STENOFOLIA Recruits TOPLESS to Repress ASYMMETRIC LEAVES2 at the Leaf Margin and Promote Leaf Blade Outgrowth in Medicago truncatula[C][W]
Identifieur interne : 000015 ( Pmc/Corpus ); précédent : 000014; suivant : 000016STENOFOLIA Recruits TOPLESS to Repress ASYMMETRIC LEAVES2 at the Leaf Margin and Promote Leaf Blade Outgrowth in Medicago truncatula[C][W]
Auteurs : Fei Zhang ; Yewei Wang ; Guifen Li ; Yuhong Tang ; Elena M. Kramer ; Million TadegeSource :
- The Plant Cell [ 1040-4651 ] ; 2014.
Abstract
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DOI: 10.1105/tpc.113.121947
PubMed: 24585835
PubMed Central: 3967031
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">STENOFOLIA Recruits TOPLESS to Repress <italic>ASYMMETRIC LEAVES2</italic> at the Leaf Margin and Promote Leaf Blade Outgrowth in <italic>Medicago truncatula</italic><xref ref-type="fn" rid="fn1"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn2"><sup>[W]</sup></xref></title><author><name sortKey="Zhang, Fei" sort="Zhang, Fei" uniqKey="Zhang F" first="Fei" last="Zhang">Fei Zhang</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Wang, Yewei" sort="Wang, Yewei" uniqKey="Wang Y" first="Yewei" last="Wang">Yewei Wang</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Li, Guifen" sort="Li, Guifen" uniqKey="Li G" first="Guifen" last="Li">Guifen Li</name><affiliation><nlm:aff id="aff2">Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Tang, Yuhong" sort="Tang, Yuhong" uniqKey="Tang Y" first="Yuhong" last="Tang">Yuhong Tang</name><affiliation><nlm:aff id="aff2">Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Kramer, Elena M" sort="Kramer, Elena M" uniqKey="Kramer E" first="Elena M." last="Kramer">Elena M. Kramer</name><affiliation><nlm:aff id="aff3">Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138</nlm:aff></affiliation></author><author><name sortKey="Tadege, Million" sort="Tadege, Million" uniqKey="Tadege M" first="Million" last="Tadege">Million Tadege</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24585835</idno><idno type="pmc">3967031</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967031</idno><idno type="RBID">PMC:3967031</idno><idno type="doi">10.1105/tpc.113.121947</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000015</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">STENOFOLIA Recruits TOPLESS to Repress <italic>ASYMMETRIC LEAVES2</italic> at the Leaf Margin and Promote Leaf Blade Outgrowth in <italic>Medicago truncatula</italic><xref ref-type="fn" rid="fn1"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn2"><sup>[W]</sup></xref></title><author><name sortKey="Zhang, Fei" sort="Zhang, Fei" uniqKey="Zhang F" first="Fei" last="Zhang">Fei Zhang</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Wang, Yewei" sort="Wang, Yewei" uniqKey="Wang Y" first="Yewei" last="Wang">Yewei Wang</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Li, Guifen" sort="Li, Guifen" uniqKey="Li G" first="Guifen" last="Li">Guifen Li</name><affiliation><nlm:aff id="aff2">Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Tang, Yuhong" sort="Tang, Yuhong" uniqKey="Tang Y" first="Yuhong" last="Tang">Yuhong Tang</name><affiliation><nlm:aff id="aff2">Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author><author><name sortKey="Kramer, Elena M" sort="Kramer, Elena M" uniqKey="Kramer E" first="Elena M." last="Kramer">Elena M. Kramer</name><affiliation><nlm:aff id="aff3">Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138</nlm:aff></affiliation></author><author><name sortKey="Tadege, Million" sort="Tadege, Million" uniqKey="Tadege M" first="Million" last="Tadege">Million Tadege</name><affiliation><nlm:aff id="aff1">Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</nlm:aff></affiliation></author></analytic><series><title level="j">The Plant Cell</title><idno type="ISSN">1040-4651</idno><idno type="eISSN">1532-298X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The <italic>M. truncatula</italic> WOX protein STENOFOLIA (STF) physically interacts with TOPLESS (Mt-TPL) and TPL-related corepressors via its conserved WUS box and STF box motifs and directly represses <italic>ASYMMETRIC LEAVES2</italic> expression at the leaf margin to promote leaf blade outgrowth in <italic>M. truncatula</italic>.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Cell</journal-id><journal-id journal-id-type="iso-abbrev">Plant Cell</journal-id><journal-id journal-id-type="hwp">plantcell</journal-id><journal-id journal-id-type="publisher-id">aspb</journal-id><journal-title-group><journal-title>The Plant Cell</journal-title></journal-title-group><issn pub-type="ppub">1040-4651</issn><issn pub-type="epub">1532-298X</issn><publisher><publisher-name>American Society of Plant Biologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24585835</article-id><article-id pub-id-type="pmc">3967031</article-id><article-id pub-id-type="publisher-id">121947</article-id><article-id pub-id-type="doi">10.1105/tpc.113.121947</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title>STENOFOLIA Recruits TOPLESS to Repress <italic>ASYMMETRIC LEAVES2</italic> at the Leaf Margin and Promote Leaf Blade Outgrowth in <italic>Medicago truncatula</italic><xref ref-type="fn" rid="fn1"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn2"><sup>[W]</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Fei</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yewei</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Guifen</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Yuhong</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kramer</surname><given-names>Elena M.