 3–4 μm, bearing up to three conidiogenous loci of 1–1.5 μm diam, darkened and refringent.
<italic>Ramoconidia</italic>
aseptate, subcylindrical to cylindrical, 18–36 × 2–3.5 μm, pale brown, smooth or finely roughened.
<italic>Conidia</italic>
forming branched chains, with up to four conidia in the terminal unbranched part, pale green-brown, smooth- and thin-walled, with protuberant, not darkened conidial hila; small terminal conidia aseptate, obovate to short ellipsoidal 4–5 × 2–2.5 μm (av. (± SD) 4.3 (± 0.3) × 2.2 (± 0.2)); intercalary conidia aseptate, ellipsoidal to limoniform, 5–7 × 2.5–3.5 μm (av. (± SD) 5.8 (± 0.6) × 2.6 (± 0.3)); secondary ramoconidia 0–1-septate, subcylindrical, sometimes slightly constricted at the centre, 10–28 × 3–4 μm (av. (± SD) 15.7 (± 5.2) × 3.3 (± 0.4)).</p>
<p>Cardinal temperature for growth — Optimum 20 °C, maximum 30 °C, minimum 5 °C.</p>
<p>
<italic>Specimen examined</italic>
. USA, Texas, from human bronchoalveolar lavage fluid, Sept. 2010,
<italic>D.A. Sutton</italic>
(holotype CBS H-22388, culture ex-type CBS 140691 = UTHSC DI-13-211 = FMR 13324).</p>
<p>Notes — This species belongs to the
<italic>C. cladosporioides</italic>
species complex and clusters with
<italic>C. angulosum</italic>
and
<italic>C. perangustum</italic>
, forming a basal lineage characterised by narrow conidia and slightly roughened conidiophores and conidia.
<xref rid="R1" ref-type="bibr">Bensch et al. (2012)</xref>
considered
<italic>C. perangustum</italic>
a species with considerable genetic variability but morphologically uniform. The new species, however, is genetically (99.1 %, 75 % and 89.1 % sequence similarity for ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
, respectively) and phenotypically well differentiated from
<italic>C. perangustum</italic>
.
<italic>Cladosporium xantochromaticum</italic>
has smaller ramoconidia (18–36 × 2–3.5 μm) and smooth-walled conidiophores, while in
<italic>C. perangustum</italic>
the ramoconidia are 25–45 × 2.5–3(–4.5) μm and the conidiophores are more or less rough-walled especially towards the base, asperulate-verruculose, and smooth to almost so at the apex (
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
).</p>
</sec>
<sec id="s5">
<title>DISCUSSION</title>
<p>The genus
<italic>Cladosporium</italic>
has been extensively reviewed in recent years in efforts to clarify the phylogeny and taxonomic structure of its species and allied fungi, and has resulted in a modern redefinition of the genus (
<xref rid="R8" ref-type="bibr">Crous et al. 2007a</xref>
,
<xref rid="R9" ref-type="bibr">b</xref>
,
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
,
<xref rid="R1" ref-type="bibr">2012</xref>
,
<xref rid="R2" ref-type="bibr">2015</xref>
). However, until recently, no attempt had been made to study the impact of these new approaches in the diversity of
<italic>Cladosporium</italic>
species of clinical interest.</p>
<p>In a previous study, we demonstrated that the species diversity of
<italic>Cladosporium</italic>
associated to clinical samples was underestimated (
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). Furthermore, we found that species traditionally considered clinically relevant, identified by phenotypic criteria alone, were among the least represented. In fact, several morphologically similar sibling species were found to be more prevalent, including putative new taxa (
<xref rid="R15" ref-type="bibr">De Hoog et al. 2011</xref>
,
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). Those previously undescribed lineages are characterised here using both molecular and phenotypic criteria and resulting in the proposal of 10 new
<italic>Cladosporium</italic>
species. Sampling for this study was limited to isolates from the USA, and a wider sampling area is expected to provide a more precise reflection of the real distribution of these new species around the world.</p>
<p>The new species proposed here have been mostly isolated from human respiratory samples, which might be explained by the fact that
<italic>Cladosporium</italic>
conidia are easily dispersed by air (
<xref rid="R13" ref-type="bibr">David 1997</xref>
). However, the clinical relevance of the species of this genus, at least to produce invasive disease, has been questioned by their inability to grow at 37 °C (
<xref rid="R15" ref-type="bibr">De Hoog et al. 2011</xref>
,
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
), which was also confirmed with the new species. Nevertheless, despite the large number of species involved in this study, some of them were represented by numerous isolates, such as
<italic>C. anthropophilum</italic>
, which could be linked to a certain degree of specialisation towards colonisation of the human respiratory tract.</p>
<p>Within a given species complex, the different species of
<italic>Cladosporium</italic>
are often difficult to identify from morphological characters alone. However, some key differential features have been identified and have been detailed in a series of monographic papers (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). We have followed the criteria from those papers in order to distinguish potentially new species from their closest phylogenetic and morphological relatives. As is usual in this genus, no sexual morphs were observed in any of them
<italic>.</italic>
In fact, sexual structures have been observed in vitro in only eight accepted species of
<italic>Cladosporium</italic>
(
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Among the species described here, the most relevant differential morphological traits were the presence of ramoconidia, the length, complexity and ornamentation of the conidiophores, intercalary and terminal conidia. However, given the overlapping of these features, and the need for standardisation using special culture media and scanning electron microscopy procedures, the use of a molecular approach should be mandatory for correct identification of the species in this complex fungal group. With these studies, we have considerably expanded the list of
<italic>Cladosporium</italic>
species as potential human opportunistic fungi, which makes their identification difficult given their high morphological similarity (
<xref rid="R14" ref-type="bibr">De Hoog et al. 2015</xref>
). That said, distinguishing morphologically similar species of
<italic>Cladosporium</italic>
seems not to be as relevant from a clinical perspective because the in vitro antifungal response does not differ considerably between species of the same species complex (
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
). In contrast, in vitro antifungal susceptibilities do differ between species complexes, with the
<italic>C. sphaerospermum</italic>
complex showing higher inhibitory concentrations against amphotericin B, azoles and caspofungin (
<xref rid="R31" ref-type="bibr">Sandoval-Denis et al. 2015</xref>
).</p>
<p>Our phylogenetic studies agree with previous revisions of the genus (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
,
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). The most phylogenetic informative markers were
<italic>actA</italic>
and
<italic>tef1</italic>
, while ITS sequences were usually identical for species of the same complex as previously reported by
<xref rid="R3" ref-type="bibr">Bensch et al. (2010)</xref>
. Although most of the taxa in the present study are consistently separated in terms of their genetic and morphological differences, a high genetic variability was observed in the clades representing the new species
<italic>C. anthropophilum</italic>
and
<italic>C. tuberosum</italic>
, as well in clades representing well-known species, i.e.
