Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions
Identifieur interne : 001010 ( Pmc/Checkpoint ); précédent : 001009; suivant : 001011Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions
Auteurs : Jian-You Lin ; Christopher Roman ; Steve ReillySource :
- Brain research [ 0006-8993 ] ; 2009.
Abstract
Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.
Url:
DOI: 10.1016/j.brainres.2009.07.033
PubMed: 19631620
PubMed Central: 2752605
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions</title><author><name sortKey="Lin, Jian You" sort="Lin, Jian You" uniqKey="Lin J" first="Jian-You" last="Lin">Jian-You Lin</name></author><author><name sortKey="Roman, Christopher" sort="Roman, Christopher" uniqKey="Roman C" first="Christopher" last="Roman">Christopher Roman</name></author><author><name sortKey="Reilly, Steve" sort="Reilly, Steve" uniqKey="Reilly S" first="Steve" last="Reilly">Steve Reilly</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19631620</idno><idno type="pmc">2752605</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752605</idno><idno type="RBID">PMC:2752605</idno><idno type="doi">10.1016/j.brainres.2009.07.033</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000A53</idno><idno type="wicri:Area/Pmc/Curation">000A52</idno><idno type="wicri:Area/Pmc/Checkpoint">001010</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions</title><author><name sortKey="Lin, Jian You" sort="Lin, Jian You" uniqKey="Lin J" first="Jian-You" last="Lin">Jian-You Lin</name></author><author><name sortKey="Roman, Christopher" sort="Roman, Christopher" uniqKey="Roman C" first="Christopher" last="Roman">Christopher Roman</name></author><author><name sortKey="Reilly, Steve" sort="Reilly, Steve" uniqKey="Reilly S" first="Steve" last="Reilly">Steve Reilly</name></author></analytic><series><title level="j">Brain research</title><idno type="ISSN">0006-8993</idno><idno type="eISSN">1872-6240</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0045503</journal-id><journal-id journal-id-type="pubmed-jr-id">1920</journal-id><journal-id journal-id-type="nlm-ta">Brain Res</journal-id><journal-title>Brain research</journal-title><issn pub-type="ppub">0006-8993</issn><issn pub-type="epub">1872-6240</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19631620</article-id><article-id pub-id-type="pmc">2752605</article-id><article-id pub-id-type="doi">10.1016/j.brainres.2009.07.033</article-id><article-id pub-id-type="manuscript">NIHMS134542</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Jian-You</given-names></name></contrib><contrib contrib-type="author"><name><surname>Roman</surname><given-names>Christopher</given-names></name></contrib><contrib contrib-type="author"><name><surname>Reilly</surname><given-names>Steve</given-names></name></contrib><aff id="A1">Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA</aff></contrib-group><author-notes><corresp id="FN1">Correspondence: Steve Reilly, Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, Tel: (312) 413-2625, Fax: (312) 413-4122, Email: <email>sreilly@uic.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>7</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>23</day><month>7</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>6</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>9</month><year>2010</year></pub-date><volume>1292</volume><fpage>52</fpage><lpage>60</lpage><abstract><p id="P2">Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.</p></abstract><kwd-group><kwd>Insular cortex</kwd><kwd>Taste</kwd><kwd>Odor</kwd><kwd>Morphine</kwd><kwd>Rat</kwd></kwd-group><contract-num rid="DC1">R01 DC006456-03</contract-num><contract-num rid="DC1">R01 DC004341-05</contract-num><contract-sponsor id="DC1">National Institute on Deafness and Other Communication Disorders : NIDCD</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Lin, Jian You" sort="Lin, Jian You" uniqKey="Lin J" first="Jian-You" last="Lin">Jian-You Lin</name><name sortKey="Reilly, Steve" sort="Reilly, Steve" uniqKey="Reilly S" first="Steve" last="Reilly">Steve Reilly</name><name sortKey="Roman, Christopher" sort="Roman, Christopher" uniqKey="Roman C" first="Christopher" last="Roman">Christopher Roman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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