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tadege</surname><given-names>Million</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><label>a</label>Department of Plant and Soil Sciences, Institute for Agricultural Biosciences, Oklahoma State University, Ardmore, Oklahoma 73401</aff><aff id="aff2"><label>b</label>Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401</aff><aff id="aff3"><label>c</label>Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138</aff></contrib-group><author-notes><corresp id="cor1"><label>1</label>Address correspondence to <email>million.tadege@okstate.edu</email>.</corresp><fn id="afn1"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantcell.org">www.plantcell.org</ext-link>) is: Million Tadege (<email>million.tadege@okstate.edu</email>).</p></fn><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantcell.org/cgi/doi/10.1105/tpc.113.121947">www.plantcell.org/cgi/doi/10.1105/tpc.113.121947</ext-link></p></fn></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>2</month><year>2014</year></pub-date><volume>26</volume><issue>2</issue><fpage>650</fpage><lpage>664</lpage><history><date date-type="received"><day>14</day><month>12</month><year>2013</year></date><date date-type="rev-recd"><day>28</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>03</day><month>2</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 American Society of Plant Biologists. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:role="icon" xlink:type="simple" xlink:href="PC_121947_ic1.gif"></self-uri><abstract abstract-type="precis"><p>The <italic>M. truncatula</italic> WOX protein STENOFOLIA (STF) physically interacts with TOPLESS (Mt-TPL) and TPL-related corepressors via its conserved WUS box and STF box motifs and directly represses <italic>ASYMMETRIC LEAVES2</italic> expression at the leaf margin to promote leaf blade outgrowth in <italic>M. truncatula</italic>.</p></abstract><abstract><p>The <italic>Medicago truncatula WUSCHEL</italic>-related homeobox (<italic>WOX</italic>) gene, <italic>STENOFOLIA</italic> (<italic>STF</italic>), plays a key role in leaf blade outgrowth by promoting cell proliferation at the adaxial-abaxial junction. <italic>STF</italic> functions primarily as a transcriptional repressor, but the underlying molecular mechanism is unknown. Here, we report the identification of a protein interaction partner and a direct target, shedding light on the mechanism of <italic>STF</italic> function. Two highly conserved motifs in the C-terminal domain of STF, the WUSCHEL (WUS) box and the STF box, cooperatively recruit TOPLESS (Mt-TPL) family corepressors, and this recruitment is required for STF function, as deletion of these two domains (STFdel) impaired blade outgrowth whereas fusing Mt-TPL to STFdel restored function. The homeodomain motif is required for direct repression of <italic>ASYMMETRIC LEAVES2</italic> (Mt-<italic>AS2</italic>), silencing of which partially rescues the <italic>stf</italic> mutant phenotype. <italic>STF</italic> and <italic>LAMINALESS1</italic> (<italic>LAM1</italic>) are functional orthologs. A single amino acid (Asn to Ile) substitution in the homeodomain abolished the repression of Mt-<italic>AS2</italic> and STF’s ability to complement the <italic>lam1</italic> mutant of <italic>Nicotiana sylvestris</italic>. Our data together support a model in which STF recruits corepressors to transcriptionally repress its targets during leaf blade morphogenesis. We propose that recruitment of TPL/TPL-related proteins may be a common mechanism in the repressive function of modern/WUS clade <italic>WOX</italic> genes.</p></abstract><counts><page-count count="15"></page-count></counts></article-meta><notes><glossary><title>Glossary</title><def-list><def-item><term id="term1">NTD</term><def id="def1"><p>N-terminal domain</p></def></def-item><def-item><term id="term2">HD</term><def id="def2"><p>homeodomain</p></def></def-item><def-item><term id="term3">MD</term><def id="def3"><p>middle domain</p></def></def-item><def-item><term id="term4">CTD</term><def id="def4"><p>C-terminal domain</p></def></def-item><def-item><term id="term5">EAR</term><def id="def5"><p>ethylene-responsive element binding factor–associated amphiphilic repression</p></def></def-item><def-item><term id="term6">Y2H</term><def id="def6"><p>yeast two-hybrid</p></def></def-item><def-item><term id="term7">BiFC</term><def id="def7"><p>bimolecular fluorescence complementation</p></def></def-item><def-item><term id="term8">ChIP</term><def id="def8"><p>chromatin immunoprecipitation</p></def></def-item><def-item><term id="term9">EMSA</term><def id="def9"><p>electrophoretic mobility shift assay</p></def></def-item><def-item><term id="term10">L<italic>er</italic></term><def id="def10"><p>Landsberg <italic>erecta</italic></p></def></def-item><def-item><term id="term11">RNAi</term><def id="def11"><p>RNA interference</p></def></def-item></def-list></glossary></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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