<italic>C. allicinum</italic>
,
<italic>C. perangustum</italic>
,
<italic>C. pseudocladosporioides</italic>
,
<italic>C. sinuosum</italic>
and
<italic>C. tenuissimum.</italic>
This might indicate an ongoing process of active divergence and speciation as it has been described for other fungi, which demands further study (
<xref rid="R20" ref-type="bibr">Gao et al. 2015</xref>
).</p>
<p>Several studies have shown a higher number of species in the
<italic>C. cladosporioides</italic>
complex (
<xref rid="R3" ref-type="bibr">Bensch et al. 2010</xref>
,
<xref rid="R1" ref-type="bibr">2012</xref>
,
<xref rid="R2" ref-type="bibr">2015</xref>
) and our results agree with them. Of the taxa that were newly described here, six species belonged to the
<italic>C. cladosporioides</italic>
complex, whereas only three and one, belonged to the
<italic>C. herbarum</italic>
and
<italic>C. sphaerospermum</italic>
species complexes, respectively. The
<italic>C. cladosporioides</italic>
complex is phylogenetically well defined and includes a large group of species characterised by unbranched or branched, almost cylindrical conidiophores, bearing ovoid to ellipsoidal intercalary and terminal conidia, smooth or rarely showing a fine ornamentation (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). Although most of the known species of this complex do not tolerate high temperatures, our results showed that in the
<italic>C. cladosporioides</italic>
complex at least three of the new species (
<italic>C. angulosum</italic>
,
<italic>C. anthropophilum</italic>
and
<italic>C. flavovirens</italic>
), as well as several isolates identified as
<italic>C. pseudocladosporioides</italic>
are able to grow at 35 °C, which might explain their relatively high rate of isolation from homoeothermic hosts.</p>
<p>The
<italic>C. herbarum</italic>
species complex is also phylogenetically and morphologically well defined and contains a less diverse group of species characterized by nodulose conidiophores, bearing distinctly ornamented, globose to subglobose terminal conidia (
<xref rid="R33" ref-type="bibr">Schubert et al. 2007</xref>
). It is interesting that none of the new species of this complex were able to grow at temperatures higher than 30 °C. In contrast, the only new species described in the
<italic>C. sphaerospermum</italic>
complex was able to growth and sporulate, although poorly, at 35 °C. The members of the
<italic>C. sphaerospermum</italic>
species complex are morphologically homogeneous, characterised by conidiophores that are usually branched and lacking nodose inflations, producing both smooth-walled and ornamented conidia (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
). Most species currently included in this group exhibit a high degree of osmotic tolerance, but are unable to grow at temperatures exceeding 30 °C (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). However, it has been suggested previously that this complex does not represent a monophyletic group, but most likely represents various species complexes instead (
<xref rid="R1" ref-type="bibr">Bensch et al. 2012</xref>
). This was also suggested by our phylogenetic results which revealed that the species currently included in the
<italic>C. sphaerospermum</italic>
complex consistently grouped together as a polyphyletic arrangement in both combined and individual analyses, forming at least five different lineages with high statistical support and important genetic differences. The new species
<italic>C. succulentum</italic>
grouped in a lineage with
<italic>C. aciculare</italic>
,
<italic>C. fusiforme</italic>
,
<italic>C. longissimum</italic>
,
<italic>C. sphaerospermum</italic>
and
<italic>C. velox</italic>
. However, as previously described, there are no phenotypic differences to discriminate among these closely related taxa that would warrant the establishment of additional species complexes to accommodate these lineages (
<xref rid="R39" ref-type="bibr">Zalar et al. 2007</xref>
,
<xref rid="R2" ref-type="bibr">Bensch et al. 2015</xref>
).</p>
<p>In this study, the analysis of isolates from human and animal clinical specimens has allowed us to considerably increase the known diversity of species for the genus, expanding substantially the spectrum of species of potential clinical interest. Further studies are needed to fully understand the ecology and importance of these new species in the aetiology of infections in warm-blooded hosts.</p>
</sec>
</body>
<back>
<ack>
<p>This study was supported by the Spanish Ministerio de Economía y Competitividad, grants CGL 2011-27185 and CGL2013-43789-P.</p>
</ack>
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<floats-group>
<fig id="F1" orientation="portrait" position="float">
<label>Fig. 1</label>
<caption>
<p>Maximum likelihood (ML) tree obtained from the combined ITS,
<italic>tef1</italic>
and
<italic>actA</italic>
sequences of 196 strains from
<italic>Cladosporium</italic>
species. The tree is rooted with
<italic>Cercospora beticola</italic>
CBS 116456. Numbers on the branches represent ML bootstrap support values of 70 % and higher, followed by Bayesian posterior probabilities (pp) above 0.94. Fully supported branches are thickened and names of species newly described here are indicated in
<bold>bold</bold>
. Coloured blocks represent the species complex affinity of the novelties described here. Branch lengths are proportional to distance.</p>
<p>
<sup>T</sup>
Ex-type strain.
<sup>ET</sup>
Ex-epitype strain.
<sup>NT</sup>
Ex-neotype strain.</p>
</caption>
<graphic xlink:href="per-36-281-g001a"></graphic>
<graphic xlink:href="per-36-281-g001b"></graphic>
<graphic xlink:href="per-36-281-g001c"></graphic>
</fig>
<fig id="F2" orientation="portrait" position="float">
<label>Fig. 2</label>
<caption>
<p>
<italic>Cladosporium alboflavescens</italic>
CBS 140690. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–f. conidiophores and conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g002"></graphic>
</fig>
<fig id="F3" orientation="portrait" position="float">
<label>Fig. 3</label>
<caption>
<p>
<italic>Cladosporium angulosum</italic>
CBS 140692. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–f. conidiophores and chains of conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g003"></graphic>
</fig>
<fig id="F4" orientation="portrait" position="float">
<label>Fig. 4</label>
<caption>
<p>
<italic>Cladosporium anthropophilum</italic>
CBS 140685. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–e. conidiophores and chains of conidia; f–g. detail of conidial ornamentation. — Scale bars: a–c = 10 mm; d–e = 5 μm; f–g = 1 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g004"></graphic>
</fig>
<fig id="F5" orientation="portrait" position="float">
<label>Fig. 5</label>
<caption>
<p>
<italic>Cladosporium crousii</italic>
CBS 140686. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–e. conidiophores and chains of conidia; f. conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g005"></graphic>
</fig>
<fig id="F6" orientation="portrait" position="float">
<label>Fig. 6</label>
<caption>
<p>
<italic>Cladosporium flavovirens</italic>
CBS 140462. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d, e. conidiophores and chains of conidia; f. conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g006"></graphic>
</fig>
<fig id="F7" orientation="portrait" position="float">
<label>Fig. 7</label>
<caption>
<p>
<italic>Cladosporium floccosum</italic>
CBS 140463. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–e. conidiophores and conidia; f. chain of conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g007"></graphic>
</fig>
<fig id="F8" orientation="portrait" position="float">
<label>Fig. 8</label>
<caption>
<p>
<italic>Cladosporium subcinereum</italic>
CBS 140465. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–e. conidiophores and chains of conidia; f–g. detail of conidial ornamentation. — Scale bars: a–c = 10 mm; d–e = 5 μm; f–g = 1 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g008"></graphic>
</fig>
<fig id="F9" orientation="portrait" position="float">
<label>Fig. 9</label>
<caption>
<p>
<italic>Cladosporium succulentum</italic>
CBS 140466. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–e. conidiophores and chains of conidia; f. conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g009"></graphic>
</fig>
<fig id="F10" orientation="portrait" position="float">
<label>Fig. 10</label>
<caption>
<p>
<italic>Cladosporium tuberosum</italic>
CBS 140693
<italic>.</italic>
a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–f. conidiophores, conidiogenous cells and conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g010"></graphic>
</fig>
<fig id="F11" orientation="portrait" position="float">
<label>Fig. 11</label>
<caption>
<p>
<italic>Cladosporium xantochromaticum</italic>
CBS 140691. a–c. Colonies on (a) PDA, (b) SNA and (c) OA after 14 d at 25 °C; d–f. conidiophores and chains of conidia. — Scale bars: a–c = 10 mm, d–f = 5 μm.</p>
</caption>
<graphic xlink:href="per-36-281-g011"></graphic>
</fig>
<table-wrap id="T1" orientation="portrait" position="float">
<label>Table 1</label>
<caption>
<p>Isolates and GenBank accession numbers of sequences included in this study.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" rowspan="1" colspan="1">Species
<xref ref-type="table-fn" rid="tfn1">
<sup>a</sup>
</xref>
</th>
<th align="left" rowspan="1" colspan="1">Strain number
<xref ref-type="table-fn" rid="tfn2">
<sup>b</sup>
</xref>
</th>
<th align="left" rowspan="1" colspan="1">Substrate
<xref ref-type="table-fn" rid="tfn3">
<sup>c</sup>
</xref>
</th>
<th colspan="3" align="center" rowspan="1">GenBank accession numbers
<hr></hr>
</th>
</tr>
<tr>
<th align="left" rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1">ITS</th>
<th align="left" rowspan="1" colspan="1">
<italic>tef1</italic>
</th>
<th align="left" rowspan="1" colspan="1">
<italic>ActA</italic>
</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cercospora beticola</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 116456</td>
<td align="left" rowspan="1" colspan="1">
<italic>Beta vulgaris</italic>
</td>
<td align="left" rowspan="1" colspan="1">NR_121315</td>
<td align="left" rowspan="1" colspan="1">AY840494</td>
<td align="left" rowspan="1" colspan="1">AY840458</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium acalyphae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125982
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Acalypha australis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM147994</td>
<td align="left" rowspan="1" colspan="1">HM148235</td>
<td align="left" rowspan="1" colspan="1">HM148481</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium aciculare</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140488
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Syzygium corynanthum</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600411</td>
<td align="left" rowspan="1" colspan="1">KT600509</td>
<td align="left" rowspan="1" colspan="1">KT600607</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium aggregatocicatricatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140493
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Culture contaminant</td>
<td align="left" rowspan="1" colspan="1">KT600448</td>
<td align="left" rowspan="1" colspan="1">KT600547</td>
<td align="left" rowspan="1" colspan="1">KT600645</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium alboflavescens</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140690
<sup>T</sup>
= UTHSC DI-13-225 = FMR 13338</td>
<td align="left" rowspan="1" colspan="1">Animal, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834420</td>
<td align="left" rowspan="1" colspan="1">LN834516</td>
<td align="left" rowspan="1" colspan="1">LN834604</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium allicinum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121.47</td>
<td align="left" rowspan="1" colspan="1">Food, frozen
<italic>Phaseolus vulgaris</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600364</td>
<td align="left" rowspan="1" colspan="1">KT600461</td>
<td align="left" rowspan="1" colspan="1">KT600560</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 121624
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Hordeum vulgare</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679350</td>
<td align="left" rowspan="1" colspan="1">EF679425</td>
<td align="left" rowspan="1" colspan="1">EF679502</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 160.59</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">KT600366</td>
<td align="left" rowspan="1" colspan="1">KT600463</td>
<td align="left" rowspan="1" colspan="1">KT600562</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 374.53</td>
<td align="left" rowspan="1" colspan="1">
<italic>Centaurea rhapontica = Rhaponticum scariosum</italic>
subsp
<italic>. rhaponticum</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600368</td>
<td align="left" rowspan="1" colspan="1">KT600465</td>
<td align="left" rowspan="1" colspan="1">KT600564</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 16759</td>
<td align="left" rowspan="1" colspan="1">
<italic>Alnus glutinosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600374</td>
<td align="left" rowspan="1" colspan="1">KT600471</td>
<td align="left" rowspan="1" colspan="1">KT600570</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-170 = FMR 13295</td>
<td align="left" rowspan="1" colspan="1">Human, toenail</td>
<td align="left" rowspan="1" colspan="1">LN834409</td>
<td align="left" rowspan="1" colspan="1">LN834505</td>
<td align="left" rowspan="1" colspan="1">LN834593</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-173 = FMR 13298</td>
<td align="left" rowspan="1" colspan="1">Human, lung</td>
<td align="left" rowspan="1" colspan="1">LN834353</td>
<td align="left" rowspan="1" colspan="1">LN834449</td>
<td align="left" rowspan="1" colspan="1">LN834537</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium allii</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 101.81</td>
<td align="left" rowspan="1" colspan="1">
<italic>Allium porrum</italic>
</td>
<td align="left" rowspan="1" colspan="1">JN906977</td>
<td align="left" rowspan="1" colspan="1">JN906983</td>
<td align="left" rowspan="1" colspan="1">JN906996</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium angulosum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140692
<sup>T</sup>
= UTHSC DI-13-235 = FMR 13348</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834425</td>
<td align="left" rowspan="1" colspan="1">LN834521</td>
<td align="left" rowspan="1" colspan="1">LN834609</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11526</td>
<td align="left" rowspan="1" colspan="1">
<italic>Acacia mangium</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148127</td>
<td align="left" rowspan="1" colspan="1">HM148371</td>
<td align="left" rowspan="1" colspan="1">HM148616</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14566</td>
<td align="left" rowspan="1" colspan="1">
<italic>Corymbia foelscheana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148147</td>
<td align="left" rowspan="1" colspan="1">HM148391</td>
<td align="left" rowspan="1" colspan="1">HM148636</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 18494</td>
<td align="left" rowspan="1" colspan="1">
<italic>Ananas comosus</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600413</td>
<td align="left" rowspan="1" colspan="1">KT600511</td>
<td align="left" rowspan="1" colspan="1">KT600609</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 18496</td>
<td align="left" rowspan="1" colspan="1">
<italic>Ananas comosus</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600414</td>
<td align="left" rowspan="1" colspan="1">KT600512</td>
<td align="left" rowspan="1" colspan="1">KT600610</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium angustiherbarum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140479
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Pinus ponderosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600378</td>
<td align="left" rowspan="1" colspan="1">KT600475</td>
<td align="left" rowspan="1" colspan="1">KT600574</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium angustisporum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125983
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Alloxylon wickhamii</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM147995</td>
<td align="left" rowspan="1" colspan="1">HM148236</td>
<td align="left" rowspan="1" colspan="1">HM148482</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-240 = FMR 13353</td>
<td align="left" rowspan="1" colspan="1">Human, nail</td>
<td align="left" rowspan="1" colspan="1">LN834356</td>
<td align="left" rowspan="1" colspan="1">LN834452</td>
<td align="left" rowspan="1" colspan="1">LN834540</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium angustiterminale</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140480
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Banksia grandis</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600379</td>
<td align="left" rowspan="1" colspan="1">KT600476</td>
<td align="left" rowspan="1" colspan="1">KT600575</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium antarcticum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 690.92
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Caloplaca regalis</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679334</td>
<td align="left" rowspan="1" colspan="1">EF679405</td>
<td align="left" rowspan="1" colspan="1">EF679484</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium anthropophilum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 117483</td>
<td align="left" rowspan="1" colspan="1">Unknown</td>
<td align="left" rowspan="1" colspan="1">HM148007</td>
<td align="left" rowspan="1" colspan="1">HM148248</td>
<td align="left" rowspan="1" colspan="1">HM148494</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 140685
<sup>T</sup>
= UTHSC DI-13-269 = FMR 13382</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834437</td>
<td align="left" rowspan="1" colspan="1">LN834533</td>
<td align="left" rowspan="1" colspan="1">LN834621</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11122</td>
<td align="left" rowspan="1" colspan="1">
<italic>Phytolacca americana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148019</td>
<td align="left" rowspan="1" colspan="1">HM148260</td>
<td align="left" rowspan="1" colspan="1">HM148506</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-168 = FMR 13293</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834407</td>
<td align="left" rowspan="1" colspan="1">LN834503</td>
<td align="left" rowspan="1" colspan="1">LN834591</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-169 = FMR 13294</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834408</td>
<td align="left" rowspan="1" colspan="1">LN834504</td>
<td align="left" rowspan="1" colspan="1">LN834592</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-178 = FMR 13303</td>
<td align="left" rowspan="1" colspan="1">Animal, abscess</td>
<td align="left" rowspan="1" colspan="1">LN834410</td>
<td align="left" rowspan="1" colspan="1">LN834506</td>
<td align="left" rowspan="1" colspan="1">LN834594</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-179 = FMR 13304</td>
<td align="left" rowspan="1" colspan="1">Human, hand</td>
<td align="left" rowspan="1" colspan="1">LN834411</td>
<td align="left" rowspan="1" colspan="1">LN834507</td>
<td align="left" rowspan="1" colspan="1">LN834595</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-207 = FMR 13320</td>
<td align="left" rowspan="1" colspan="1">Human, CSF</td>
<td align="left" rowspan="1" colspan="1">LN834413</td>
<td align="left" rowspan="1" colspan="1">LN834509</td>
<td align="left" rowspan="1" colspan="1">LN834597</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-226 = FMR 13339</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834421</td>
<td align="left" rowspan="1" colspan="1">LN834517</td>
<td align="left" rowspan="1" colspan="1">LN834605</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-228 = FMR 13341</td>
<td align="left" rowspan="1" colspan="1">Human, foot skin</td>
<td align="left" rowspan="1" colspan="1">LN834423</td>
<td align="left" rowspan="1" colspan="1">LN834519</td>
<td align="left" rowspan="1" colspan="1">LN834607</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-244 = FMR 13357</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834428</td>
<td align="left" rowspan="1" colspan="1">LN834524</td>
<td align="left" rowspan="1" colspan="1">LN834612</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-246 = FMR 13359</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834430</td>
<td align="left" rowspan="1" colspan="1">LN834526</td>
<td align="left" rowspan="1" colspan="1">LN834614</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-271 = FMR 13384</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834439</td>
<td align="left" rowspan="1" colspan="1">LN834535</td>
<td align="left" rowspan="1" colspan="1">LN834623</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium aphidis</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 132182
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Echium pininana</italic>
</td>
<td align="left" rowspan="1" colspan="1">JN906978</td>
<td align="left" rowspan="1" colspan="1">JN906984</td>
<td align="left" rowspan="1" colspan="1">JN906997</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium arthropodii</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 124043
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf lesions of rock lily</td>
<td align="left" rowspan="1" colspan="1">JN906979</td>
<td align="left" rowspan="1" colspan="1">JN906985</td>
<td align="left" rowspan="1" colspan="1">JN906998</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium asperulatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126339</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus</italic>
leaf litter</td>
<td align="left" rowspan="1" colspan="1">HM147997</td>
<td align="left" rowspan="1" colspan="1">HM148238</td>
<td align="left" rowspan="1" colspan="1">HM148484</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126340
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Protea susannae</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM147998</td>
<td align="left" rowspan="1" colspan="1">HM148239</td>
<td align="left" rowspan="1" colspan="1">HM148485</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium australiense</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125984
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus moluccana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM147999</td>
<td align="left" rowspan="1" colspan="1">HM148240</td>
<td align="left" rowspan="1" colspan="1">HM148486</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium austroafricanum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140481
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf litter</td>
<td align="left" rowspan="1" colspan="1">KT600381</td>
<td align="left" rowspan="1" colspan="1">KT600478</td>
<td align="left" rowspan="1" colspan="1">KT600577</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium austrohemisphaericum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140482
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Lagunaria patersonia</italic>
, black mould on fruit surface</td>
<td align="left" rowspan="1" colspan="1">KT600382</td>
<td align="left" rowspan="1" colspan="1">KT600479</td>
<td align="left" rowspan="1" colspan="1">KT600578</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium basiinflatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 822.84
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Hordeum vulgare</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148000</td>
<td align="left" rowspan="1" colspan="1">HM148241</td>
<td align="left" rowspan="1" colspan="1">HM148487</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium chalastosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125985
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Fruiting bodies of
<italic>T. proteae-arboreae</italic>
on leaves of
<italic>Protea arborea</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148001</td>
<td align="left" rowspan="1" colspan="1">HM148242</td>
<td align="left" rowspan="1" colspan="1">HM148488</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium chubutense</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 124457
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Needles of
<italic>Pinus ponderosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">FJ936158</td>
<td align="left" rowspan="1" colspan="1">FJ936161</td>
<td align="left" rowspan="1" colspan="1">FJ936165</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium cladosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 113738</td>
<td align="left" rowspan="1" colspan="1">Grape bud</td>
<td align="left" rowspan="1" colspan="1">HM148004</td>
<td align="left" rowspan="1" colspan="1">HM148245</td>
<td align="left" rowspan="1" colspan="1">HM148491</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 112388
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Indoor air</td>
<td align="left" rowspan="1" colspan="1">HM148003</td>
<td align="left" rowspan="1" colspan="1">HM148244</td>
<td align="left" rowspan="1" colspan="1">HM148490</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14292</td>
<td align="left" rowspan="1" colspan="1">Soil, pea field</td>
<td align="left" rowspan="1" colspan="1">HM148046</td>
<td align="left" rowspan="1" colspan="1">HM148287</td>
<td align="left" rowspan="1" colspan="1">HM148533</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-215 = FMR 13328</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834360</td>
<td align="left" rowspan="1" colspan="1">LN834456</td>
<td align="left" rowspan="1" colspan="1">LN834544</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium colocasiae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 386.64
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Colocasia antiquorum</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148067</td>
<td align="left" rowspan="1" colspan="1">HM148310</td>
<td align="left" rowspan="1" colspan="1">HM148555</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 119542</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Colocasia esculanta</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148066</td>
<td align="left" rowspan="1" colspan="1">HM148309</td>
<td align="left" rowspan="1" colspan="1">HM148554</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium colombiae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 274.80B
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Dead leaf, Cortaderia</td>
<td align="left" rowspan="1" colspan="1">FJ936159</td>
<td align="left" rowspan="1" colspan="1">FJ936163</td>
<td align="left" rowspan="1" colspan="1">FJ936166</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium crousii</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140686
<sup>T</sup>
= UTHSC DI-13-247 = FMR 13360</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834431</td>
<td align="left" rowspan="1" colspan="1">LN834527</td>
<td align="left" rowspan="1" colspan="1">LN834615</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium cucumerinum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 171.52
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">Fruit of
<italic>Cucumis sativus</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148072</td>
<td align="left" rowspan="1" colspan="1">HM148316</td>
<td align="left" rowspan="1" colspan="1">HM148561</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 173.54</td>
<td align="left" rowspan="1" colspan="1">Fruit of
<italic>Cucumis sativus</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148074</td>
<td align="left" rowspan="1" colspan="1">HM148318</td>
<td align="left" rowspan="1" colspan="1">HM148563</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium cycadicola</italic>
</td>
<td align="left" rowspan="1" colspan="1">CPC 17251
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaves of
<italic>Cycas media</italic>
</td>
<td align="left" rowspan="1" colspan="1">KJ869122</td>
<td align="left" rowspan="1" colspan="1">KJ869236</td>
<td align="left" rowspan="1" colspan="1">KJ869227</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium delicatulum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126342</td>
<td align="left" rowspan="1" colspan="1">Indoor building material</td>
<td align="left" rowspan="1" colspan="1">HM148079</td>
<td align="left" rowspan="1" colspan="1">HM148323</td>
<td align="left" rowspan="1" colspan="1">HM148568</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126344</td>
<td align="left" rowspan="1" colspan="1">Leaves of
<italic>Tilia cordata</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148081</td>
<td align="left" rowspan="1" colspan="1">HM148325</td>
<td align="left" rowspan="1" colspan="1">HM148570</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium dominicanum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119415
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">DQ780353</td>
<td align="left" rowspan="1" colspan="1">JN906986</td>
<td align="left" rowspan="1" colspan="1">EF101368</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium echinulatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 123191</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Dianthus barbatus</italic>
</td>
<td align="left" rowspan="1" colspan="1">JN906980</td>
<td align="left" rowspan="1" colspan="1">JN906987</td>
<td align="left" rowspan="1" colspan="1">JN906999</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium exasperatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125986
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus tintinnans</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148090</td>
<td align="left" rowspan="1" colspan="1">HM148334</td>
<td align="left" rowspan="1" colspan="1">HM148579</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium exile</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125987
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Chasmothecia of
<italic>P. guttata</italic>
on leaves of
<italic>Corylus avellana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148091</td>
<td align="left" rowspan="1" colspan="1">HM148335</td>
<td align="left" rowspan="1" colspan="1">HM148580</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium flabelliforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126345
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Melaleuca cajuputi</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148092</td>
<td align="left" rowspan="1" colspan="1">HM148336</td>
<td align="left" rowspan="1" colspan="1">HM148581</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-267 = FMR 13380</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834361</td>
<td align="left" rowspan="1" colspan="1">LN834457</td>
<td align="left" rowspan="1" colspan="1">LN834545</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium flavovirens</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140462
<sup>T</sup>
= UTHSC DI-13-273 = FMR 13386</td>
<td align="left" rowspan="1" colspan="1">Human, toenails</td>
<td align="left" rowspan="1" colspan="1">LN834440</td>
<td align="left" rowspan="1" colspan="1">LN834536</td>
<td align="left" rowspan="1" colspan="1">LN834624</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium floccosum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140463
<sup>T</sup>
= UTHSC DI-13-212 = FMR 13325</td>
<td align="left" rowspan="1" colspan="1">Human, ethmoid sinus</td>
<td align="left" rowspan="1" colspan="1">LN834416</td>
<td align="left" rowspan="1" colspan="1">LN834512</td>
<td align="left" rowspan="1" colspan="1">LN834600</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium funiculosum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 122128</td>
<td align="left" rowspan="1" colspan="1">
<italic>Ficus carica</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148093</td>
<td align="left" rowspan="1" colspan="1">HM148337</td>
<td align="left" rowspan="1" colspan="1">HM148582</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 122129
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Vigna umbellata</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148094</td>
<td align="left" rowspan="1" colspan="1">HM148338</td>
<td align="left" rowspan="1" colspan="1">HM148583</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-175 = FMR 13300</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834362</td>
<td align="left" rowspan="1" colspan="1">LN834458</td>
<td align="left" rowspan="1" colspan="1">LN834546</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium fusiforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119414
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">DQ780388</td>
<td align="left" rowspan="1" colspan="1">JN906988</td>
<td align="left" rowspan="1" colspan="1">EF101372</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium gamsianum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125989
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Strelitzia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148095</td>
<td align="left" rowspan="1" colspan="1">HM148339</td>
<td align="left" rowspan="1" colspan="1">HM148584</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium globisporum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 812.96
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Meat stamp</td>
<td align="left" rowspan="1" colspan="1">HM148096</td>
<td align="left" rowspan="1" colspan="1">HM148340</td>
<td align="left" rowspan="1" colspan="1">HM148585</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium grevilleae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 114271
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaves of
<italic>Grevillea</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">JF770450</td>
<td align="left" rowspan="1" colspan="1">JF770472</td>
<td align="left" rowspan="1" colspan="1">JF770473</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium halotolerans</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119416
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">DQ780364</td>
<td align="left" rowspan="1" colspan="1">JN906989</td>
<td align="left" rowspan="1" colspan="1">EF101397</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-250 = FMR 13363</td>
<td align="left" rowspan="1" colspan="1">Human, scalp</td>
<td align="left" rowspan="1" colspan="1">LN834374</td>
<td align="left" rowspan="1" colspan="1">LN834470</td>
<td align="left" rowspan="1" colspan="1">LN834558</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium herbaroides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121626
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">EF679357</td>
<td align="left" rowspan="1" colspan="1">EF679432</td>
<td align="left" rowspan="1" colspan="1">EF679509</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium herbarum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121621
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Hordeum vulgare</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679363</td>
<td align="left" rowspan="1" colspan="1">EF679440</td>
<td align="left" rowspan="1" colspan="1">EF679516</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-220 = FMR 13333</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834378</td>
<td align="left" rowspan="1" colspan="1">LN834474</td>
<td align="left" rowspan="1" colspan="1">LN834562</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium hillianum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125988
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaves of
<italic>Grevillea</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148097</td>
<td align="left" rowspan="1" colspan="1">HM148341</td>
<td align="left" rowspan="1" colspan="1">HM148586</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium inversicolor</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 143.65</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Tilia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148100</td>
<td align="left" rowspan="1" colspan="1">HM148344</td>
<td align="left" rowspan="1" colspan="1">HM148589</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 401.80
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Triticum aestivum</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148101</td>
<td align="left" rowspan="1" colspan="1">HM148345</td>
<td align="left" rowspan="1" colspan="1">HM148590</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium ipereniae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140483
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Puya</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600394</td>
<td align="left" rowspan="1" colspan="1">KT600491</td>
<td align="left" rowspan="1" colspan="1">KT600589</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 16855</td>
<td align="left" rowspan="1" colspan="1">
<italic>Arctostaphylos pallida</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600395</td>
<td align="left" rowspan="1" colspan="1">KT600492</td>
<td align="left" rowspan="1" colspan="1">KT600590</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium iranicum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126346
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Citrus sinensis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148110</td>
<td align="left" rowspan="1" colspan="1">HM148354</td>
<td align="left" rowspan="1" colspan="1">HM148599</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium iridis</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 138.40
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf of
<italic>Iris</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">EF679370</td>
<td align="left" rowspan="1" colspan="1">EF679447</td>
<td align="left" rowspan="1" colspan="1">EF679523</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium langeronii</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 189.54
<sup>NT</sup>
</td>
<td align="left" rowspan="1" colspan="1">Man</td>
<td align="left" rowspan="1" colspan="1">DQ780379</td>
<td align="left" rowspan="1" colspan="1">JN906990</td>
<td align="left" rowspan="1" colspan="1">EF101357</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium licheniphilum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125990
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">From
<italic>P. orbicularis</italic>
and
<italic>Physcia</italic>
sp. on
<italic>Acer platanoides</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148111</td>
<td align="left" rowspan="1" colspan="1">HM148355</td>
<td align="left" rowspan="1" colspan="1">HM148600</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium limoniforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 113737</td>
<td align="left" rowspan="1" colspan="1">Grape berry</td>
<td align="left" rowspan="1" colspan="1">KT600396</td>
<td align="left" rowspan="1" colspan="1">KT600493</td>
<td align="left" rowspan="1" colspan="1">KT600591</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 140484
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Musa acuminata</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600397</td>
<td align="left" rowspan="1" colspan="1">KT600494</td>
<td align="left" rowspan="1" colspan="1">KT600592</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium longicatenatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140485
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Unknown plant</td>
<td align="left" rowspan="1" colspan="1">KT600403</td>
<td align="left" rowspan="1" colspan="1">KT600500</td>
<td align="left" rowspan="1" colspan="1">KT600598</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium longissimum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 300.96
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Soil along coral reef coast</td>
<td align="left" rowspan="1" colspan="1">DQ780352</td>
<td align="left" rowspan="1" colspan="1">EU570259</td>
<td align="left" rowspan="1" colspan="1">EF101385</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium lycoperdinum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 574.78C</td>
<td align="left" rowspan="1" colspan="1">
<italic>Aureobasidium caulivorum</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148115</td>
<td align="left" rowspan="1" colspan="1">HM148359</td>
<td align="left" rowspan="1" colspan="1">HM148604</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126347</td>
<td align="left" rowspan="1" colspan="1">From galls of
<italic>Apiosporina morbosa</italic>
on
<italic>Prunus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148112</td>
<td align="left" rowspan="1" colspan="1">HM148356</td>
<td align="left" rowspan="1" colspan="1">HM148601</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium macrocarpum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121623
<sup>NT</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Spinacia oleracea</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679375</td>
<td align="left" rowspan="1" colspan="1">EF679453</td>
<td align="left" rowspan="1" colspan="1">EF679529</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-191 = FMR 13316</td>
<td align="left" rowspan="1" colspan="1">Human, face</td>
<td align="left" rowspan="1" colspan="1">LN834379</td>
<td align="left" rowspan="1" colspan="1">LN834475</td>
<td align="left" rowspan="1" colspan="1">LN834563</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium montecillanum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140486
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Pine needles</td>
<td align="left" rowspan="1" colspan="1">KT600406</td>
<td align="left" rowspan="1" colspan="1">KT600504</td>
<td align="left" rowspan="1" colspan="1">KT600602</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 15605</td>
<td align="left" rowspan="1" colspan="1">
<italic>Taraxacum</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600407</td>
<td align="left" rowspan="1" colspan="1">KT600505</td>
<td align="left" rowspan="1" colspan="1">KT600603</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium myrtacearum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126350
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Corymbia foelscheana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148117</td>
<td align="left" rowspan="1" colspan="1">HM148361</td>
<td align="left" rowspan="1" colspan="1">HM148606</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium ossifragi</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 842.91
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Narthecium ossifragum</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679381</td>
<td align="left" rowspan="1" colspan="1">EF679459</td>
<td align="left" rowspan="1" colspan="1">EF679535</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium oxysporum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125991</td>
<td align="left" rowspan="1" colspan="1">Soil</td>
<td align="left" rowspan="1" colspan="1">HM148118</td>
<td align="left" rowspan="1" colspan="1">HM148362</td>
<td align="left" rowspan="1" colspan="1">HM148607</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126351</td>
<td align="left" rowspan="1" colspan="1">Indoor air</td>
<td align="left" rowspan="1" colspan="1">HM148119</td>
<td align="left" rowspan="1" colspan="1">HM148363</td>
<td align="left" rowspan="1" colspan="1">HM148608</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium paracladosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 171.54
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Unknown</td>
<td align="left" rowspan="1" colspan="1">HM148120</td>
<td align="left" rowspan="1" colspan="1">HM148364</td>
<td align="left" rowspan="1" colspan="1">HM148609</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium parapenidielloides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140487
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600410</td>
<td align="left" rowspan="1" colspan="1">KT600508</td>
<td align="left" rowspan="1" colspan="1">KT600606</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium penidielloides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140489
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Acacia verticillata</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600412</td>
<td align="left" rowspan="1" colspan="1">KT600510</td>
<td align="left" rowspan="1" colspan="1">KT600608</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium perangustum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125996
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Cussonia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148121</td>
<td align="left" rowspan="1" colspan="1">HM148365</td>
<td align="left" rowspan="1" colspan="1">HM148610</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126365</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chasmothecia</italic>
of
<italic>Phyllactinia guttata</italic>
on leaves of
<italic>Corylus avellana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148123</td>
<td align="left" rowspan="1" colspan="1">HM148367</td>
<td align="left" rowspan="1" colspan="1">HM148612</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11663</td>
<td align="left" rowspan="1" colspan="1">
<italic>Oncoba spinosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148128</td>
<td align="left" rowspan="1" colspan="1">HM148372</td>
<td align="left" rowspan="1" colspan="1">HM148617</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11815</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chasmothecia</italic>
of
<italic>Phyllactinia guttata</italic>
on leaves of
<italic>Corylus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148130</td>
<td align="left" rowspan="1" colspan="1">HM148374</td>
<td align="left" rowspan="1" colspan="1">HM148619</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11819</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chasmothecia</italic>
of
<italic>Phyllactinia guttata</italic>
on leaves of
<italic>Corylus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148131</td>
<td align="left" rowspan="1" colspan="1">HM148375</td>
<td align="left" rowspan="1" colspan="1">HM148620</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11821</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chasmothecia</italic>
of
<italic>Phyllactinia guttata</italic>
on leaves of
<italic>Corylus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148132</td>
<td align="left" rowspan="1" colspan="1">HM148376</td>
<td align="left" rowspan="1" colspan="1">HM148621</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11831</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chasmothecia</italic>
of
<italic>Phyllactinia guttata</italic>
on leaves of
<italic>Corylus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148133</td>
<td align="left" rowspan="1" colspan="1">HM148377</td>
<td align="left" rowspan="1" colspan="1">HM148622</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 12216</td>
<td align="left" rowspan="1" colspan="1">
<italic>Morus rubra</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148135</td>
<td align="left" rowspan="1" colspan="1">HM148379</td>
<td align="left" rowspan="1" colspan="1">HM148624</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13727</td>
<td align="left" rowspan="1" colspan="1">
<italic>Teratosphaeria maculiformis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148139</td>
<td align="left" rowspan="1" colspan="1">HM148383</td>
<td align="left" rowspan="1" colspan="1">HM148628</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13730</td>
<td align="left" rowspan="1" colspan="1">
<italic>Protea caffra</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148140</td>
<td align="left" rowspan="1" colspan="1">HM148384</td>
<td align="left" rowspan="1" colspan="1">HM148629</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13774</td>
<td align="left" rowspan="1" colspan="1">
<italic>Protea caffra</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148141</td>
<td align="left" rowspan="1" colspan="1">HM148385</td>
<td align="left" rowspan="1" colspan="1">HM148630</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13870</td>
<td align="left" rowspan="1" colspan="1">
<italic>Teratosphaeria fibrillosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148142</td>
<td align="left" rowspan="1" colspan="1">HM148386</td>
<td align="left" rowspan="1" colspan="1">HM148631</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-208 = FMR 13321</td>
<td align="left" rowspan="1" colspan="1">Canine, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834380</td>
<td align="left" rowspan="1" colspan="1">LN834476</td>
<td align="left" rowspan="1" colspan="1">LN834564</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium phaenocomae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 128769
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf bracts of
<italic>Phaenocoma prolifera</italic>
</td>
<td align="left" rowspan="1" colspan="1">JF499837</td>
<td align="left" rowspan="1" colspan="1">JF499875</td>
<td align="left" rowspan="1" colspan="1">JF499881</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium phlei</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 358.69
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Phleum pratense</italic>
</td>
<td align="left" rowspan="1" colspan="1">JN906981</td>
<td align="left" rowspan="1" colspan="1">JN906991</td>
<td align="left" rowspan="1" colspan="1">JN907000</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium phyllactiniicola</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126353</td>
<td align="left" rowspan="1" colspan="1">Chasmothecia of
<italic>P. guttata</italic>
on leaves of
<italic>Corylus avellana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148151</td>
<td align="left" rowspan="1" colspan="1">HM148395</td>
<td align="left" rowspan="1" colspan="1">HM148640</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126355
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Chasmothecia of
<italic>P. guttata</italic>
on leaves of
<italic>Corylus avellana</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148153</td>
<td align="left" rowspan="1" colspan="1">HM148397</td>
<td align="left" rowspan="1" colspan="1">HM148642</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium phyllophilum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125992
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">Fruits of
<italic>Prunus cerasus</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148154</td>
<td align="left" rowspan="1" colspan="1">HM148398</td>
<td align="left" rowspan="1" colspan="1">HM148643</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium pini-ponderosae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 124456
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Pinus ponderosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">FJ936160</td>
<td align="left" rowspan="1" colspan="1">FJ936164</td>
<td align="left" rowspan="1" colspan="1">FJ936167</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium pseudiridis</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 116463
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Iris</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">EF679383</td>
<td align="left" rowspan="1" colspan="1">EF679461</td>
<td align="left" rowspan="1" colspan="1">EF679537</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium pseudochalastosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140490
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Pine needles</td>
<td align="left" rowspan="1" colspan="1">KT600415</td>
<td align="left" rowspan="1" colspan="1">KT600513</td>
<td align="left" rowspan="1" colspan="1">KT600611</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium pseudocladosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 667.80</td>
<td align="left" rowspan="1" colspan="1">
<italic>Malus sylvestris</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148165</td>
<td align="left" rowspan="1" colspan="1">HM148409</td>
<td align="left" rowspan="1" colspan="1">HM148654</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 125993
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Outside air</td>
<td align="left" rowspan="1" colspan="1">HM148158</td>
<td align="left" rowspan="1" colspan="1">HM148402</td>
<td align="left" rowspan="1" colspan="1">HM148647</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13683</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus placita</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148173</td>
<td align="left" rowspan="1" colspan="1">HM148417</td>
<td align="left" rowspan="1" colspan="1">HM148662</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14020</td>
<td align="left" rowspan="1" colspan="1">Wheat</td>
<td align="left" rowspan="1" colspan="1">HM148185</td>
<td align="left" rowspan="1" colspan="1">HM148429</td>
<td align="left" rowspan="1" colspan="1">HM148674</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14295</td>
<td align="left" rowspan="1" colspan="1">Soil</td>
<td align="left" rowspan="1" colspan="1">HM148188</td>
<td align="left" rowspan="1" colspan="1">HM148432</td>
<td align="left" rowspan="1" colspan="1">HM148677</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-165 = FMR 13290</td>
<td align="left" rowspan="1" colspan="1">Human, arm drainage</td>
<td align="left" rowspan="1" colspan="1">LN834406</td>
<td align="left" rowspan="1" colspan="1">LN834502</td>
<td align="left" rowspan="1" colspan="1">LN834590</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-190 = FMR 13315</td>
<td align="left" rowspan="1" colspan="1">Human, CSF</td>
<td align="left" rowspan="1" colspan="1">LN834412</td>
<td align="left" rowspan="1" colspan="1">LN834508</td>
<td align="left" rowspan="1" colspan="1">LN834596</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-210 = FMR 13323</td>
<td align="left" rowspan="1" colspan="1">Human, skin</td>
<td align="left" rowspan="1" colspan="1">LN834414</td>
<td align="left" rowspan="1" colspan="1">LN834510</td>
<td align="left" rowspan="1" colspan="1">LN834598</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium pseudocladosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-218 = FMR 13331</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834418</td>
<td align="left" rowspan="1" colspan="1">LN834514</td>
<td align="left" rowspan="1" colspan="1">LN834602</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">(cont.)</td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-227 = FMR 13340</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834422</td>
<td align="left" rowspan="1" colspan="1">LN834518</td>
<td align="left" rowspan="1" colspan="1">LN834606</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-234 = FMR 13347</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834424</td>
<td align="left" rowspan="1" colspan="1">LN834520</td>
<td align="left" rowspan="1" colspan="1">LN834608</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-238 = FMR 13351</td>
<td align="left" rowspan="1" colspan="1">Human, leg</td>
<td align="left" rowspan="1" colspan="1">LN834426</td>
<td align="left" rowspan="1" colspan="1">LN834522</td>
<td align="left" rowspan="1" colspan="1">LN834610</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-241 = FMR 13354</td>
<td align="left" rowspan="1" colspan="1">Human, foot</td>
<td align="left" rowspan="1" colspan="1">LN834427</td>
<td align="left" rowspan="1" colspan="1">LN834523</td>
<td align="left" rowspan="1" colspan="1">LN834611</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-245 = FMR 13358</td>
<td align="left" rowspan="1" colspan="1">Human, toe</td>
<td align="left" rowspan="1" colspan="1">LN834429</td>
<td align="left" rowspan="1" colspan="1">LN834525</td>
<td align="left" rowspan="1" colspan="1">LN834613</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-251 = FMR 13364</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834432</td>
<td align="left" rowspan="1" colspan="1">LN834528</td>
<td align="left" rowspan="1" colspan="1">LN834616</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-261 = FMR 13374</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834384</td>
<td align="left" rowspan="1" colspan="1">LN834480</td>
<td align="left" rowspan="1" colspan="1">LN834568</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-265 = FMR 13378</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834435</td>
<td align="left" rowspan="1" colspan="1">LN834531</td>
<td align="left" rowspan="1" colspan="1">LN834619</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-268 = FMR 13381</td>
<td align="left" rowspan="1" colspan="1">Human, toenail</td>
<td align="left" rowspan="1" colspan="1">LN834436</td>
<td align="left" rowspan="1" colspan="1">LN834532</td>
<td align="left" rowspan="1" colspan="1">LN834620</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-270 = FMR 13383</td>
<td align="left" rowspan="1" colspan="1">Human, nail</td>
<td align="left" rowspan="1" colspan="1">LN834438</td>
<td align="left" rowspan="1" colspan="1">LN834534</td>
<td align="left" rowspan="1" colspan="1">LN834622</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium psychrotolerans</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119412
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">DQ780386</td>
<td align="left" rowspan="1" colspan="1">JN906992</td>
<td align="left" rowspan="1" colspan="1">EF101365</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium puyae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 274.80A
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Puya goudotiana</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600418</td>
<td align="left" rowspan="1" colspan="1">KT600516</td>
<td align="left" rowspan="1" colspan="1">KT600614</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium ramotenellum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121628
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">EF679384</td>
<td align="left" rowspan="1" colspan="1">EF679462</td>
<td align="left" rowspan="1" colspan="1">EF679538</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-166 = FMR 13291</td>
<td align="left" rowspan="1" colspan="1">Human, nasal tissue</td>
<td align="left" rowspan="1" colspan="1">LN834385</td>
<td align="left" rowspan="1" colspan="1">LN834481</td>
<td align="left" rowspan="1" colspan="1">LN834569</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium rectoides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125994
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Vitis flexuosa</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148193</td>
<td align="left" rowspan="1" colspan="1">HM148438</td>
<td align="left" rowspan="1" colspan="1">HM148683</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium rhusicola</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140492
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Rhus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600440</td>
<td align="left" rowspan="1" colspan="1">KT600539</td>
<td align="left" rowspan="1" colspan="1">KT600637</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium ruguloflabelliforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140494
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Diatrapaceae</italic>
sp. on
<italic>Aloe</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600458</td>
<td align="left" rowspan="1" colspan="1">KT600557</td>
<td align="left" rowspan="1" colspan="1">KT600655</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium rugulovarians</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140495
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Leaf sheaths of unidentified
<italic>Poaceae</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600459</td>
<td align="left" rowspan="1" colspan="1">KT600558</td>
<td align="left" rowspan="1" colspan="1">KT600656</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium salinae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119413
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">DQ780374</td>
<td align="left" rowspan="1" colspan="1">JN906993</td>
<td align="left" rowspan="1" colspan="1">EF101390</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium scabrellum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126358
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Ruscus hypoglossum</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148195</td>
<td align="left" rowspan="1" colspan="1">HM148440</td>
<td align="left" rowspan="1" colspan="1">HM148685</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium silenes</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 109082</td>
<td align="left" rowspan="1" colspan="1">
<italic>Silene maritima</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679354</td>
<td align="left" rowspan="1" colspan="1">EF679429</td>
<td align="left" rowspan="1" colspan="1">EF679506</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium sinuosum</italic>
</td>
<td align="left" rowspan="1" colspan="1">ATCC 11285</td>
<td align="left" rowspan="1" colspan="1">Unidentified moss</td>
<td align="left" rowspan="1" colspan="1">KT600441</td>
<td align="left" rowspan="1" colspan="1">KT600540</td>
<td align="left" rowspan="1" colspan="1">KT600638</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 393.68</td>
<td align="left" rowspan="1" colspan="1">Air</td>
<td align="left" rowspan="1" colspan="1">KT600442</td>
<td align="left" rowspan="1" colspan="1">KT600541</td>
<td align="left" rowspan="1" colspan="1">KT600639</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 121629
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Fuchsia excorticata</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679386</td>
<td align="left" rowspan="1" colspan="1">EF679464</td>
<td align="left" rowspan="1" colspan="1">EF679540</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14000</td>
<td align="left" rowspan="1" colspan="1">Wheat</td>
<td align="left" rowspan="1" colspan="1">KT600443</td>
<td align="left" rowspan="1" colspan="1">KT600542</td>
<td align="left" rowspan="1" colspan="1">KT600640</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 15454</td>
<td align="left" rowspan="1" colspan="1">
<italic>Crocus sativus</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600444</td>
<td align="left" rowspan="1" colspan="1">KT600543</td>
<td align="left" rowspan="1" colspan="1">KT600641</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 18365</td>
<td align="left" rowspan="1" colspan="1">
<italic>Iris pseudacorus</italic>
</td>
<td align="left" rowspan="1" colspan="1">KT600446</td>
<td align="left" rowspan="1" colspan="1">KT600545</td>
<td align="left" rowspan="1" colspan="1">KT600643</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium soldanellae</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 132186
<sup>NT</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Soldanella alpina</italic>
</td>
<td align="left" rowspan="1" colspan="1">JN906982</td>
<td align="left" rowspan="1" colspan="1">JN906994</td>
<td align="left" rowspan="1" colspan="1">JN907001</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium sphaerospermum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 193.54
<sup>NT</sup>
</td>
<td align="left" rowspan="1" colspan="1">Human, nail</td>
<td align="left" rowspan="1" colspan="1">DQ780343</td>
<td align="left" rowspan="1" colspan="1">EU570261</td>
<td align="left" rowspan="1" colspan="1">EU570269</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-237 = FMR 13350</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834390</td>
<td align="left" rowspan="1" colspan="1">LN834486</td>
<td align="left" rowspan="1" colspan="1">LN834574</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium spinulosum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119907
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">EF679388</td>
<td align="left" rowspan="1" colspan="1">EF679466</td>
<td align="left" rowspan="1" colspan="1">EF679542</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium subinflatum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121630
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">EF679389</td>
<td align="left" rowspan="1" colspan="1">EF679467</td>
<td align="left" rowspan="1" colspan="1">EF679543</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-189 = FMR 13314</td>
<td align="left" rowspan="1" colspan="1">Human, toenail</td>
<td align="left" rowspan="1" colspan="1">LN834391</td>
<td align="left" rowspan="1" colspan="1">LN834487</td>
<td align="left" rowspan="1" colspan="1">LN834575</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium subtilissimum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 113754
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Grape berry</td>
<td align="left" rowspan="1" colspan="1">EF679397</td>
<td align="left" rowspan="1" colspan="1">EF679475</td>
<td align="left" rowspan="1" colspan="1">EF679551</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium subuliforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126500
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Chamaedorea metallica</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148196</td>
<td align="left" rowspan="1" colspan="1">HM148441</td>
<td align="left" rowspan="1" colspan="1">HM148686</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-214 = FMR 13327</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834394</td>
<td align="left" rowspan="1" colspan="1">LN834490</td>
<td align="left" rowspan="1" colspan="1">LN834578</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium subcinereum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140465
<sup>T</sup>
= UTHSC DI-13-257 = FMR 13370</td>
<td align="left" rowspan="1" colspan="1">Human, sputum</td>
<td align="left" rowspan="1" colspan="1">LN834433</td>
<td align="left" rowspan="1" colspan="1">LN834529</td>
<td align="left" rowspan="1" colspan="1">LN834617</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium succulentum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140466
<sup>T</sup>
= UTHSC DI-13-262 = FMR 13375</td>
<td align="left" rowspan="1" colspan="1">Dolphin, bronchus</td>
<td align="left" rowspan="1" colspan="1">LN834434</td>
<td align="left" rowspan="1" colspan="1">LN834530</td>
<td align="left" rowspan="1" colspan="1">LN834618</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium tenellum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121634
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Hypersaline water</td>
<td align="left" rowspan="1" colspan="1">EF679401</td>
<td align="left" rowspan="1" colspan="1">EF679479</td>
<td align="left" rowspan="1" colspan="1">EF679555</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium tenuissimum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125995
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">Fruits of
<italic>Lagerstroemia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148197</td>
<td align="left" rowspan="1" colspan="1">HM148442</td>
<td align="left" rowspan="1" colspan="1">HM148687</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 10882</td>
<td align="left" rowspan="1" colspan="1">
<italic>Gnaphalium affine</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148204</td>
<td align="left" rowspan="1" colspan="1">HM148449</td>
<td align="left" rowspan="1" colspan="1">HM148694</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11555</td>
<td align="left" rowspan="1" colspan="1">
<italic>Citrus sinensis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148205</td>
<td align="left" rowspan="1" colspan="1">HM148450</td>
<td align="left" rowspan="1" colspan="1">HM148695</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11805</td>
<td align="left" rowspan="1" colspan="1">
<italic>Strelitzia</italic>
sp</td>
<td align="left" rowspan="1" colspan="1">HM148207</td>
<td align="left" rowspan="1" colspan="1">HM148452</td>
<td align="left" rowspan="1" colspan="1">HM148697</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 12795</td>
<td align="left" rowspan="1" colspan="1">
<italic>Musa</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148209</td>
<td align="left" rowspan="1" colspan="1">HM148454</td>
<td align="left" rowspan="1" colspan="1">HM148699</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 13222</td>
<td align="left" rowspan="1" colspan="1">
<italic>Callistemon viminalis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148210</td>
<td align="left" rowspan="1" colspan="1">HM148455</td>
<td align="left" rowspan="1" colspan="1">HM148700</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 14250</td>
<td align="left" rowspan="1" colspan="1">
<italic>Magnolia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148211</td>
<td align="left" rowspan="1" colspan="1">HM148456</td>
<td align="left" rowspan="1" colspan="1">HM148701</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-258 = FMR 13371</td>
<td align="left" rowspan="1" colspan="1">Human, thorancentesis fluid</td>
<td align="left" rowspan="1" colspan="1">LN834404</td>
<td align="left" rowspan="1" colspan="1">LN834500</td>
<td align="left" rowspan="1" colspan="1">LN834588</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium tuberosum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140693
<sup>T</sup>
= UTHSC DI-13-217 = FMR 13330</td>
<td align="left" rowspan="1" colspan="1">Human, nasal</td>
<td align="left" rowspan="1" colspan="1">LN834417</td>
<td align="left" rowspan="1" colspan="1">LN834513</td>
<td align="left" rowspan="1" colspan="1">LN834601</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">UTHSC DI-13-219 = FMR 13332</td>
<td align="left" rowspan="1" colspan="1">Human, foot</td>
<td align="left" rowspan="1" colspan="1">LN834419</td>
<td align="left" rowspan="1" colspan="1">LN834515</td>
<td align="left" rowspan="1" colspan="1">LN834603</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium variabile</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 121635
<sup>ET</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Spinacia oleracea</italic>
</td>
<td align="left" rowspan="1" colspan="1">EF679402</td>
<td align="left" rowspan="1" colspan="1">EF679480</td>
<td align="left" rowspan="1" colspan="1">EF679556</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium varians</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126362
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Catalpa bungei</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148224</td>
<td align="left" rowspan="1" colspan="1">HM148470</td>
<td align="left" rowspan="1" colspan="1">HM148715</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium velox</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 119417
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">Bamboo</td>
<td align="left" rowspan="1" colspan="1">DQ780361</td>
<td align="left" rowspan="1" colspan="1">JN906995</td>
<td align="left" rowspan="1" colspan="1">EF101388</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium verrucocladosporioides</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 126363
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Rhus chinensis</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148226</td>
<td align="left" rowspan="1" colspan="1">HM148472</td>
<td align="left" rowspan="1" colspan="1">HM148717</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium versiforme</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140491
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Hordeum</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">KT600417</td>
<td align="left" rowspan="1" colspan="1">KT600515</td>
<td align="left" rowspan="1" colspan="1">KT600613</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<bold>
<italic>Cladosporium xantochromaticum</italic>
</bold>
</td>
<td align="left" rowspan="1" colspan="1">CBS 140691
<sup>T</sup>
= UTHSC DI-13-211 = FMR 13324</td>
<td align="left" rowspan="1" colspan="1">Human, BAL</td>
<td align="left" rowspan="1" colspan="1">LN834415</td>
<td align="left" rowspan="1" colspan="1">LN834511</td>
<td align="left" rowspan="1" colspan="1">LN834599</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CBS 126364</td>
<td align="left" rowspan="1" colspan="1">
<italic>Erythrophleum chlorostachys</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148122</td>
<td align="left" rowspan="1" colspan="1">HM148366</td>
<td align="left" rowspan="1" colspan="1">HM148611</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11133</td>
<td align="left" rowspan="1" colspan="1">
<italic>Eucalyptus</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148126</td>
<td align="left" rowspan="1" colspan="1">HM148370</td>
<td align="left" rowspan="1" colspan="1">HM148615</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11609</td>
<td align="left" rowspan="1" colspan="1">
<italic>Musa</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">EF679356</td>
<td align="left" rowspan="1" colspan="1">EF679431</td>
<td align="left" rowspan="1" colspan="1">EF679508</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11806</td>
<td align="left" rowspan="1" colspan="1">
<italic>Strelitzia</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148129</td>
<td align="left" rowspan="1" colspan="1">HM148373</td>
<td align="left" rowspan="1" colspan="1">HM148618</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 11856</td>
<td align="left" rowspan="1" colspan="1">
<italic>Acacia mangium</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148134</td>
<td align="left" rowspan="1" colspan="1">HM148378</td>
<td align="left" rowspan="1" colspan="1">HM148623</td>
</tr>
<tr>
<td rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">CPC 12792</td>
<td align="left" rowspan="1" colspan="1">
<italic>Musa</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">HM148136</td>
<td align="left" rowspan="1" colspan="1">HM148380</td>
<td align="left" rowspan="1" colspan="1">HM148625</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">
<italic>Cladosporium xylophilum</italic>
</td>
<td align="left" rowspan="1" colspan="1">CBS 125997
<sup>T</sup>
</td>
<td align="left" rowspan="1" colspan="1">
<italic>Picea abies</italic>
</td>
<td align="left" rowspan="1" colspan="1">HM148230</td>
<td align="left" rowspan="1" colspan="1">HM148476</td>
<td align="left" rowspan="1" colspan="1">HM148721</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="tfn1">
<p>
<sup>a</sup>
New species described in this study are in
<bold>
<italic>bolditalic</italic>
</bold>
.</p>
</fn>
<fn id="tfn2">
<p>
<sup>b</sup>
ATCC, American Type Culture Collection, Manassas, VA, USA; CBS, CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherlands; CPC, collection of Pedro Crous at CBS; FMR, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain; UTHSC, Fungus Testing Laboratory at the University of Texas Health Science Center, San Antonio, Texas, USA.</p>
</fn>
<fn id="tfn3">
<p>
<sup>c</sup>
BAL fluid, bronchoalveolar lavage fluid specimen; CSF, cerebrospinal fluid.</p>
</fn>
<fn id="tfn4">
<p>
<sup>T</sup>
Ex-type strain.</p>
</fn>
<fn id="tfn5">
<p>
<sup>ET</sup>
Ex-epitype strain.</p>
</fn>
<fn id="tfn6">
<p>
<sup>NT</sup>
Ex-neotype strain.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>

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